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Adrafinil Vs Modafinil, Yomwe Imayenera Kwa Inu
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Adrafinil Vs Modafinil, Ndi Yiti Yemwe Ali Yothandiza Kwa Inu?

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3. Kodi Adrafinil Ndi Yolimbikitsa?

onse Adrafinil ndipo Modafinil ndi zosangalatsa nootropics kuti apititse patsogolo ntchito zamaganizo. Eugeroics iwiri imalimbikitsa brainpower ndikulimbikitsa kukweza. Kotero, iwo akhoza kukhala chinthu choyambirira pamene iwe uli mtulo kwambiri, komabe iwe uyenera kuti uzigwira ntchito kudutsa usiku wako.

Caffeine, amphetamines, ndi zowonjezereka zowonjezereka nthawi zonse zimayambitsa dongosolo lonse la mitsempha komanso ntchito za thupi. Komabe, adrafinil ndi modafinil adzasindikizira ziwalo za ubongo.

Zochita za nootropics pa ubongo nthawi zambiri zimatha. Amayesetsa kukhala osamala popanda kuletsa mavuto ochotsera odwala, monga kupweteka, kusokonezeka, kapena kutopa. Mankhwalawa mosakayikitsa amalangizi abwino kwambiri a matenda osokoneza bongo komanso matenda okhudza kugona.

Kotero, ndi chiyani chomwe chimayankhula adrafinil vs modafinil? Tiyeni tiwone.

Mbiri ya Adrafinil vs Modafinil aasraw

Adrafinil anapezeka koyamba ku France mu 1974 ndi Lafon Pharmaceuticals zomwe anapezazo zinali ndi chiwonongeko cha chiwonongeko kuyambira pamene akatswiri anali kuyesa kupanga zinyama. Kampaniyi inagwirizana ndi wofufuza kafukufuku wotchuka, Michel Jouvet, kuti ayese mbali ya chigawo ichi mu kugona kwa maganizo ndi ubongo wa ubongo.

Mu 1984, Lafon Pharmaceuticals anamasulidwa adrafinil mu msika wa France. Mankhwalawa pambuyo pake adalangizidwa ngati mankhwala osokoneza bongo mu 1985. Zaka zinayi pambuyo pake, chinthucho chinali mkwiyo wonse ku US ndi dziko lonse lapansi.

Mu 1976, a psychonauts a Lafon adrafinil adapeza kuti panali chogwiritsidwa ntchito, chomwe chinayambitsa zotsatira za adrafinil. Ophunzirawo anatsimikizira kuti anali mankhwala a metabolite. Adrafinil ndi prodrug, yomwe iyenera kuyamba yoyambitsidwa ndi chiwindi mu modafinil.

Akatswiri ofufuza a Lafon anayamba ntchito yochotsa mitsempha yotchedwa metabolite yogwira ntchito. Pambuyo podzipatula bwino, gululo linabwera ndi mankhwala osokoneza bongo. Chigawocho chinali champhamvu kwambiri, ndipo chinapereka zotsatira zofulumira kuposa zowonjezerapo. Pogwiritsa ntchito 1994, akuluakulu a ku France anali atavomereza.

Mu 1998, modafinil adagonjetsa mgwirizano wa FDA monga mankhwala osokoneza bongo. Patapita zaka zisanu, mankhwalawa anawonetsedwa kwa odwala omwe amadwala matenda a tsiku ndi tsiku, omwe amalepheretsa munthu kugona tulo komanso anthu omwe ali ndi vuto la kugona.

Mu 2001, Cephalon Inc., kampani inayake ya ku America, anagula Laboratoire Lafon kwa $ 450 miliyoni. Zaka khumi pambuyo pake, kampaniyi inaletsa kulembetsa adrafinil monga FDA inachotsa chilolezo chawo.

Raw adrafinil ndi chigawo ndi nambala ya CAS 63547-13-7 pamene modafinil ikuyimiridwa ndi 68693-11-8.

Brand NMamuna wa Adrafinil vs Modafinil aasraw

Laboratoire Lafon poyamba anagulitsa adrafinil ufa pansi pa dzina, Olmifon.

