Chidule cha Cycloastragenol

Cycloastragenol (CAG) yomwe imadziwikanso kuti T-65 ndi chilengedwe cha tetracyclic triterpenoid yochokera ku Astragalus membranaceus chomera. Choyamba chidapezeka pomwe Astragalus membranaceus Chotsitsacho chinali kuyesedwa chifukwa cha zinthu zomwe zimagwira ntchito zotsutsana ndi kukalamba.

Cycloastragenol ikhozanso kutengedwa kuchokera ku Astragaloside IV kudzera pa hydrolysis kanthu. Astragaloside IV ndizofunikira kwambiri mu Astragalus membranaceus therere. Ngakhale kuti Cycloastragenol ndi Astragaloside IV ndizofanana pamankhwala awo, cycloastragenol ndiyopepuka m'molemera am'mimba kuposa Astragaloside IV. Chifukwa chake, Cycloastragenol imagwira ntchito bwino chifukwa chopezeka kwambiri bioavailability motero imathandizira kwambiri kagayidwe kake ka cycloastragenol. Kuchuluka kwa kagayidwe kake ka cycloastragenol kumadziwika m'matumbo a epithelial kudzera pakungoyenda pang'ono.

Zitsamba za astragalus zakhala zikugwiritsidwa ntchito ngati mankhwala achi China kwazaka zambiri ndipo zikugwiritsidwanso ntchito masiku ano. Chomera cha Astragalus chakhala chikugwiritsidwa ntchito chifukwa chazothandiza zake kuphatikiza anti-bakiteriya, anti-inflammatory komanso kuthekera kokulitsa chitetezo chokwanira.

CAG imawonetsedwa ngati chida cholimbana ndi ukalamba chomwe chimalimbikitsa ntchito ya enzyme telomerase ndikuchiritsa bala. Pakadali pano ndi gulu lalikulu lomwe limadziwika kuti limapangitsa telomerase mwa anthu, motero ndi chiyembekezo chowonjezera chachitukuko.

Cycloastragenol amadziwika kuti ndi telomerase activator, yomwe imathandizira kukulitsa kutalika kwa ma telomere. Ma Telomeres ndi zisoti zoteteza zopangidwa ndi ma nucleotide obwereza kumapeto kwa chromosome. Ma telomere awa amakhala afupikitsa pambuyo pamagawo aliwonse am'magazi omwe amachititsa kuti khungu lizisokonekera komanso kuwonongeka. Komanso, ma telomere amathanso kufupikitsidwa ndi kupsinjika kwa oxidative.

Kufupikitsa kwakukulu kwa ma telomere kumalumikizidwa ndi ukalamba, imfa ndi zovuta zina zokhudzana ndi ag. Mwamwayi, ma enzyme a telomerase amatha kuwonjezera kutalika kwa ma telomere.

Ngakhale kulibe maphunziro ochulukirapo otsimikizira kuthekera kwa cycloastragenol kutalikitsa moyo, ndi chida cholimbikitsa kukalamba. Zatsimikiziridwa kuti zimachotsa zizindikilo za ukalamba kuphatikiza mizere yabwino ndi makwinya. CAG amathanso kuchepetsa chiwopsezo chokhala ndi matenda obwera chifukwa cha Parkinson, Alzheimer, ndi ng'ala.

Ngakhale ambiri cycloastragenol zaumoyo, pali nkhawa kuti zingayambitse khansa kapena kufulumizitsa khansa. Komabe, kafukufuku wina yemwe adachitika ndi mitu ya nyama amafotokoza za cycloastragenol popanda vuto lililonse la khansa.

Cycloastragenol powder yogulitsa imapezeka mosavuta pa intaneti ndipo itha kugulidwa kwa ambiri odziwika bwino omwe amapereka cycloastragenol.

Ngakhale, zabwino zambiri za cycloastragenol zaumoyo zikuwonetsedwa, akadali membala watsopano wophunziridwa. Kuphatikiza apo, zotsatira zoyipa za cycloastragenol sizodziwika bwino, chifukwa chake ziyenera kugwiritsidwa ntchito mosamala.

Kodi Cycloastragenol ndi chiyani?

Cycloastragenol

Cycloastragenol ndi triterpenoid saponin mankhwala omwe amachokera muzu wa zitsamba za Astragalus. Astragalus membranaceus Chomera chakhala chikugwiritsidwa ntchito mu mankhwala achikhalidwe achi China (TCM) kwazaka zopitilira 2000 ndipo chikugwiritsidwabe ntchito pokonza zitsamba.

