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Zomwe Muyenera Kudziwa Zokhudza Kuchuluka Kwa Mankhwala Osokoneza Ubongo Linaclotide
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Zomwe Muyenera Kudziwa Zokhudza Kuchuluka Kwa Mankhwala Osokoneza Ubongo Linaclotide

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1. Kodi Linaclotide (Linzess) ndi chiyani?
2. Kodi Linaclotide amagwiritsidwa ntchito bwanji?
3. Kodi makina a Linaclotide ndi ati?
4. Kodi Linaclotide azigwiritsidwa ntchito bwanji?
5. Mlingo wa Linaclotide (Linzess) ndi uti?
6. Zotsatira zoyipa zomwe Linaclotide zimabweretsa?
7. Ndi mankhwala ati kapena othandizira omwe angalumikizane ndi Linaclotide?
8. Kodi pali kusiyana kwanji pakati pa Linaclotide ndi lubiprostone?
9. Ndi zidziwitso zinanso ziti za Linaclotide zomwe ndiyenera kudziwa?


1. Kodi Linaclotide (Linzess) ndi chiyani?Phcoker

Linaclotide (Linzess) Ndi mankhwala ovomerezeka a pakamwa a FDA omwe amagwiritsidwa ntchito kwambiri ndi anthu achikulire omwe amatha kudzimbidwa kapena kudzimbidwa chifukwa cha matumbo osakwiya. Linaclotide 851199-59-2 imabwera pamwamba pamndandanda wa gulu latsopano la mankhwala omwe amatchedwa guanylate cyclase-C agonists.

Dzina la mtundu wa Linaclotide ndi Linzess ndipo ndikofunikira kukumbukira kuti pakadali pano palibe mtundu wa Linaclotide generic. Chifukwa chake, ngati mukufuna Linaclotide yogulitsa kapena yogwiritsa ntchito, khalani osamala ndi ogulitsa pa intaneti omwe achinyengo omwe angakhale akugulitsa popanda chilolezo Linaclotide generic mankhwala.

Linzess ndi guanylate cyclase-C agonist ndi 14-amino acid peptide. dzina la mankhwala ndi L-cysteinyl-L-cysteinyl-L-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-cyarainyiny-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl- L-cysteinyl-L-tyrosine, cyclic (1-6), (2-10), (5-13) -tris (disulfide).

Makulidwe ake a maselo ndi C59H79N15O21S6 pomwe kulemera kwamaselo ndi 1526.

Linaclotide ufa ndi loyera komanso loyera pang'ono m'madzi. Itha kusungunuka pang'ono mumadzimadzi a sodium chloride (0.9%).

Chotsatira Linzess ili mu mawonekedwe a makapisozi olimba a gelatin okhala ndi mikanda yoluka ya Linaclotide. Calcium chloride dihydrate, L-leucine, titanium dioksidi, cellcrystalline cellulose, gelatin, limodzi ndi hypromellose ndi ena mwa zida zomwe zimagwira mu Linzess

2. Kodi Linaclotide amagwiritsidwa ntchito bwanji?Phcoker

Zikafika pakulankhula kwa Linaclotide, anthu amagwiritsa ntchito ngati chithandizo pazinthu zina zamatumbo monga zotumphukira matumbo zomwe zimadziwika ndi kudzimbidwa komanso kupweteka kwambiri kwa idiopathic.

Zomwe Muyenera Kudziwa Zokhudza Kuchuluka Kwa Mankhwala Osokoneza Ubongo Linaclotide

Linaclotide wa azitsegula zizindikiro

Matenda owopsa a m'mimba (IBS) ndi vuto lomwe limakhala nthawi yayitali lomwe limalepheretsa matumbo ake kugwira ntchito bwino. Chizindikiro cha Linaclotide chimatchulidwanso spon colon ndipo nthawi zina matendawa amagwira ntchito. Zizindikiro zazikulu za matendawa ndi kudzimbidwa, kutsekula m'mimba ndi kupweteka pamimba ndi kudzimbidwa kapena kusinthana ndi m'mimba.