Modafinil amagulitsidwa ngati Provigil®. Maina ena ogulitsa malonda amphatikizapo;

  • Modalert
  • Alertec
  • Yakelert
  • Alertex
  • Vigimax
  • Mentix
  • Zalux
  • Forcilin
  • Modasomil
  • Modafinilo
  • Osavuta
  • Aspendos
  • Movigil
  • Vigil
  • Modanil
  • Modvigil
  • Modaheal
  • Sinthani kusintha
  • Altasomil
  • Cholinga

Kodi Adrafinil Cholimbikitsa? aasraw

Inde! Adrafinil ndi yolimbikitsa. Mbali iyi mwina ndi chifukwa chake mabungwe odana ndi doping amaletsa izo mu masewera. The mankhwala osokoneza bongo kumalimbikitsa dongosolo lalikulu la mitsempha mwa njira ziwiri. Choyamba, zimachepetsa kugona. Chachiwiri, izo zimapangitsa kukhala maso.

Mosiyana ndi zokopa zina zomwe zimayambitsa kuyendetsa galimoto, adrafinil ali ndi ubongo wokha. Choncho, mankhwalawa sangayambitse kupweteka kwa jitto kapenanso kusakhudzidwa.

Adrafinil Vs Modafinil, Yomwe Imayenera Kwa Inu

Adrafinil vs Modafinil: Kodi Zofanana Ndi Ziti? aasraw

Onse adrafinil ndi modafinil amagwira ntchito mofanana. Choncho, ma nootropics awiri amachititsa zotsatira zofanana ndi zopindulitsa. Pakamwa, thupi limayambitsa chiwindi. Adrafinil amasandulika kukhala modafinil ngati metabolite yogwira ntchito.

Njira Zogwira Ntchito

Manotropics awiriwa amagwiritsa ntchito hypothalamic ndi amygdala neurons, zomwe zimayambitsa ubongo wa hypocretin. Adrafinil ndi modafinil bump mmwamba pamagulu a histamine ndi norepinephrine. Zochitazi sizingowonjezera kuchenjeza komanso kutsekemera ndondomeko komanso kudzuka.

Kuphatikizanso apo, neurons zowonjezera zimawonjezera kupezeka kwa glutamate. Mphuphu imeneyi imapangitsa chidwi kukumbukira ndipo zimathandiza kuti anthu azidziŵa bwino zomwe zimachitika.

Adrafinil ndi modafinil amagwiritsanso ntchito kuwonjezera ma dopamine mu ubongo. Zokometsera zachikhalidwe zimangotulutsa kutulutsa dopamine. Komabe, kutenga eugeroics kumayima m'njira ya neural receptors, zomwe ziyenera kuthamangitsidwa ndi neurotransmitter iyi yayikulu. Chipangizo cha dopaminergic chimalimbikitsa chidwi ndikukweza maganizo.

Zotsatira ndi Mapindu

Ngakhale kuti mankhwalawa ndi othandiza kwambiri kuti athetse ubongo, modafinil ndi yowonjezera kuposa adrafinil.

Ma eugeroics awa anapanga mwachangu kuti athetse vuto lakumana ndi matenda komanso kuthandizira kupuma kosasunthika / kosasinthasintha panthaŵi ya tulo. Komabe, maphunziro ambiri ndi mayesero a zachipatala amathandiza kuti mankhwalawa alimbikitse nzeru zamadzi ndi kuwonjezera maganizo. Kuphatikizanso apo, iwo amasonyeza zinthu zamagetsi, kotero, kusewera mbali yaikulu mu ubongo wonse wa thanzi.

Adrafinil ndi modafinil ndi mawonekedwe opititsa patsogolo. Ngati ndinu wophunzira ovuta kutsogolo, mungagwiritse ntchito mankhwalawa ngati kutentha kwa mafuta pakati pa usiku. Amachepetsa kutopa, kutopa, ndi kugona pogwiritsa ntchito chidwi.

Zotsatira za Adrafinil zimatha kufika maola a 15 musanalole. Ena oyendetsa ndege a ku France amazitenga ngati njira yothetsera vutoli. Kuwonjezera apo, akuluakulu a asilikali, oyendetsa galimoto, ndi ogwiritsa ntchito makina amagwiritsira ntchito mapiritsi abwino kuti awathandize kukhalabe tcheru ndi kupirira kusagona kwagona. Ku France, ku US, ndi ku UK, akuluakulu a usilikali amatha kutenga modafinil m'malo mwa amphetamines, makamaka pochita mautumiki aatali.

Ngakhale kuti zidziwitso zokhudzana ndi chidziwitso zimadzetsa chilakolako chogona; simudzakhala ndi vuto lopweteka kwambiri lomwe limakhala ndi zovuta zina.

Ponena za ntchito za ubongo, eugeroics iwiri ndi mchenga pakuthandizira luso la kulingalira. Mwachitsanzo, amathandiza kukumbukira ntchito komanso kugwiritsira ntchito malingaliro a wogwiritsa ntchito, makamaka pazimene zimafuna kuganiza mozama.

