Chithunzithunzi cha Coluracetam

Mbiri ya Coluracetam

Coluracetam amatchedwanso BCI-540 kapena 2- (2-oxopyrrolidin-1-yl) -N- (2, 3-dimethyl-5, 6, 7, 8-tetrahydrofuro2, 3-b quinolin-4-yl kale anali acetoamide kale imadziwika kuti MKC-231. Coluracetam ndi yatsopano yopanga nootropic kuchokera ku banja la racetam Komabe, imakhala yolimba kwambiri ya nootropic pakukweza kukumbukira ndikugwira ntchito konse kwanzeru.

Coluracetam kwenikweni ndi chakudya kuwonjezera zochokera ku piracetam. Coluracetam idapangidwa koyamba ndi Mitsubishi Tanabe Pharma Corporation mu 2005. Iwo adapanga ngati njira yochizira matenda a Alzheimer's. Ngakhale zotsatira zoyambirira zidawonetsa kuthekera kwina, adalephera kufikira kumapeto.

Pambuyo pake layisensiyo idasamutsidwira ku BrainCells Inc. yomwe idayipanga kuti ichiritse matenda ovutika maganizo (MDD) ndi nkhawa yapafupipafupi (GAD). Adafika pamaphunziro a chipatala cha gawo la 2a omwe adanena zina zokhoza kuthandiza odwala ku matenda ovutika maganizo komanso nkhawa.

Tsoka ilo, Brain Cells Inc. sinakhazikike mokwanira komanso kampaniyo idatsekedwa mu 2014. Coluracetam tsopano yakhala ikupezeka chilolezo kuyambira 2012.

Ngakhale zonsezi, coluracetam imawonedwa ngati yamphamvu kwambiri nootropic pawiri. Nthawi zambiri imagwira mwachangu chifukwa imatha kufikira milingo yayikulu kwambiri mkati mwa mphindi 30 kuchokera pakumwa. Komabe, magawo amatsika mkati mwa maola atatu ogwiritsira ntchito zomwe zikutanthauza kuti munthu akhoza kupeza phindu lalikulu maola atatu atangogwiritsidwa ntchito.

Monga ma racetams ena, coluracetam imakulitsa milingo ya acetylcholine, komabe momwe amagwirira ntchito amawonekera. Coluracetam makamaka imakweza njira yayikulu yogwirizira choline (HACU) motero imawonjezera kutembenuka kwa choline kukhala acetylcholine. Mitsempha ya neurotransmitter, acetylcholine, imalumikizidwa ndi chidziwitso chazidziwitso ndikukumbukira, chifukwa chake mphamvu ya coluracetam monga gawo la nootropic.

Zopindulitsa zina zomwe zimakhudzana ndi coluracetam zimaphatikizapo kukonza masomphenya, kupititsa patsogolo kumvetsetsa komanso kukumbukira kukumbukira kwaulere, kulimbikitsa kusintha, kumasuka ku nkhawa komanso kukhumudwa komanso chinthu chomangirira thupi.

Coluracetam imapezeka kuchokera ku mapiritsi a f, makapisozi kapena madzi. Itha kutengedwa pakamwa kapena pang'ono. Coluracetam ndi nootropic yokhala ndi mafuta osasintha motero kuyamwa mwachangu kuyenera kugwiritsidwa ntchito limodzi ndi mafuta / mafuta athanzi monga mafuta a maolivi a namwali.

Izi nootropic zimagwira ntchito kwakanthawi kochepa kwambiri chifukwa zimafika pakulowa kwa plasma pasanathe mphindi 30 pambuyo pa dongosolo.

Coluracetam ndi chiyani?

Coluracetam ndimapangidwe opanga ndi mafuta osungunulira nootropic m'mabanja a racetam. Coluracetam amatchedwanso Gulani-540 kale amadziwika kuti MKC-231.

Ngakhale ndichilengedwe chatsopano, zopindulitsa za coluracetam nootropic zikulonjeza. Amakhulupirira kuti imapereka phindu lalikulu pakupititsa patsogolo kukumbukira, kuphunzira, kuthetsa nkhawa, kusweka mtima kwakukulu komanso kukonza masomphenya.

Coluracetam limagwirira ntchito

Kodi coluracetam imagwira ntchito bwanji mu ubongo?

Monga ma racetams ena, coluracetam imapindulitsa bongo mwa kukhudza choline ndipo kenako acetylcholine mosiyanasiyana. Kafukufuku pano omwe apangidwa akuwonetsa kuti zotsatira za coluracetam mu ubongo zimadutsa m'njira zitatu zazikulu. Njira izi za coluracetam zimakonzedwa pansipa;

Coluracetam

(1) Kuthandizira kuyanjana kwambiri ndi choline

Nootropics m'kalasi la racetam amadziwika kuti amachititsa kuti acetylcholine ipangidwe mwa kulimbikitsa olandila udindo. Komabe, coluracetam limagwirira ntchito ndizopadera chifukwa zimathandizira kupanga acetylcholine pakukweza kukhudzana kwapamwamba kwa choline (HACU).