Pakafukufuku wazachipatala kuti akhazikitse kufunikira kwa Linaclotide pothandizidwa ndi matumbo osakwiya a matumbo, odwala akuluakulu adagwiritsidwa ntchito pazoyeserera kawiri konse, zamitundu yambiri. Kuyesedwa koyambirira kunakhudza odwala a 800 omwe adayikidwa pa 290 mcg tsiku lililonse njira yophunzitsira pomwe 804 idapatsidwa gawo lachiwiri lomwe linali pa placebo.

Odwala onse omwe amagwiritsidwa ntchito m'magulu onsewa anakwaniritsa njira za IBS Rome II ndipo amayembekezeredwa kukwaniritsa kuchuluka kwa ululu wam'mimba wa 3 osachepera pamlingo wofika zero mpaka khumi komanso matumbo atatu omasuka okha sabata iliyonse nthawi.

Pakutha kwa nthawi yamankhwala, odwala omwe anali ndi chithandizo chamankhwala othandizira adapeza zambiri za BIS poyerekeza ndi anzawo a placebo malinga ndi:

  • Pafupipafupi matumbo kuyenda
  • Kusasinthika kwa Stool
  • Kuchulukitsa nthawi ndi mphamvu zolimbitsa thupi zomwe munthu amagwiritsa ntchito kuti adutse chopondapo.
  • Kupweteka kwam'mimba

Izi zimatsimikiziradi chidziwitso cha Linaclotide ngati chithandizo chokwanira cha BIS.

Linaclotide wa Chronic Idiopathic Constipation (CIC) zizindikiro

Pakuwunika kuti athe kuyesa kugwiritsa ntchito Linzess kwa CIC Zizindikiro zoyendetsera, odwala akuluakulu omwe ali ndi vuto losakhudzidwa la idiopathic adayikidwa mwachisawawa, mayesero azachipatala ambiri, chimodzimodzi ndi kafukufuku wapadera wa BIS.

Wodwala aliyense anali atakumana ndi njira yosinthika yothandizira ku Roma II ndipo adalandira 72mg, 145 mcg Linzess, 290 mcg Linzess kapena chithandizo cha placebo tsiku lililonse nthawi yonse ya 12-sabata.

Nthawi yotsiriza itatha, ofufuzawo adazindikira kusintha kwakukulu kwa mawonekedwe a CIC mwa odwala omwe anali pamankhwala a Linzess poyerekeza ndi omwe anali pa placebo. Makamaka, adakumana ndi kusintha kwapamwamba malinga ndi kuchuluka kwa pafupipafupi, kusasunthika kwa chopondapo ndi matumbo osautsa.

Mwa mitundu itatu yonse ya Linzess, panali zovuta zochepa kupatula kupereka zazikulu za CIC. Izi zikutsimikizira chizindikiro cha Linaclotide pakutha kwake kuchiza CIC.

Zomwe Muyenera Kudziwa Zokhudza Kuchuluka Kwa Mankhwala Osokoneza Ubongo Linaclotide

3. Kodi makina a Linaclotide ndi ati?Phcoker

Mosiyana ndi mankhwala ena omwe amagwiritsidwa ntchito pochiza matenda omwe atchulidwawa, limagwirira a Linaclotide ndi osiyana- samakamizidwa kulowa m'thupi lanu. Limaclotide limagwirira zimachitika m'matumbo mwanu mwakukula kwamadzimadzi, zimapangitsa kuti matumbo asamayende bwino komanso kuti muchepetse ululu womwe ungakhale chifukwa cha matumbo.

Linaclotide (Linzess) imapangitsa matumbo kuti atulutse madzi ambiri mwakuwonjezera kupanga kwa cyclic guanosine monophosphate.

Linaclotide akamagwiritsa ntchito mphamvu zake kuwonjezera madzi m'matumbo anu, chakudya chimayenda m'matumbo mwachangu ndipo mawonekedwe ake amakhala bwino. Izi zimawonetsa zizindikilo za matenda okhudzana ndi matumbo ngati kutulutsa, kupweteka m'mimba / m'mimba komanso kusamva bwino kwa matumbo.

