Kodi ndinu wakufa mukutsutsana ndi ukalamba? Chabwino, mankhwala odana ndi kukalamba mosakayikira ndi njira yodalirika yothetsera nthawi yanu yachilengedwe. Yang'anani pa zovuta za Nicotinamide Mononucleotide (NMN), gawo lake mu senescence, ndi momwe angapezere chithandizo.

Introduction

Kukalamba sikungapeweke. Komabe, pali zotheka kubwezeretsa ukalamba pogwiritsa ntchito Nicotinamide Mononucleotide. Gwiritsani mahatchi anu chifukwa ndikupatsani inu zambiri zokhudza momwe zamatsenga zimagwirira ntchito m'maselo aumunthu.

Tsitsi lofanana ndi nzeru!

Chikhulupiliro chimenechi ndi chinthu chabwino kwambiri chimene munganene kuti chikhale chachikulu. Komabe, kumwetulira kwanu kudzakhala kanthawi kochepa mukayamba kuzindikira makwinya pa khungu lanu lonse. Komanso, ukalamba umakhudza zonse zomwe zimagwira ntchito komanso zamaganizo.

Tivomerezane. Pulogalamu ya odana ndi ukalamba zodzoladzola kumaso ndi maopaleshoni okongoletsa zakhala zikupezeka m'zaka zaposachedwa. Zomwe muyenera kudziwa ndikuti njirazi ndizofupikitsa ndipo zimatha kuyambitsa zovuta.

Mwachidziwikire, muyenera kuthana ndi ukalamba poyamba kumvetsa njira zamagulu ndi zamagulu zomwe zimathandiza pazomwe zikugwirizana ndi zaka. Pambuyo pake, zimakhala zovuta kufotokoza njira zotsutsana ndi senescence. Nicotinamide Mononucleotide yotsutsa-kukalamba amagwira ntchito yobwezeretsa unyamata.

Tonsefe tikufuna kusinthana bwino, chabwino? Chabwino, izi zikhoza kukhala zosatheka pamene thupi lanu likupitirizabe kufooketsa, ndipo mumatha kukhala maginito a matenda amtundu wanji, Alzheimer's, kukumbukira kukumbukira, ndi zina zambiri.

2019 Mankhwala Otsutsa Otsutsa Okalamba: Nicotinamide Mononucleotide (NMN)

 

Wodabwitsa Nicotinamide Mononucleotide (NMN)phcoker

Kotero, kodi vuto lonse la Nicotinamide Mononucleotide ndi lotani? Ndiloleni ndifotokoze.

NMN ilipo m'ma alpha (α) ndi ma beta (β) mawonekedwe. Komabe, β-NMN ndi mawonekedwe omwe amagwira ntchito kwambiri. Nucleotide imeneyi imakhala pakati pa biosynthesis ya nicotinamide adenine dinucleotide kapena NAD +.

Izi zimakhala mwachibadwa m'magayala, tomato, nkhaka, cabbages, broccoli, ndi ng'ombe yaiwisi. Mu labotale, imapezeka ngati nicotinamide mononucleotide poda wambiri.

Mu mawonekedwe ake opangira, amadziwika ndi nambala ya CAS, 1094-61-7. Mgwirizanowu umayamba chifukwa cha zomwe zimachitika pakati pa nucleoside, monga nicotinamide riboside ndi gulu la phosphate.

M'maphunziro oyeserera, Nicotinamide Mononucleotide imagwira mbewa zatsimikizira kuti ndizothandiza pamagulu azinthu zamagetsi, kasamalidwe ka matenda a Alzheimer's, matenda okhudzana ndi matenda ashuga, zovuta zomwe zimadza chifukwa cha kunenepa kwambiri, komanso kuteteza mtima. Ngakhale zonsezi zimachitika ndi mankhwala okhudzana ndi Nicotinamide Mononucleotide, chodziwika bwino kwambiri ndichakuti amatenga nawo gawo pazochita zotsutsana ndi ukalamba.

Mu thupi la munthu, NMN ndiye gwero lalikulu la mphamvu mkati mwa maselo. Pamene mukukalamba, mphamvu zamagetsi zimachepetsa chifukwa cha nicotinamide mononucleotide ndi kuchepa kwa NAD +. Kulamulira NMN kudzasinthira ndondomekoyi ndi kulipira malire.

 

(1) Kodi NMN ndi yodabwitsa bwanji?

Mankhwala olimbana ndi ukalambawa amayenda ngati mphezi kuchokera m'matumbo kulowa m'magazi. Mu mphindi zochepa, adzakhala atatengedwa kupita m'magazi. Pachifukwa ichi, zikuwonekeratu kuti mwina sipangakhale zochitika zamankhwala zam'magazi zomwe zimachitika panjira yama molekyulu.

Kuthamanga kodabwitsa kumeneku kwapangitsa ochita kafukufuku kuzindikira kuti kuthekera konyamula, komwe kumathandizira kupatsira mafuta kwama cell. Mwachitsanzo, Imai ndi mnzake adayamba kupeza yankho kudzera mu kafukufuku wake waposachedwa wofalitsidwa pa Januware 7, 2019.

Ndikukalamba, thupi limagwiritsa ntchito NAD + kuposa momwe limapangira. Ngakhale mumagwiritsa ntchito nicotinamide mononucleotide, njirayi ikhalabe kuwononga nthawi bola kulibe molekyulu yothandizira mayendedwe ake. Pitilizani kupukusa kuti mumvetsetse wotumiza wodabwitsa yemwe angathetse 90% yazovuta zakukalamba.

