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2019 Mankhwala Otsutsa Otsutsa Okalamba: Nicotinamide Mononucleotide (NMN)
KUTHA KWAMBIRI

2019 Mankhwala Otsutsa Otsutsa Okalamba: Nicotinamide Mononucleotide (NMN)

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1. Zovuta Kwambiri Nicotinamide Mononucleotide (NMN)
2. Nicotinamide Mononucleotide ndi NAD +
3. Kafukufuku watsopano wa Nicotinamide Mononucleotide amagwira ntchito pa mbewa
4. Ubwino wa Nicotinamide Mononucleotide (NMN)
5. Kodi Nicotinamide Mononucleotide (NMN) Ikugwira Ntchito Pa Munthu?
6. Mmene Mungagwiritsire ntchito Nicotinamide Mononucleotide (NMN) Yotsutsa Kukula?
7. Zotsatira Zake za Nicotinamide Mononucleotide Muyenera Kudziwa
8. Kodi Ndingapeze Kuti Mankhwala Osokoneza Bongo-Nicotinamide Mononucleotide (NMN)?
9. Chidule

Kodi ndinu wakufa mukutsutsana ndi ukalamba? Chabwino, mankhwala odana ndi kukalamba mosakayikira ndi njira yodalirika yothetsera nthawi yanu yachilengedwe. Yang'anani pa zovuta za Nicotinamide Mononucleotide (NMN), gawo lake mu senescence, ndi momwe angapezere chithandizo.

Introduction

Kukalamba sikungapeweke. Komabe, pali zotheka kubwezeretsa ukalamba pogwiritsa ntchito Nicotinamide Mononucleotide. Gwiritsani mahatchi anu chifukwa ndikupatsani inu zambiri zokhudza momwe zamatsenga zimagwirira ntchito m'maselo aumunthu.

Tsitsi lofanana ndi nzeru!

Chikhulupiliro chimenechi ndi chinthu chabwino kwambiri chimene munganene kuti chikhale chachikulu. Komabe, kumwetulira kwanu kudzakhala kanthawi kochepa mukayamba kuzindikira makwinya pa khungu lanu lonse. Komanso, ukalamba umakhudza zonse zomwe zimagwira ntchito komanso zamaganizo.

Tiyeni tiyang'ane nazo. Opaleshoni yokhudzana ndi kukalamba ndi opaleshoni zokongoletsa zakhala zofunikira muzaka za nzeru izi. Chimene mukufunikira kudziwa ndi chakuti njirazi ndizofupikitsa ndipo zikhoza kuyambitsa mavuto.

Mwachidziwikire, muyenera kuthana ndi ukalamba poyamba kumvetsa njira zamagulu ndi zamagulu zomwe zimathandiza pazomwe zikugwirizana ndi zaka. Pambuyo pake, zimakhala zovuta kufotokoza njira zotsutsana ndi senescence. Nicotinamide Mononucleotide yotsutsa-kukalamba amagwira ntchito yobwezeretsa unyamata.

Tonsefe tikufuna kusinthana bwino, chabwino? Chabwino, izi zikhoza kukhala zosatheka pamene thupi lanu likupitirizabe kufooketsa, ndipo mumatha kukhala maginito a matenda amtundu wanji, Alzheimer's, kukumbukira kukumbukira, ndi zina zambiri.


2019 Mankhwala Otsutsa Otsutsa Okalamba: Nicotinamide Mononucleotide (NMN)

1. Zovuta Kwambiri Nicotinamide Mononucleotide (NMN) aasraw

Kotero, kodi vuto lonse la Nicotinamide Mononucleotide ndi lotani? Ndiloleni ndifotokoze.

NMN ilipo m'ma alpha (α) ndi ma beta (β) mawonekedwe. Komabe, β-NMN ndi mawonekedwe omwe amagwira ntchito kwambiri. Nucleotide imeneyi imakhala pakati pa biosynthesis ya nicotinamide adenine dinucleotide kapena NAD +.

Izi zimakhala mwachibadwa m'magayala, tomato, nkhaka, cabbages, broccoli, ndi ng'ombe yaiwisi. Mu labotale, imapezeka ngati nicotinamide mononucleotide poda wambiri.

Mu mawonekedwe ake opangira, amadziwika ndi nambala ya CAS, 1094-61-7. Kachigawo kamakhalapo kuchokera ku zomwe zimachitika pakati pa nucleoside, monga nicotinamide riboside ndi gulu la phosphate.