4. Kodi Linaclotide azigwiritsidwa ntchito bwanji?Phcoker

Mukapanga Linaclotide mugule, zachidziwitso ndi dokotala, ndikofunikira kuti muwonetsetse kuti muwerenga malangizo omwe mudzapatsidwe ndi omwe mumupangira mankhwala musanayambe kumwa mankhwalawo. Maupangiri akuwuzani mlingo woyenera wa Linaclotide, nthawi yoyenera komanso nthawi yayitali.

Ngati mungafunikire kumvetsetsa kulikonse Mlingo wa Linaclotide, musazengereze kulumikizana ndi dokotala kapena wamankhwala kuti mupewe kuyambitsa zotsatira za Linaclotide kapena kuyanjana ndi Linaclotide.

Pokhala mankhwala pakamwa, Linaclotide ayenera kumwedwa ndi pakamwa. Muyenera kumwa ngakhale m'mimba mulibe kanthu, makamaka mphindi za 30 musanadye chakudya chanu choyamba patsiku. Mankhwala omaliza a Linaclotide ali mu mawonekedwe a kapisozi ndipo ayenera kumezedwa kwathunthu. Simuyenera kuswa kapena kutafuna makapisozi a Linaclotide.

Komabe, ngati mwayesera kumeza makapuwo koma osachita, mutha kutsegula ndi kusakaniza zomwe zili mu chipuni cha apulo. Ndiye kumeza kuphatikiza pompopompo ndipo monga momwe zilili-musamayipeze. Sakanizani kuchuluka kokha komwe mukuyenera kutenga nthawi imeneyo chifukwa kusunga chisakanizo kumapangitsa kuti mankhwala asamayende bwino.

Ngati mulibe apulosi, mutha kugwiritsa ntchito madzi ngati njira ina. Pangani madzi amodzi kapena 30mm ya madzi, tsegulani mapiritsi apamwamba a Linaclotide ndikutsitsa zomwe zili m'madzi. Finyani zokhala ndi madzi a Linaclotide kwa pafupifupi masekondi a 20 ndikumwa nthawi yomweyo. Monga momwe amaphatikiza msipu wa applesaise, musayameze zonsezo.

Ngati mankhwalawa adakonzedwa kuti aperekedwe kudzera m'maso a nasogastric kapena chubu chapamimba, pezani chitsogozo pa makonzedwe kuchokera kwa wogulitsa mankhwala kapena adokotala. Komabe, nayi njira zonse zoyendetsera kuyendetsa kwa chubu.

  • Muziyesa 30 ml ya madzi oyera ndi otentha m'chipinda ndikuyiyika mu chiwiya choyera.
  • Tsegulani kapisozi ka Linaclotide ndikutulutsa zonse (mikanda) m'madzi
  • Pakatikati pamadzi ndi mikanda ya Linaclotide posunthira osakaniza osachepera masekondi a 20.
  • Jambulani msanganizo wamadzi wamadzi a Linaclotide mu syringe yolondola ndi nsonga yofanana ndi ya catheter ndi kukula koyenera. Kenako perekani zosakanikazo mu chubu la nasogastric kapena chapamimba chogwiritsidwa ntchito ndi wodwalayo pogwiritsa ntchito mosasunthika koma mwachangu kwa masekondi a 10 mL / 10 pa syringe.
  • Ngati mikanda ingapo ya Linaclotide yomwe idatsalamo, onjezerani 30ml yamadzi oyera, ikulowetsani kusakaniza, ndikuyiyendetsa monga momwe idafotokozedwera kale.
  • Mukamaliza kuyang'anira kusakaniza kwa mikanda ya Linaclotide ndi madzi, gwiritsani ntchito 10 ml ya madzi kuti muwoneke chubu yoyang'anira.