Dongosolo la HACU ndiye njira yapakati yomwe choline chimatumizira ku ubongo. Ndi gawo lomwe lingachepetse gawo la acetylcholine kupanga. Acetylcholine ndi neurotransmitter yomwe imalumikizidwa ndi kukumbukira, kuphunzira komanso kugwira ntchito kwanzeru konse.

Coluracetam zowonjezera kumawonjezera kuchuluka komwe choline imatumizidwira muubongo zomwe zimapangitsa kuti acetylcholine ipangidwe. Imakulitsa makamaka CHT1, woyendetsa choline wothandizana kwambiri, motero zimabweretsa kupezeka kwakukulu kwa choline kuti atenge.

Panthawi yakusokonekera kwa HACU, wina amakumana ndi zomwe zimafotokozedwa kuti ndi chifunga cha ubongo ndipo amakumbukira ndi kuphunzira. Coluracetam mosangalatsa imachulukitsa kuchuluka kwa choline m'madzi a m'magazi omwe amathandiza dongosolo la HACU kugwira ntchito bwino, ngakhale ma neuron ena atawonongeka.

Kupanga kwa acetylcholine mu neurons kumathandizira kukumbukira kwakanthawi komanso kwanthawi yayitali, kuphunzira, komanso kuthekera kosankha bwino.

(2) Kupititsa patsogolo kukonzekera kwa AMPA

Kafukufuku waulula kuti coluracetam ikhoza kupititsa patsogolo alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) potentiation. Ma receptors a AMPA amathandizidwa ndi glutamate yomwe imakhudza kuthekera kwakutali kwa nthawi yayitali (LTP) komwe kumapangitsa kuti pakhale kuphunzira ndi kukumbukira.

Pakadali pano, a Serotonin Selective Reuptake Inhibitors (SSRIs) ndiwo mankhwala omwe amagwiritsidwa ntchito pochiza matenda amisempha komanso kukhumudwa. Izi SSRIs, komabe, zimakhudza milingo ya serotonin mu ubongo yomwe imayambitsa mavuto ambiri.

Coluracetam imakhala yothandiza ngati chithandizo cha kuvutika kwachisoni ndi nkhawa pakukulitsa ntchito ya glutamate chifukwa chake sichimayambitsa zovuta zilizonse zokhudzana ndi serotonin.

(3) Kuteteza zolandilira za NMDA ku kuvulaza kwa glutamate kawopsedwe

Njira ina yomwe ingagwiritsidwe ntchito ndi coluracetam kagwiritsidwe ntchito ndikutha kuteteza ma N-Methyl-D-aspartate (NMDA) zolandilira ku glutamate kawopsedwe. Receptor ya NMDA ndi glutamate receptor komanso mapuloteni ion njira amapezeka m'maselo am'mitsempha. NMDA receptor imagwira gawo lalikulu pakuwongolera kwa synaptic plasticity ndi kukumbukira zochitika.

Zowonongeka kwa ma NMDA receptors zimalumikizidwa ndi zovuta zazikulu za ubongo monga kugwidwa, kuvulala kwamtundu wa ubongo, matenda a Alzheimer's pakati pa matenda ena a ubongo.

Ubwino wa Coluracetam

Kafukufuku wa Coluracetam amazindikira kuti ndiwothandiza nootropic wothandizira kuphatikiza ndi zabwino zomwe zimachitikira coluracetam ndi ogwiritsa ntchito '. Coluracetam ndichisangalalo chosangalatsa chazidziwitso chifukwa cha magwiridwe antchito ake abwino. Komabe, popeza ndi gawo latsopano maphunziro owonjezera mwa anthu amafunikira kuti atsimikizire zopindulitsa za coluracetam zomwe zanenedwa.

M'munsimu muli mapindu a coluracetam kuti munthu amatha kudziwa kuchokera ku kugwiritsa ntchito kolimba kolingana ndi moyenera;

(1) Sinthani Memori ndi KuphunziraColuracetam

Coluracetam imawonjezera kupanga kwa neurotransmitter, acetylcholine yokhudzana ndi kuphunzira ndi kukumbukira.

Kafukufuku wowerengeka akuwonetsa kuti coluracetam imatha kukulitsa kukumbukira ndikuzindikira ntchito mu makoswe. Komabe, kafukufukuyu sanachitikebe ndi anthu koma zotsatira zake zingafanane.

Mwachitsanzo, pophunzira makoswe omwe ali ndi vuto lolephera kukumbukira, kuperekera pakamwa pa coluracetam pa 1-10mg / kg kunapezeka kuti kumapangitsa kukumbukira kukumbukira popanda kuyambitsa zotsatirapo zoyipa.