Maphunziro odziwika bwino, Nicotinamide Mononucleotide amagwira ntchito pa makoswe akhala akuthandiza pazinthu zamagetsi zam'thupi, kuyang'anira matenda a Alzheimer, matenda a shuga a zaka zakubadwa, mavuto omwe amabwera chifukwa cha kunenepa kwambiri, ndi matenda a mtima. Ngakhale ntchito zonse za mankhwala zomwe zimagwirizanitsidwa ndi Nicotinamide Mononucleotide, zomwe zimawoneka bwino kwambiri ndikupanga nawo ntchito zotsutsana ndi ukalamba.

Mu thupi la munthu, NMN ndiye gwero lalikulu la mphamvu mkati mwa maselo. Pamene mukukalamba, mphamvu zamagetsi zimachepetsa chifukwa cha nicotinamide mononucleotide ndi kuchepa kwa NAD +. Kulamulira NMN kudzasinthira ndondomekoyi ndi kulipira malire.

(1) Kodi NMN ndi yodabwitsa bwanji?

Mankhwala odana ndi okalamba amayenda ngati mphezi kuchokera m'matumbo kupita m'magazi. Mu mphindi zingapo, iwo adzalandidwa m'magazi. Pachifukwa ichi, zikuwonekeratu kuti pangakhalebe njira zina zamagetsi zomwe zimachitika mu njira ya mamolekyu.

Liwiro la phokoso lachititsa ochita kafukufuku kuganiza kuti akhoza kutenga nthumwi, zomwe zimapangitsa kuti maselo aperekedwe. Mwachitsanzo, Imai ndi anzake adayesetsa kupeza yankho kupyolera mu kufufuza kwake posachedwa kumene kunafalitsidwa pa January 7, 2019.

Ndili wokalamba, thupi limagwiritsa ntchito zambiri NAD + kuposa momwe zingakhalire. Ngakhale mutagwiritsa ntchito nicotinamide mononucleotide, ndondomekoyi idzakhala yowonongeka kwa nthawi malinga ngati palibe molekyulu yothandiza kayendetsedwe kake. Pitirizani kufufuza kuti mutsegulire wotengera wodabwitsa yemwe adzathetsa 90% ya mavuto okalamba.

(2) Nicotinamide Mononucleotide Structure Form

Mphamvu ya Nicotinamide Mononucleotide powder (1094-61-7) Opanga - Phcoker Chemical

(3) Malingaliro a Nicotinamide Mononucleotide

dzina mankhwala Mphungu yaikulu ya Nicotinamide Mononucleotide (NMN)
CAS ayi. 1094-61-7
Zolemba zamatsenga C11H15N2O8P
Kuchuluka kwa maselo 334.221 g / mol
Maonekedwe White crystalline powder
Chiyeretso > 98%
Kutupa Madzi sungunuka
yosungirako kutentha -20 ° C
mayina ena · Nicotinamide-1-ium-1-β-D-ribofuranoside 5'-phosphate

· Β-nicotinamide mononucleotide

Beta-NMN

· Nicotinamide ribonucleotide

· 3- (Aminocarbonyl) -1- (5-O-phosphonato-beta-D-ribofuranosyl) pyridinium

· Nicotinamide ribonucleoside 5'-phosphate

2. Nicotinamide Mononucleotide ndi NAD + aasraw

onse Nicotinamide Mononucleotide ndi NAD + ndizomwe zimakhala zofunikira kwambiri m'mafakitale a mafuta.

NMN ili pakati pa biosynthesis ya Nicotinamide adenine dinucleotide (NAD +). Thupi limakhala ngati gawo lapansi la michere yeniyeni monga nicotinamide mononucleotide adenylyltransferase, yomwe imatembenukira ku NAD + mu thupi laumunthu. Powonongeka, gawoli limasintha ku nicotinamide. Pambuyo pake, izi zimagwirizananso ndi nicotinamide phosphoribosyltransferase (NAMPT) yopanga NMN.

Mamolekyu awiriwa ndi ogwirizana kotero kuti kusowa kwa aliyense wa iwo kudzakhudza wina. Mwachitsanzo, taganizirani pamene ma NMN akugwera pansi, mwina chifukwa cha senescence, kuchuluka kwa NAD + kudzatha.