Adrafinil ndi modafinil zimayambitsa kuchuluka kwa histamines, dopamine, ndi norepinephrine. Mazira atatuwa amachititsa kuwonjezeka kwa mphamvu za thupi. Choncho, mankhwalawa ndi malo othandizira ochita masewera olimbitsa thupi akugwira ntchito mwakhama. Tawonani kuti nootropics iwiriyi imaletsedwa mochita masewera olimbirana.

Ndemanga za adrafinil amazon zimatsimikizira kuti mapiritsi apamwamba amatha kugwiritsa ntchito bwino ADHD, matenda otopa, ndi kupsinjika maganizo. Kuphatikiza apo, kafukufuku wina wam'mbuyo amalingalira kuti modafinil ufa amathandiza cocaine osokoneza kulimbana ndi kudalira mankhwala.

Adrafinil vs Modafinil: Wchipewa The Kusiyanaizi? aasraw

Sizovuta kukhazikitsa kusiyana pakati paziwirizi chifukwa zotsatira zake ndi zofanana. Komabe, muyenera kuzindikira kuti adrafinil ndi prodrug. Ndilo mankhwala osakanikirana, omwe ayenera kudutsa m'chiwindi chifukwa cha metabolism musanapereke ubwino wa ubongo.

Mlingo

Modafinil ali ndi mphamvu yoposa adrafinil. Chifukwa chake, mudzafunika kuwirikiza kawiri adrafinil mlingo ngati mukufuna zotsatira zosiyana. Si mankhwala onse osokoneza bongo omwe angasinthire modafinil pomwe akudwala chiwindi. Pachifukwa ichi, mufunikira kupanga mawonekedwe osalumikizidwa mwa kutenga adrafinil mlingo waukulu.

Mankhwala amodzi a tsiku ndi tsiku a pakati pa 100mg ndi 200mg. Komabe, anthu ena akhoza kuchita mpaka 400mg tsiku limodzi.

Kwa adrafinil, mlingo wokwanira uli pakati pa 300mg ndi 600mg. Ena ogwiritsa ntchito amphamvu angapangitse mlingoyo ku 1200mg. Kwa katswiri, ndibwino kugwiritsa ntchito mankhwala ochepa kwambiri mpaka mutatsimikiza kuti thupi lanu likhoza kulekerera ndalama zambiri.

Ndalamazo zimakhudza thupi lanu. Mwachitsanzo, madokotala ndi othandizira zaumoyo amalimbikitsa 10mg wa mankhwala pa kilogalamu. Pankhaniyi, ngati muyeza 90kg, muyenera kugwiritsa ntchito 900mg ya adrafinil.

Zowonjezera zamaganizozi zimapezeka mu ufa, kapule, kapena piritsi. Popeza ali ndi kutsika kwambiri, mukhoza kuwatenga ndi madzi kapena madzi, makamaka pamimba yopanda kanthu. Chakudya chamadzulo chimatha kusokoneza kayendedwe kake. Ngati mukudwala matenda osokoneza bongo kapena matenda ogonana, muyenera kutsatira malangizo a dokotala.

Adrafinil ndi zotsatira za modafinil zingathe kukhala pakati pa 12 ndi ma 15 maola. Choncho, mumayenera kutenga chakudya cham'mawa kwambiri kuti musasokoneze m'mene mukugona.

Komabe, ngati muli zakutchire zotsalira za nootropic, ndiye kuti muyenera kuzigwiritsa ntchito nthawi zina. Mwachitsanzo, tengani adrafinil pokhapokha mutagwira ntchito maola owonjezera kuti mugonjetse nthawi zochepa kapena nthawi yopita usiku.

Toxicity

Tiyeni tiyerekeze adrafinil vs modafinil. Kotero, ndi iti yomwe ili poizoni kuposa inayo? Ndiloleni ndikuwonongeni.

Adrafinil ali ndi chiyeso choyamba choyambitsa metabolism kupyolera mu chiwindi pamene icho chimasandulika kukhala modafinil. Zotsatira zake, mankhwalawa akhoza kupweteka chiwalo ichi, kutengera hepatoxicity. Nthawi zina, nootropic iyi imayambitsa kuchuluka kwa michere ya chiwindi.

Musamangokangana chifukwa chiwindi cha chiwindi sichiri chosowa. Ngati mutangoyang'anira adrafinil ufa kwa kanthawi kochepa, simungagwidwe ndi vutoli.