Ndemanga za Coluracetam zikuwonetsa kuti zitha kukulitsa kukumbukira kwakanthawi komanso kwakanthawi.

(2) Sinthani Kuwerenga Kumvetsetsa komanso Kukumbukira Kwaulere

Coluracetam zowonjezera imatha kusintha kukumbukira kwakanthawi kochepa, kukulitsa chidwi komanso kukumbukira kwaulere. Izi zimathandizira ophunzira ndi aliyense ali m'malo ampikisano kuti azitha kuchita bwino.

zingapo zokumana ndi coluracetam ndi ogwiritsa ntchito pawokha amawonetsa kuthekera kwa coluracetam kuti ichititse chidwi chake pakuwerenga momvetsetsa komanso kukumbukira kwaulere pazinthu zomwe zaphunziridwa.

(3) Kupititsa Kukhazikika Kwa Kachidziwikire

Coluracetam akuti amathandizira dongosolo la choline kutenga zomwe zimathandizira kuzindikira kwa nthawi yayitali atatha kugwiritsa ntchito mlingo wochepa kwambiri wa coluracetam.

(4) Pewani Kuthana ndi Matenda OchiritsaColuracetam

Kafukufuku akuwonetsa kuti zowonjezera za coluracetam ndizotheka kuchiritsa kwa anthu omwe ali ndi anti-depressants.

Kuyesedwa kwa gawo 2a kunachitidwa ndi BrainCells Inc., pa odwala omwe sagwirizana ndi omwe ali ndi nkhawa kuti ayese kuyesa kwa coluracetam motsutsana ndi kukhumudwa kwakukulu (MDD) ndi nkhawa yapafupipafupi (GAD). Zotsatira zoyambirira zinawonetsa kuti coluracetam pa 240mg / tsiku anali otsutsa MDD ndi GAD.

(5) Kupititsa patsogolo kwa Neurogeneis

Neurogeneis ndi njira yomwe maselo atsopano aubongo amapangidwira. Njirayi ndiyofunikira kwambiri pakugwira ntchito mwamphamvu komanso ubongo wonse.

Coluracetam amatha kupititsa patsogolo neurogeneis koma njira yoyambira yochita sizikudziwika. Kafukufuku akuwonetsa kuti ikhoza kukhala yokhudzana ndi kuthekera kwa coluracetam kukulitsa milingo ya acetylcholine makamaka makamaka hippocampus.

(6) Itha kukonza kukhumudwa kwa Mental

Coluracetam imachulukitsa zochitika za acetylcholine zomwe zimatha kuthandiza anthu omwe akuvutika ndi Schizophrenia momwe ma enzyme omwe amaphatikizidwa ndi kaphatikizidwe ka acetylcholine nthawi zambiri amakhala operewera.

Zitha kuthandizanso kuphunzira kwa odwala omwe ali ndi vuto lina lazitsulo monga matenda a Alzheimer's.

(7) Pangani Zowoneka bwinoColuracetam

Coluracetam ndiyosangalatsa nootropic chophatikizira chomwe sichimangothandiza kuzindikira kokha komanso chitha kukulitsa masomphenya anu kudzera pakuwona bwino kwamitundu, kuzindikira bwino mawonekedwe ndikuwona bwino. Itha kulimbikitsa kukula kwa mitsempha mwa anthu omwe akhudzidwa ndi matenda opatsirana a diso.

Ogwiritsa ntchito a coluracetam amakumana ndi zosiyana zotsatira za coluracetam kuphatikiza mitundu yowala, kusiyanitsa kwakukulu, kuyang'ana kwambiri mawonekedwe ndi magetsi kuyaka.

(8) Kusintha kwa chizindikiro cha Bowel Syndrome

Irritable matumbo amisala (IBS) ndimatenda akulu opezeka m'matumbo omwe amachitika chifukwa cholamulira chosavomerezeka cha choline transporter 1 (CHT1).

Kafukufuku wa 2018 akuwonetsa kuti coluracetam imatha kuyendetsa molekyulu ya CHT 1 motero imathandizanso kutsegula matendawa ngati matumbo osakwiya.

(9) Coluracetam zosangalatsa ntchito

Coluracetam ndichabwino chopititsa patsogolo ndipo chimapereka mpumulo pang'onopang'ono. Zakhala zofunikira kuti zithandizire kukula kwa mahomoni amtunduwu kotero kuti amapanga thupi. Komabe, sizikusonyezedwa ngati chilimbikitso cha mphamvu chifukwa chake ziyenera kugwiritsidwa ntchito ndi chowonjezera pa zotsatira zabwino.

Coluracetam Vs aniracetam, fasoracetam, pramiracetam ndi Piracetam. Kodi pali kusiyana kotani?