Pamene mukukalamba, ntchito zina zowonjezera mavitamini zimakonda kudya NAD + kuposa thupi limene lingathe kupanga mafuta. The Sirtu, NADase, ndi poly-ADP-ribose polymerase (PARP) ndi mbali ya michere, yomwe imatentha NAD + kutsogolera kuyambanso.

Komabe, kuchepa kwa mafuta a ma apulosi sikungokhala mosavuta. Mwachitsanzo, taganizirani zomwe zimachitika pothandizira pulojekiti zomwe zimaphatikizapo thandizo la PARP pokonza DNA yoonongeka. Komanso, timititi imathandizira kwambiri pakukonza kagetsi ka maselo.

Ngakhale pali mgwirizano wamagulu pakati pa anthu awiriwa, simungathe kuika NAD + mwadongosolo. Mulimonse momwe njirayi ingathere, zotsatira zake zimakhala zosasinthika. Mwachitsanzo, mlingo waukulu umatopa, nkhawa, ndi kusowa tulo. Kuonjezera apo, chigawocho sichitha kupyolera mu membrane ya plasma.

(1) Njira Yokometsera

The Nicotinamide Mononucleotide ilipo ngati mankhwala osokoneza bongo. Kutentha kwake kupyolera mu matope a m'matope ndi mu kayendedwe ka kayendetsedwe kake kumayambira pafupi maminiti atatu. Ndi 15th min, zonsezi zidzatengedwa. Kafukufuku wambiri wa Imai ndi ochita kafukufuku amatsimikiza kuti pali mapuloteni omwe amachititsa kuti phindu limeneli lifulumire.

Pogwiritsa ntchito mankhwalawa, NMN imasintha mosavuta ku NAD + kuti isungidwe bwino. Njira ya metabolism ikhoza kutenga theka la ora. NAD + imakhala yambiri m'matumbo, minofu yoyera, chiwindi, ndi cortex. Komabe, kulamulira kwa nthawi yaitali kwa Nicotinamide Mononucleotide kunapitirira msinkhu wa NAD + mu ziwalo zina monga minofu yofiira adipose.

(2) NMN Biosynthetic Njira

M'maselo a mammalia, pali njira zitatu zosiyana zedi zamagetsi zomwe zimaperekera kufooka kwa NAD +.

De Novo Pathway

De Novo ndi mawu otchedwa "Lain", omwe amatanthauza "kuyambira pachiyambi." Pano, nucleotide imachokera ku tryptophan kapena nicotinic acid, yomwe imachokera ku zakudya za NMN.

Panjirayi, momwe zinthu zimagwirira ntchito zimayambitsa mapangidwe a nicotinic acid mononucleotide, nicotinic acid adenine dinucleotide, ndipo potsirizira pake kuyembekezera kwambiri NAD +. De Novo imapanga pafupifupi 15% ya mafuta onse.

Njira ya Salvage

Apa, njirayo imapezanso nucleosides pamene DNA imatha. Zimapanga zoposa 80% za chiwerengero cha NAD +, chimene thupi la munthu limafuna ntchito zapulogalamu. Njirayo imagwiritsira ntchito nicotinic asidi ndi nicotinamide kuti apange NAD yatsopano.

Nthenda yotchedwa phosphoribosyltransferase imathandizira kupanga mapangidwe a nicotinic acid mononucleotide kuchokera ku nicotinic acid. Pambuyo pake, nicotinamide mononucleotide adenylyltransferase 1 imapangitsa kuti adenylation iwonongeke kwa mankhwalawa ndi nicotinic acid adenine mononucleotide, ndipo potsiriza ku NAD +.

NMN ntchito pa munthu imadalira njira iyi.

NR Conversion

Nicotinamide Riboside ndi wotsutsa wina wa NAD +. Pa phosphorylation pamaso pa nicotinamide riboside kinase, biomarker imapereka NMN musanayambe kukhala ndi enzymatic kutembenuzidwa kukhala NAD +.

  • Mbiri ya NAD + ndi NMN mu Research

Kwa zaka zambiri, phunziroli ndi njira zothandizira za nicotinamide adenine dinucleotide ndi zotsatila zake zakhala zikupsya mtima. Komabe, muyenera kuzindikira kuti izi anti-aging supplements akhala akugwiritsidwa ntchito mufukufuku kuyambira pakati pa 1900s.

Mu 1906, akatswiri oyamba adanena kuti NAD + imachepetsa kuchulukitsa kwa yisiti. Pambuyo pake, akatswiri a sayansi ya sayansi ya zakuthambo anatsatizana ndi kuikonza kuti ikhale nucleotide.