 

(2) Nicotinamide Mononucleotide Structure Form

Mphamvu ya Nicotinamide Mononucleotide powder (1094-61-7) Opanga - Phcoker Chemical

 

(3) Malingaliro a Nicotinamide Mononucleotide
dzina mankhwala Mphungu yaikulu ya Nicotinamide Mononucleotide (NMN)
CAS ayi. 1094-61-7
Zolemba zamatsenga C11H15N2O8P
Kuchuluka kwa maselo 334.221 g / mol
Maonekedwe White crystalline powder
Chiyeretso > 98%
Kutupa Madzi sungunuka
yosungirako kutentha -20 ° C
mayina ena · Nicotinamide-1-ium-1-β-D-ribofuranoside 5'-mankwala

· Nic-nicotinamide mononucleotide

· Beta-NMN

· Nicotinamide ribonucleotide

· 3- (Aminocarbonyl) -1- (5-O-phosphonato-beta-D-ribofuranosyl) pyridinium

· Nicotinamide ribonucleoside 5'-phosphate

Nicotinamide Mononucleotide ndi NAD +phcoker

onse Nicotinamide Mononucleotide ndi NAD + ndizomwe zimakhala zofunikira kwambiri m'mafakitale a mafuta.

NMN ili pakati pa biosynthesis ya Nicotinamide adenine dinucleotide (NAD +). Thupi limakhala ngati gawo lapansi la michere yeniyeni monga nicotinamide mononucleotide adenylyltransferase, yomwe imatembenukira ku NAD + mu thupi laumunthu. Powonongeka, gawoli limasintha ku nicotinamide. Pambuyo pake, izi zimagwirizananso ndi nicotinamide phosphoribosyltransferase (NAMPT) yopanga NMN.

Mamolekyu awiriwa ndi ogwirizana kotero kuti kusowa kwa aliyense wa iwo kudzakhudza wina. Mwachitsanzo, taganizirani pamene ma NMN akugwera pansi, mwina chifukwa cha senescence, kuchuluka kwa NAD + kudzatha.

Pamene mukukalamba, ntchito zina zowonjezera mavitamini zimakonda kudya NAD + kuposa thupi limene lingathe kupanga mafuta. The Sirtu, NADase, ndi poly-ADP-ribose polymerase (PARP) ndi mbali ya michere, yomwe imatentha NAD + kutsogolera kuyambanso.

Komabe, kuchepa kwa mafuta a ma apulosi sikungokhala mosavuta. Mwachitsanzo, taganizirani zomwe zimachitika pothandizira pulojekiti zomwe zimaphatikizapo thandizo la PARP pokonza DNA yoonongeka. Komanso, timititi imathandizira kwambiri pakukonza kagetsi ka maselo.

Ngakhale pali ubale wamankhwala pakati pa akatswiri awiriwa, simungathe kupereka NAD + mwachindunji m'dongosolo lino. Momwe njirayi ingathere, zotsatirapo zake sizikhala zovuta. Mwachitsanzo, mlingo waukulu umadziwika ndi kutopa, nkhawa, ndi kusowa tulo. Kuphatikiza apo, pompopompo silingaloledwe kulowa kudzera m'mitsempha yamagazi.

 

(1) Njira Yokometsera

The Nicotinamide Mononucleotide ilipo ngati mankhwala osokoneza bongo. Kutentha kwake kupyolera mu matope a m'matope ndi mu kayendedwe ka kayendetsedwe kake kumayambira pafupi maminiti atatu. Ndi 15th min, zonse zidzakhala zitatengedwa. Kafukufuku wochuluka wa Imai ndi omwe adafufuza nawo akuwona kuti pali puloteni yomwe imathandizira kuthamanga kwakanthawi.

Pogwiritsa ntchito mankhwalawa, NMN imasintha mosavuta ku NAD + kuti isungidwe bwino. Njira ya metabolism ikhoza kutenga theka la ora. NAD + imakhala yambiri m'matumbo, minofu yoyera, chiwindi, ndi cortex. Komabe, kulamulira kwa nthawi yaitali kwa Nicotinamide Mononucleotide kunapitirira msinkhu wa NAD + mu ziwalo zina monga minofu yofiira adipose.

 

(2) NMN Biosynthetic Njira

M'maselo a mammalia, pali njira zitatu zosiyana zedi zamagetsi zomwe zimaperekera kufooka kwa NAD +.

 

 De Novo Pathway

De Novo ndi mawu otchedwa "Lain", omwe amatanthauza "kuyambira pachiyambi." Pano, nucleotide imachokera ku tryptophan kapena nicotinic acid, yomwe imachokera ku zakudya za NMN.

Panjirayi, momwe zinthu zimagwirira ntchito zimayambitsa mapangidwe a nicotinic acid mononucleotide, nicotinic acid adenine dinucleotide, ndipo potsirizira pake kuyembekezera kwambiri NAD +. De Novo imapanga pafupifupi 15% ya mafuta onse.

 

 Njira ya Salvage

Apa, njirayo imapezanso nucleosides pamene DNA imatha. Zimapanga zoposa 80% za chiwerengero cha NAD +, chimene thupi la munthu limafuna ntchito zapulogalamu. Njirayo imagwiritsira ntchito nicotinic asidi ndi nicotinamide kuti apange NAD yatsopano.

Nthenda yotchedwa phosphoribosyltransferase imathandizira kupanga mapangidwe a nicotinic acid mononucleotide kuchokera ku nicotinic acid. Pambuyo pake, nicotinamide mononucleotide adenylyltransferase 1 imapangitsa kuti adenylation iwonongeke kwa mankhwalawa ndi nicotinic acid adenine mononucleotide, ndipo potsiriza ku NAD +.

Ntchito ya NMN pamunthu imadalira njirayi.

 

 NR Conversion

Nicotinamide Riboside ndi wotsutsa wina wa NAD +. Pa phosphorylation pamaso pa nicotinamide riboside kinase, biomarker imapereka NMN musanayambe kukhala ndi enzymatic kutembenuzidwa kukhala NAD +.

