1. Kodi leuprorelin acetate ndi chiyani?
2. Leuprolide acetate ntchito
3. Kodi leuprolide acetate imagwira ntchito bwanji
4. Momwe mungagwiritsire leuprorelin acetate?
5. Leuprorelin acetate Mlingo ndi leuprorelin acetate Administration
6. Leuprorelin acetate mbali zotsatira
7. Kutsiliza

1. Kodi leuprorelin acetate ndi chiyani? Phcoker

Leuprorelin acetate ndi mtundu wa peptide womwe umagwiritsidwa ntchito limodzi ndi mankhwala ena pochiza khansa ya prostate mwa abambo. Komabe, sikuchiritsa matendawa koma kuiletsa kuti isafalikire ndikuthandizira kupewetsa khansa ya Prostate m'thupi lanu. Leuprorelin imagulitsidwa ku United States of America pansi pa dzina la Lupron, ndipo ikhoza kupezeka m'maiko osiyanasiyana pansi pa dzina lina.

Mitundu yambiri ya khansa ya Prostate imadalira mahomoni a testosterone kuti akule ndikufalikira m'thupi lanu. Komabe, Leuprorelin acetate ufa amagwira ntchito mwa kukakamiza kupangika kwa ma testosterone a testosterone ndikupangitsa kuti ikhale yosavuta kuchepetsa kukula kwa maselo a khansa ya prostate komanso kuchepetsa ululu kapena mavuto omwe odwala amakumana nawo.

Kumbali inayo, Lupron amagwiritsidwa ntchito ndi amayi kuchiza matenda a endometriosis, omwe amadziwika kuti uterine fibroids. Leuprolide acetate ndi mimba ndizovuta kwambiri kwa amayi, musatenge mankhwalawa ngati mukuyembekezera kukhala ndi mwana koma mutha kukambirana ndi dokotala. Lupron ndi mankhwala omwe angathe kubayidwa omwe amayenera kubayidwa m'matumbo nthawi iliyonse ya miyezi ya 1-6. Nthawi zonse onetsetsani kuti mukumwa mankhwalawa kuchokera kwa dokotala, koma mutha kuphunzitsidwanso za momwe mungadzipiritsire nokha pakayendetsedwe ka mankhwala mosavuta kunyumba kwanu.

Kugula kwa leuprolide acetate kumapezeka mosavuta mumafakitori onse azintaneti komanso akuthupi. Mtengo wa leuprolide acetate nthawi zina umatha kukhala wosiyana ndi komwe mumagula. Komabe, nthawi zonse ndibwino kuti mulandire mankhwala oyenera kuchokera kwa akatswiri azachipatala. Kumbukirani kuti kuledzera kapena kugwiritsa ntchito molakwika leuprorelin acetate kumatha kudzetsa mavuto ambiri, ndipo muyenera kupewa kutero popanda kumuyesa dokotala. Khansa ndi matenda oopsa, ndipo simuyenera kuyika pachiwopsezo kumwa mankhwalawo. Lankhulani ndi dokotala wanu kuti mumve zambiri za leuprorelin acetate ufa Mlingo.

Chidziwitso chofunikira cha leuprorelin acetate side effect, mlingo

2. Leuprolide acetate ntchito Phcoker

Leuprolide acetate ufa ndi agonist wamphamvu wa gonadotropin-releasing receptor (GnRHR), ndipo watsimikizira kukhala wofunikira pakugwiritsa ntchito kachipatala kosiyanasiyana. Mwachitsanzo, mankhwalawa uterine fibroids, khansa ya prostate, kutha msambo (zomwe zimapangitsa kuti ana azitha msanga kuposa momwe amafunikira), komanso endometriosis. M'mikhalidwe yonseyi yazaumoyo, leuprolide ingagwiritsidwe ntchito kokha kapena ndi mankhwala ena. Mankhwalawa amathanso kugwiritsidwa ntchito limodzi ndi mankhwala ena othandizira magazi, omwe amayamba chifukwa cha chiberekero cha uterine.

The leuprorelin acetate mlingo iyenera kukhala yolumikizidwa m'thupi lanu kudzera minofu. Gwiritsani ntchito syringe ya insulini ya U-100 kuti mupeze mlingo wanu komanso onetsetsani kuti mumagwiritsa ntchito ma syringe omwe amapanga. Ngati mungagwiritse ntchito syringe yosiyanasiyana, ndiye gwiritsani ntchito 0.5-mL yokha yotaya. Kumbukirani kuti leuprorelin acetate ufa uyenera kusakanikirana ndi wopanga musanagwiritse ntchito. Kugwiritsa ntchito yankho sikungakupatseni kusakaniza kokwanira. Kuyanjana kwa Leuprolide kudzakuthandizani kuti mukwaniritse zotsatira zomwe mukufuna koma nthawi zonse muzipeza kuchokera kwa dokotala.

