1. Kodi Pterostilbene ndi chiyani?

Pterostilbene ndi mankhwala ofunikira mwachilengedwe opangidwa ndi moyo wa mbewu zina ngati njira yolimbana ndi matenda. Pulogalamuyi ndi yofanana ndi phula lina lomwe limadziwika kuti resveratrol ndipo limapezeka mosavuta mu mawonekedwe owonjezera. Zowonjezera za Pterostilbene ndizopezeka kwambiri. Izi zikutanthauza kuti zimatha kulowerera mthupi mosavuta komanso mwachangu ndipo sizinawonongeke pakugaya. Pterostilbene ufa ndiwothandizanso, komabe, theka lake la moyo ndi lalifupi kwambiri popeza ali pansi pa mphindi 100.

Pterostilbene magwero chakudya

Pterostilbene Chakudya chimaphatikizapo ma buluu, ma almond, ma cranberries, mabulosi amphaka, chinangwa, vinyo wofiira, mphesa zofiira, masamba a mphesa, mtengo wa Indian ano bark, Red sandalwood, ndi cocoa. Blueberries, komabe, ndiye gwero lapamwamba kwambiri la chakudya cha Pterostilbene, koma kuchuluka kwake kwa Blueberries kumakhalabe kochepa poyerekeza ndi zowonjezera za Pterostilbene. Mitundu ya Pterostilbene blueberries imakhulupirira kuti inali pafupifupi 99 mpaka 52 nanograms, mu gramu iliyonse ya blueberries.

pterostilbene-ufa

2.Pterostilbene limagwirira ntchito

Pterostilbene limagwirira ntchito ndi losiyana ndi la resveratrol. Pterostilbene phata ndiye stilbene wamphamvu kwambiri. Maubwino osiyanasiyana a Pterostilbene ufa amafanananso ndi magwiritsidwe osiyana siyana. Pharmacological zochita za trans-pterostilbene zimaphatikizapo antineoplastic, antioxidant, ndi anti-kutupa.

Pterostilbene amawonetsa zochitika zogwira mtima za antifungal zomwe zimakhala zamphamvu kwambiri kakhumi kuposa resveratrol. Pterostilbene pawiri imawonetseranso zotsatira zoyipa. Kutetezedwa kwa chomera kuchokera kuma tizilombo toyambitsa matenda angapo tikuwoneka kuti ndi gawo lofunikira la stilbenes, kuphatikiza Pterostilbene, ndipo izi zimafikiranso ku nyama ndi anthu.

Pterostilbene amawonetsanso zotsatira za anticancer kudzera ma ma cell angapo ma cell. Kafukufuku akuwonetsa kuti zochita za Pterostilbene zimaphatikizapo majini a tumor suppressor, masinthidwe amachitidwe opatsirana ndi ma signor, oncogene, majini osiyanitsa maselo, ndi mitundu yama cell olamulira.

Ma antioxidative a Pterostilbene ndi osiyana kwambiri ndi a resveratrol. Mu resveratrol, magulu atatu a ma hydroxyl amathandizira ROS (mitundu yogwira ya okosijeni) m'magulu okhala patali ndi magazi athunthu pomwe Pterostilbene, yemwe ali ndi gulu la 1 hydroxyl ndi magulu a 2 methoxy amachepetsa extracellular ROS. Kudziwa kwachuma kwa antioxidation kumathandizira kugwiritsidwa ntchito kwa Pterostilbene ufa kuthira mitundu ya okosijeni ya extracellular, yomwe imayambitsa minofu kuwonongeka panthawi yotupa.

Pansipa pali njira zambiri za pterostilbene zomwe zimafotokozedwera mwatsatanetsatane;

Pterostilbene limagwirira ntchito; Kugwiritsa ntchito kwa Sirtuin

Pterostilbene imakulitsa njira ya SIRT1 yolowera mu maselo yomwe imateteza ku kuwonongeka kwa ma cell, potero imayambitsa. Njira iyi imakulitsa mawu a p53. P53 ndipuloteni yomwe imateteza DNA ku chiwonongeko ndipo imateteza maselo ku masinthidwe omwe angayambitse khansa.