(1). Coluracetam motsutsana Aniracetam

Onse a coluracetam ndi aniracetam ndi am'banja la racetam. Onsewa ndi ma nootropic othandizira. Aniracetam idapezeka koyamba kumayambiriro kwa zaka za m'ma 1970. Aniracetam amadziwika kuti amathandizira kukumbukira komanso kusinthasintha, kuchepetsa nkhawa komanso zizindikiro za kukhumudwa komanso kukonza malingaliro.

Pamene onse awiri coluracetam ndi aniracetam zimakhudza milingo ya acetylcholine mu ubongo wanu, zimasiyana momwe zimakhudzira. Aniracetam imatsogolera kutulutsidwa kwa acetylcholine pamene njira yayikulu yolumikizirana ndi coluracetam imakhala njira yotsogola komanso kuwongolera kukhala acetylcholine.

Kuphatikiza apo, coluracetam yakhala ikuwoneka kuti ikuwongolera kwambiri ndikuwonjezera tsatanetsatane pomwe Aniracetam imatsogolera kukodzedwa kwamitundu yambiri.

Ngakhale aniracetam ndi coluracetam nootropics ndizophatikiza zogwirizira, Coluracetam ndi chowonjezera chowongolera kuposa aniracetam.

Kuphatikiza apo, ogwiritsa ntchito ena a aniracetam akuti amapanga kusintha kwatsopano. Coluracetam mbali inayo amasintha masomphenya.

(2). Coluracetam ndi Fasoracetam

Fasoracetam ndiye nootropic watsopano kwambiri wabanja la racetam. Imakonzedwa ngati chithandizo chotheka kapena Attention Deficit Hyperaciture Disorder (ADHD) mwa ana.

Monga coluracetam, Fasoracetam ndi nootropic yaubongo yomwe ingathandize kusintha kukumbukira ndikugwira ntchito konse. Onsewa amalimbikitsa kukoka kwa choline komwe kumagwiritsidwa ntchito pakupanga acetylcholine.

Imodzi mwazida zopambana kwambiri za fasoracetam ndikutha kwake kukweza ma GAB Ab receptors. Ma GABA receptors amaphatikizidwa ndi kuphunzira, zopatsa mphamvu zomwe zimathandizira kuthetsa nkhawa komanso kupsinjika komanso kusintha kugona.

Izi nootropics zitha kukhala ndi zotsatira zofanana. Komabe, chikhalidwe chosiyanitsa ndikuti, coluracetam imatulutsa acetylcholine pamlingo wokwera kuposa fasoracetam. Kuphatikiza apo, kuthekera kwa coluracetam pakukweza machitidwe kumatsimikiziridwa bwino pamene a fasoracetam satsimikiziridwa mokwanira.

Monga ma racetams ena, Fasoracetam imafunika kuti igwiritsidwe ntchito limodzi ndi gwero labwino la choline monga Alpha GPC. Komabe, ndizovuta kuyimangiriza ndi zina zowonjezera. Zokondweretsa, coluracetam fasoracetam okwanira ndiye okhawo amene adalimbikitsa.

(3). Coluracetam vs Pramiracetam

Pramiracetam ndi imodzi mwamphamvu kwambiri nootropics kuchokera ku banja la racetam. Ili ndi mphamvu zokulitsa kukumbukira zomwe zimapangitsa. Mosiyana ndi ma racetams ena, omwe sagwiritsidwa ntchito kwambiri pamaphunziro athanzi, pramiracetam ingagwiritsidwenso ntchito anthu athanzi.

Monga coluracetam, pramiracetam imakulitsa neurotransmitter mu ubongo. Komabe, mosiyana ndi coluracetam kapena ma racetams ena omwe amakhudza ma neuron receptors, pramiracetam ikhoza kuwakhudza onse komanso kukopa hippocampus.

Ngakhale onse amatha kupititsa patsogolo kukumbukira, pramiracetam imaperekanso zabwino zakukondweretsa. Komabe, coluracetam imaperekanso phindu lina kuchokera ku pramiracetam yothetsa nkhawa komanso kukulitsa chisangalalo.

(4). Coluracetam vs Piracetam

Piracetam ndiye woyamba nootropic wopangidwa kukhala wolimba komanso wamphamvu kwambiri pakati pa ma nootropics ena mu kalasi la racetam. Piracetam ndi othandizira ozindikira mwanzeru makamaka kwa achikulire ndi anthu omwe ali ndi vuto lofooka. Komabe, sizingakhale zothandiza kwa anthu athanzi.

Ngakhale onse piracetam ndi coluracetam amalimbikitsa kuchuluka kwa acetylcholine mu ubongo momwe amagwirira ntchito mosiyanasiyana. Piracetam imapangitsa kuti acetylcholine receptors azikhala ndi chidwi kwambiri ndi acetylcholine, pomwe, coluracetam imawonjezera kutembenuka kwa choline kukhala acetylcholine pokopa njira yayikulu yogwirizira choline.