Kupyolera mufukufuku wake mu 1937, Conrad Elvehjem adapeza kuti nicotinamide ndi nicotinic ndi mavitamini ndi zowonongeka za NAD +. Patapita nthawi, anapeza kuti awiriwa akhoza kuchepetsa agalu. Chifukwa chake ndi chakuti ma nicotinic acid ndi nicotinamide anali otsika kwambiri kwa anthu omwe akudwala matendawa.

Mu 1963, gulu la asayansi linakhazikitsa kuti Nicotinamide Mononucleotide imagwira ntchito pa mbewa zikhoza kulimbikitsa mavitamini omwe amadalira DNA, zomwe zinali zofunikira kwambiri pakuwonjezera ma makina. Patadutsa zaka ziwiri, ofufuza ena anafotokoza njira za NAD + zamaganizo zogwirizana ndi tryptophan ndi nicotinic acid.

Kuchokera nthawi imeneyo, akatswiri a sayansi ya zakuthambo akhala akupitiriza kusonyeza chidwi pa NMN ndi NAD + kafukufuku. Mu nthawi ino, chofunika kwambiri ndi kufunikira kwa izi mankhwala osokoneza bongo kukhala ndi moyo wautali komanso kuchepetsa mavuto okalamba.

3. Kafukufuku watsopano wa Nicotinamide Mononucleotide amagwira ntchito pa mbewa aasraw

Pali mitundu yambiri yophunzirira pazithunzi zamakono zomwe zimasonyeza ubwino wa mankhwala a Nicotinamide Mononucleotide (1094-61-7).

Tiye tikambirane ochepa chabe, omwe athandizidwa ndi kusintha kwa chilengedwe.

(1) Malingana ndi Sinclair, NAD + ndi Kasupe wa Achinyamata

Dr. Sinclair ndi anzake achita kafukufuku angapo ponena za ubwino wa nicotinamide mononucleotide ndi NAD + potembenuza kukalamba. Malingana ndi kafukufuku wake wa 2013, Sinclair ndi gulu adapeza kuti mbewa za 22 zamwezi zomwe zimatenga NMN kwa masiku asanu ndi limodzi zinasonyeza kusintha kwa minofu, kuchepa kwa thupi, ndi chipiriro.

Pambuyo pake pa pepala la kafukufuku wa 2016, gululo linatsimikizira kuti NMN inali ndi mapindu omwewo monga kuchita. M'malo mothamanga tsiku lililonse, mutha kukhala ndi zotsatira zofanana mukamagwiritsira ntchito mankhwala a Nicotinamide Mononucleotide m'malo mwake.

Malingana ndi Harvard Geneticist, a NMN imagwira ntchito pa anthu Zimayendera kuzungulira magazi pa okalamba ndi othamanga othamanga.

(2) Mphero Zimatsimikizira kuti NMN imachepetsanso kuchepa kwa thupi kwa azimuna okalamba

Pofotokoza phunziro la 2016, Mills et al. anapeza kuti chithandizo cha NMN chikhoza kutsutsana ndi kuchepa kwa thupi ndi maumunthu m "makoswe akale. Kumapeto kwa NMN supplement kafukufuku, makoswe amalembera kuwonjezeka kwa maonekedwe a maselo a chitetezo cha mthupi, kuwonjezeka kwa mitsempha yotchedwa lymphocytic, ndi kutayika mu neutrophils.

Poyamba, mu 2011, Mills, Yoshino, ndi Imai adagwiritsa ntchito mbewa kuti adziwe ntchito ya NAD + pochiza matenda okhudzana ndi zakudya komanso matenda a shuga. Mufukufuku wina wa 2016, adagwirizanitsa manja ndi ochita kafukufuku omwe adaonetsetsa kuti NMN supplementation ikanaletsa kusokonezeka kwa mthupi ndi kukanika kwa mitsempha m'magulu akale.

(3) Matenda a NMN a Alzheimer (AD) mu Murine Models

Mu 2015, Long et al. anafufuza zotsatira za NMN pa ubongo wa mitochondrial kuperewera kwa mbewa ndi matenda a Alzheimer. Gululi linanena kuti mankhwala a NMN adatha kuwonetsa chidziwitso cha AD, kuphatikizapo otsika OCR (okwera magetsi), NAD +, ndi zovuta za mitochondria.