 

Mbiri ya NAD + ndi NMN mu Research

Kwa zaka zambiri, phunziroli ndi njira zothandizira za nicotinamide adenine dinucleotide ndi zotsatila zake zakhala zikupsya mtima. Komabe, muyenera kuzindikira kuti izi anti-aging supplements akhala akugwiritsidwa ntchito mufukufuku kuyambira pakati pa 1900s.

Mu 1906, akatswiri oyamba adanena kuti NAD + imachepetsa kuchulukitsa kwa yisiti. Pambuyo pake, akatswiri a sayansi ya sayansi ya zakuthambo anatsatizana ndi kuikonza kuti ikhale nucleotide.

Kupyolera mufukufuku wake mu 1937, Conrad Elvehjem adapeza kuti nicotinamide ndi nicotinic ndi mavitamini ndi zowonongeka za NAD +. Patapita nthawi, anapeza kuti awiriwa akhoza kuchepetsa agalu. Chifukwa chake ndi chakuti ma nicotinic acid ndi nicotinamide anali otsika kwambiri kwa anthu omwe akudwala matendawa.

Mu 1963, gulu la asayansi lidakhazikitsa kuti Nicotinamide Mononucleotide imagwira mbewa zimathandizira ma enzyme omwe amadalira DNA, omwe anali othandiza pakupititsa patsogolo ma cell. Patadutsa zaka ziwiri, ofufuza ena adatulutsa njira za NAD + zamagetsi zama tryptophan ndi nicotinic acid.

Kuchokera nthawi imeneyo, akatswiri a sayansi ya zakuthambo akhala akupitiriza kusonyeza chidwi pa NMN ndi NAD + kafukufuku. Mu nthawi ino, chofunika kwambiri ndi kufunikira kwa izi mankhwala osokoneza bongo kukhala ndi moyo wautali komanso kuchepetsa mavuto okalamba.

 

Kafukufuku watsopano wa Nicotinamide Mononucleotide amagwira ntchito pa mbewa phcoker

Pali mitundu yambiri yophunzirira pazithunzi zamakono zomwe zimasonyeza ubwino wa mankhwala a Nicotinamide Mononucleotide (1094-61-7).

Tiye tikambirane ochepa chabe, omwe athandizidwa ndi kusintha kwa chilengedwe.

 

(1) Malingana ndi Sinclair, NAD + ndi Kasupe wa Achinyamata

Dr. Sinclair ndi anzake achita kafukufuku angapo ponena za ubwino wa nicotinamide mononucleotide ndi NAD + potembenuza kukalamba. Malingana ndi kafukufuku wake wa 2013, Sinclair ndi gulu adapeza kuti mbewa za 22 zamwezi zomwe zimatenga NMN kwa masiku asanu ndi limodzi zinasonyeza kusintha kwa minofu, kuchepa kwa thupi, ndi chipiriro.

Pambuyo pake pa pepala la kafukufuku wa 2016, gululo linatsimikizira kuti NMN inali ndi mapindu omwewo monga kuchita. M'malo mothamanga tsiku lililonse, mutha kukhala ndi zotsatira zofanana mukamagwiritsira ntchito mankhwala a Nicotinamide Mononucleotide m'malo mwake.

Malingana ndi Harvard Geneticist, a NMN imagwira ntchito pa anthu Zimayendera kuzungulira magazi pa okalamba ndi othamanga othamanga.

 

(2) Mphero Zimatsimikizira kuti NMN imachepetsanso kuchepa kwa thupi kwa azimuna okalamba

Pofotokoza phunziro la 2016, Mills et al. anapeza kuti chithandizo cha NMN chikhoza kutsutsana ndi kuchepa kwa thupi ndi maumunthu m "makoswe akale. Kumapeto kwa NMN supplement kafukufuku, makoswe amalembetsa kuwonjezeka kwamawonedwe am'magazi amthupi, kuchuluka kwa ma lymphocytic, ndi kuchepa kwa ma neutrophils.

M'mbuyomu, mu 2011, Mills, Yoshino, ndi Imai adagwiritsa ntchito mbewa kuti atsimikizire udindo wa NAD + pochiza matenda ashuga obwera chifukwa cha zakudya. Pakafukufuku wina wa 2016, adalumikizana ndi ofufuza ena omwe adatsimikiza kuti kuwonjezera kwa NMN kuthana ndi kupsinjika kwa oxidative komanso kusokonekera kwa mitsempha mu mbewa zakale.

 

(3) Matenda a NMN a Alzheimer (AD) mu Murine Models

Mu 2015, Long et al. adasanthula momwe NMN imathandizira pakuchepa kwa kupuma kwa mitochondrial pa mbewa ndi matenda a Alzheimer's. Gululi lidazindikira kuti chithandizo cha NMN chidatha kuthana ndi zamatsenga za AD, kuphatikiza otsika OCR (kuchuluka kwama oxygen), NAD + falloff, ndi zovuta za mitochondria.

Mu 2016, Wang ndi anzawo adasindikiza kafukufuku wawo, pomaliza kuti awa odana ndi ukalamba Mankhwala osokoneza bongo amalimbana ndi kuwonongeka kwazindikiritso ndi mitsempha, zomwe zimachokera ku ig-amyloid (Aβ) oligomer. Puloteni iyi ya Aβ ndi neurotoxic ndipo imayambitsa mapangidwe a zolengeza muubongo wa odwala AD. Wang et al. adamaliza kuti kayendetsedwe ka NMN mu mbewa zidapangitsa kuchepa kwa Aβ oligomers, potero kulimbitsa magwiridwe antchito.

Kutsatira kafukufuku wa 2017, Hou ndi anzawo adazindikira kuti NAD + supplementation yachepetsa kupanga kwa ig-amyloid oligomers. Chaka chotsatira, Yao ndi gulu lake adakhazikitsa kuti Nicotinamide Mononucleotide imachepetsa kudzikundikira kwa Aβ ndi kutayika kwa synaptic mu mitundu ya AD-Tg murine.

