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Gwiritsani ntchito Enfuvirtide mu HIV, mulingo, mbali & machenjezo
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Gwiritsani ntchito Enfuvirtide mu HIV, mulingo, mbali & machenjezo

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1. Kodi Enfuvirtide ndi chiyani?
2. Njira ya ntchito ya enfuvirtide?
3. Kugwiritsa ntchito mosaganizira za HIV
4. Momwe mungagwiritsire ntchito enfuvirtide ufa?
5. Mlingo wa Enfuvirtide?
6. Zotsatira zoyipa za enfuvirtide ndi ziti?
7. Kodi ufa wa enfuvirtide uyenera kusungidwa bwanji?
8. Kufufuza kowonjezereka ndi kugwiritsa ntchito pa Enfuvirtide ufa

1. Kodi Enfuvirtide ndi chiyani? Phcoker

Enfuvirtide (159519-65-0) ndi mtundu wina wa peptide womwe umagwiritsidwa ntchito kuchipatala kuti uteteze chitetezo cha mthupi cha anthu (HIV) posokoneza ma cell ako athanzi omwe angalimbikitse zotsatira za matenda mthupi lako. Enfuvirtide kapena T-20 imagulitsidwa madera osiyanasiyana padziko lapansi pansi pa dzina la Fuzeon. Komabe, kutengera komwe mumachokera, mutha kupeza kugulitsa kwa enfuvirtide pansi pa dzina lina, koma onsewa amagwira ntchito yomweyo.

Enfuvirtide ufa (159519-65-0amagwiritsidwa ntchito limodzi ndi mankhwala ena pofuna kuchiza matenda a Edzi, omwe ali ndi kachilombo koyambitsa matenda a Edzi. Dziwinso kuti Enfuvirtide samachiritsa kachilombo ka HIV, koma imathandizanso pakuchepetsa mphamvu ndi zotsatira zake mthupi lanu. Anthu omwe akutenga izi amakhala ndi moyo wabwino komanso wathanzi popeza maselo ake amatetezedwa ku kachilomboka. Malinga ndi kafukufuku, kachilombo ka HIV kamafalitsa ma cell oyera mthupi lanu omwe amalimbana ndi matenda. Ichi ndichifukwa chake, nthawi zambiri, odwala HIV / Edzi amakhala ndi chitetezo chochepa kwambiri. Komabe, Enfuvirtide imathandiza kuteteza maselo anu athanzi kuti asawonongeke, motero imakulitsa thanzi lanu.

Enfuvirtide acetate imachepetsa kuchuluka kwa HIV mthupi lanu, zomwe zimathandizira kukulitsa chitetezo chanu cha mthupi. Mankhwalawa amakuthandizani kuti muchepetse mwayi wotenga kachilombo ka HIV monga matenda omwe amayambitsa odwala omwe ali ndi HIV. Mukamamwa mankhwala ena a HIV / Edzi, nthawi zonse ndimaganizo abwino kutsagana nawo ndi Enfuvirtide chifukwa zimathandizira kuti mankhwalawa azigwira bwino komanso kuti azichita bwino.

Enfuvirtide imapezeka pamapulatifomu osiyanasiyana koma ikuyenera kugulitsidwa motsogozedwa ndi dokotala. Chifukwa chake, musanayambe kumwa mankhwalawa, onetsetsani kuti mukupita kokayezetsa kuchipatala, ndipo mumalandira mlingo woyenera kuchokera kwa dokotala. Enfuvirtide acetate imapezeka pa intaneti, ndipo mutha kupanga oda yanu kuchokera ku nyumba yanu kapena ofesi. Komabe, fufuzani moyenera kuti mumvetsetse wopanga ndi othandizira musanapange oda yanu. Mtengo wa enfuvirtide ukhoza kukhala wosiyana kutengera wogulitsa. Pali zinthu zambiri zachinyengo pamsika zomwe zitha kuvulaza. Ngati mukutsimikiza kuti mankhwalawo mumawatenga kuti, lankhulani ndi dokotala kuti akuthandizeni.