Coluracetam

Mlingo wa Coluracetam, Stack, Supplementation

(1) Mlingo wa Coluracetam

Ulamuliro wazakudya ndi mankhwala osokoneza bongo (FDA) amawona coluracetam ndi mitundu ina ya racetam nootropics ngati mankhwala atsopano osavomerezeka ndipo chifukwa chake mulibe kuchuluka kwa mulingo wa coluracetam. Pankhaniyi analimbikitsa Mlingo wa coluracetam zimachokera ku maphunziro azachipatala aumunthu koma mwatsoka kafukufuku wochepa wokha wachitika ndi maphunziro a anthu.

Tonse, zonse sizimatayika pomwe ndemanga zambiri za coluracetam kuchokera kwa ogwiritsa ntchito zimathandizira kupeza mlingo woyenera wa coluracetam. Mlingo wogwira uli pakati pa 5-20 mg patsiku, koma kuyerekeza kolimba ya coluracetam pamlomo wothandizidwa ndiye kuti mlingo ungasinthidwe molondola.

Mukamasankha coluracetam pamlomo ndikuchepetsa, mulingo woyenera uyenera kutsikira. Kuwongolera kwa zinthu zingapo kumaphatikizapo kuyika coluracetam pansi pa lilime ndikulola kuti lipasuka kudzera pakhungu. Izi zimalola coluracetam nootropic kuyenda molunjika kumtsempha wamagazi komwe kumapangitsa zotsatira za coluracetam.

Ogwiritsa ntchito ambiri amapereka kuchuluka kwa mankhwalawa a coluracetam a 20-80 mg tsiku lililonse omwe amatengedwa mu Mlingo wachiwiri, m'mawa kwambiri ndipo winayo masanawa.

Komabe, mlingo waukulu wa coluracetam pafupifupi 100 mg tsiku lililonse amatengedwa katatu amafunika kuchiritsa matenda okhumudwa komanso nkhawa zambiri. Mlingo wa mpaka 240 mg wololedwa tsiku lililonse wogwiritsidwa ntchito poyesedwa popanda zovuta zoyipa.

Monga momwe zilili ndi mankhwala ena aliwonse kapena zakudya zanu, nthawi zonse muziyamba pa mlingo wotsika kwambiri ndikukula pang'onopang'ono monga thupi lanu lingafunikire. Coluracetam iyenera kutengedwa ndi gwero labwino la choline kuti izithandiza zolakwika za choline zomwe zingayambitse mutu.

(2) Coluracetam okwana

Ma Racetams ndi zina zowonjezera za nootropic zimabala bwino pamene zidasungidwa ndi zowonjezera zina. Ma Racetams amafunikira kutengedwa limodzi ndi gwero labwino la choline kuti mupewe zovuta zomwe zimakhudzana ndi choline osakwanira mu ubongo monga mutu. Coluracetam sikuti ndi zosiyana.

Ngati mungaganizire za coluracetam alpha GPC nootropic stack, kuchuluka kwa 300-600 mg tsiku lililonse kungakhale koyenera mwanjira ina 250-750 mg patsiku la CDP choline ikhoza kukhala ndi zotsatira zabwino zotenga ndi 10-20 mg ya coluracetam tsiku lililonse.

Coluracetam imakhala bwino ndi zowonjezera zambiri kuphatikiza, phenylpiracetam, tianeptine, noopept, modafinil, pramiracetam, piracetam ndi wochita pakati pa ena nootropics.

Popeza kukhala wambiri kumatha kukhala kotalikirapo popeza coluracetam imapereka malo oyesera, lingalirani za kuchuluka komwe kumakulitsa chidwi chanu chazindikiritso kwinaku kumalimbikitsa mphamvu zazikulu zamaganizidwe ndi thupi komanso kuperewera kwa choline. Zambiri monga zokhala ndi khola ndizophatikiza ndi coluracetam oxiracetam, coluracetam fasoracetam stack pakati pa ena.

Chitsanzo cha kuchuluka kwathunthu kwa coluracetam oxiracetam ndi

  • 20 mg coluracetam - othandizira chidwi chachikulu
  • 200 mg oxiracetam - amapatsa phindu la synergetic ndi coluracetam
  • 200 mg khofi - kuti achite zinthu zotsutsa
  • 400 mg L-Theanine-kulimbikitsa mpumulo
  • 300 mg ya magwero a choline monga Alfa GPC owonjezera

(3) Kuphatikiza kwa Coluracetam

Coluracetam yowonjezera ikhoza kupezeka mawonekedwe amtundu wa coluracetam ufa, madzi nthawi zambiri amatengedwa mosavuta komanso ngati makapisozi a coluracetam.