SIRT1 imatha kukulepheretsani kuwonongeka ndi kuwonongeka kwa maselo, omwe amakula mukamakula.

Zotsatira Zotsutsana ndi Kutupa

Kafukufuku angapo adawonetsa kuti pterostilbene mankhwala ophatikizira am'madzi omwe amayendetsedwa ndi TNF-alpha (tumor necrosis factor-alpha). Kupanikizika kwa Oxidative kumabweretsa kutupa; Pterostilbene imalepheretsa mitundu ya interleukin-1b ndi TNF-alpha pakuchepetsa mitundu ya oxygen.

Pulogalamuyi imatetezanso kupsinjika mkati mwa makina a ma cell omwe amatchedwa ER (endoplasmic reticulum). Pofufuza, pamene mabatani am'magazi amatulutsidwa ndi Pterostilbene ufa, kukhazikika kwawo sikunayankhe pazizindikiro zam'mimba, ndipo sanawonekere kuti anali ndi vuto.

Pterostilbene limagwirira ntchito; Zotsatira za Khansa

Zodabwitsa, ngakhale atachepetsa kupsinjika kwa ma ER (endoplasmic reticulum) pakulowa kwamitsempha yamagazi, Pterostilbene imakulitsa kupsinjika mu endoplasmic reticulum ya maselo a khansa yapakhosi. Chifukwa chake, imasankha maselo a khansa komanso imateteza pamavuto a oxidative m'maselo athanzi.

M'maselo a khansa ya msana kapena muubongo (glioma), Pterostilbene amatsitsa Bcl-2 ndikweza Bax; Kusintha kumeneku kumakulitsa chizimba cha “kudzipha” kwa maselo omwe amachititsa kuti msana kapena ubongo ufe.

Ma cell a khansa amagwiritsa ntchito njira yotchedwa Notch-1, kuti adziteteze okha kuti asagwiritsidwe ntchito ndi mankhwala a chemotherapy, kuphatikizapo oxaliplatin ndi fluorouracil. Pterostilbene imalepheretsa Notch-1 kuwonetsa kupangitsa zotupa kukhala zofunikira kwambiri pa chithandizo cha chemotherapy.

Pterostilbene amachepetsa kupanga mitundu ingapo yolimbikitsira khansa yamapapu, kuphatikizapo MUC1, b-catenin, Sox2, NF-κB, ndi CD133. Zotsatira zonsezi zimachepetsa kutupa ndikupangitsa kuti zikhale zosatheka kukula kwa maselo a khansa.

neuroprotection

Pterostilbene imatha kulunjika dera la hippocampus mosankha mu ubongo. Apa, imathandizira CREB (mapulani othandizira kupanga cAMP), BDNF (neurotrophic factor), ndi MAPK (mitogen-activated protein kinases),

Mapuloteni atatuwa amathandizira ma neuron kuchulukitsa, kukula, komanso kuyankha moyenera kuzungulira kwawo. Ma SNRI antidepressants amathandizanso kutsata njirazi.

Pterostilbene imakulitsanso mapuloteni ena omwe amadziwika kuti Nrf2 mu hippocampus, omwe amathandizira kuwonjezera mapuloteni a antioxidant.

Pterostilbene imalepheretsa thupi kulimbana ndi matenda a Alzheimer's mwa kupereka chitetezo ku ubongo motsutsana ndi beta-amyloid (Aβ). Zimachita izi pophatikiza Akt ndi PI3K, mapuloteni awiri omwe amathandizira kukula kwa neuron, kukumbukira, ndi kuphunzira.