2. Enfuvirtide limagwirira ntchito? Phcoker

Monga tanenera kale, Enfuvirtide jakisoni Ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda a chitetezo cha mthupi aanthu. Kachilomboka sikamakula kapena kudzichulukitsa paokha, chifukwa chake, kamalowa m'maselo a thupi kugwiritsa ntchito kagayidwe kake. HIV imakonda kulimbana ndi maselo chitetezo chathupi chomwe chimadziwika kuti CD4 T-assist lymphocyte kapena maselo oyera amwazi. Maselo amagwira ntchito polimbana ndi matenda aliwonse, kuyesera kulowa m'thupi lanu. Mukubwereza, kachilombo ka HIV kamapha maselo othandizira a CD4 T, ndipo chifukwa chake, thupi lanu limakhala lofooka, ndikupangitsa kuti lisathe kulimbana ndi matenda omwe amadza pambuyo pake. Izi zikutanthauza kuti mudzatengedwera ndi matenda ambiri omwe mudzaonekere popeza thupi lanu silingathe kulimbana nawo.

Njira ya ntchito ya enfuvirtide ikuwonetsetsa kuti ma CD4 anu maselo amatetezedwa ku HIV. Chochita chimamangiriza kumapuloteni kuzungulira kachilomboka, kamene kamathandizira kudziphatika ndi ma CD4 cell. Enfuvirtide ikangophatikizidwa ndi mapuloteni awa, imalepheretsa HIV kuti isokoneze nembanemba ya CD4 yanu. Dziwani kuti, kachilombo ka HIV kangangotembenukiranso ndikuchulukana pomwe ma genetic ake alowa m'maselo anu a CD4. Chifukwa chake, enfuvirtide imawonetsanso kuti kachilomboka sikaberekanso ndikukula.

izi Enfuvirtide limagwirira ntchito Ndiwosiyana ndi mankhwala ena onse omwe amaletsa kufalitsa kachilombo ka HIV pamsika, omwe amangolimbana ndi kachilomboka mutatenga kachilombo ka CD4. Vuto la HIV la Enfuvirtide, ndi limodzi mwa mankhwala othandizira kwambiri ku kachilombo ka HIV ndipo angagwiritsidwe ntchito polimbana ndi kukula kwa kachilomboka mukayamba kugonjetsedwa ndi mankhwala ena. Komabe, mutha kutenga Enfuvirtide nokha kapena kupanga kusankha koyamba, ndipo kukupatsani zotsatira zomwe mukufuna. Mpaka pano, palibe chithandizo chodziwika cha kachirombo ka HIV, koma ndi enfuvirtide, mutha kukhala otsimikiza kuti muchepetse kuchuluka kwa kachilomboka mthupi lanu ndikuchepetsa kupitilira kwa matenda aliwonse chifukwa cha kachilombo ka HIV / AIDS.

Gwiritsani ntchito Enfuvirtide mu HIV, mulingo, mbali & machenjezo


Akatswiri amalimbikitsa kuti mutenge ufa wa enfuvirtide pamodzi ndi mankhwala ena omwe amaletsa kachilomboka m'njira zosiyanasiyana. Powonjezera peptide ufa ku chithandizo chomwe chilipo chitha kukhala chilingaliro chachikulu, makamaka ngati kachilomboka kakugonjetsedwa ndi mankhwalawo. Mankhwalawa akuti ndi amodzi mwa mankhwala othandizira kwambiri ku kachirombo ka HIV, ndipo adawalembera makamaka odwala omwe amamwa mankhwala ena osakhudzidwa. Titha kuthandizidwanso kwa anthu omwe ali ndi vuto lodana ndi zotsutsana ndi kachilomboka.

3. Kugwiritsa ntchito mosavomerezeka mu HIV Phcoker

Fuzeon ili ndi enfuvirtide ufa monga chinthu chomwe chimagwira, chomwe chimapangitsa kukhala mankhwala abwino omenyera kachirombo ka HIV mthupi lanu. Fuzeon ndi m'gulu lamankhwala omwe amadziwika kuti fusion inhibitor. Mankhwala omwe ali mgululi ngati Fuzeon, amalepheretsa kachilombo ka HIV kuphatikiza ma cell a CD4 ndipo pamapeto pake amawalepheretsa kubwereza komanso kuchuluka. Peptide ufa umagwiritsidwa ntchito limodzi ndi mankhwala ena odana ndi HIV kuti mupeze zotsatira zabwino. Monga tafotokozera pamwambapa, enfuvirtide imagwira ntchito pomanga ndi mapuloteni omwe amachititsa kuti HIV ikhale yosavuta kugwiritsa ntchito CD4.