Nthawi yoyamba

Zisanayambe kugwira ntchito pamagulu a ubongo, adrafinil ayenera kuchotsedwa pachiwindi. Choncho, ntchito ya mankhwala m'thupi ikhoza kukhala yaulesi. Mankhwala osokoneza bongo amatha kufalikira mkati mwa maola atatu kapena asanu.

Modafinil amachita mofulumira, chifukwa sichimafuna kuchepetsa thupi kapena kutembenuka. Zidzatenga pakati pa 60 ndi 90 mphindi za nootropic izi kuti zifike pamtunda.

Theka lamoyo

Modafinil ali ndi hafu ya maola pafupifupi 14. Mosiyana ndi zimenezo, adrafinil amatsalira pa kachitidwe kaumunthu kwa ola limodzi kapena awiri asanatembenuke kukhala chogwiritsidwa ntchito. Miyoyo yake ndi ya 15 kwa maola 16.

Lmwachitsanzo

Kwa adrafinil ndi modafinil, njira yokhayo yotsimikizira kuti iwafotokozere iwo ndiyo kudodometsa mphamvu yawo. Komabe, zomwe zimasiyanitsa ndizovomerezeka.

Mosiyana ndi modafinil, adrafinil imaletsedwa m'maiko ambiri. Simudzasowa chithandizo chovomerezeka kuti mupeze. Kupeza mankhwala osokoneza bongo ndi ophweka ngati kutuluka pa sneakers.

Mosiyana ndi zimenezo, modafinil ufa ndi mankhwala olamulidwa ku US, mayiko ena a ku Ulaya, Canada, China, Japan, ndi Australia. Mudzafunika mankhwala ovomerezeka kuchokera kwa dokotala wovomerezeka kuti mupeze mankhwala. Maiko ena monga Mexico, UK, Finland, ndi Sweden sanatchulepo modafinil ngati mankhwala olamulidwa, koma mankhwala adakali ofunika.

Kugwiritsiridwa ntchito kwa adrafinil kapena modafinil sikuloledwa m'sitima. Kuchokera ku 2004, bungwe la World Anti-Doping Agency lakhala likuyendetsa ntchito yake kapena kutuluka masewera olimbirana.

Cost

Modafinil ndi okwera mtengo kwambiri. Komabe, ndalama zimangogulitsa wogulitsa. Mtengo wa adrafinil ndi gawo limodzi la modafinil.

Kulankhula za ndalama, ndikukusiya ndikudabwa kumene kugula adrafinil, chabwino? Ngati mukufunafuna mwamtheradi, fufuzani ndi ife ndikusangalala ndi mitengo yathu yochepetsedwa.

Spano zotsatira

Onse adrafinil ndi modafinil amapereka zotsatira zofanana. Komabe, chakale chingakhale chakupha kwambiri ku chiwindi, makamaka pa nthawi yayitali.

Zotsatira za adrafinil ndi modafinil zimaphatikizapo kupweteka kwa mutu, kuthamanga kwa magazi, kusintha kwa mtima, komanso kuchepa kwa m'mimba. Kutenga mlingo waukulu wa adrafinil kungathe kuchepetsa nthawi ya mkodzo. Kuphatikizanso apo, mlingo wautali wautali ndithu ukhoza kuchititsa khunyu ndi kuperewera kwa impso.

Kufufuza mofulumira pa ndemanga za adrafinil kumatsimikizira kuti chowonjezeracho chimalepheretsanso kudya. Ambiri ogwiritsa ntchito amanena kuti nthawi zambiri samva njala ali pa mankhwala. Zotsatira izi zingakhale dalitso pobisala, makamaka kwa anthu omwe akufuna kusiya kulemera kwa thupi.

Ngati simutenga adrafinil panthawi, mwayiwo mutha kulimbana ndi kusowa tulo. Kuyambira nthawi yogalamuka ikufika pa maola 15, mumayenera kudzuka m'mawa kwambiri kuti mutenge mankhwalawa. Kulephera kutsatira ndandanda iyi kudzakhala kuti mukuvutika ndi zotsatira za kukhala mochedwa.

Adrafinil Vs Modafinil, Yomwe Imayenera Kwa Inu

Adrafinil vs Modafinil: Ndi Ndani Amene Ali Woyenera Kwa Inu? aasraw

Pulogalamu yabwino kwambiri ya mapiritsi imadalira mkhalidwe wanu, zomwe mumayang'ana mu nootropic wothandizira, ndi moyo wanu. Mankhwala aliwonse ali ndi kusowa kwawo. Tenga Mwachitsanzo, adrafinil ufa ndilovomerezeka mu mayiko ambiri, koma ali ndi theka la moyo ndipo akhoza kudwalitsa chiwindi. Komabe, kupeza zofunika modafinil ndilo lamulo loyenera. Komabe, mankhwalawa amachititsa mofulumira ndipo ndi amphamvu kwambiri.

