Chidule cha J-147

J-147 ufa unapezeka mu 2011 ku Cellular Neurobiology Laboratory ya Salk Institute. Chiyambireni kwake, pakhala pali maphunziro ambiri omwe adatsimikizira kuti ndi othandiza pochizira matenda a Alzheimer's ndikusintha ukalamba.

Dr. Dave Schubert ndi omwe adafufuza nawo ku Salk Institute adachita mbali yayikulu pophunzira za J-147 curcumin. Mu 2018, ma neurobiologists adafukula momwe J-147 imagwirira ntchito nootropic ndi gawo lake pakuwongolera matenda amitsempha.

Kuphunzira ndi kufufuza za mankhwalawa ndizofunika kwambiri pakuwongolera Alzheimer's chikhalidwe. Komabe, ogwiritsa ntchito athanzi akhala ndi chidwi ndi maubwino a J-147 monga kukulitsa kukumbukira, kupititsa patsogolo kuphunzira, ndikukonzanso ma neuron.

Mu 2019, asayansi adayesa kuyesa mankhwala a J-147 Alzheimer's pa anthu.

Kodi Nootropic J-147 Powder ndi chiyani?

J-147 ufa amachokera ku curcumin ndi Cyclohexyl-Bisphenol A. Mankhwala anzeruwa amakhala ndi ma neuroprotective komanso neurogenic. Mosiyana ndi ma nootropics ambiri, anti-kukalamba J-147 kuwonjezera imathandizira kuzindikira popanda kukhudza michere ya acetylcholine kapena phosphodiesterase.

Curcumin ndi gawo lamtundu wa turmeric ndipo ndiwothandiza kuthana ndi matenda amanjenje. Komabe, polyphenol iyi sichidutsa chotchinga cha magazi ndi ubongo moyenera. Zotsatira zake, J-147 nootropic idakhala gawo lalikulu kwambiri pomwe imadutsa chotchinga cha magazi ndi ubongo mosavuta.

Kodi J-147 imagwira ntchito bwanji?

Mpaka 2018, mphamvu ya J-147 pa seloyo idakhalabe yosamvetsetseka mpaka Salk Institute Neurobiologists isanadziwe bwino. Mankhwalawa amagwira ntchito pomanga ATP synthase. Puloteni iyi ya mitochondrial imathandizira kupanga mphamvu zamagetsi, motero, kuwongolera ukalamba.

Kupezeka kwa chowonjezera cha J-147 m'dongosolo laumunthu kumaletsa poizoni wokhudzana ndi zaka zomwe zimachokera ku mitochondria yosagwira ntchito komanso kuchulukitsa kwa ATP.

J-147 njira yogwirira ntchito Zithandizanso kuwonjezera ma neurotransmitter angapo kuphatikiza NGF ndi BDNF. Kuphatikiza apo, imagwira ntchito pamagulu a beta-amyloid, omwe nthawi zonse amakhala apamwamba pakati pa odwala omwe ali ndi Alzheimer's ndi matenda amisala.

Zotsatira za J-147 zimaphatikizapo kuchepetsa kukula kwa Alzheimer's, kupewa kuchepa kwa chikumbukiro, ndikuwonjezera kupangidwa kwa maselo amitsempha.

Ubwino Wotheka wa J-147

Kukulitsa Kuzindikira

Chowonjezera cha J-147 chimathandizira kukumbukira kwakanthawi ndi kukumbukira kwakanthawi. Mankhwalawa amasintha zolakwika pakati pa okalamba omwe ali ndi vuto lakuzindikira. J-147 yogulitsa imapezeka ngati chiwongola dzanja ndipo achinyamata akutenga kuti akalimbikitse kuphunzira.

kutenga J-147 anti-kukalamba mankhwala amathandizanso kukumbukira, masomphenya, komanso kuwunikira kwamaganizidwe.

Kusamalira Matenda a Alzheimer's

j-147

J-147 amapindulitsa odwala omwe ali ndi Alzheimer's pochepetsa kuchepa kwa vutoli. Mwachitsanzo, kutenga kuwonjezera amachepetsa kuchuluka kwa sungunuka beta-amyloid (Aβ), zomwe zimabweretsa kusazindikira kwazindikiritso. Kuphatikiza apo, J-147 curcumin imathandizira kuwonetsa ma neurotrophin kutsimikizira kupulumuka kwa mitsempha, chifukwa chake, kukumbukira kukumbukira ndi kuzindikira.

Odwala omwe ali ndi AD amakhala ndi zochepa zochepa za neurotrophic. Komabe, kutenga J-147 Alzheimer's supplement kumalimbikitsa NGF ndi BDNF. Ma neurotransmitters awa amathandizira kupanga kukumbukira, kuphunzira, ndi magwiridwe antchito.

neuroprotection

J-147 nootropic Imaletsa kufa kwa neuronal komwe kumachitika chifukwa cha kupsinjika kwa oxidative.