Chitsamba cha astragalus chadziwika chifukwa chokhoza kuteteza chitetezo, kuteteza amoyo, kukhala diuretic komanso kukhala ndi thanzi lina katundu monga anti-hypersensitivity, antibacterial, odana ndi ukalamba ndi ma anti-stress.

Cycloastragenol amadziwika kuti TA-65 koma amatchedwanso Cyclogalagenin, Cyclogalegenin, Cyclogalegigenin, ndi Astramembrangenin. Cycloastragenol kuwonjezera Amadziwika kuti anti-okalamba, komabe, ma cycloastragenol ena othandizira azaumoyo ndi kuphatikiza chitetezo chamthupi, anti-inflammatory and anti-oxidative.

Cycloastragenol

Cycloastragenol ndi Astragaloside IV

Ma cycloastragenol onse ndi Astragaloside IV amapezeka mwachilengedwe mu chomera cha astragalus. Astragaloside IV ndiye chinthu chofunikira kwambiri mu astragalus membranaceus, komabe, zimapezeka muzambiri zazing'ono muzu. Njira yochotsera ma saponins, cycloastragenol ndi astragaloside IV, nthawi zambiri imakhala yovuta chifukwa cha kuyeretsa kwakukulu kofunikira.

Pamene onse awiri cycloastragenol ndi astragaloside IV amachokera ku zitsamba za astragalus, cycloastragenol itha kupezekanso ku astragaloside IV kudzera mu njira ya hydrolysis.

Mankhwala awiriwa ali ndi mawonekedwe ofanana, komabe, cycloastragenol ndiyopepuka m'malemera amtundu kuposa astragaloside IV ndipo imapezekanso.

Njira Yogwirira Ntchito ya Cycloastragenol

i. Kutsegula kwa Telomerase

Ma Telomeres amabwereza ma nucleotide kumapeto kwa ma chromosomes okhala ndi mzere ndipo amakhala ndi mapuloteni enaake. Ma Telomere mwachilengedwe amafupikitsidwa ndimagawo onse. Telomerase, makina a ribonucleoprotein okhala ndi ma enzyme othandizira (transERasease enzymes (TERT) ndi telomerase RNA (TERC) amatalikitsa ma telomere. Popeza gawo lalikulu la ma telomere ndikuteteza ma chromosomes ku maphatikizidwe ndi kuwonongeka, maselo nthawi zambiri amazindikira ma telomere amafupikitsa kwambiri ngati DNA yowonongeka.

Kupititsa patsogolo kwa cycloastragenol telomerase kumapangitsa kutalika kwa ma telomere omwe amawonetsa phindu.

ii. Amalimbitsa kagayidwe kamadzimadzi

Lipids mwachilengedwe imakhala ngati malo ogulitsira mphamvu mthupi lathu. Komabe, ma lipids ochulukirapo atha kuwononga thanzi lathu.

Cycloastragenol imalimbikitsa kagayidwe kabwino ka lipid kudzera pama lipid metabolism biomarkers osiyanasiyana.

Choyamba, pamlingo wochepa, CAG imachepetsa zotupa za cytoplasmic lipid mu 3T3-L1 adipocytes. Kachiwiri, ikagwiritsidwa ntchito kwambiri, CAG imalepheretsa kusiyanitsa kwa preadipocytes a 3T3-L1. Pomaliza, CAG imatha kuyambitsa kashiamu mu 3T3-L1 preadipocytes.

Popeza calcium yayikulu yama cell imatha kupondereza kusiyanitsa kwa ma adipocyte, CAG imabweretsa kuchepa kwa kagayidwe ka lipid polimbikitsa kuchuluka kwa calcium.

iii. Ntchito ya antioxidant

Kupsinjika kwa oxidative ndiye komwe kumayambitsa matenda ambiri komanso senescence yama cell. Kupsyinjika kwa okosijeni kumachitika pakakhala kuchuluka kwa zopitilira muyeso mthupi.

Cycloastragenol imawonetsa mphamvu zotsutsana ndi zowonjezera poonjezera mphamvu ya antioxidant. Ntchito iyi ya antioxidant ndiyokhudzana ndi gulu la hydroxyl lomwe limapezeka mu CAG.