Pali njira zazikulu za momwe coluracetam ingatengeredwe mwachitsanzo coluracetam pamlomo vs sublingual kasamalidwe. Dongosolo lothandizirana ndi othandizirana ndilothandiza kwambiri kuposa pakamwa. Chowonjezeracho chikaikidwa pansi pa lilime chimalowa mwachindunji m'mitsempha, motero kulowa mwachangu komanso kosavuta.

Coluracetam ndi yotchuka chifukwa chogwira ntchito yayikulu pakukweza kukumbukira komanso kuphunzira limodzi ndi zina monga kukonza masomphenya, kuthetsa nkhawa komanso kukhumudwa kwakukulu komanso kuchiza matumbo osapweteka.

Coluracetam imagwira ntchito makamaka mwakuwonjezera kuchuluka kwa acetylcholine mu ubongo. Njira ina yothandizira kuphatikizira kwa coluracetam ndikumadya zakudya zamafuta a choline monga mazira, chiwindi, ng'ombe ndi nyama ya nkhuku, broccoli pakati pa ena.

Ogwiritsa ntchito ambiri a coluracetam amadzaza ndi gwero labwino la choline monga CDP-Choline kapena Alpha-GPC kuti alimbikitse zotsatira za coluracetam ndikuchepetsa zotsatira zoyipa.

Coluracetam ndi mafuta osungunuka a nootropic chifukwa chake imayenera kutengedwa ndi mafuta athanzi monga mafuta a kokonati osagulitsidwa, kapena mafuta owonjezera aamwali osakwatiwa kuti athandizike bwino.

Zotsatira zoyipa & Kuyanjana

Coluracetam mavuto

Coluracetam ndi malo otetezedwa komanso ovomerezeka a nootropic omwe agwiritsidwa ntchito popanda kuyambitsa mavuto. Komabe, zovuta zina zoyipa pang'ono. Zotsatira za coluracetam nthawi zambiri zimachitika pakakhala mankhwala osokoneza bongo.

Zotsatira zoyipa za coluracetam zimaphatikizapo;

Mutu: Izi ndizofala kwambiri ndi ma racetams onse chifukwa chakuti kuwonjezeka kwa kutembenuka kwa choline kukhala acetylcholine. Ma choline osakwanira muubongo nthawi zambiri amatulutsa mutu kumutu. Ogwiritsa ntchito ena a coluracetam anena za mutu. Izi zimakonzedwa ndikusungika ndi gwero labwino la choline komanso kutsitsa mlingo.

Phulusa laubongo: izi zimangotanthauza kusayang'anira ndi kusokoneza. Ena ogwiritsa ntchito a coluracetam adanenapo za kusokonezeka komanso kusayang'ana. Komabe, izi nthawi zambiri zimazimiririka ndikugwiritsidwa ntchito kosasinthika kwa coluracetam pa mlingo woyenera.

Kutsika kwamtunduwu: Uku ndikutsutsana kwamaubwino othandizira. Pomwe imadziwika kuti imapangitsa chidwi cha ogwiritsa ntchito ena a coluracetam amamva kutentha koyamba pachiwonetsero ndi zina zambiri. Mwamwayi, kutsitsa mlingo kungathandizire kukulitsa kusintha kwamthupi ndikugwiritsanso ntchito mopititsa patsogolo bwino.

Kuchepetsa mseru: coluracetam ikamamwa mankhwala osokoneza bongo munthu amatha kumva mseru.

Kugona tulo masana: Mankhwala osokoneza bongo amatha kuchepetsa kuchepa kwanu masanawa ngakhale masana.

Zotsatira zina zoyipa za coluracetam zidawunikidwa ndikukwiya, nkhawa, malingaliro ofuna kudzipha, komanso kusokonezeka kwa kugona kwina usiku.

Nkhani yabwino ndiyakuti zotsatira zonse za coluracetam zimapeweka ndi;

  • Kugwiritsa ntchito gwero la choline,
  • Kugwiritsa ntchito mlingo woyenera,
  • Kutenga chakudya m'mawa ndi masana,
  • Kutenga madzi okwanira.

Coluracetam

Kuchita kwa Coluracetam

ena coluracetam mogwirizana zidanenedwa ndipo chifukwa chake munthu ayenera kusamala kwambiri akaganizira zowonjezera izi. Kulankhula ndi dokotala wanu ndikulangizidwa kwambiri kuti musakudziwitseni zilizonse zomwe mungagwiritse ntchito popanga mankhwala komanso pazisankho zomwe mumadya.

Pansipa pali zina mwazochita;

Coluracetam ikhoza kulepheretsa kugwiritsa ntchito mankhwala a anticholinergic, kuphatikizapo mankhwala a Parkinson, Benadryl, ndi antipsychotic ena.

Coluracetam ndi cholinergic chowonjezera ndipo mwina chitha kuwonjezera zotsatira za mankhwala a cholinergic, monga mankhwala a Alzheimer's ndi glaucoma.