 

(4) NMN ndi Cardio-chitetezo

Malinga ndi zomwe 2014 Yamamoto ndi anzawo adalemba mu XNUMX, NMN amateteza mtima ku kuvulala kwa ischemic ndikubwezeretsanso. Asanaphunzire izi, Yamamoto anali mgulu la 2012, lomwe lidapeza kuti NAD + imawerengera kunenepa kwambiri kwama mbewa.

Mu 2016, De Picciotto et al. ndipo amzake amzake amaphunzira momwe mphamvu ya NMN imathandizira pakamagwira mbewa zokalamba. Kuchokera pamalingaliro, nicotinamide mononucleotide idakhala yothandiza pothetsa kuchepa kwa mitsempha, kupsinjika kwa oxidative, ndikuchepetsa elastin.

 

(5) Kupeza Kwa Njira Yatsopano ya Mafuta Akutumizidwa ndi Shin-Ichiro Imai

Mu kafukufuku waposachedwapa, gulu la asayansi motsogoleredwa ndi Imai adapeza ndipo adasula nthumwi yodabwitsa ya NMN m'maselo.

Kafukufukuyu wa NMN supplement poyamba anapezeka mu January 2019 mkati Chilengedwe cha Metabolism. Imai anakhazikitsa kuti puloteni inayake, Slc12a8, ndi yomwe imayambitsa kutembenuka kwa NMN kwa NAD + mofulumira ndikuyendetsa mu selo. Enzyme imeneyi imakhala yaikulu kwa anthu akale osati achinyamata kapena thanzi labwino.

M'maphunziro onse am'mbuyomu, asayansi ofufuza amatha kusungunula ufa wambiri m'madzi asanawapatse mbewa.

Ubwino wa Nicotinamide Mononucleotide (NMN)phcoker

NMN ili ndi ntchito zambiri zochiritsira komanso zotsatira za mankhwala pa thupi la munthu. Pasanathe zaka khumi, asayansi apatulira nthawi yawo yophunzira zonse za Nicotinamide Mononucleotide kuphatikizapo njira zomwe zimalongosola ukalamba ndi matenda okhudzana ndi zaka.

Tiyeni tiwunikire maubwino ampangidwe wa makina amunthu.

 

(1) Kutsegula Mitundu ya Zamoyo

Kufikira kuyambika kwa 21st zaka zapitazi, akatswiri anali ndi zifukwa zokwanira zowonetsera ukalamba ngati njira yosasinthika. Komabe, lingaliro limeneli lakhala lopanda kanthu chifukwa cha kufufuza kwapadera anti-aging supplements monga Nicotinamide Mononucleotide.

NMN imachitika mwachibadwa m'maselo aumunthu ndipo imayambitsa biosynthesis ya NAD + ndi kupanga mphamvu. Pamene mukukalamba, izi zimakhala zochepa kwambiri zomwe zimayambitsa matenda a maselo. Kumbukirani, magulu ogwira ntchitowa amafunikira mafuta okwanira okwanira nthawi zonse, choncho, kugwa kumachepetsa msinkhu wa moyo wa maselo.

Kuwongolera mankhwala ogwira ntchito odana ndi ukalamba monga NMN idzasinthira ndondomeko ndi kuchepetsa ukalamba.

 

(2) Kulimbikitsa Maselo Achinyamata Achinyamata

Chiyambi chachikulu cha matenda ambiri okhudzana ndi ukalamba ndi wocheperachepera mpaka pamaselo a ma selo. Kuchepa kwa kupanga mphamvu m'kati mwa maselo ndizo zikuluzikulu zowonjezera zizindikiro za ukalamba.

Pokhala chithunzithunzi cha NAD +, NMN ili ndi gawo lomwe liyenera kuthandizira kusunga mphamvu zamagetsi za mitochondria. Kukalamba kumapangitsa kuchepa kwa NAD +. Chifukwa chaichi, ukalamba umatenga nthawi pang'ono kuti ukhale ndi matenda okalamba.

Dontho m'magulu a mphamvu zam'manja mkati mwa ziwalo zofunikira monga minofu, mitsempha ya magazi, impso, chiwindi, kapena mphukira nthawi zonse zimasokoneza thanzi labwino ndi thanzi. Ndi chifukwa chake matenda omwe amatchedwa ischemia, matenda a mtima, impso, matenda osokoneza bongo, ndi ena akuwombera.

Yankho langwiro ndilowonjezera thupi Nicotinamide mononucleotide ndi NAD + ndimankhwala akunja a NMN. Izi Mankhwala olimbana ndi kukalamba amapereka mwayi watsopano wamaselo okalamba, omwe amawoneka ngati achichepere.

 

(3) Kupititsa patsogolo Kuthamanga kwa Magazi

Chimodzi mwa kusintha komwe kumachitika nthawi yakale ndi kuchepa kwa mitsempha ya magazi mkati mwa thupi la mamamia. Choncho, ma circulatory system imakumana ndi mavuto ambiri pakanyamula zakudya, mpweya, kutentha, kapena kuchotsa zida kuchokera ku ziwalo. Popeza kuti zinthu zikupitirirabe, zimaipiraipira patapita nthawi kuti zizindikiro za matenda a nthawi yaitali zichitike.

Nicotinamide Mononucleotide ndiyomwe imayambitsa kupanga mitsempha ya magazi. Ndiloleni ndifotokoze. Pulogalamuyi imapanga NAD +, yomwe imathandizanso puloteni ya Sirir deacetylase (SIRT1).