Kuphatikiza apo, kupsinjika kwa oxidative ndiye komwe kumapangitsa kufupikitsa kwa telomere, chifukwa chake chitetezo cha CAG telomere chimachokera ku zonse antioxidant zochita ndi telomerase activation.

iv. Ntchito yotsutsa-kutupa

Ngakhale kutupa ndimachitidwe achilengedwe momwe thupi limamenyera motsutsana ndi matenda kapena kuvulala, kutupa kosatha ndikovulaza. Kutupa kwanthawi yayitali kumalumikizidwa ndi zovuta zambiri monga chibayo, matenda ashuga, matenda amtima ndi nyamakazi.

Cycloastragenol ufa amawonetsa zotsutsana ndi zotupa. Ubwino wotsutsa-kutupa wa cycloastragenol umachitika kudzera munjira zosiyanasiyana kuphatikizapo kuletsa kuchuluka kwa ma lymphocyte ndikukweza phosphorylation ya AMP-activated kinase (AMPK).

Ubwino wa Cycloastragenol

i.Cycloastragenol ndi chitetezo cha mthupi

Cycloastragenol itha kuthandizira kukonza chitetezo chokwanira kudzera pakukulitsa kuchuluka kwa T lymphocyte. Kukhoza kwa cycloastragenol supplement kuyambitsa telomerase kumathandizira kuyambitsa kukonza kwa DNA kwinaku kukutsogolera o kukula ndi kukulitsa kwa telomere.

ii.Cycloastragenol ndi Anti-ukalamba

Cycloastragenol anti-kukalamba Katundu ndiye chidwi chachikulu pakufufuza masiku ano. CAG yawonetsedwa kuti imachedwetsa ukalamba mwa anthu komanso kuchepetsa zizindikilo za ukalamba monga makwinya ndi mizere yabwino. Ntchito yolimbana ndi ukalamba ya Cycloastragenol imatheka kudzera munjira zinayi zosiyanasiyana. Njira zotsutsana ndi kukalamba za cycloastragenol ndizo;

Cycloastragenol

  • Kulimbana ndi kupsinjika kwa okosijeni

Kupsinjika kwa okosijeni kumachitika mwachilengedwe pakakhala kusamvana pakati pa zopitilira muyeso ndi antioxidant mthupi. Ngati sichilamuliridwa, kupsinjika kwa oxidative kumathandizira kukalamba komanso kumabweretsa matenda monga khansa, matenda amtima ndi matenda ashuga.

Kuchokera kwa cycloastragenol astragalus ndi mankhwala ophera antioxidant komanso amakulitsa mphamvu zama antioxidants omwe amapezeka mwachilengedwe. Izi zimathandiza kuchepetsa kukalamba komanso kupewa zovuta zomwe zimakhudzana ndi ukalamba.

  • Cycloastragenol imagwira ntchito ngati telomerase activator

Monga tafotokozera m'gawo lino pamwambapa za momwe amagwirira ntchito, cycloastragenol imathandizira kutalikitsa ma telomere. Izi zimagwira gawo lofunikira pakuwonetsetsa kuti magawo azigawika ndikupitilira kukalamba. Izi zimathandizanso kuti ziwalo za thupi zizigwira ntchito moyenera.

  • Cycloastragenol imapereka chitetezo ku cheza cha UV

Munthu akawunika ndi dzuwa kwa nthawi yayitali maselo amthupi amatha kuwonongeka ndipo chifukwa chake amalephera kugwira ntchito bwino. Izi zimabweretsa mtundu wamakalamba asanakwane omwe amatchedwa kukalamba pazithunzi.

Cycloastragenol ufa umathandizira ngati akuwonetsedwa kuti amateteza khungu ku ngozi zoyipa za cheza cha UV.

  • Cycloastragenol imalepheretsa mapuloteni glycation

Glycation ndi njira yomwe shuga monga glucose kapena fructose imagwirizira ndi lipid kapena protein. Glycation ndi imodzi mwazomwe zimayambitsa matenda ashuga ndipo imalumikizidwa ndi ukalamba komanso zovuta zina.

Zowonjezera za cycloastragenol Amathandiza kupewa kukalamba chifukwa cha glycation poletsa mapangidwe a glycation.

iii.Ubwino Wina Wathanzi Labwino wa Cycloastragenol:
  • Chithandizo cha khansa ya cycloastragenol

Njira yothandizira khansa ya cycloastragenol imawonetsedwa ndi kuthekera kwake kuwononga maselo a khansa, kukonza chitetezo chokwanira komanso kuteteza munthu ku zomwe zingachitike ndi chemotherapy.

Pakafukufuku wa anthu omwe ali ndi khansa ya m'mawere, khansa ya cycloastragenol chithandizo chinawonetsedwa ndi kuthekera kwake kochepetsa kufa kwa pafupifupi 40%.