5. Mlingo wa Linaclotide (Linzess) ndi uti?Phcoker

Mlingo woyenera wa Linaclotide umasiyanasiyana kuchokera kwa munthu ndi mnzake, kutengera mtundu womwe umagwiritsidwa ntchito popereka mankhwalawo. Apanso, ndikofunikira kudziwa kuti mankhwalawa sayenera kugwiritsidwa ntchito ndi anthu omwe sanakwanitse zaka 18.

Ana ang'onoang'ono ali pachiwopsezo chachikulu chokumana ndi mavuto akulu Zotsatira za Linaclotide azigwiritsa ntchito mankhwalawa.

(1) Mulingo Wothandiza Wachikulire wa Irritable Bowel Syndrome

Kwa munthu wamkulu yemwe akuvutika ndi Irritable Bowel Syndrome yomwe imayenda limodzi ndi kudzimbidwa, ayenera kumwa mlingo wa Linaclotide wa 290 mcg tsiku lililonse. Monga tanena kale, mankhwalawa amayenera kumwa pamimba yopanda kanthu. Kuti muwonetsetse, idyani musanadye chakudya chanu choyamba patsiku limodzi.

(2) Mlingo Wothandiza Akuluakulu Kudzimbidwa

Malinga ndi US Food and Drug Administration, mulingo wa Linaclotide womwe umalimbikitsa munthu wamkulu wadzimbidwa (CIC) ndi 72 mcg.

Komabe, mlingo wa 145 mcg ungalimbikitsidwenso kwa wodwala wamkulu ndi CIC, kutengera mawonekedwe ake komanso kulekerera kwake. Mutha kutuluka makonda a XZUMX mcg kuti mudziwe momwe mankhwalawo amagwirira ntchito komanso ogwiritsa ntchito omwe adapindula nawo.

Malinga ndi ziwonetsero zosiyanasiyana za 72 mcg, pakati pa zovuta zina zokhudzana ndi mankhwalawa, wodwala yemwe akambirana zomwe zatchulidwa kale ndikuyembekeza kupindula ndi kuthekera kwake azigwiritsa ntchito pafupipafupi kukwaniritsa zotsatira zomwe mukufuna. Kuphatikiza apo, iyenera kumwa nthawi yofananira tsiku lililonse nthawi yonse yokhazikitsidwa ya chithandizo.

Ndikofunika kudziwa kuti Linzess mwina amachititsa kuyanjana kwa Linaclotide ndi mankhwala osiyanasiyana. Mwakutero, muyenera kufotokozera dokotala za mankhwala omwe muli nawo musanayambe kumugwiritsa ntchito (Linaclotide).

Komanso amayi apakati amayenera kusamala kwambiri akaganizira za kutenga Linaclotide chifukwa mankhwalawa angadzetse chiopsezo kwambiri kwa mwana wosabadwayo. Ayenera kufunsa dokotala kuti atsimikizire chitetezo chawo komanso kuti ana awo osabadwa akamwa mankhwalawo. Zomwezi zimagwiranso ntchito kwa azimayi oyamwitsa ndi omwe mumafuna kutenga pakati mukamamwa mankhwalawa.

Komabe, ngakhale atakhala ndi CIC kapena Irritable Bowel Syndrome, odwala omwe ali ndi zaka zosakwana 6 sayenera kutenga Linzess ufa (851199-59-2). Kuyesa kwa kachipatala kunawona kuti mankhwalawa adayambitsa kufa kwa mbewa zazing'ono zokhala ndi zaka zomwe ndizofanana ndi zaka zapansi pa 6 mwa anthu.

Mwakutero, mankhwalawa amalephereka kwa odwala omwe sanakwanitse zaka chifukwa amawayika pachiwopsezo chachikulu chotenga matenda otsekula m'mimba komanso zovuta zake zoyipa.

Kupatula apo, pali data yachipatala yowonetsa chitetezo ndi kufunikira kwa chizolowezi pakati pa odwala azaka za 6 mpaka zaka za 17. Mwakutero, ngati mwana kapena wachinyamata wazaka zosakwana 18 yemwe akufuna mpumulo wa ICI kapena BIS, upangiri wa dokotala uyenera kufunidwa kaye.