Mosiyana ndi zimenezi, SIRT1 imapangitsanso mabwinja a lysine omwe amathandiza kupanga mpweya wabwino wa oxygen. Njirayi imamenyana ndi zovuta zowonjezera zowonjezereka, kutsekemera, kapena kuvulala kwa kasupe. Nthawi zambiri, thupi lomwelo lidzagonjetsa ischemia ndi zochitika zogwirizana ndi ischemic preconditioning (IPC). IPC idzachitapo kanthu pofuna kulimbikitsa kupanga SIRT1.

Mukhoza kupereka NMN musanachitike chochitika chachilendo kapena panthawi yake. Zisanachitike, kampaniyi imapereka chitetezo cha cardio popititsa patsogolo ATP kupanga kudzera mwa glycolysis.

Pankhani ya Ischemia, mutha kugwiritsabe ntchito Nicotinamide Mononucleotide chifukwa ingayambitse acidosis ndikupangitsa kusowa kwa mitochondrial; chifukwa chake, kutsimikizira kutetezedwa kwa dongosolo la mtima.

 

(4) Muscle Endurance

Mukuyembekezera chiyani magazi akuchepa? Boma litsogolera kutayika kwa minofu. Sitikukayika kuti mudzawona kuti anthu akale amakhala ndi magwiridwe antchito, kupirira pang'ono, kusayenda, komanso otopa kwambiri nthawi zonse.

Chimodzi mwazinthu zodziwika bwino zomwe a Dr. Sinclair adachita ndichakuti mphamvu ya NMN ikuthandizira kulimbikitsa minofu. Malinga ndi kafukufuku wake wa 2013 komanso 2018 yaposachedwa, mbewa zakale zomwe zidapatsidwa mankhwala a masiku asanu ndi awiri a NMN zidakhala zolimbitsa thupi komanso zolimba ngati anzawo achichepere.

Mphamvu ya minofu ndi kupirira kwa mbewa zakale (miyezi ya 30) zinali zofanana ndi za mwana wachinyamata wa miyezi isanu. Mibadwo imeneyi ikufanana ndi pafupifupi 70 ndi zaka 20 kwa anthu. Kuchokera pazofukufuku, mungathe kuchepetsa kuti NMN ikhale yogwira ntchito paumunthu ndikutsimikiza ngati imfa.

 

(5) Kulimbana ndi Matenda a Neurodegenerative

Ubongo uli ngati mphamvu ya dongosolo lanu. Izi zikhoza kukhala chifukwa chomwe madokotala amakhulupirira nthawi zonse pa ubongo pamene akulengeza nthawi ya imfa.

Kuchepetsa chiwerengero cha NAD + mu ubongo kumayambitsa thanzi labwino pakati pa okalamba. Ulamuliro wa NMN ukufulumizitsa kupanga NAD +, motero, kuteteza ntchito za neural.

Maphunziro ambiri amatsimikizira kuti Nicotinamide Mononucleotide imapindula kuzindikira, sitiroko, komanso kulepheretsa kukumbukira kukumbukira, komwe kumafala ndi ukalamba. Mwachidule, izi odana ndi ukalamba zowonjezerazo ndizoyang'anira ma neuron.

NMN imalunjika makamaka pamalingaliro amtundu uliwonse wamanjenje. Mwachitsanzo, Alzheimer's Matendawa amapezeka chifukwa cha kuchepa kwa NAD +, kugwiritsidwa ntchito kocheperako kwa mpweya muubongo, komanso zovuta za mitochondrial. Kuchulukitsa kuchuluka kwa NMN mthupi kuwerengera zotsatirazi.

Malinga ndi kafukufuku wofalitsidwa mu 2012, Nicotinamide Mononucleotide idzawongolera kuwonongeka kwa ubongo, komwe kumayambitsa sitiroko. Mbewa zakale zomwe zinali pansi pa kuchuluka kwa NMN zidalembetsa kusintha kwakukulu pakupanga kwa NAD +. Mitundu yofufuzayi inali ndi chitetezo chokwanira motsutsana ndi kupwetekedwa kwa ischemic, kufa kwa neural, ndi kutupa kwamitsempha.

 

(6) Kusintha Metabolism mu Ukalamba

Ofufuza ambiri afufuza ndi kutsimikizira kuti NMN imayambitsa kulekerera kwa glucose pamene imapangitsa kuti shuga yambiri isamakhale ndi zakudya zambiri. Phunziroli likugwiranso ntchito kwa anthu okalamba omwe amayamba shuga kapena chifukwa cha shuga kapena zakudya zoperewera. Kuonjezera apo, kudya zakudya zochuluka kumawonjezera insulini kukana.

Nicotinamide Mononucleotide ili ndi chiwerengero chachikulu cha NAD +, zomwe zimachepetsanso kutupa kwa zaka zomwe zimapangitsa kuti thupi likhale ndi mafuta ambiri.

 

2019 Mankhwala Otsutsa Otsutsa Okalamba: Nicotinamide Mononucleotide (NMN)

 

(7) Kuchiza kwa Shuga

Anthu omwe ali ndi matenda ashuga amtundu wachiwiri nthawi zonse amakhala osagwirizana ndi insulin. Khalidwe ili chifukwa chakugwa mu NAD +. Zotsatira zake, maselowo amakhala ndi nkhawa ya oxidative komanso kutupa. Ngati mudakali achichepere, thupi limadzilimbitsa lokha mwazinthu zina zakuthupi. Komabe, ndi ukalamba, milingo ya NAD + imachepa m'ziwalo zothandizira moyo monga mafupa, chiwindi, ubongo, ndi kapamba.

Chinanso chimene chimayambitsa matenda a shuga ndicho kudya zakudya zamafuta ambiri. Mafuta osakwanira okwanira amalepheretsa biosynthesis ya NAD +. Pofuna kutsimikizira kuti Nicotinamide Mononucleotide imathandiza bwanji pochiza matenda ashuga okhudzana ndi msinkhu komanso zakudya, Yoshino ndi anzawo adagwiritsa ntchito mbewa ziwiri.