Mu 2016, Wang ndi anzake adatulutsa kafukufuku wawo, poganiza kuti mankhwala okalambawa amatsutsana ndi chidziwitso ndi matenda a neural, omwe amachokera ku β-amyloid (Aβ) oligomer. Puloteni iyi ya Aβ ndi neurotoxic ndipo imayambitsa mapangidwe apangidwe mu ubongo wa AD odwala. Wang et al. anaganiza kuti NMN kayendetsedwe ka makoswe inachititsa kuchepa kwa oligomers Aβ, motero kumathandiza kuti azidziŵa bwino ntchito.

Potsatira phunziro la 2017, Hou ndi anzake adapeza kuti NAD + supplementation inachepetsa kupanga oligomers a β-amyloid. Chaka chotsatira, Yao ndi gulu lake anakhazikitsa kuti Nicotinamide Mononucleotide amachepetsa kuwonjezeka kwa Aβ ndi synaptic yotayika mu zitsanzo za AD-Tg murine.

(4) NMN ndi Cardio-chitetezo

Malingana ndi zofalitsa za 2014 za Yamamoto ndi anzake, NMN imateteza mtima kuvulala ndi ischemic. Pambuyo pa phunziro lino, Yamamoto anali m'gulu la 2012, lomwe linapeza kuti NAD + yowonjezera zakudya zowonjezera kwambiri mu makoswe.

Mu 2016, De Picciotto et al. ndipo anzake a sayansi ya sayansi ya zakuthambo anaphunzira zotsatira za NMN supplementation pamtunda wa makoswe okalamba. Kuchokera ku chiwerengero, nicotinamide mononucleotide inakhala yothandiza kuthetsa kusokonezeka kwa mitsempha, kupsinjika kwa okosijeni, ndi kuchepa mu elastin.

(5) Kupeza Kwa Njira Yatsopano ya Mafuta Akutumizidwa ndi Shin-Ichiro Imai

Mu kafukufuku waposachedwapa, gulu la asayansi motsogoleredwa ndi Imai adapeza ndipo adasula nthumwi yodabwitsa ya NMN m'maselo.

Kafukufukuyu wa NMN supplement poyamba anapezeka mu January 2019 mkati Chilengedwe cha Metabolism. Imai anakhazikitsa kuti puloteni inayake, Slc12a8, ndi yomwe imayambitsa kutembenuka kwa NMN kwa NAD + mofulumira ndikuyendetsa mu selo. Enzyme imeneyi imakhala yaikulu kwa anthu akale osati achinyamata kapena thanzi labwino.

Phunziro lonse labwino, asayansi apeza kafukufuku wamadzi omwe amadziwika kuti ndi nicotinamide mononucleotide.

4. Ubwino wa Nicotinamide Mononucleotide (NMN) aasraw

NMN ili ndi ntchito zambiri zochiritsira komanso zotsatira za mankhwala pa thupi la munthu. Pasanathe zaka khumi, asayansi apatulira nthawi yawo yophunzira zonse za Nicotinamide Mononucleotide kuphatikizapo njira zomwe zimalongosola ukalamba ndi matenda okhudzana ndi zaka.

Tiyeni tifufuze mu ubwino wa mgwirizano mu dongosolo laumunthu.

(1) Kutsegula Mitundu ya Zamoyo

Kufikira kuyambika kwa 21st zaka zapitazi, akatswiri anali ndi zifukwa zokwanira zowonetsera ukalamba ngati njira yosasinthika. Komabe, lingaliro limeneli lakhala lopanda kanthu chifukwa cha kufufuza kwapadera anti-aging supplements monga Nicotinamide Mononucleotide.

NMN imachitika mwachibadwa m'maselo aumunthu ndipo imayambitsa biosynthesis ya NAD + ndi kupanga mphamvu. Pamene mukukalamba, izi zimakhala zochepa kwambiri zomwe zimayambitsa matenda a maselo. Kumbukirani, magulu ogwira ntchitowa amafunikira mafuta okwanira okwanira nthawi zonse, choncho, kugwa kumachepetsa msinkhu wa moyo wa maselo.

Kuwongolera mankhwala ogwira ntchito odana ndi ukalamba monga NMN idzasinthira ndondomeko ndi kuchepetsa ukalamba.