Mukhoza kutenga milungu iwiri musanayambe kumva bwino chifukwa cha mankhwalawa. Chifukwa chake, khalani oleza mtima pang'ono nazo. Pitilizani kugwiritsa ntchito monga momwe mwawongolera.

Komabe, ngati chizindikiro chanu sichingakule kapena kuipira ngakhale mutatha kugwiritsa ntchito kunenepa, musamamwe mlingo wopitilira kuchuluka kwake. Simuyenera kuchita izi mulimonse. M'malo mwake, dziwitsani dokotala wanu kuti adziwitse chomwe chimapangitsa osagwiritsa ntchito mankhwalawo ndi upangiri wotsatira.

Ndikofunika kuti musagwiritse ntchito Linaclotide ngati mukusowa kapena matumbo anu ali ndi vuto.

Ngati mwaphonya mulingo wa Linaclotide, musayese kubwereza muyeso womwe mwaphonya. Iwalani za izi ndikupitiliza kumwa Mlingo wotsatira panthawi yoyenera.

Ngati inu kapena wokondedwa wanu mutamwa mlingo waukulu wa mankhwala a Linaclotide (mankhwala osokoneza bongo), ndiye kuti madokotala azidziwitsidwa nthawi yomweyo. Mwinanso, mutha kulumikizana ndi Maofesi a Poison Powerenga ndi 1-800-222-1222.

Zomwe Muyenera Kudziwa Zokhudza Kuchuluka Kwa Mankhwala Osokoneza Ubongo Linaclotide

6. Zotsatira zoyipa zomwe Linaclotide zimabweretsa?Phcoker

Malinga ndi osiyanasiyana Ndemanga za Linaclotide ndi maphunziro asayansi, zotsatirazi ndizotsatira zoyipa za Linaclotide:

  • Kutsegula m'mimba pang'ono
  • Zopweteka m'mimba kapena kusasangalala
  • bloating
  • kupweteketsa mtima
  • kusanza,
  • mutu
  • Zizindikiro zozizira ngati pamphuno / zam'maso zam'mimba, zilonda zowawa zapakhosi kapena kutupa
  • zovuta
  • makutu
  • malungo
  • kutaya mawu
  • kudutsa mpweya
  • chakudyacho kapena mphuno
  • magazi otupa
  • khunyu
  • maso owala
  • chifuwa cholimba

Ngakhale sizachilendo, mutha kukumvanso chimodzi mwazotsatira zoyipa za Linaclotide:

  • Zowawa kapena kutsegula m'mimba kosalekeza
  • Kutsekula m'mimba komwe kumayendetsedwa ndi chizungulire kapena kumverera komwe kumakupangitsani kuti mumve ngati mukutha kutha
  • Mitundu ya malamulo
  • Chikhalidwe chimasintha
  • Kumva osakhazikika
  • Kusokonezeka kwina
  • Mavutowo amtima
  • Kuchulukitsa ludzu
  • Khungu lachifuwa
  • Kumverera kwa limp
  • Kufooka kwa minofu
  • Zowawa m'mimba
  • ndowe zakuda, zamagazi, kapena zoterera
  • ming'oma
  • kupuma movutikira
  • kumaso, milomo, lilime, kapena kutupira pakhosi

Muyenera kufunafuna thandizo mwadzidzidzi ngati mukukumana ndi zotupa pazomwe tafotokozazi, vuto la kupuma kapena ming'oma.

Ngati muli ndi mavuto ena osowa a Linaclotide, muyenera kusiya kugwiritsa ntchito mankhwalawa ndikulankhulana ndi dokotala nthawi yomweyo kuti mupeze malangizo.