  • Tetezani mtima wanu kuti usawonongeke

Cycloastragenol itha kuteteza ku kukanika kwa mtima.

Pofufuza makoswe omwe amachititsa kuti mtima uwonongeke, cycloastragenol supplementation inapezeka kuti ikuthandizira kukanika kwa mtima polimbikitsa autophagy m'maselo am'minyewa komanso kupondereza mawu a matrix metalloproteinase-2 (MMP-2) ndi MMP-9.

Kutengera kuwunika kwa cycloastragenol, zitha kutero kusintha tulo. Komabe, maphunziro azachipatala adzafunika kuti apereke umboni wokwanira pakuthandizira kugona.

Cycloastragenol

  • Zitha kuthandizira kulimbana ndi kukhumudwa

Telomere yofupikitsidwa yapezeka mwa anthu omwe ali ndi vuto la kukhumudwa monga zovuta zamatenda ndi matenda monga Alzheimer's.

Pofufuza mbewa poyesa kukakamiza kusambira, cycloastragenol supplement yomwe idaperekedwa masiku a 7 idapezeka kuti ichepetsa kuchepa kwawo. Adawonetsedwa kuti ayambitse telomerase mu ma neuron komanso m'maselo a PC1, omwe amafotokozera kuthekera kwake kotsutsana ndi kukhumudwa.

  • Limbikitsani kuchiritsa kwa bala

Kuchiritsidwa kwa bala ndi vuto lalikulu kwa odwala matenda ashuga. Njira yochiritsa mabala imachitika kudzera muntchito zingapo. Izi ndi izi; zotupa, kutseketsa, kubwezeretsa kwa epithelium, kumanganso ndipo pamapeto pake kuwongolera kwa maselo am'munsi. Maselo amtundu wa epithelial awa ndiofunikira pakuchiritsa kwa bala kwa ashuga.

Zikuwonetsedwa kuti kuwonongeka kwa telomere kumakhudza kwambiri kuchiritsa kwa bala. Apa ndipomwe cycloastragenol ufa amabwera kudzakonzetsa ma telomere omwe amafupikitsidwa komanso kupititsa patsogolo kuchuluka ndi mayendedwe am'magazi. Izi zimathandizanso kukonza bala mwachangu.

  • Sinthani thanzi la tsitsi

Ndemanga za Cycloastragenol ndi ogwiritsa ntchito akuwonetsa kuti cycloastragenol itha kuthandizira kupewa kutayika kwa tsitsi, kulimbikitsa kukula kwa tsitsi ndikutulutsa utoto.

Zowonjezera zowonjezera za cycloastragenol astragalus ndizo;

  1. Amapereka ma anti-virus anti-virus motsutsana ndi ma CD4 + amunthu.
  2. Kulimbikitsa mphamvu.
  3. Bwino khungu.
  4. Zitha kusintha masomphenya.

Mlingo Woyambira wa Cycloastragenol

Muyeso cycloastragenol mlingo pafupifupi 10 mg tsiku lililonse. Komabe, popeza izi ndi zatsopano kuwonjezera Mlingo wake umadalira kwambiri kagwiritsidwe ntchito, zaka komanso zovuta zamankhwala.

Mulingo woyenera wa cycloastragenol uyenera kuchulukitsidwa mwa okalamba azaka zopitilira 60 kuti akwaniritse kukokomeza kwa telomere ndikuchepetsa ukalamba.

Kodi Cycloastragenol ndi yotetezeka?

Cycloastragenol ufa nthawi zambiri imawonedwa ngati yotetezeka pamiyeso ina. Komabe, popeza ndiyatsopano kuwonjezera zotsatira zoyipa za cycloastragenol sizikudziwika.

Ndemanga zochepa za cycloastragenol pazopindulitsa za cycloastragenol sizotsimikizika zokwanira kuti zigwiritsidwe ntchito.

Kuphatikiza apo, pali nkhawa kuti cycloastragenol supplement imathamangitsa khansa polimbikitsa kukula kwa zotupa. Awa ndi malingaliro abodza potengera kuti njira yayikulu ya cycloastragenol ndiyodutsira telomere. Chifukwa chake akuganiza kuti zithandizira kukula kwa khansa.

Ndikofunika kuti mupewe kupereka cycloastragenol kwa odwala khansa mpaka chidziwitso chodalirika chikupezeka pankhani iyi komanso kupewa chilichonse chosadziwika cha cycloastragenol kawopsedwe.