(2) Kulimbikitsa Maselo Achinyamata Achinyamata

Chiyambi chachikulu cha matenda ambiri okhudzana ndi ukalamba ndi wocheperachepera mpaka pamaselo a ma selo. Kuchepa kwa kupanga mphamvu m'kati mwa maselo ndizo zikuluzikulu zowonjezera zizindikiro za ukalamba.

Pokhala chithunzithunzi cha NAD +, NMN ili ndi gawo lomwe liyenera kuthandizira kusunga mphamvu zamagetsi za mitochondria. Kukalamba kumapangitsa kuchepa kwa NAD +. Chifukwa chaichi, ukalamba umatenga nthawi pang'ono kuti ukhale ndi matenda okalamba.

Dontho m'magulu a mphamvu zam'manja mkati mwa ziwalo zofunikira monga minofu, mitsempha ya magazi, impso, chiwindi, kapena mphukira nthawi zonse zimasokoneza thanzi labwino ndi thanzi. Ndi chifukwa chake matenda omwe amatchedwa ischemia, matenda a mtima, impso, matenda osokoneza bongo, ndi ena akuwombera.

Njira yothetsera vutoli ndi kupatsiriza thupi la Nicotinamide mononucleotide ndi NAD + ndi chithandizo chamankhwala cha kunja kwa NMN. Izi Mankhwala odana ndi okalamba amapereka mgwirizano watsopano wa maselo kwa maselo okalamba, omwe amawoneka mwachiwonekere.

(3) Kupititsa patsogolo Kuthamanga kwa Magazi

Chimodzi mwa kusintha komwe kumachitika nthawi yakale ndi kuchepa kwa mitsempha ya magazi mkati mwa thupi la mamamia. Choncho, ma circulatory system imakumana ndi mavuto ambiri pakanyamula zakudya, mpweya, kutentha, kapena kuchotsa zida kuchokera ku ziwalo. Popeza kuti zinthu zikupitirirabe, zimaipiraipira patapita nthawi kuti zizindikiro za matenda a nthawi yaitali zichitike.

Nicotinamide Mononucleotide ndiyomwe imayambitsa kupanga mitsempha ya magazi. Ndiloleni ndifotokoze. Pulogalamuyi imapanga NAD +, yomwe imathandizanso puloteni ya Sirir deacetylase (SIRT1).

Mosiyana ndi zimenezi, SIRT1 imapangitsanso mabwinja a lysine omwe amathandiza kupanga mpweya wabwino wa oxygen. Njirayi imamenyana ndi zovuta zowonjezera zowonjezereka, kutsekemera, kapena kuvulala kwa kasupe. Nthawi zambiri, thupi lomwelo lidzagonjetsa ischemia ndi zochitika zogwirizana ndi ischemic preconditioning (IPC). IPC idzachitapo kanthu pofuna kulimbikitsa kupanga SIRT1.

Mukhoza kupereka NMN musanachitike chochitika chachilendo kapena panthawi yake. Zisanachitike, kampaniyi imapereka chitetezo cha cardio popititsa patsogolo ATP kupanga kudzera mwa glycolysis.

Pankhani ya Ischemia, ukhoza kugwiritsira ntchito Nicotinamide Mononucleotide chifukwa idzayambitsa acidosis ndipo idzachititsa kuti mitochondrial izilephera; motero, kutsimikizira chitetezo cha mtima.

(4) Muscle Endurance

Kodi mukuyembekeza chiyani pamene magazi akuchepa? Chabwino, boma lidzatsogolera ku imfa ya misala. Ndizosakayikitsa kuti mudzaona anthu akale akugwira ntchito zochepa, opirira, osasunthika, ndi otopa kwambiri nthawi zonse.

Chimodzi mwa zovuta zomwe anapeza ndi Dr. Sinclair zinkangoganizira za momwe NMN ingakhalire ndi mphamvu zolimbitsa thupi. Malingana ndi 2013 yake ndi maphunziro a 2018 aposachedwapa, mbewa zakale zomwe zinawonetsedwa ku mankhwala a NMN masiku asanu ndi awiri zinakhala zolimba mwakuthupi komanso zofanana ndi zazing'ono zawo.

Mphamvu ya minofu ndi kupirira kwa mbewa zakale (miyezi ya 30) zinali zofanana ndi za mwana wachinyamata wa miyezi isanu. Mibadwo imeneyi ikufanana ndi pafupifupi 70 ndi zaka 20 kwa anthu. Kuchokera pazofukufuku, mungathe kuchepetsa kuti NMN ikhale yogwira ntchito paumunthu ndikutsimikiza ngati imfa.