7. Ndi mankhwala ati kapena othandizira omwe angalumikizane ndi Linaclotide?Phcoker

Kuyanjana kwa Linaclotide zitha kuchitika ngati Linaclotide amagwiritsidwa ntchito limodzi ndi mankhwala ena kuphatikiza owerengera, mankhwala opangira mavitamini, mankhwala azitsamba ndi mankhwala ena. Ena mwa mankhwala omwe akuti akuti amayambitsa kuyambitsidwa kwa Linaclotide ndi awa:

  • Abilify
  • Amitiza
  • Aspir 81
  • Aspirin Mphamvu Zochepa
  • Ativan
  • Colace
  • Dulcolax (mogwirizana pang'ono)
  • Concerta
  • Cymbalta
  • Wotsogola
  • Flexeril
  • Metamucil (mogwirizana pang'ono)
  • Levothyroxine (mogwirizana)
  • lubiprostone
  • Metoprolol Succinate ER
  • Norco
  • Paracetamol
  • Kubwezeretsa
  • Chizindikiro
  • vitamini B12
  • vitamini C
  • vitamini D3
  • Xanax
  • Zyrtec

8. Kodi pali kusiyana kotani?s pakati Linaclotide ndi lubiprostone?Phcoker

onse Linaclotide ndi lubiprostone ndi mankhwala ovomerezeka a DFA a idiopathic aakulu a kudzimbidwa komanso matenda a matumbo osakwiya. Ngati mukufuna kuchuluka kwamatumbo, mutha kusankha chilichonse mwanjira ziwiri.

Komabe, ali ndi zosiyana zingapo malinga ndi:

(1)Maphunziro awo

Lubiprostone ndi m'gulu la anthu omwe amadziwika kuti ndi chloride activ activ. Mbali inayi, Linaclotide (Linzess) ndi m'modzi mwa gulu la mankhwala omwe amatchedwa guanylate cyclase-C agonists.

(2)Mlingo watsiku ndi tsiku

Ngakhale kuti mlingo wa Linaclotide wovomerezeka umayenera kumwa kamodzi patsiku, makamaka asanadye kadzutsa, Lubiprostone nthawi zambiri amatengedwa kawiri patsiku. Chifukwa chake, ngati mukuvutikira kukumbukira kumwa mankhwalawa tsiku lililonse, Linaclotide ikhala njira yabwino kwambiri kwa inu.

Chinthu china chomwe chimasiyanitsa awiriwo mwanjira ya kuchuluka ndi kuchuluka komwe munthu ayenera kumwa nthawi imodzi. Mwachitsanzo, kwa CIC, mlingo umodzi wa Linaclotide womwe uli wolimbikitsidwa ndi 72 mcg pomwe wa Lubiprostone ndi 8 mcg.

(3)Kuyanjana kwa mankhwala osokoneza bongo

Kusiyana kwina Linaclotide ufa (851199-59-2) ndipo lubiprostone ali mukumagwiritsa ntchito mankhwala. Ndi pafupifupi whopping 58 mankhwala omwe amadziwika kuti amalumikizana ndi Linaclotide, kuyanjana kwa Linaclotide ndizochuluka kwambiri poyerekeza ndi lubiprostone yomwe imalumikizidwa ndi mgwirizano umodzi wokha wa mankhwala.

(4)Tsiku lovomerezeka

Linzess idavomerezedwa pa 30th August 2012 pomwe kuvomerezedwa kwa lubiprostone kunachitika pa Januwale 31, 2006

(5)Kuyanjana kwa chakudya

Mukakhala ndi chakudya m'mimba mwanu ndipo mumamwa Linaclotide, zizindikiro zanu zam'mimba monga kutsegula m'mimba, kupweteka kwam'mimba ndi mpweya zimatha kukulira, chifukwa cha kuyanjana kwa Linaclotide-chakudya. Mukayamba kutsegula m'mimba kwambiri ndipo mukumwa mankhwala ena akumwa, mayamwidwe akewo atha kusokonezeka.

Kuti muchepetse kusokonezeka kwa m'mimba chifukwa cha kuyanjana kwa chakudya, Linaclotide akuyenera kutengedwa pamimba yopanda kanthu.