3. Pterostilbene ufa umapindula

Zomwe takambirana m'munsimu ndizofunikira kwambiri pterostilbene ufa phindu;

pterostilbene-ufa-2

i. Pterostilbene monga nootropics

Tikamakalamba, malingaliro atsopano amakhala ovuta kukhazikitsa, ndipo kukumbukira kumakhala kovuta kupeza. Kulephera kugwira ntchito yanzeru kumatsikanso. Zowonjezera za Pterostilbene zimathandizira pakupanga malo obwezerezedwanso a neural pazaka zilizonse.

Pterostilbene ndi nootropic yamphamvu, yomwe imathandizira kupumula kwamalingaliro ndi kupititsa patsogolo kuzindikira. Amamvedwanso pafupipafupi asanayambe kulimbitsa thupi chifukwa chothandizira kuthandizira kwamitsempha yamagazi. Chifukwa chake, imapereka zotsatira zofanana ndi zina za zina za nitric oxide zokulitsa.

Mapindu a Pterostilbene nootropic amakhulupirira kuti amatha chifukwa chokhoza kuwonjezera milingo ya dopamine. M'makola, Pterostilbene adachepetsa nkhawa ndikuwonjezera kusintha kwamphamvu. Kafukufuku wokhudzana ndi makoswe okalamba, othandizira a pterostilbene adakweza milingo ya dopamine ndikuwonjezera kuzindikira. Komanso, pomwe Pterostilbene anapezeka mu ubongo wa makoswe, hippocampus, kukumbukira kwawo ntchito kunakulitsidwa.

Kafukufuku wina wokhudza makoswe, Pterostilbene adathandizanso kukula kwatsopano kwa maselo mu hippocampus. Komanso, maselo amtundu wotengedwa mu ubongo wa mbewa zazing'ono amakula mwachangu atayang'aniridwa ndi Pterostilbene.

Malinga ndi kafukufuku wamaselo, pterostilbene ufa umalepheretsa MAO-B (monoamine oxidase B) ndikuonjezera dopamine m'matumbo athu. Kuchita izi ndikofanana ndi mankhwala omwe amachiza matenda a Parkinson, monga rasagiline, safinamide, ndi selegiline. Pofufuza, Pterostilbene amatetezanso ma neurons ku kuwonongeka kokhudzana ndi matenda a AD (matenda a Alzheimer's).

Mphamvu yoletsa nkhawa ya Pterostilbene imadziwikanso kuti imachitika chifukwa chakutha kwake kuletsa monoamine oxidase B. Mu kafukufuku wina, Pterostilbene adawonetsa ntchito ya nkhawa pambuyo pa magawo awiri ndi amodzi mg / kg. Ntchito yodetsa nkhawa ya pawiriyi inali yofanana ndi ya diazepam imodzi ndi ziwiri mg / kg mu EPM.

ii. Pterostilbene ndipo kunenepa

Kafukufuku adafufuza kuthekera kwa Pterostilbene kusamalira kunenepa kunawonetsa kuti pali kuphatikiza kwakukulu pakati pa pterostilbene supplement ndikuwongolera kunenepa. Asayansiwa amakhulupirira kuti Pterostilbene ufa amatha kuthana ndi misempha yamafuta ambiri chifukwa chakuchepa kwake kwama lipogenis. Lipogeneis ndi njira yopanga maselo owonjezera amafuta. Pterostilbene komanso imathandizira kuwotcha mafuta kapena makutidwe ndi mafutawa m'magazi.

Kafukufuku wokhudzana ndi anthu azaka zapakati omwe ali ndi cholesterol yayikulu, gulu la omwe sanamwe mankhwala a cholesterol adataya thupi pomwe amamwa mankhwala a pterostilbene. Zotsatira izi zidadabwitsa akatswiri ofufuza chifukwa kafukufukuyu sanapangidwe kuti aziyeza zowonjezera za pterostilbene ngati chithandizo chakuchepetsa thupi.