(5) Kulimbana ndi Matenda a Neurodegenerative

Ubongo uli ngati mphamvu ya dongosolo lanu. Izi zikhoza kukhala chifukwa chomwe madokotala amakhulupirira nthawi zonse pa ubongo pamene akulengeza nthawi ya imfa.

Kuchepetsa chiwerengero cha NAD + mu ubongo kumayambitsa thanzi labwino pakati pa okalamba. Ulamuliro wa NMN ukufulumizitsa kupanga NAD +, motero, kuteteza ntchito za neural.

Maphunziro ambiri amatsimikizira kuti Nicotinamide Mononucleotide imapindula kuzindikira, kupweteka, komanso kusokoneza kukumbukira kukumbukira, komwe kumakhala kokalamba. Mwachidziwikire, chowonjezera chotsutsana ndi kukalamba ndicho kuyang'anira ma neurons.

NMN makamaka imalimbikitsa chidziwitso cha mtundu uliwonse wa matenda a ubongo. Mwachitsanzo, matenda a Alzheimer amapezeka chifukwa cha kuchepa kwa NAD +, kutsika kwa mpweya wa okosijeni mu ubongo, ndi zolakwika za mitochondrial. Kuchulukitsa kuchuluka kwa NMN mu thupi kuwerengera zotsatira zonsezi.

Malingana ndi kafukufuku wofalitsidwa mu 2012, Nicotinamide Mononucleotide idzayendetsa bwino kuwonongeka kwa ubongo, zomwe nthawi zambiri zimayambitsa matenda. Mphaka akale omwe anali pansi pa mlingo wa NMN analembetsedwa bwino kwambiri mu intracerebral NAD + yopanga. Zitsanzo zofufuzirazi zinali ndi chitetezo chokwanira pa sitiroko ya ischemic, neural death, ndi kutupa kwa ubongo.

(6) Kusintha Metabolism mu Ukalamba

Ofufuza ambiri afufuza ndi kutsimikizira kuti NMN imayambitsa kulekerera kwa glucose pamene imapangitsa kuti shuga yambiri isamakhale ndi zakudya zambiri. Phunziroli likugwiranso ntchito kwa anthu okalamba omwe amayamba shuga kapena chifukwa cha shuga kapena zakudya zoperewera. Kuonjezera apo, kudya zakudya zochuluka kumawonjezera insulini kukana.

Nicotinamide Mononucleotide ili ndi chiwerengero chachikulu cha NAD +, zomwe zimachepetsanso kutupa kwa zaka zomwe zimapangitsa kuti thupi likhale ndi mafuta ambiri.

2019 Mankhwala Otsutsa Otsutsa Okalamba: Nicotinamide Mononucleotide (NMN)

(7) Kuchiza kwa Shuga

Anthu omwe ali ndi matenda a shuga a mtundu wachiwiri amasonyeza kuti amatha kusamalidwa ndi insulini. Chikhalidwe ichi chimachokera ku vuto ku NAD +. Zotsatira zake, maselo amakhala ndi nkhawa yowonjezera ndi kutupa. Ngati mudakali wamng'ono, thupi lidzitsitsimutsanso palokha pogwiritsa ntchito zochitika zokhudzana ndi thupi. Komabe, pokhala okalamba, ziwerengero za NAD + zimachepetsa mu ziwalo zothandizira moyo monga minofu ya chigoba, chiwindi, ubongo, ndi ziphuphu.

Chinthu chinanso chothandizira ku matenda a shuga okalamba ndi zakudya zamtengo wapatali. Ndalama zopanda malire za mafuta odzaza amalepheretsa kusokonekera kwa NAD +. Pofuna kutsimikizira kuti mphamvu ya Nicotinamide Mononucleotide imathandiza bwanji pa matenda a shuga ndi matenda odwala matenda a shuga, Yoshino ndi anzake amagwiritsa ntchito mbewa ziwiri.

Atapereka mlingo wa tsiku ndi tsiku wa NMN kwa masiku osachepera a 10, akatswiriwo ankanena kuti mbewa, zomwe zinali ndi zakudya zamtengo wapatali, zinalembera kusagwirizana kwa insulini. Komano, mbewa za shuga zinasonyeza kusintha kwakukulu mu hyperlipidemia.