Kumbali ina, pali zotsimikizika zasayansi zakuchitikira kwa chakudya kwa Lubiprostone. Komabe, sikukutanthauza kuti mungasiyane. Mwakutero, ndikofunikira kufunafuna chidziwitso chambiri pa nthawi yabwino yogwiritsira ntchito mankhwalawo kuchokera kwa omwe akukuthandizani

(6)Chiwopsezo cha fetal mwa amayi apakati

Pakadali pano, gawo la kafukufuku woyenera ndi kuwunika kwa Linaclotide zikuwonetsa kuti Lubiprostone akhoza kuvulaza mwana wosabadwayo ngati mayi wapakati atamwa mankhwalawo. Kumbali ina, palibe kafukufuku m'modzi yemwe akuwonetsa kuti Linzess ikhoza kuvulaza fetal ngati itachitika ndi mayi woyembekezera.

Asayansi amati izi zimawathandiza kuti azitsatira mankhwalawo. Komabe, chiwopsezo sichingadziwike bwino lomwe chifukwa kafukufuku wambiri akuchitika kuti atsimikizire chitetezo kapena chiwopsezo cha mankhwalawa kwa mwana wosabadwa.

Chifukwa chake, ngati mukufuna kutenga Lubiprostone kapena Linaclotide, mayi woyembekezera ayenera kufunsa adokotala kuti adziwe zoyenera kusankha.

(7)Mankhwala

Zomwe Muyenera Kudziwa Zokhudza Kuchuluka Kwa Mankhwala Osokoneza Ubongo Linaclotide

Kupatula CIC, lubiprostone ikhoza b

e amagwiritsidwa ntchito ngati chithandizo cha kudzimbidwa kwa Opioid-ikiwaletsa (OIC) komanso matenda a matumbo osakwiya omwe amakhala ndi kudzimbidwa mwa amayi omwe ali ndi zaka pafupifupi 18.

Zikafika ku Linaclotide, kupatula CIC, imakhudzanso matumbo osakwiya omwe amakhala ndi kudzimbidwa (IBS-C) mwa amayi ndi abambo. Sikugwiritsidwa ntchito ngati chithandizo cha OIC.

(8)Mtengo wa Linaclotide

Zikafika pa Mtengo wa Linaclotide, ndizokwera pang'ono kuposa za lubiprostone. Pakadali pano, mtengo wa Linaclotide uli pafupifupi $ 450 ya 30 makapulogalamu pomwe 60 makapisozi a lubiprostone atha pafupifupi $ 396 Komabe, mitengoyo imasiyanasiyana kuchokera kwaogulitsa wina kupita kwina komanso nthawi ndi nthawi.

(9)wopanga

Opanga Linaclotide ndi kampani yomwe imadziwika kuti Allergan pomwe lubiprostone ndiopanga kampani ya Sucampo.

Ngakhale pali zosiyana pamwambapa, ndikofunikira kudziwa kuti lubiprostone ndi Linaclotide zimagulitsidwa kwa ogula mu mawonekedwe apamwamba amkamwa ndipo alibe ma genetic. Mankhwala onsewa amafunika kuti dokotala amupatse mankhwala kuti awapatse kwa ogulitsa aliyense.

9. Chani zambiri za Linaclotide ndiyenera kudziwa?Phcoker

Monga mankhwala ena aliwonse, Linaclotide ufa (851199-59-2) kapena makapisozi amayenera kusungidwa kuti ana asamawavulaze kuti asamuwononge. Komanso, pokhala mankhwala omwe mumalandira, anthu ena atha kufunitsitsa kuti agawane mankhwalawo ndi ena kuti apewe zovuta zopita kwa dokotala kuti akamwe mankhwala.

Komabe, kugawana Linaclotide ndi kowopsa chifukwa dokotala amayenera kuganizira zambiri asanapereke mankhwala ndikudutsa njirayo kumatha kukhala ndi zotsatirapo zoyipa kwambiri.

Ngati mukufuna kupanga Linaclotide mugule, muyenera kudziwa kuti m'maiko ambiri, kuphatikizapo US, mufunikira mankhwala omwe dokotala mumalandira kuti mupeze mankhwalawo. Izi sizikusonyeza kuti mukufuna kugulagula pa intaneti kapena pa intaneti.