Kuchita izi kumapangitsa kuti zikhale zosatheka kuti kachilomboka kalowe m'magazi oyera ndikukhudza chitetezo chanu cha mthupi. Nthawi zambiri, enfuvirtide acetate imalembedwa kwa anthu omwe amamwa mankhwala ena, ndipo kachilomboka adayamba kugonjetsedwa ndi mankhwala ena onse. Lankhulani ndi dokotala wanu kuti mumve zambiri za momwe mungagwiritsire ntchito bwino izi.

4. Momwe mungagwiritsire ntchito enfuvirtide ufa?Gwiritsani ntchito Enfuvirtide mu HIV, mulingo, mbali & machenjezo Phcoker

Musanayambe kumwa mankhwalawa, onetsetsani kuti mukuwerenga malangizo ogwiritsa ntchito opanga enfuvirtide papepala lomwe lili mkati mwake. Malangizowo akupatsirani zambiri zamomwe mungapangire malonda. Ena Otsatsa a Enfuvirtide ngakhale kukupatsirani zina mwazotsatira zoyipa za enfuvirtide kuti mudziwe nthawi yomwe mungafikire dokotala. Amakupatsaninso machenjezo enfuvirtide kuti mukhale otetezeka mukamamwa mankhwalawo.

Enfuvirtide ndi mankhwala a jakisoni, mosiyana ndi mankhwala ena a anti-HIV omwe amakamwa pakamwa. Ufa wa peptide uli ndi mamolekyu akulu omwe amatha kuphwanyika m'thupi lanu atatengedwa pakamwa ndikulephera kupereka zotsatira zomwe mukufuna. Pa peptide ufa, onetsetsani kuti mwalandira bwino kapena musalole kuti dokotala akuchitireni. Komabe, dokotala angakuphunzitseni momwe mungakonzekere ufa wa enfuvirtide ndi solvent musanalowe jakisoni wa enfuvirtide.

Kukonzekera

Tsatirani zonse pokonzekera mwachidwi pokonzekera ufa wa enfuvirtide. Ufawo uyenera kusakanikirana ndi madzi osalala ndikuwonetsetsa yankho kuti liwoneke bwino.

  • Yambani ndikuchotsa chipukupuku ndikuchotsa madzi osaberekera jakisoni woipa.
  • Pukutani pang'onopang'ono chilichonse ndi mankhwala osokoneza bongo kenako musiyire kwakanthawi kuti nsonga ziume.
  • Gwiritsani ntchito syringe yayikulu ya 3ML ndikubwezerani pulawo mpaka 1ml, kenako jekeseni mpweya mu madzi osavunda pang'onopang'ono.
  • Tsopano ikani singano yosalala mu vial kudzera pakumira.
  • Ikani syringe ndi madzi osabala mu Fuzeon vial pakona.
  • Kenako yikani madzi osalala, ndikuwonetsetsa kuti akutsikira pang'onopang'ono mu ufa wa Fuzeon.
  • Osasunthira vial koma gwiritsani ntchito chala chanu kuti mupeze kwa masekondi 10 kuti asungunuke.
  • Ikayamba kusungunuka, ikani pambali kuti isungunuke kwathunthu komwe kungatenge pafupifupi mphindi 45.
  • Mukasakanikirana kwathunthu, yankho lake liyenera kukhala lopanda utoto, wowoneka bwino, wopanda thovu lililonse, ngati yankho lake limapukutira, apatseni nthawi yambiri yodzipukutira musanadzibise. Njira yothetsera vutoli ikakwaniritsidwa komanso momveka bwino tsopano mutha kuyendetsa mankhwalawo. Musatengere mankhwalawa ngati muwona tinthu tating'onoting'ono kapena yankho lisanachitike.

Mlingo wamba kwa akulu ndi 90ml patsiku womwe umayenera kumwa kawiri pa tsiku. Jakisoni amayenera kuperekedwa pa mkono wanu wapamwamba kapena kumtunda kwa ntchafu yanu. Ngati mukupatsa mwana mankhwala, dokotala adzakuuzani mulingo woyenera ndi kuchuluka kwa jakisoni. Ndikofunika kutembenuza malo omwe jakisoni wawapatsa kuti athe kupeza nthawi yochira. Komanso dziwitsani dokotala ngati mukumwa mankhwala ena aliwonse musanayambe kumwa enfuvirtide.