Kodi Tingapeze Kuti cycloastragenol Yabwino Kwambiri?

Chabwino, cycloastragenol ufa wogulitsa amapezeka mosavuta pa intaneti komanso m'malo ogulitsira osiyanasiyana. Komabe, nthawi zonse fufuzani za cycloastragenol powder yogulitsa kuchokera kwa ovomerezeka ndi otchuka a cycloastragenol ogulitsa kuti muwonetsetse kuti mwayeretsedwa kwambiri cycloastragenol.

Kafukufuku wowonjezera

Cycloastragenol powder yasonyezedwa kuti ili ndi zotsatira zambiri zopindulitsa komanso makamaka cycloastragenol anti-aging properties. Cycloastragenol telomerase activation ndiyo njira yayikulu yomwe imathandizanso kuwonjezera ma telomere. Izi zawonetsedwa m'mitundu yambiri yazinyama komanso zochepa owoyimira maphunziro.

Mayeso azachipatala a cycloastragenol astragalus omwe amathandizira kukulitsa ma telomere ndi ochepa kwambiri motero maphunziro owonjezera kuti apereke umboni wokwanira amafunikira.

Mphamvu za TA-65 pakuchepetsa kukanika kwamtima ndizochepa kwambiri popeza kafukufuku wochepa kwambiri alipo pothandizira izi TA-65.

Kuwerenga kagayidwe kake ka cycloastragenol mwatsatanetsatane kungathandizenso kupeza zomwe zilipo komanso kuwulula poizoni aliyense wa cycloastragenol yemwe angachitike chifukwa chakuchulukitsitsa.

Kafukufuku wowonjezeranso kuti awunikire momwe cycloastragenol imathandizira muubwino womwe udanenedwa. Zotsatira za cycloastragenol sizikudziwika. Chifukwa chake, kafukufuku akuyenera kuwunikira kuti adziwe zomwe zingatheke cycloastragenol zoyipa komanso kuyanjana ndi mankhwala ena.

Pozindikira zaumoyo wa cycloastragenol, zithandizira kuwunika momwe zikuyendera ndi izi za CAG.

Kuphatikiza apo, mulingo woyenera wa cycloastragenol umafunikira maphunziro ochulukirapo kuti awunikire kuchuluka kwa mlingo wazaka zosiyanasiyana. Osiyanasiyana omwe amapereka ma cycloastragenol amapereka mankhwala osiyanasiyana omwe amayenera kugwirizanitsidwa ndikufufuza.

Zothandizira
  1. Yuan Yao ndi Maria Luz Fernandez (2017). "Zotsatira Zabwino za Telomerase Activator (TA-65) Kulimbana ndi Matenda Aakulu". Zakudya za EC 6.5: 176-183.
  2. Wang, J., Wu, M.-L., Cao, S.-P., Cai, H., Zhao, Z.-M., & Nyimbo, Y.-H. (2018). Cycloastragenol imalimbikitsa kuwonongeka kwa mtima kwamiyeso mwa makoswe polimbikitsa myocardial autophagy kudzera poletsa chizindikiro cha AKT1-RPS6KB1. Biomedicine & Pharmacotherapy, 107, 1074-1081. onetsani: 10.1016 / j.biopha.2018.08.016
  3. Dzuwa, C., Jiang, M., Zhang, L., Yang, J., Zhang, G., Du, B.,… Yao, J. (2017). Cycloastragenol imathandizira kuyambitsa ndi kufalikira kwa kuchuluka kwa concanavalin A-yomwe imayambitsa mbewa ya lymphocyte pan-activation model. Immunopharmacology ndi Immunotoxicology, 39 (3), 131-139. onetsani: 10.1080 / 08923973.2017.1300170.
  4. Ip F, C, F, Ng Y, P, An H, J, Dai Y, Pang H, H, Hu Y, Q, Chin A, C, Harley C, B, Wong Y, H, Ip N, Y: Cycloastragenol Ndi Woyambitsa wa Telomerase Activator mu Maselo a Neuronal: Zomwe Zimakhudza Kutaya Matenda. Zolemba 2014; 22: 52-63. onetsani: 10.1159 / 000365290.
  5. Yu, Yongjie & Zhou, Limin & Yang, Yajun & Liu, Yuyu. (2018). Cycloastragenol: Wosangalatsa wonena zofananira ndi matenda amisamba ‑ (Kubwereza). Katswiri Wodziwitsa komanso Chithandizo. 16. 10.3892 / etm.2018.6501.
  6. CYCLOASTRAGENOL POWDER (78574-94-4)

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