Kafukufuku wazinyama ndi ma cell amawonetsanso kuti pterostilbene poda ingathandizire kukulitsa chidwi cha insulin. Zomwe Pterostilbene amachita ndikuti zimalepheretsa njira yosinthira shuga kukhala mafuta. Zimalepheretsanso ma cell mafuta kukula ndikuchulukana.

Pterostilbene amasinthanso kupanga matumbo m'matumbo ndikuthandizira kugaya chakudya.

Makola omwe adadyetsedwa ndi Pterostilbene anali ndi zipatso zamatumbo zabwino komanso mphamvu kwambiri ku Akkermansia muciniphila. A. muciniphila ndi mtundu wa mabakiteriya womwe umawoneka kuti umalepheretsa kuchepa kwamthupi, kunenepa kwambiri, komanso matenda ashuga. Bacteria uyu wakhala chidwi chachikulu cha kafukufuku waposachedwa posachedwapa.

iii. Pterostilbene Amalimbikitsa Kukhala Ndi Moyo Wautali

Phindu la kukalamba kwa Pterostilbene limalumikizidwa ndi mankhwala omwe amadziwika kuti Trans-pterostilbene. Mankhwala awa akuwonetseredwa kuti amachepetsa kutupa, kusintha kwachidziwitso, komanso kukhazikitsa shuga m'magazi. Mu maphunziro a vivo ndi mu vitro amathandizira kupewa ndi kuchiritsa kwa Pterostilbene. Mankhwalawa amagwiranso ntchito ngati kutsitsa kwa caloric, komwe kumapangitsa kuti thupi lizitulutsa michere, kuphatikizapo adiponectin yomwe imachepetsa kukalamba pomwe ukupangitsa machiritso.

Chowonjezera chotsutsa ukalambayu chimadziwika kwambiri poteteza ku matenda okhudzana ndi ukalamba, mwakutero ndikukulitsa moyo. Mu makoswe, Mlingo wochepetsetsa wa mankhwala amenewa amachepetsa zizindikiro zokhudzana ndi ukalamba. Kafukufukuyu adanenanso kuti kudya zakudya zambiri za pterostilbene monga blueberries kungachedwetse zovuta zokhudzana ndi ukalamba, kuphatikizapo matenda a dementia ndi khansa.

pterostilbene-ufa-3

4. Pterostilbene ndi resveratrol

Palibe kukayika kuti Pterostilbene ndi resveratrol ndizogwirizana kwambiri. Resveratrol amadziwika kuti ndi bioactive mankhwala mu vinyo wofiira ndi mphesa.

Ubwino wazotsatira za resveratrol ndiwofanana ndi wa Pterostilbene ndipo umaphatikizapo kutetezedwa ku Alzheimer's, zotsatira za anticancer, kupititsa patsogolo mphamvu, kuthana ndi zotupa, zotsatira za anti-matenda a shuga, ndi mapindu a mtima.

Pterostilbene kwenikweni ali mwanjira yofanana ndi resveratrol, koma kafukufuku wanena kale kuti Pterostilbene ikhoza kukhala yamphamvu kwambiri kuposa resveratrol pakuwongolera zina zathanzi. Pterostilbene awonetsa kuthekera kokulirapo kwamphamvu yogwira ntchito, thanzi la mtima, komanso kuchuluka kwa glucose.

Moyo wa Pterostilbene ndi wamfupi kwambiri kuposa theka la moyo wa resveratrol. Pterostilbene kwenikweni imachulukitsa kanayi kuyamwa kuchokera pakulowetsa chakudya kulowa m'thupi kuposa resveratrol. Mwachidziwitso, izi zitha kupangitsa Pterostilbene kukhala wogwira ntchito kangapo kuposa resveratrol. Komabe, maphunziro ochulukirapo akuyenera kuchitidwa kuti atsimikizire izi.

Pterostilbene ndi resveratrol nthawi zina amaphatikizidwanso kuti apereke zowonjezera mumapangidwe a kapisozi. Zowonjezera izi zimakhulupirira kuti ndizochulukirapo chifukwa zimaphatikiza phindu la mankhwala awiriwa.