5. Mlingo wa Enfuvirtide? Phcoker

Enfuvirtide akuyenera kutengedwa ndi aliyense wodwala yemwe ali ndi kachirombo ka HIV / Edzi kuti aziteteza chitetezo cha mthupi chifukwa chimalepheretsa kachiromboka kuphatikiza ma cell a CD4 komanso kuwaletsa kuti asangobwerezanso. Mlingo, komabe, ndi wosiyana kwa ana ndi akulu. Enfuvirtide synthesis imathandiza kwambiri polimbana ndi kachilombo ka HIV kamene kamapanga mankhwala ena odana ndi kachilombo ka HIV.

  • Mlingo woyenera

Mlingo wa anthu akuluakulu achikulire omwe ali ndi vuto la HIV ndi 90mg patsiku womwe umayenera kugawidwa pawiri. Muyenera kupereka jakisoni ngakhale ntchafu yakunja, mkono wam'mwamba kapena pamimba.

Mlingo wa ana kwa zaka 6 mpaka 16, ndi 2mg pa kilogalamu, ndipo mlingo uyenera kutumikiridwa kawiri pa tsiku. Mlingo woyenera kwambiri wa ana a msinkhu uno ndi 90mg patsiku. Kwa ana a zaka 17 zakubadwa mlingo woyenera ndi 90 mg tsiku lililonse ndipo uyenera kugawidwa pawiri.

  • Mlingo wa Enfuvirtide?

Ngati mungayiwale kumwa mankhwalawa omwe mumapezeka kuti muli ndi kachilombo ka HIV, tengani nthawi yomweyo, mukukumbukira. Komabe, mutha kudumpha mlingo wake ngati ili pafupi nthawi yotsatira. Osamagwiritsa ntchito mlingo wowonjezerera kuti muthandizire wosowa; zitha kuyambitsa zovuta. Komanso, kumbukirani kuti mupeze mankhwala ena osankhidwa munthawi yomweyo mankhwala asanaperekedwe kwathunthu.

  • Mlingo wa Enfuvirtide?

Ngati vuto lililonse la ana lingathe kufunsa kuchipatala msanga chifukwa lingathe kukuvulaza.

  • Chenjezo la enfuvirtide

Mukamamwa enfuvirtide acetate musayipatse jekete pafupi ndi bondo lanu, nsapato, mbewa kapena matako. Komanso pewani kubayidwa jakisoni mu zipsera, ma moles, zikwapu kapena khungu lililonse lopanda thanzi. Kutenga enfuvirtide sikumakutetezani kufalitsa matendawa, chifukwa chake khalani otetezeka nthawi zonse, pewani kugawana zinthu zakuthwa ndi bulashi lanu. Onani malangizo onse omwe mungamwe kuti musangalale nawo. Kuti mumve zambiri, lankhulani ndi dokotala kuti akuwongolereni munjira zosiyanasiyana zopewera kufala kwa kachiromboka.

6. Zotsatira zoyipa za enfuvirtide ndi ziti?Gwiritsani ntchito Enfuvirtide mu HIV, mulingo, mbali & machenjezo Phcoker

Vuto lonse la HIV ngati mankhwala ena aliwonse amathanso kukudziwitsani zotsatira zoyipa malinga ndi momwe mankhwalawo amachitikira ndi thupi lanu. Nthawi zina mavuto obwera chifukwa cha enfuvirtide amayamba chifukwa cha bongo kapena kugwiritsidwa ntchito molakwika. Komabe, pali zovuta zina zomwe zimapezeka pafupifupi kwa onse ogwiritsa ntchito enfuvirtide. Kusungidwa koperewera kwa enfuvirtide kumatha kubweretsanso zovuta zina. Zina mwazofala Zotsatira zoyipa za enfuvirtide onaninso;

  • Kuchepetsa chilakolako cha kudya, nseru, kutsegula m'mimba ndi kudzimbidwa
  • kuwonda
  • Zowawa, zotupa kapena zotupa pamalo a jekeseni
  • Kufoka minofu ndi zowawa

Funsani kwa dokotala wanu nthawi yomweyo kuti mumve zotsatirazi zoyipa;

  • Kutupa kuzungulira khosi pakhosi panu, kusabala kapena kusintha kwa msambo
  • Zizindikiro za matenda atsopano monga zotupa zotupa, kupindika kapena zilonda zozizira.
  • Magazi mumkodzo
  • Matenda opweteka

Zotsatira zoyipa zakusiyana-siyana zitha kukhala zosiyana kwa munthu wina chifukwa chake, musatenge mwachidule chilichonse. Dziwitsani dokotala ngati zotsatira zoyipa sizimatha pakapita nthawi. Kuti mukhale otetezeka mukamamwa mankhwalawa, samalani malangizo onse omwe atumizidwa ndi dokotala.