Chowonjezera ichi chimaletsanso kuchepa kwa ma NMDA (N-Methyl-D-aspartate) receptors, omwe amachititsa kuti magazi asatuluke.

Kutenga mankhwala a J-147 kumakulitsa zinthu zomwe zimachokera muubongo (BDNF) komanso minyewa ikukula (NGF). Ma neurotransmitters awiriwa amayendetsa matenda amitsempha monga Alzheimer's ndi dementia. Kuphatikiza apo, BDNF ndiyofunika mu neurogeneis.

Kuwonjezera Ntchito ya Mitochondrial

j-147

Kutenga mankhwala a J-147 kungathetseretu milingo ya ATP polimbikitsa ntchito za mitochondrial.

Kukalamba kumayambitsa kuchepa kwa mitochondria chifukwa cha kusokonekera komanso kuchuluka kwa mitundu yama oxygen. Komabe, J-147 chowonjezera amalimbana ndi njirayi poletsa ATP5A synthase. Kafukufuku wosaneneka amawerengera mankhwalawa kuti atalikitse moyo wamunthu.

J-147 ndi Anti-ukalamba

Malinga ndi Salk Researchers, J-147 zowonjezerapo kukalamba zimapangitsa kuti maselo okalamba awonekere achichepere.

Kusagwira ntchito kwa mitochondria kumathandizira kukalamba. Ma homeostasis amachepetsa, chifukwa chake, kuchepa kwa thupi. Kuphatikizanso apo, kuwonongeka kwa maselo ndi kuwonongeka kwa mitochondrial kudzachitika chifukwa cha kupanga ROS (mitundu yama oxygen yokhazikika). Kutenga ufa wa J-147 kuthana ndi izi, chifukwa chake, kuchepa kwa senescence.

Kukalamba kumagwirizananso ndi kuchepa kwa chidziwitso komanso zovuta zama neurodegenerative. Komabe, zingapo Zochitika za J-147 onetsetsani kuti mankhwalawa ndi othandiza pobweza kukumbukira kukumbukira, kukonza magwiridwe antchito, ndikuchiza matenda amisala, Alzheimer's, ndi matenda ena okhudzana ndi msinkhu.

Mlingo Wokhazikika wa J-147

(1) Mlingo wokhazikika

Mlingo wamba wa J-147 tsiku lililonse umakhala pakati pa 5mg ndi 30mg. Mutha kugawaniza J-147 mlingo awiri. Makamaka, mlingo wanu uyenera kukhala wotsika ndikukulitsa kutengera kulolerana kwa thupi lanu.

Chowonjezera ichi chimagwira pakamwa. Muyenera kupewa kutenga madzulo kapena usiku chifukwa ena J-147 amawunikiranso kuti atha kusokoneza mawonekedwe anu ogona.

(2) Mlingo wodwala

Ochita kafukufuku adagwiritsa ntchito 10mg / kg ya J-147 mulingo wothandizira Alzheimer's matenda mumitundu yama mbewa.

Komabe, mlingo wanu uyenera kudalira momwe mulili. Tengani, mwachitsanzo, ngati mutatha kupititsa patsogolo kuzindikira kwanu, muyenera kuonetsetsa kuti mumamwa 5mg mpaka 15mg. Mosiyana ndi izi, poteteza minyewa ndikuwongolera zovuta zama neurodegenerative, mutha kukulitsa mlingowu kukhala pafupifupi 20mg ndi 30mg.

In Mayeso azachipatala a J-147, omverawo amatenga mlingowu atangotha ​​kudya kwa ola limodzi la 8.

Kusiyanitsa pakati pa J-147 ndi T-006

T-006 ndichotengera cha J-147 nootropic. Chipindacho chidapangidwa posintha gulu la methoxyphenyl la J-147 curcumin ufa ndi tetramethylpyrazine.

Kuphatikiza ndi T-006 pafupifupi miyezi itatu ichepetsa utsi wamaubongo ndikuwonjezera mphamvu yonse. Kuphatikiza apo, ufa umawonjezera mawu ndikuwonjezera wosuta bata. Mosiyana ndi izi, zokumana nazo za J-147 zimaphatikizapo kukumbukira bwino, kuwona, ndi kununkhiza.

Ngakhale pali kusiyana kochepa kotereku, zowonjezera ziwirizi zimakhala ndi zotsatirapo zofanana.

Kodi J-147 ndiyotetezeka mukamagwiritsa ntchito?

Mankhwala a J-147 ndi otetezeka. Wapambana mayeso a poizoni m'mayesero a nyama monga amafunira a Food and Drug Administration (FDA). Kuphatikiza apo, mayesero azachipatala a J-147 akhala akuchitika kwakanthawi.

Palibe zolemba zotsutsa J-147 zotsatira m'mayesero am'mbuyomu komanso amunthu.

J-147 mayesero azachipatala

Gawo loyambirira la mayeso azachipatala a J-147 adayamba koyambirira kwa 2019 monga adathandizidwa ndi Abrexa Pharmaceuticals, Inc. Cholinga cha phunziroli chinali kuyesa chitetezo ndi kulolerana kotenga nootropic, ndi zida zake zama pharmacokinetic m'mitu yathanzi.