Modafinil ndiyamphamvu kwambiri, ndipo idzapereka zotsatira mosakhalitsa. Kuwonjezera pamenepo, alibe chiwopsezo chakupha pachiwindi. Komabe, muyenera kungotenga dokotalayo akakuuzani.

Chinthu chofunika kwambiri cha modafinil ndi nusu yake yaifupi. Choncho, kukonzekera mlingo ndi kosavuta monga chiwerengero cha atatu. Mukamachita zimenezi, simungathe kusokoneza machitidwe anu ogona nthawi zonse kapena chizunguliro cha circadian.

Ngati muyang'ana kudzera muzotsatira za wiki za adrafinil, mudzazindikira kuti mosakayika ndi kusankha kopambana kwa wina aliyense. Ndiloleni ndifotokoze. Mankhwala osokoneza bongo amaletsedwa m'maiko angapo. Chotsatira chake, ambiri aboma sangapereke chiwongoladzanja kaya mwagula icho kapena popanda mankhwala. Kotero, ngati inu mukufuna kuyang'ana zopindulitsa za nootropic za nootropics m'malo moyang'anira matenda a tulo, adrafinil ndiyo njira yopita.

Mankhwalawa amatengeranso ndalama zambiri. Simukusowa kuswa banki, ndipo simungayesetse ngakhale inshuwalansi kuti muphimbe mbali imodzi ya ndalamazo.

Adrafinil Vs Modafinil Mapeto aasraw

Onse adrafinil ndi modafinil ndi otetezeka, ololera, komanso ogwira ntchito kwa ogwiritsa ntchito. Ngakhale kuti amawoneka ofanana, modafinil ndi yabwino ngati dokotala akuyamikira.

Komabe, ngati mukufuna kugwiritsa ntchito mwayiwu zopindulitsa za nootropic za eugeroics, adrafinil ndiyo njira yabwino kwambiri. Amapezeka mwalamulo popanda mankhwala ndipo amapezedwanso ngati chakudya chowonjezera. Ngakhale ndemanga za adrafinil zimakhala zabwino, muyenera kukhala osamala za mankhwalawa ndi zotsatira zake.

Kaya mukugwira ntchito kumanda kapena kumakhala mochedwa ku ofesi chifukwa cha ntchito zazikulu, adrafinil adzakusandutsani mu usiku. Ngati mukuphunzira mayeso, mankhwala osokoneza bongo sangakuthandizeni kuti mukhale ndi nzeru komanso mumakumbukira.

Kulimbana ndi zotsatira za adrafinil, onetsetsani kutenga mankhwalawa kwa nthawi yochepa. Mu sabata, musadutse masiku atatu.

Zothandizira

  1. Robertson, P., ndi Hellriegel, ET (2003). Clinical Pharmacokinetic Mbiri ya Modafinil. Clinical Pharmacokinetics.
  2. Ballas, CA, Kim, D., Baldassano, CF, ndi Hoeh, N. (2002). Modafinil: Zakale, Zamtsogolo, ndi Zamtsogolo.Akatswiri Ofufuza za Neurotherapeutics.
  3. Mereu, M., Bonci, A., Newman, AH, ndi Tanda, G. (2013). The Neurobiology ya Modafinil monga Wowonjezereka wa Zoganizira Zomwe Zimagwiritsidwa Ntchito ndi Chithandizo Chothandizira Kugwiritsa Ntchito Matenda Osokoneza Bongo.
  4. Dongsoo Kim. (2012). Gwiritsani Ntchito Zowonongeka ndi Kuopsa kwa Modafinil, Mankhwala Osakaniza Atsopano. Environmental Health ndi Toxicology.
  5. Siwak, CK, Callahan, H., ndi Milgram, NW (2000). Adrafinil: Zotsatira za Khalidwe ndi Kuzindikiridwa mu Agines Old.

Kusiya ndemanga

Shangke Chemical ndi makampani apamwamba kwambiri omwe amagwiritsa ntchito mankhwala omwe amathandiza kwambiri. Pofuna kuyendetsa khalidweli panthawi yopanga, akatswiri ambiri odziwa bwino ntchito, makina oyambirira kupanga zipangizo komanso ma laboratori ndi mfundo zofunika kwambiri.

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