Chidziwitso chofunikira cha leuprorelin acetate side effect, mlingo

3. Kodi leuprolide acetate amagwira ntchito bwanji? Phcoker

Leuprorelin acetate limagwirira zake zimatengera mkhalidwe waumoyo wokhala ndi chithandizo. Mwachitsanzo, akagwiritsidwa ntchito pochiza khansa ya prostate, amachepetsa kupanga ma testosterone, omwe amathandiza kukula ndi kufalikira kwa maselo a khansa. Ngakhale ufa wa Leuprorelin Acetate (74381-53-6) Kugwiritsa ntchito sikuchiritsa khansa ya prostate, kumathandizira kuchepetsa ululu ndi kukula kwa maselo a khansa m'thupi lanu. Komabe, mankhwalawa atha kumwa okha, koma azachipatala amalimbikitsa kuti mutengere limodzi ndi mankhwala ena a khansa ya Prostate kuti mumve bwino.

Ngakhale mankhwalawa sakuvomerezedwa kuti agwiritsidwe ntchito mwa akazi m'maiko ena, akuwoneka kuti ndi othandiza pochiza matenda a endometriosis. Pano, mankhwalawa amagwira ntchito kupanikizira kupanga kwa estrogen mthupi lanu, lomwe limadziwika kuti "estrogen surge." Apa, leuprorelin acetate limayendedwe limangoyang'ana kwambiri kuchepetsa estrogen, mahomoni omwe amayang'anira nthawi yanu. Mukayamba kumwa mlingo wa leuprorelin acetate, milingo ya estrogen imadzuka kwa masabata angapo oyamba, pambuyo pake milingo ya estrogen imatsika. Izi zitha kuimitsa kaye kwakanthawi, ndipo zotsatira zake, zizindikiro za endometriosis zimatsitsimuka.

Khansa ya m'mawere ya Leuprorelin acetate, inayo, imathandizira polimbana ndi matenda omwe amafa mwa azimayi. Ngakhale progesterone ndi estrogen sizomwe zimayambitsa khansa ya m'mawere, iwo amathandiza kwambiri pakukula kwawo ndikufalikira. Kupanga kwa mahomoni awiriwa kumatha kuimitsidwa pogwiritsa ntchito opaleshoni yochotsa mazira kapena njira yachipatala.

Luteinizing timadzi timene timatulutsa pituitary gland, timayambitsa kupanga kwa progesterone ndi estrogen ndi thumba losunga mazira. Leuprorelin acetate imagwiritsa ntchito kupondereza kwa kupangika kwa mahomoni a luteinizing, potero amachepetsa kuchuluka kwa estrogen ndi progesterone m'thupi lanu. Izi zikutanthauza kuti kukula kwa maselo a khansa ndikufalikira kudzachepetsedwa, ndikupangitsa kuti khansa ya m'mawere ikhale yosavuta.

Chidziwitso chofunikira cha leuprorelin acetate side effect, mlingo

4. Momwe mungagwiritsire leuprorelin acetate? Phcoker

Dongosolo la leuprorelin acetate limatha kuchitika m'njira ziwiri zazikulu kudzera pakubaya mwachindunji kapena ufa, womwe nthawi zambiri umamangidwanso ndi chosungunulira musanayambe kumwa. Madokotala ndi anthu abwino kunyamula njira zathu zonse, koma mukaphunzitsidwa, mutha kuzichita mosavuta kunyumba.

(1) Leuprorelin acetate jakisoni

Leuprorelin acetate jakisoni ndi mankhwala omwe atenga nthawi yayitali ndipo adalandira jakisoni wambiri ndipo amayenera kuperekedwa ndi katswiri wazachipatala. Jakisoni amaperekedwa kamodzi pamwezi uliwonse kapena ngakhale kamodzi pa 3, 4, kapena 6 miyezi kutengera momwe muliri. Kumbali ina, jekeseni wa leuprorelin acetate nthawi zina amatha kuperekedwa ngati kuyimitsidwa kwakanthawi kodziwika bwino (Eligard) komwe kumabayidwa m'misempha mwanu miyezi iliyonse ya 1, 3, 4, kapena 6.