Pambuyo popereka mlingo wa tsiku ndi tsiku wa NMN kwa masiku pafupifupi 10, ophunzirawo adatsimikiza kuti mbewa, zomwe zimadya mafuta ambiri, zidalembetsa kusagwirizana kwa insulin. Kumbali inayi, mbewa za matenda ashuga zimawonetsa kusintha kwakukulu kwa hyperlipidemia.

 

(8) Kusintha Kukalamba

Zovuta zaumoyo nthawi zonse zimayendera limodzi ndi ukalamba. Pamene thupi likumana ndi kusintha kwambiri kwa thupi, ntchito zina zimagwera kubwerera. Mwachitsanzo, taganizirani kuti nicotinamide adenine dinucleotide imachepa mu ziwalo zingapo, zomwe zimapangitsa kuchepa kwa mphamvu za magetsi pogwiritsa ntchito mitochondrion ya selo.

Kukalamba kumayambitsa zinthu zosiyanasiyana monga kuwonongeka kwa DNA chifukwa cha mamolekyu osatulutsidwa, kupsinjika kwa magazi, ndi mavuto ena. Kodi mukudziwa zomwe zimachitika? Chabwino, pali DNA yokonza mapuloteni (PARP1) mu dongosolo laumunthu. Pankhani ya kuwonongeka kwa DNA, NAD + idzayambitsa mapuloteniwa kuti akonze selo yogwidwa.

Kafukufuku wochuluka wadza ndi zopindulitsa za nicotinamide mononucleotide mu ukalamba. Mwachitsanzo, a Mills ndi anzawo adagwiritsa ntchito mbewa zoyeserera pofufuza momwe kuchepa kwa thupi kwa NMN kumathandizira kuchepa kwa thupi.

Phunziroli, ochita kafukufuku adanena kuti nthawi yayitali chithandizo cha mankhwalachi chinapangitsa kuti kuwonjezeka kwa majeremusi osokonezeka mu chiwindi, mitsempha, ndi minofu. Kuwonjezera pamenepo, zomwe anapezazi zinatsimikizira kuti maselo a chitetezo cha m'magulu, chitetezo cha ma lymphocytes, ndi kuchititsidwa kwa leukocyte.

Chinthu china cha ukalamba ndi kukhalapo kwa mawanga owala mu thumba la maso. Matendawa kuphatikizapo kuperewera kwa mafupa kufooka komanso kulephera kubweretsa misozi kwawerengedwa bwino pa makoswe. Asayansi ananena kuti mbewa, zomwe zinayikidwa pa chithandizo cha mwezi wa XMUMX wa NMN, zinasintha zinthu zonsezi.

Zaka zambiri ndizo chifukwa chokha chomwe anthu amachitira Gulani Nicotinamide Mononucleotide.

 

(9) Kuchiza kwa Kunenepa Kwambiri

Kwa okalamba, NMN ikhoza kuchepetsa mpaka 10% ya kulemera kwa thupi koyamba popanda kupeza pakati pakati pa njala ndi kukula. Zomwe zimayambitsa kunenepa kwambiri ndi shuga zimagwirizana. Maseŵera a NAD + otsika amachititsa kulephera kwa mitochondrial; chotero, kuchepa kwa kupanga ATP.

Kunenepa kumachepetsa mphamvu ya mitochondria pakupanga ATP mphamvu kwa maselo. Mukapereka Nicotinamide Mononucleotide, mankhwalawa amachititsa kusagwirizana kwa shuga ndi ntchito zina zamagetsi zokhudzana ndi kunenepa kwambiri.

Zikafika pakukweza magazi, NMN yokhudza kunenepa kwambiri imachitanso chimodzimodzi ndi kuchita masewera olimbitsa thupi. Piritsi limodzi lingakhale lofanana ndi kugwiritsa ntchito chopondera tsiku lililonse. Komabe, kusiyana kumabwera m'magulu azomwe zili ndi NAD + m'ziwalo zathupi. Pomwe Nicotinamide Mononucleotide imakulitsa NAD + m'chiwindi ndi minofu yamphamvu, kuchita masewera olimbitsa thupi kumangomangika pakapangidwe kake mkati mwa minofu.

 

Kodi Nicotinamide Mononucleotide (NMN) Ikugwira Ntchito Pa Munthu?phcoker

Mwina ili ndi funso lomwe likupezeka m'mutu mwanu. Mulimonsemo, kafukufuku ndi Preclinical kafukufuku wokhazikika pa Nicotinamide mononucleotide ndi NAD + akhala akuwongolera mitundu ya murine.

Ngati muli ndi zosungira za momwe NMN ikugwirira ntchito paumunthu, ndizo zonse zomwe mukuyenera kuzidziwa. Dr. David Sinclair, wofufuza kapamwamba, ndi geneticist ku Harvard University ndi mmodzi mwa omwe adalandira NMN.

Sinclair avomereza kuti amatenga chowonjezera. Pakadali pano, wophunzirayo sanalembe zotsatira zoyipa za nicotinamide mononucleotide. M'malo mwake, akunena kuti amadzimva wachichepere wokhala ndi malingaliro owoneka bwino. Zobisalira ndi jet lags tsopano ndi nthawi yapitayi kwa iye. Ananenanso kuti abambo ake, omwe ali kumapeto kwa zaka makumi asanu ndi awiri, amatenganso chowonjezera.

Kuwonjezera apo, Dr. Sinclair wakhala akugwiritsa ntchito mankhwalawa monga oyambirira ku Brigham ndi Women's Hospital. Ali ndi ndondomeko zowonjezeretsa kuyesa kwa okalamba omwe ali ndi thanzi labwino. Ngakhale kuti phunziro lake limodzi ndi lathunthu, adakalibe buku lovomerezeka. Sinclair adayamba gawo lachiwiri lachipatala ichi NMN supplement kafukufuku mu 2018.