Zingathenso kugwiritsa ntchito mankhwala a NMDA receptor, monga mankhwala a chifuwa ndi mankhwala oletsa kupindika.

Kafukufuku wamankhwala & Zomwe Akugwiritsa Ntchito

Kufufuza kwamankhwala ku Coluracetam

Mayeso azachipatala a anthu okhudzana ndi coluracetam amangoyesedwa pamayeso amodzi omwe a Brain Cell Inc. kafukufukuyu adakhudza anthu opitirira 100 omwe ali ndi vuto la kukhumudwa komanso nkhawa zambiri. Zotsatira zoyambirira zikusonyeza kuti coluracetam anali ndi kuthekera kwakukulu komabe, sanapeze zowonjezera.

Zochitika Zosuta

Ngakhale coluracetam kukhala yatsopano yatsopano ya nootropic yokhala ndi maphunziro ochepa aumunthu ena ogwiritsa ntchito ena amapeza maubwino ena komanso zovuta zina. Zina mwa zochitika za coluracetam zomwe zidanenedwa ndi;

  • mitundu Tsogolo
  • Maso opitilira
  • Zolimbikitsa
  • Kukumbukira bwino
  • Kumasulidwa ku nkhawa
  • Zowongolera bwino
  • Mphamvu zambiri
  • Kukulitsa kwamtsogolo
  • Kuthandizira kuwerenga kumvetsetsa ndi kukumbukira kwamaulere

Komabe, ena ndemanga za coluracetam fotokozerani zovuta zina:

  • litsipa
  • Utsi wa ubongo
  • nkhawa
  • Maganizo odzipha
  • Zotsatira zosagwirizana
  • Kusokonezeka kugona tulo
  • Tulo tulo

Chifukwa chakusowa kwa sayansi yakuthandizira pazotsatira za coluracetam pamwambapa, tikukulangizani kuti mufunse othandizira anu asanadye zowonjezera.

Ndani angagwiritse ntchito coluracetam?

Coluracetam ufa kapena yankho ndi labwino kwa aliyense amene angafune kututa zabwino zake. Komabe, anthu omwe ali ndi mavuto azachipatala monga matenda a Parkinson, komanso amayi apakati amalangizidwa kuti asagwiritse ntchito zowonjezera izi.

Anthu omwe ali ndi vuto la kukumbukira chifukwa cha zaka komanso matenda monga Schizophrenia ndi matenda a Alzheimer's pakati pazinthu zina zomwe zimapangitsa kukumbukira, angathe kupindula ndi zowonjezera za coluracetam.

Coluracetam ufa ndi woyenera anthu omwe ali ndi nkhawa komanso kukhumudwa chifukwa amatha kupangitsa kuti azisangalala komanso azitha kuganiza bwino. Coluracetam iyi imachulukitsa acetylcholine mu ubongo, yomwe imathandizira kukumbukira komanso kuyang'ana. Coluracetam ya nkhawa ndichabwino.

Coluracetam ndiyabwino komanso yowonjezera kwa anthu omwe akufuna kukonza masomphenya. Izi zimathandizira kuti munthu azitha kuwona bwino powonjezera masomphenya, kukulitsa masanjidwe ake ndikuwunikira. Zawonekeranso kuti zikuthandizira kukonza mitsempha yowonongeka ndi kuwala.

Coluracetam ufa kapena mawonekedwe ake amadzimadzi ndiowonjezera chabwino kwa ophunzira. Imatha kupangitsa kuti kumvetsetsa komanso kuitana kwaulere kungathe kukonza magwiridwe antchito.

Omanga thupi samasiyidwa popeza izi zimathandizira pakuchita zosangalatsa zomwe zimathandizira kupuma komanso kupanga masewera olimbitsa thupi.

Coluracetam

Kugula Coluracetam?

Coluracetam yogulitsa imapezeka pa intaneti. Ngati mukuganiza kugula coluracetam kuti mugulitse kapena kugwiritsa ntchito nokha, yang'anani mosamalitsa kwa ogulitsa otchuka pa intaneti. Popeza izi ndizowonjezera zatsopano osati makampani ambiri omwe akupereka coluracetam kuti agulitse motero angathe kusankha mwanjira zina zomwe zikupezeka.

Kutsiliza

Coluracetam ndi membala watsopano wabanja la racetam ndipo watchuka chifukwa cha luso lakudziwonetsa bwino, komanso kuwongolera maso.

Makina akuluakulu a coluracetam amagwira ntchito kudzera pakukopa njira yayikulu yolumikizirana (HACU). Izi zimapangitsa kuti ikhale yapadera komanso yapamwamba pakati pa mitundu ina ngati ma phenylpiracetam okha omwe ali ndi makina ofanana.