7. Kodi ufa wa enfuvirtide uyenera kusungidwa bwanji? Phcoker

Enfuvirtide ufa (159519-65-0) opanga nthawi zonse amawonetsa momwe mungasungire zinthuzo mukazigwiritsa ntchito komanso momwe mungazitayire. Ufa wosungika wosasanjika wa enfuvirtide womwe umakhala pamalo osungirako kutentha pafupifupi 20 mpaka 25 digiri Celsius. Komabe, ngati mukulephera kutentha kutentha kwa chipindacho, mutha kuchisunga m'firiji pafupifupi 2 mpaka 8 Celsius. Komanso sungani madzi osalala m'chipindacho nthawi zonse.

Mukasakaniza yankho la enfuvirtide sungani mu firiji 2 mpaka 8 Celsius. Njira yothira enfuvirtide iyenera kutengedwa pasanathe maola 24. Musamagwiritse ntchito chinthucho chikamaliza komanso musachigulitse pamene chidindo chaduka kapena chikasowa. Mukatha kugwiritsa ntchito ufa wa enfuvirtide, tsatirani malangizo a FDA amomwe mungatayire zida ndi mankhwala osagwiritsidwa ntchito.

Gwiritsani ntchito Enfuvirtide mu HIV, mulingo, mbali & machenjezo

8. Kafukufuku wowonjezereka ndi kugwiritsa ntchito pa Enfuvirtide ufa Phcoker

Mukamagula enfuvirtide ufa kuchokera kwa ogulitsa osiyanasiyana, onetsetsani kuti mumafufuza moyenera kuti muwonetsetse kuti mwapeza chinthu chabwino chomwe chingakutsimikizireni zabwino. Ngakhale dzina la enfuvirtide dzina loti Fuzeon ndi lodziwika pamsika, mutha kupezanso malonda akugulitsidwa pansi pa dzina lina lakunja. Pali ogulitsa ambiri enfuvirtide pamsika, ndipo nthawi zonse muyenera kupita zabwino. The Mitengo ya Enfuvirtide Zitha kusiyanasiyana kuchokera kwa wogulitsa wina, osachigwiritsa ntchito ngati chinthu chofunikira posankha wogulitsa woyenera.

Zonse, pakufunika maphunziro owonjezera azachipatala ndi kafukufuku kuti adziwe ntchito zina za enfuvirtide ndi momwe zimagwiritsidwira ntchito. Monga chogwiritsidwa ntchito nthawi zonse jakisoni, ogwiritsa ntchito ambiri akweza nkhawa, ndipo maphunziro owonjezera angathandize kukulitsa mulingo wa pakamwa. Kapenanso, chinthucho chitha kupangidwanso kuti chizilowetsedwa kamodzi kapena kawiri pamwezi. Pakadali pano, enfuvirtide ikadali mankhwala othandizira komanso oopsa oletsa kutenga kachilomboka. Khalani omasuka kuyankhula ndi dokotala wanu za enfuvirtide ndi gp41.

Zothandizira:

  1. Zhu, X., Zhu, Y., Ye, S., Wang, Q., Xu, W., Su, S.,… & Zhang, T. (2015). Kupititsa patsogolo njira zamankhwala komanso kapangidwe ka HIV fusion inhibitor AP3 pa enfuvirtide: kuwonetsa maubwino a njira yokumba peptide. Malipoti asayansi, 5, 13028.
  2. Blanco, JL, & Martinez-Picado, J. (2012). HIV inclase inhibitors mwa odwala omwe ali ndi ma ART. Maganizo apano pa HIV ndi Edzi, 7(5), 415-421.
  3. Chowdhury, S., & Roy, PK (2016). Kutengera masamu a enfuvirtide ndi proteinase inhibitors ngati chithandizo cha HIV. International Journal of Nonlinear Sayansi ndi Manambala Simulation, 17(6), 259-275.

Shangke Chemical ndi makampani apamwamba kwambiri omwe amagwiritsa ntchito mankhwala omwe amathandiza kwambiri. Pofuna kuyendetsa khalidweli panthawi yopanga, akatswiri ambiri odziwa bwino ntchito, makina oyambirira kupanga zipangizo komanso ma laboratori ndi mfundo zofunika kwambiri.

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