Pambuyo pakufufuza zamankhwala, dokotala amakulangizani mofanananso ndikukupatsirani mankhwala abwino kwambiri a peptide ufa. Nthawi yomwe dosage yanu imatenga idzawonekeranso ndi dokotala mukawunika momwe muliri. Jakisoni nthawi zambiri amasiyanasiyana wodwala wina.

Chidziwitso chofunikira cha leuprorelin acetate side effect, mlingo

(2) Leuprorelin acetate ufa wobwezeretsanso

Nthawi zina mungasankhe kugwiritsa ntchito leuprorelin ufa, yemwenso ndi mtundu wamphamvu wa mankhwalawa yemwe amathandiza kulimbana ndi zovuta zosiyanasiyana zaumoyo, monga tanena kale. Komabe, Leuprorelin acetate ufa uyenera kukonzedwa bwino kapena kusinthidwanso musanalowe mkatikati mwa minofu yanu. Ufa uyenera kuyesedwa ndipo simukuyenera kugwiritsa ntchito sindito yoyipitsidwa. Pokonzekera leuprorelin acetate, gwiritsani ntchito madzi ozungulira operekera mankhwala opangira mankhwala. Sungani yoyera yoyeserera poyimitsa mpaka itayamba kutembenuka, onetsetsani kuti mukusunga syringe. Tsopano kumasula chiwombankhanga pokankha pang'onopang'ono pang'onopang'ono kwa masekondi a 8 mpaka topper ifike pamzere wamtambo pakati pa mbiya. Nthawi yonseyi sungani syringe.

Pang'onopang'ono phatikizani ufa kuti muwonetsetse ngati pali yunifolomu yoyimitsidwa. Zikatero kuti tinthu tating'onoting'ono tisafafanizike mu yankho, pitani syringe mpaka tinthu tonse titha kusungunuka kwathunthu. Osamamwa mlingo ngati Leuprorelin Acetate ufa (74381-53-6) sanapite kuyimitsidwa kwathunthu. Mukakonzanso, tengani dosage yanu mwachangu kuyambira kuyimitsidwa kwakanthawi kochepa kwambiri. Komanso, musatenge china chilichonse chomwe sichinagwiritsidwe ntchito maola awiri mutangomanganso chifukwa chilibe chitetezo ndipo chingakhale chowononga thanzi lanu.

5. Leuprorelin acetate Mlingo ndi leuprorelin acetate Administration Phcoker

Leuprorelin acetate management imangokhala jekeseni, ndipo muyenera kupeza mlingo wanu kuchokera kwa akatswiri azachipatala kuti mupeze zotsatira zabwino. Monga momwe mumaganizira kuti muli ndi vuto lomwe lingathe kuthandizidwa ndi peptide ufa uyu, osagula ndikuyamba kumwa popanda kumuyesa kuchipatala. Opanga a Leuprolide acetate Itha kuwonetsa kuchuluka kwa mankhwalawa pazomwe mungagwiritse ntchito, koma sizingakugwireni.

Matupi aumunthu ndiosiyana, ndipo mitundu ina imakhala yokwezeka kwambiri kuti ingakuwonetseni zotsatira zoyipa za leuprolide acetate kapena kutsika kwambiri kuti mulephera kupereka zotsatira zomwe mukufuna. Mlingo wa Leuprolide acetate umasiyana kuchokera kwa munthu wina, ndipo amatsimikizidwanso ndi momwe amathandizidwira komanso zaka za wogwiritsa ntchito. Leuprolide acetate ndi mankhwala omwe ayenera kumwedwa motsogozedwa ndi dokotala chifukwa amatha kukhala owopsa akamagwiritsa ntchito molakwika kapena mopitirira muyeso. Nayi mitundu yosiyanasiyana ya leuprolide acetate osiyanasiyana aumoyo;

Mlingo wakale wa leuprorelin acetate wa khansa ya Prostate

Pano pali mitundu yosiyanasiyana yomwe ingakusokonezeni, koma adokotala amakusankhirani yoyenera. Mlingo wake ndi motere;

  • 1mg jakisoni kamodzi patsiku
  • 5mg jakisoni wa intramuscular womwe umayenera kutengedwa kamodzi pamwezi.
  • Muthanso kupita ku 22.5 mg yomwe mudzatenge kamodzi m'miyezi itatu iliyonse.
  • Palinso mlingo wa jakisoni wa 30mg wotengedwa kamodzi m'miyezi inayi iliyonse.
  • 45mg jakisoni wa intramuscular womwe mudzatenge kamodzi m'miyezi isanu ndi umodzi.
  • Mutha kusankha kuti mupitilize kuyika ma 65mg subcutaneous omwe ali osinthika pang'ono chifukwa mumangotenga kamodzi kamodzi pamiyezi ya 12 kapena pachaka.