 

chipatala Mayesero

Phunziro lachipatala lomwe limayenera ku 1st June 2020, ofufuza akuyang'ana kuti asinthe kusintha kwa mphamvu ndi beta-selo ikugwira ntchito ndi NMN supplementation mwa anthu. Ophunzirawo akuchokera ku Sunivesite ya Washington University of Medicine ndi Keio University School of Medicine ku Tokyo.

Mu kuyesedwa kwaumunthu komwe kunayamba ku 2016 ku Keio University, akatswiriwa anali kuyang'ana kuti aone ngati NMN ndi otetezeka kwambiri. Mu gawo lachiŵiri lopitirira, bungwe lomwelo, lotsogoleredwa ndi Shin-Ichiro, likufufuza kafukufuku wa NMN wa nthawi yayitali. Zowonjezerapo, gululi likufuna kufufuza njira zokhudzana ndi matenda opatsirana pogonana, NMN kinetics, ndi mankhwala omwe amachititsa kuti shuga isamagwiritsidwe ntchito.

Mu phunziro lachipatala la 2017 ndi University of Washington, ophunzirawo anali ndi akazi a 50 a zaka 55 mpaka zaka 75. Gululi linaikidwa pa mlingo wa tsiku ndi tsiku wa 250mg wa NMN kwa masabata asanu ndi atatu. Ngakhale kuti anali a thanzi labwino, akaziwa anali ndi shuga kwambiri, triglyceride, ndi BMI. Phunziro silinamalire.

Pakadali pano, palibe zofalitsa zomwe zimatsimikizira kuti NMN imagwira ntchito pa anthu. Komabe, muyenera kuyimilira chifukwa china chake chikuphika ndipo mayesero azachipatala atha kukhala olonjeza.

2019 Mankhwala Otsutsa Otsutsa Okalamba: Nicotinamide Mononucleotide (NMN)

 

Mmene Mungagwiritsire ntchito Nicotinamide Mononucleotide (NMN) Yotsutsa Kukula? phcoker

Ngati mukuyang'ana kugula nicotinamide mononucleotide, pali zinthu zingapo zomwe muyenera kudziwa.

Mungathe kutenga mankhwala monga chakudya chowonjezera chifukwa sanalandire mgwirizano womaliza wa FDA kukhala mankhwala osokoneza bongo.

Mlingo uli pakati pa 25mg ndi 300mg malingana ndi ubwino wa thanzi lomwe mukufuna kuti mukwaniritse. Komabe, anthu ena amavomereza kutenga 1000mg patsiku. Tenga Mwachitsanzo, Dr. Sinclair amatenga 750mg / tsiku. Kuphatikiza apo, akuwonjezera mphamvuyi ndi resveratrol ndi metformin.

Mu mayesero a chipatala a NMN, ambiri ofufuza adzaika maphunziro awo pamtundu wa 100mg kwa 250mg.

 

Mvetserani pamagulu osiyana

Ngati mukufuna kupititsa patsogolo mankhwalawa, muyenera kugula mapiritsi a Nicotinamide Mononucleotide kuti muwongolera. Kugwiritsa ntchito mankhwalawa kumachepetsa kuchepetsa ndalama zomwe zimalowa m'matumbo. Chifukwa chake n'chakuti imayambitsa matenda ndi kuchepa pamene imadutsa m'magazi ndi chiwindi.

NMN yamagulu amodzi mwachindunji alowa mwazi popanda zitsulo zilizonse. Kuchuluka kwake kwa njira iyi yobereka ndi pafupifupi kasanu kuposa kulamulira komlomo. Pachifukwa ichi, mufunika kuwonjezera mlingo kuti mupange choyamba chamagetsi pachiwindi. Tiyerekeze kuti mukufufuza, mungafunikire ufa wochuluka wa nicotinamide mononucleotide kuti mutsirize phunzirolo.

 

Zotsatira Zake za Nicotinamide Mononucleotide Muyenera Kudziwaphcoker

Zofananira ndizofanana ndi zomwe zimawonetsedwa ndi niacinamide ndi zina za vitamini B3 komposionotinamide mononucleotide zoyipa s. Komabe, anthu ambiri samaziwona nkomwe. Mwachitsanzo, wasayansi wamkulu wofufuza ku Harvard University avomereza kuti atenga NMN, koma sanazindikire zovuta zilizonse.

Pakalipano, mu Nicotinamide Mononucleotide yomwe ilipo ikugwira ntchito pa mbewa, palibe deta yomwe imasonyeza kuti pali zotsatirapo zina zomwe zimayambitsa maonekedwe a murine. Palibe wofufuza amene adalemba chizindikiro choipa pafupipafupi komanso kwa nthawi yaitali NMN administration.

Anthu ena amatha kuona zotsatirazi zoipa;

  • nseru
  • kusanza
  • chizungulire
  • Mimba imakhumudwitsidwa
  • kutsekula
  • Zomwe zimayambitsa matendawa monga itchiness, mng'oma, kapena misampha

Nthawi zambiri, zotsatira za nicotinamide mononucleotide zikhoza kukhala zovuta kwambiri kuti mufunse kufufuza mwamsanga. Kutchula zochepa, zovuta kupuma, kupweteka mtima kwa mtima, kusanza kosalekeza, khungu la chikasu, ndi kusowa kwa njala ndi zina mwa zizindikiro zovuta.

 

Contraindications

Pakadali pano, mayesero a zachipatala amangokhala akuluakulu okalamba mu zaka za 45 mpaka zaka 75. Pa chifukwa ichi, magulu otsatirawa ayenera kukhala osamala asanayambe kuwonjezera zowonjezera kupirira kwa NMN.