Chowonadi cha nkhaniyi ndikuti matupi athu samapanga Coluracetam mwachilengedwe. Chifukwa chake, ngati wina akumana ndi mapindu a coluracetam ndiye kuti ayenera kuchokera ku zowonjezera.

Ngakhale ndizoyesa zochepa chabe za anthu zomwe zimalembedwa pazabwino, anthu ambiri adaziyesa kale ndipo adanenanso zabwino zina.

Coluracetam wa kukhumudwa ndipo nkhawa zanenedwa poyeserera kuchipatala ndipo izi zimapangitsa kukhala woyenera kuchita kafukufuku wina kuti atsimikizire mapindu omwe adanenedwa.

Chifukwa cha kafukufuku wocheperako wa anthu omwe ali ndi zowonjezera izi, zoyipa zomwe sizingachitike sizinafotokozedwe bwino, komabe, kupweteka kwa mutu ndi vuto lodziwika bwino ndi ma racetams.

Stacking coluracetam yokhala ndi gwero la choline imalangizidwa kuti ichotse zovuta zomwe zimachitika chifukwa cha kuchepa kwa choline monga kupweteka kwa mutu. Zokwanira zotere zimaphatikizapo coluracetam alpha GPC stack ndi coluracetam CDC choline stack.

Coluracetam ndi mafuta osungunuka pang'ono kuti asungunuke mosavuta m'maselo amayenera kutengedwa ndi mafuta / mafuta athanzi ngati mafuta a kokonati osagulitsidwa, kapena mafuta owonjezera aamwali.

Kafukufuku wowonjezera

Coluracetam imadzaza bwino ndi ma racetam ena komanso zowonjezera zina. Zitsanzo zotere za m'matumba a coluracetam ndi kuchuluka kwa coluracetam oxiracetam ndi kuchuluka kwa coluracetam fasoracetam. Izi zimapereka mwayi wopitiliza kufufuza mu coluracetam ndi zinthu zina. Coluracetam yokhala ndi noopept ikhoza kukhala kuphatikiza kwa synergistic kopititsa patsogolo kukumbukira ndikuzindikira ntchito.

Kuphatikiza apo, coluracetam monga ena ndi ma racetam amawonjezera kuchuluka kwa acetylcholine pomwe kuchepa kwa choline kumachitika. Izi zimapangitsa kuti pakhale coluracetam yokhala ndi magwero abwino a choline monga coluracetam Alpha GPC stack.

Mayeso ochepa a kachipatala alipo kuti atsimikizire phindu la coluracetam mopitilira apo zokumana nazo zambiri za anthu a coluracetam zimawonetsa zabwino zomwe zingakhalepo. Izi zikuwonetsa kuti kafukufuku wambiri akufunika kutsimikizira izi.

BrainCell Inc. yatseka chifukwa chake Coluracetam ili yotseguka kuti ipatsidwe zilolezo zowonjezereka zamankhwala.

Kuchita kwa Coluracetam ndi mankhwala ena ndi malo omwe amafunikira maphunziro owonjezera.

Zothandizira
  1. Akaike A, et al. (1998). Kuteteza kwa MKC-231, buku lodziwika bwino lomwe limaphatikiza zolimbitsa thupi, pa glutamate cytotoxicity mu cortical neurons yotupa. Jpn J Pharmacol.
  2. Bessho, T., Takashina, K., Tabata, R., Ohshima, C., Chaki, H., Yamabe, H., Egawa, M., Tobe, A., & Saito, K. (1996). Zotsatira za kukhudzana ndi bukuli. yl) acetoamide pakusowa kwamadzi yamadzi yophunzira mu makoswe. Chidwi-Forschung, 46(4), 369-373.
  3. Murai, S., Saito, H., Abe, E., Masuda, Y., Odashima, J., & Itoh, T. (1994). MKC-231, choline yokwanira cholimbikitsa, chimathandizira kuchepa kwa ntchito ndikuchepetsa hippocampal acetylcholine woyambitsa ndi mbewa ya ethylcholine aziridinium ion. Journal of Neural Transmission, 98 (1), 1-13.onetsani: 10.1007 / bf01277590.
  4. Shirayama, Y., Yamamoto, A., Nishimura, T., Katayama, S., & Kawahara, R. (2007). Kuwonetseranso komwe kumachitika choline MKC-231 kumatsutsana ndi kuchepa kwa machitidwe a phencyclidine ndikuchepetsa kwa septal cholinergic neurons mu makoswe. European Neuropsychopharmacology, 17 (9), 616-626. https://doi.org/10.1016/j.euroneuro.2007.02.011.
  5. BrainCells Inc. Yalengeza Zotsatira Zofufuza Phase 2a Kuyesa kwa BCI-540Zosungidwa Novembala 21, 2011, ku Wayback Machine.
  6. Yaiwisi COLURACETAM ufa (135463-81-9)

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