Chidziwitso chofunikira cha leuprorelin acetate side effect, mlingo

Akuluakulu leuprorelin acetate ufa mlingo wa Endometriosis

Mlingo woyenera wa odwala endometriosis ndi 3.75mg, womwe umayenera kubayidwa kamodzi pamwezi kwa miyezi isanu ndi umodzi. Palinso njira ina yomwe dokotala angakupangireni 11.25mg, yomwe mudzayilowetsedwa kamodzi miyezi itatu iliyonse. Amayi omwe amatenga leuprorelin chifukwa cha endometriosis ayenera kuganiziranso zopita kukalandira chithandizo chamankhwala, chomwe ndi chothandiza kuchepetsa zizindikiro za vasomotor ndi kuchepa kwa mafupa am'mimba. Komabe, kupenda maubwino aliwonse a chithandizo chamankhwala kuyeneranso kuikidwa patsogolo posankha njira zoyenera zamankhwala.

Odwala leuprorelin acetate mlingo wofatsa

Kutha msanga ndi mkhalidwe pomwe ana amakula mikhalidwe ya achikulire molingana ndi momwe amayembekezerera. Pamene kutha msinkhu kumayamba zaka za 8 zisanachitike kwa atsikana ndi 9 mwa anyamata, zimawerengedwa kuti ndizabwino. Vutoli likhoza kuyendetsedwa ndikumwa mlingo wa leuprorelin acetate. Komabe, kulemera kwa mwana ndi komwe kumatsimikizira muyezo woyenera wochizira matendawa. Kusweka kwa mlingo ndi motere;

  • Kuonda kuposa 25kg mlingo woyenera ndi jakisoni wa 7.5mg kamodzi pamwezi
  • Mwana wolemera 25 mpaka 37.5 kg ayenera kumwa mlingo wa 11.25 kamodzi pamwezi.
  • Kwa ana omwe ali pamwambapa37.5kg, mlingo wolimbikitsidwa ndi jakisoni wa 15mg kamodzi pamwezi.

Mukamamwa mankhwala anu a Leuprolide ufa, mahomoni ambiri amayeneranso kuyesedwa pambuyo pa miyezi iliyonse ya 1 kapena 2 kuti muwonetsetse kuti pali kuponderezedwa kwakukwanira kwa pituitary gonadotropin. Kumufufuza pafupipafupi kuthandizira dokotala kuti ayang'anire momwe mankhwalawo amathandizira komanso kuthana ndi zovuta zilizonse zomwe zingachitike munthawi ya chithandizo.

Kumbukirani, dokotala wanu ndiye munthu woyenera kukhazikitsa mlingo wa Leuprorelin kwa achikulire ndi ana atapima matendawo. Nthawi zina mutha kulangizidwa kuti muyambe ndi mitundu yotsika, yomwe imatha kusinthidwa pakapita nthawi mutawona kuyankha kwanu. Leuprolide acetate ndi pakati siziloledwa chifukwa mankhwalawa amatha kuvulaza mwana wosabadwa. Amayi amalangizidwa kuti asatenge peptide ufa pamene akuyembekezera kapena akukonzekera kutenga pakati posachedwa.

Chidziwitso chofunikira cha leuprorelin acetate side effect, mlingo

6. Leuprorelin acetate mbali zotsatira Phcoker

Nthawi zambiri, mukamagwiritsa ntchito mankhwala osokoneza bongo mopitirira muyeso, zimakupatsani zovuta zoyipa; komabe, mphamvu ya thupi lanu nthawi zina imatha kudziwa kukula kwa zotsatirazo. Zomwe zimachitika mukamatsatira malangizo a kumwa pamene mukumwa leuprorelin acetate. Machenjezo a Leuprolide amatha kusiyanasiyana malinga ndi zinthu zosiyanasiyana, monga kulemera kwa thupi komanso kulolera thupi. Ogwiritsa ntchito ena amakumana ndi zovuta ngakhale atatenga leuprolide amagwiritsa ntchito mitundu yotsika pomwe ena amatha kumwa okwanira ndikukhalabe ndiubwino.