Kafukufuku wamankhwala anali okhudzana ndi achinyamata komanso achikulire. Gulu lofufuzirali lidasinthidwa mosiyanasiyana, khungu kawiri, ndikuwongoleredwa ndi ma placebo ndimlingo umodzi wokwera.

Pamapeto pa kuyesedwa kwaumunthu, asayansi akuyenera kukhazikitsa zotsatirazo potengera zovuta, kugunda kwa mtima ndi mayimbidwe, kusintha kwa thupi, ndi J-147 maubwino pa dongosolo la mitsempha.

j-147

Ndemanga za ogwiritsa ntchito / zokumana nazo atagwiritsa ntchito J-147

Nawa ena mwa ndemanga za J-147;

Capybara akuti;

“… Pakhoza kukhalanso ndikumverera kwa mphamvu zambiri koyambirira. Osati mphamvu ya caffeine kapena amphetamine, koma mphamvu yowonjezera. Ndidasangalala gawo ili popeza ndimatha kuganiza zopanga zina monga kukwera njinga, ndikuzichita mosazengereza kapena kudzitsimikizira kuti ndiyamba. Chilimbikitso changa chinali chopanda ntchito. Izi zidatha patatha milungu ingapo, ndipo pomwe ndidasangalala ndikumverera kotere, enanso sangatero, motero ndikulemba izi ngati zomwe zingachitike. ”

F5fireworks akuti;

“Zikuwoneka ngati nootropic yosangalatsa komanso yolonjeza. Zikuwoneka kuti ku US adachita kafukufuku wazachipatala chaka chatha. ”

Wogwiritsa wina akuti;

“Chabwino, ndalandira dzulo ndipo ndamwa kale 10mg ya mankhwala atatu. Ndinazitenga mozama ndipo zidasungunuka bwino kwambiri. Sililawa zoipa. Zotsatira zanga zidayamba mwachangu kwambiri kwa ine. Masomphenya anga ndi malingaliro anga zimawoneka zakuthwa mwanjira ina, koma atha kukhala malowa chabe. Zikuwoneka kuti sizikhala ndi vuto lililonse, koma ndi molawirira kwambiri kuti ndinene… Ndidamva zonse kukhala bwino ndikulimbikitsidwa tsiku lonse ndi 3 mg wina m'mawa pafupifupi 10 koloko m'mawa. ”

Fafner55 akuti;

"Ndikupitiliza kumwa J147 popanda phindu lililonse kupatula kufupika kwa kutupa ndi kutupa kotchulidwa kale."

Kodi tingapeze kuti ufa wa J-147?

Makhalidwe a nootropic awa akadali fupa lamikangano koma sikungakulepheretseni kupeza zinthu zovomerezeka. Izi zili choncho, J-147 Alzheimer's mayesero azachipatala ali mkati. Mutha kugula ufa m'masitolo apaintaneti mukakhala ndi mwayi wofanizira mitengo ya J-147 pakati pa ogulitsa osiyanasiyana. Komabe, muyenera kuwonetsetsa kuti mupita kukagula kuchokera kwa ogulitsa omwe ali ndi mayeso oyeserera a labotale.

Ngati mukufuna zina J-147 yogulitsa, fufuzani ndi sitolo yathu. Timapereka ma nootropics ambiri moyenera. Mutha kugula zochuluka kapena kugula kamodzi kutengera cholinga chanu cha psychonautic. Dziwani kuti, mtengo wa J-147 ndi wochezeka pokhapokha mukagula zochuluka.

Zothandizira
  1. Lapchak, AP, Bombien, R., ndi Rajput, SP (2013). J-147 Novel Hydrazide Lead Compound yochizira Neurodegeneration: CeetoxTM Kusanthula Kwachitetezo ndi Genotoxicity. Zolemba za Neurology ndi Neurophysiology.
  2. M'mbuyomu, M., et al. (2013). Neurotrophic Compound J147 Imasinthiratu Kuwonongeka Kwazidziwitso mu Matenda Aakulu a Alzheimer's. Kafukufuku & Chithandizo cha Alzheimer's.
  3. Mankhwala Osokoneza bongo a Alzheimer Amatembenuziranso Clock mu Powerhouse Cell. Salk Institute.January 8, 2018.
  4. Qi, Chen., Et al. (2011). Mankhwala Osokoneza Bongo a Kulimbikitsanso Kuzindikira ndi Matenda a Alzheimer's. Laibulale Yapagulu la Sayansi.
  5. Daugherty, DJ, ndi al. (2017). Chotulutsa cha Novel Curcumin Chithandizo cha matenda ashuga Neuropathy.
  6. Kulipira, Lian., Et al. (2018). Zotsutsana ndi kukhumudwitsa za Novel Curcumin Derivative J147: Kuphatikizidwa kwa 5-HT1A Neuropharmacology.
  7. RAW J-147 POWDER (1146963-51-0)

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