  • Amayi oyembekezera ndi oyamwitsa
  • Anthu omwe ali ndi mbiri ya hypersensitivity kwa NMN
  • Odwala amamwa mankhwala odwala matenda aakulu

Kodi Ndingapeze Kuti Mankhwala Osokoneza Bongo-Nicotinamide Mononucleotide (NMN)? phcoker

(1) NMN Zakudya Zakudya

Mwinamwake mukukangana kuti ndi chifukwa chiyani muyenera kugula Nicotinamide Mononucleotide pamene mungapeze mosavuta zakudya zina. Ndiloleni ndikufotokozere mwachidule chifukwa chake izi zowonjezera ndizofunikira.

Monga NAD + imachepa m'thupi chifukwa cha kukalamba, maselo sangathe kulimbana ndi zotsatira zake. Panthawi imeneyi, kusankha kwanu kokha kungakhale kugwiritsa ntchito NMN supplements. Madokotala amakulimbikitsani kutenga zakudya za NMN monga broccoli, bowa, edamame, kapena shrimp. Komabe, zakudya izi zidzangopereka zosakwana 5% za zomwe thupi lanu limafuna.

FDA ikuvomereza kuti munthu aliyense akusowa pafupifupi 560mg ya NMN patsiku. Tiyerekeze kuti mutenga mafuta kuchokera ku broccoli, mudzadya mapepala a 1500 ofanana.

 

(2) Zotsatira za NMN

The nicotinamide mononucleotide ufa wambiri ilipo kugulitsidwa m'masitolo ambiri a mankhwala ndi mankhwala kapena ma laboratories. Ngati mukufuna zina pa kafukufuku wanu, mukhoza kupanga ndondomeko yowonjezera, yomwe imabwera ndi mitengo yotsika mtengo ndi zoperekera pazitsamba zotsatsira.

Kupanga malonda a pa NMN pa intaneti kumangopulumutsa nthawi yanu komanso kumapereka nsanja yabwino poyerekeza mitengo yosiyana. Ngati simuli wofufuza, mukhoza kugula Nicotinamide Mononucleotide zowonjezera kuti mugwiritse ntchito. Musanayambe dongosolo, onetsetsani kuti ndi zakudya zamakono.

 

Chidule phcoker

Zikumveka zosamveka kunena kuti NMN imawonjezera nthawi ya moyo wa anthu. Komabe, izi zikutsimikiziridwa. Chifukwa cha imfa pakati pa okalamba ndi chifukwa cha matenda omwe amachititsa zaka zambiri, zomwe zimachitika chifukwa cha ntchito zamagulu osauka.

The Nicotinamide Mononucleotide yotsutsa-kukalamba imangoyamba kuwongolera mafuta opangira mavitamini komanso kuwonjezera mphamvu za maselo. Zimagwira ntchito polepheretsa NAD +, yomwe imayamba kuchepa ngati ifeyo tikukalamba.

Kugwiritsira ntchito mankhwala okalamba, kusungunuka, dzuwa, kapena kuchita masewera olimbitsa thupi pa zakudya zabwino kungangosintha nkhope yanu. Komabe, muyenera kumvetsa chomwe chimayambitsa mavuto okalamba omwe angawachitire. Nicotinamide mononucleotide imasintha ukalamba pokonzanso DNA yowonongeka, kuteteza ubongo, mapulogalamu a mtima, kupangitsa minofu kugwira ntchito, ndi kuwonjezera chipiriro.

Ngati mukufuna nicotinamide mononucleotide ufa wambiri, fufuzani ndi ife ndipo muzisangalala ndi mtengo wabwino.

 

Zothandizira
  1. Mphero, KF, Yoshino, J., Yoshida, S., et al. (2016). Kulamulira kwa Nthaŵi Zakale za Nicotinamide Mononucleotide Zimasintha Mitengo ya Kusagwirizana Kwambiri M'magulu. Cell Metabolism.
  2. Yoshino, J., Mills, KF, Imai, SI, ndi Yoon, MJ (2011). Nicotinamide Mononucleotide, chofunika kwambiri cha NAD + Chokhazikika, Amachiza Pathophysiology Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chamakono Cell Metabolism.
  3. Yamamoto, T., Byun, J., Zhai P., Ikeda, Y., Oka, S., ndi Sadoshima, J. (2014). Nicotinamide Mononucleotide, Wopakatikati wa NAD + Synthesis, Amateteza Mtima ku Ischemia ndi Reperfusion.
  4. Sinclair, DA, Uddin, GM, Youngson, NA, ndi Morris, MJ (2016). Mutu kupita ku Mutu Kufanizitsa Chithandizo cha Nthawi Yachidule ndi Chotsutsa NAD + Chotsatira Nicotinamide Mononucleotide (NMN) ndi Ma sabata asanu ndi limodzi a Kuchita Zozizira M'magulu Okazi Amuna.
  5. Imai, S., Yoshino, J., Mills, KF, Grozio, A., et al. (2019) Slc12a8 ndi Nicotinamide Mononucleotide Transporter. Chilengedwe cha Metabolism.
  6. De Picciotto, NE, Mills, KF, Imai, S., Gano, LB, et al. (2016). Nicotinamide Mononucleotide Amatsitsimutsa Matenda Osavuta ndi Mavuto Osokoneza Bongo ndi Amphawi Okalamba.
  7. Yao, Z., Gao, Z., Yang, W., ndi Jia, P. (2017). Nicotinamide Mononucleotide Imaletsa JNK Kukonzekera Kuti Muthane ndi Matenda a Alzheimer.
  8. Hou, Y., Wang, Y., Zhang, Y., Lautrup, S., et al. (2018). NAD + Zowonjezeretsa Zomwe Zimapangitsa Makhalidwe Aakulu a Alzheimer ndi DNA Kuwonongeka Mayankho mu New AD Mouse Model ndi Kutulutsidwa DNA Kukonza Kufooka.
  9. NTHAWI NICOTINAMIDE MONONUCLEOTIDE (NMN) UTHO (1094-61-7).

 

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