5. Pterostilbene zowonjezera

Palibe kukayika kuti kuti mukwaniritse zabwino zabwino kwambiri za Pterostilbene, ndikulimbikitsidwa kuti muzitenga ngati ufa wowonjezera. Pterostilbene zowonjezera amagulitsidwa m'masitolo ogulitsa zakudya zachilengedwe komanso m'masitolo a pa intaneti omwe amakhala ndi zakudya zamagetsi. Muthanso kupeza opanga pterostilbene pa intaneti.

Pterostilbene yowonjezera imapezeka kwambiri mu mawonekedwe a makapisozi, okhala ndi mitundu yambiri. Muyenera kuwerenga cholembera kapena zolembedwamo mosamala ndikuwona kuchuluka kwa Pterostilbene pachikuto chilichonse musanagule. Izi ndizofunikira chifukwa Mlingo wosiyanasiyana ungawonetse zosiyana.

Komanso, mankhwala ena othandizira a pterostilbene amatha kukhala apamwamba kuposa omwe amafufuzidwa mwa anthu. Mlingo womwe umapezeka kwambiri umakhala pakati pa 50 mg mpaka 1,000 mg mu kapisozi iliyonse.

Monga tanena kale, kuphatikiza zowonjezera zimapezekanso, ndipo kuphatikiza komwe kumatchuka kwambiri ndi Pterostilbene ndi resveratrol. Pterostilbene imaphatikizidwanso ndi curcumin, tiyi wobiriwira, astragalus, ndi zina zachilengedwe.

Muthanso kupeza mafuta oyika dzuwa omwe ali ndi Pterostilbene ngakhale izi ndizosowa. Kuchuluka kwa Pterostilbene ofunikira kuti akutetezeni ku khansa yapakhungu sikunaphunzire, koma kungakupatseni chitetezo chowonjezera.

6. Komwe mungapeze ufa wapamwamba kwambiri wa Peterostilbene?

Ngati mukufuna pterostilbene ufa wapamwamba kwambiri, ndiye kuti muli pamalo oyenera. Ndife amodzi mwa opanga ma pterostilbene otchuka, odziwa komanso odziwa zambiri ku China. Timapereka zinthu zoyera komanso zoyikika bwino bwino zomwe nthawi zonse zimayesedwa ndi gulu lachipatala lachitatu kuti zitsimikizire kuyera ndi chitetezo. Nthawi zonse timapereka ma US ku Europe, Europe, Asia, ndi madera ena padziko lapansi. Ndiye ngati mukufuna kugula pterostilbene ufa wapamwamba kwambiri, ingolumikizanani nafe tsopano.

Zothandizira

  1. Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JR (2004). "Resveratrol, pterostilbene, ndi piceatannol mu vaccinium zipatso". J Agric Chakudya Chem. 52 (15): 4713-9.
  2. Kapetanovic IM, Muzzio M., Huang Z., Thompson TN, McCormick DL Pharmacokinetics, mkamwa bioavailability, ndi metabolic mbiri ya resveratrol ndi dimethylether analog, pterostilbene, makoswe. Chemother. Pharmacol. 2011; 68: 593-601.
  3. Chitetezo cha kapangidwe ka trans ‐ resveratrol ngati chakudya cholemba motsatira lamulo (EC) No 258/97 ″. EFSA Journal. European Food Security Authority, EFSA Panel pa Zakudya Zamtundu, Zakudya Zopatsa Thupi Ndi Allergies. 14 (1): 4368
  4. Becker L, Carré V, Poutaraud A, Merdinoglu D, Chaimbault P (2014). "MALDI misa yambiri yowonera malo amodzimodzi munthawi yotsalira, pterostilbene ndi vinigains pamasamba a mphesa". Mamolekyu. 2013 (7): 10587-600.

Zamkatimu