Pali zodziwika leuprorelin acetate zoyipa zomwe zitha kuchitidwa ndi pafupifupi aliyense wogwiritsa ntchito, koma zimazimiririka ndi nthawi. Zotsatira zoyambira zamtsogolo ndizowopsa, ndipo mukakumana nazo, muyenera kudziwitsa dokotala wanu nthawi yomweyo. Komabe, palinso zovuta zina zomwe simumakhala nazo mutamamwa leuprorelin ufa. Zotsatira zoyipa izi ndi izi;

(1) Zotsatira zoyipa za leuprorelin acetate

  • nseru
  • Khungu lenileni
  • Zowawa kuzungulira dera la jakisoni
  • mutu
  • Kukwapula
  • Matenda a urination
  • Zowawa zofanana

(2) Kwambiri leuprorelin acetate mbali zotsatira

Ngati mukukumana ndi zotsatirazi mavuto anu amayang'ana chithandizo chamankhwala mwachangu momwe mungathere;

  • Kutaya
  • Kupuma mosakhazikika kapena kupumira mwachangu
  • Kuchuluka kwa manjenje kapena kuwongola miyendo kapena manja
  • Kutupa kwa eyel
  • Zovuta kupweteka

(3) Osachepera leuprorelin acetate mbali zotsatira

Palinso zotsatira zoyipa zomwe zimakhudzana ndi mankhwalawa. Komabe, zimakhala zowawa zikachitika. Chifukwa chake, muyenera kudziwitsa dokotala wanu musanayambe kudwala. Nthawi zina zimachitika chifukwa cha overdosing, kapena ziwengo ndipo zimaphatikizapo;

  • Kutulutsa magazi kwambiri kwa azimayi.
  • Leuprolide acetate ndi shugais komanso vuto lina losowa lomwe mungakhale nalo. Mankhwalawa akuti amawonjezera mwayi wokhala ndi matenda ashuga.
  • Kukhazikika kwa mawu mwa akazi
  • Mavuto a mtima

Kutsiliza Phcoker

Pomaliza, leuprorelin acetate yatsimikizira kuti ndi mankhwala abwino akagwiritsidwa ntchito moyenera kuzachipatala. Nthawi yomweyo, kugula kwa leuprolide acetate kumapezeka ku pharmacy yanu yapafupi, ndipo mutha kupanga oda yanu pamisika yosiyanasiyana yamaintaneti. Pali ambiri opanga leuprolide acetate ndi ogulitsa pamsika masiku ano, koma nthawi zonse onetsetsani kuti mumachita kafukufuku kuti mupeze mankhwala abwino pamtengo wokwanira. The mtengo wa leuprorelin acetate zimasiyana kuchokera kwaogulitsa kamodzi, ndichifukwa chake muyenera kufufuza bwino musanagule mankhwalawo. Komabe, musatenge khansa ya m'mawere ya leuprorelin acetate musanalandire mlingo woyenera kuchokera kwa dokotala.

Zothandizira

  1. Nyimbo, G., Gao, H., & Yuan, Z. (2013). Zotsatira za leuprolide acetate pa ovarian ntchito pambuyo pa cyclophosphamide-doxorubicin-based chemotherapy mu premenopausal odwala khansa ya m'mawere: zotsatira kuchokera pagawo II mwachisawawa. Oncology yamankhwala, 30(3), 667.
  2. Köhler, G., Faustmann, TA, Gerlinger, C., Seitz, C., & Mueck, AO (2010). Mlingo ‐ kuyambira kuphunzira kuti mupeze kuyesetsa ndi chitetezo cha 1, 2, ndi 4 mg wa dienogest tsiku lililonse kwa endometriosis. International Journal of Gynecology & Obstetrics, 108(1), 21-25.
  3. Tunn, UW, Gruca, D., & Bacher, P. (2013). Miyezi isanu ndi umodzi ya leuprorelin acetate depot formapita khansa ya prostate yapamwamba: kuwunika kwachipatala. Zithandizo zamankhwala pakukalamba, 8, 457.
  4. Johnson, SR, Nolan, RC, Grant, MT, Price, GJ, Siafarikas, A., Bint, L., & Choong, CS (2012). Wosabereka mayamwidwe mapangidwe depot leuprorelin acetate mankhwala chapakati olondola kutha. Zolemba za odwala ndi ana, 48(3), E136-E139.