Zikafika posungira, kutentha kotetezedwa kwa Linaclotide 851199-59-2 ndi 25 ° C (77 ° F). Kaya mukuchita ndi Linaclotide ufa kapena makapisozi, mankhwalawa amayenera kusungidwa m'malo opanda chinyontho ndipo, sayenera kugawidwa kapena kuikidwanso. M'malo mwake, sungani mankhwala onse mu chidebe chake choyambirira.

Komanso, onetsetsani kuti chidebecho chatsekedwa mwamphamvu ndi desiccant yake mkati kuti isakhale chinyontho.

Kaya mukufuna kugula Linaclotide 851199-59-2 kuti mugwiritse ntchito mafakitale, Linaclotide yogulitsa kapena zinthu zina za Linaclotide, onetsetsani kuti mwazipeza kuchokera ku mbiri yabwino komanso yodalirika. Ndemanga za pa intaneti za Linaclotide zingakutsogolereni kwaogulitsa abwino.

Kupanda kutero, popanda kuchita khama, wogulitsa pa intaneti / pa intaneti akuti ali ndi zowona Linaclotide yogulitsa zitha kukhala kuti zikugulitsa zinthu zapa kampani kapena kuba ndalama zomwe mumapeza movutikira.

Zothandizira

  1. Andresen, V., Camilleri, M., Busciglio, IA, Grudell, A., Burton, D., McKinzie, S.,… & Currie, MG (2007). Zotsatira za masiku a 5 linaclotide pamayendedwe ndi matumbo pantchito mwa akazi okhala ndi kudzimbidwa-makamaka kosakhumudwitsa matumbo. Gastroenterology, 133(3), 761-768.
  2. Chey, WD, Lembo, AJ, Lavins, BJ, Shiff, SJ, Kurtz, CB, Currie, MG,… & Baird, MJ (2012). Linaclotide ya matumbo osavomerezeka a m'matumbo: sabata la 26-sabata, osasankhidwa, akhungu lachiwiri, loyesedwa ndi placebo kuti ayese kuyesa bwino ndi chitetezo. Nyuzipepala yaku America ya gastroenterology, 107(11), 1702.
  3. Cuppoletti, J., Blikslager, AT, Chakrabarti, J., Nighot, PK, & Malinowska, DH (2012). Kusiyanitsa kwa zotsatira za linaclotide ndi lubiprostone pakubwezeretsanso katundu wa epithelial cell zotchinga ndi cellostasis ya cellular pambuyo povumbulutsidwa ndi cell stressors. BMC pharmacology, 12(1), 3.
  4. Harris, A. (2013). LINACLOTIDE. Consultant.
  5. Johnston, JM, Kurtz, CB, Drossman, DA, Lembo, AJ, Jeglinski, BI, MacDougall, JE,… & Currie, MG (2009). Phunziro la pilot pa zotsatira za linaclotide mwa odwala omwe ali ndi kudzimbidwa kosatha. Nyuzipepala yaku America ya gastroenterology, 104(1), 125.
  6. Lembo, AJ, Kurtz, CB, MacDougall, JE, Lavins, BJ, Currie, MG, Fitch, DA,… & Johnston, JM (2010). Mphamvu ya linaclotide kwa odwala kudzimbidwa. Gastroenterology, 138(3), 886-895.
  7. Lembo, AJ, Schneier, HA, Shiff, SJ, Kurtz, CB, MacDougall, JE, Jia, XD,… & Jeglinski, BI (2011). Mayeso awiri mosasiyanitsa a linaclotide a kudzimbidwa kosatha. New England Journal of Medicine, 365(6), 527-536.

Shangke Chemical ndi makampani apamwamba kwambiri omwe amagwiritsa ntchito mankhwala omwe amathandiza kwambiri. Pofuna kuyendetsa khalidweli panthawi yopanga, akatswiri ambiri odziwa bwino ntchito, makina oyambirira kupanga zipangizo komanso ma laboratori ndi mfundo zofunika kwambiri.

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