(8) Kusintha Kukalamba

Zovuta zaumoyo nthawi zonse zimayendera limodzi ndi ukalamba. Pamene thupi likumana ndi kusintha kwambiri kwa thupi, ntchito zina zimagwera kubwerera. Mwachitsanzo, taganizirani kuti nicotinamide adenine dinucleotide imachepa mu ziwalo zingapo, zomwe zimapangitsa kuchepa kwa mphamvu za magetsi pogwiritsa ntchito mitochondrion ya selo.

Kukalamba kumayambitsa zinthu zosiyanasiyana monga kuwonongeka kwa DNA chifukwa cha mamolekyu osatulutsidwa, kupsinjika kwa magazi, ndi mavuto ena. Kodi mukudziwa zomwe zimachitika? Chabwino, pali DNA yokonza mapuloteni (PARP1) mu dongosolo laumunthu. Pankhani ya kuwonongeka kwa DNA, NAD + idzayambitsa mapuloteniwa kuti akonze selo yogwidwa.

Kafukufuku wochuluka wadza ndi zopindulitsa za nicotinamide mononucleotide atakalamba. Mwachitsanzo, Mills ndi anzake amagwiritsa ntchito mafanizo kuti azifufuza zotsatira za kuchepa kwa thupi kwa NMN.

Phunziroli, ochita kafukufuku adanena kuti nthawi yayitali chithandizo cha mankhwalachi chinapangitsa kuti kuwonjezeka kwa majeremusi osokonezeka mu chiwindi, mitsempha, ndi minofu. Kuwonjezera pamenepo, zomwe anapezazi zinatsimikizira kuti maselo a chitetezo cha m'magulu, chitetezo cha ma lymphocytes, ndi kuchititsidwa kwa leukocyte.

Chinthu china cha ukalamba ndi kukhalapo kwa mawanga owala mu thumba la maso. Matendawa kuphatikizapo kuperewera kwa mafupa kufooka komanso kulephera kubweretsa misozi kwawerengedwa bwino pa makoswe. Asayansi ananena kuti mbewa, zomwe zinayikidwa pa chithandizo cha mwezi wa XMUMX wa NMN, zinasintha zinthu zonsezi.

Zaka zambiri ndizo chifukwa chokha chomwe anthu amachitira Gulani Nicotinamide Mononucleotide.

(9) Kuchiza kwa Kunenepa Kwambiri

Kwa okalamba, NMN ikhoza kuchepetsa mpaka 10% ya kulemera kwa thupi koyamba popanda kupeza pakati pakati pa njala ndi kukula. Zomwe zimayambitsa kunenepa kwambiri ndi shuga zimagwirizana. Maseŵera a NAD + otsika amachititsa kulephera kwa mitochondrial; chotero, kuchepa kwa kupanga ATP.

Kunenepa kumachepetsa mphamvu ya mitochondria pakupanga ATP mphamvu kwa maselo. Mukapereka Nicotinamide Mononucleotide, mankhwalawa amachititsa kusagwirizana kwa shuga ndi ntchito zina zamagetsi zokhudzana ndi kunenepa kwambiri.

Pankhani yowonjezera kuthamanga kwa magazi, NMN yothandizira kwambiri imachitanso chimodzimodzi. Piritsi imodzi ingakhale yabwino kugwiritsa ntchito tsamba lopiritsika tsiku lililonse. Komabe, kusiyana kumabwera m'magulu a NAD + zomwe zili m'thupi. Ngakhale kuti Nicotinamide Mononucleotide imachulukitsa NAD + m'magulu a chiwindi ndi osagwira ntchito, kuchita masewera olimbitsa thupi kumangomanga kampeni mkati mwa minofu.

5. Kodi Nicotinamide Mononucleotide (NMN) Ikugwira Ntchito Pa Munthu? aasraw

Chabwino, uwu ukhoza kukhala funso lomwe liripo tsopano pamutu mwanu. Mulimonsemo, kufufuza konse ndi kafukufuku wamakono opangidwa ndi Nicotinamide mononucleotide ndi NAD + akhala akunena za mtundu wa murine.

Ngati muli ndi zosungira za momwe NMN ikugwirira ntchito paumunthu, ndizo zonse zomwe mukuyenera kuzidziwa. Dr. David Sinclair, wofufuza kapamwamba, ndi geneticist ku Harvard University ndi mmodzi mwa omwe adalandira NMN.

Sinclair akuvomereza kuti amatenga chowonjezera. Pakalipano, katswiriyu sanalembetse zotsatira zoopsa za nicotinamide mononucleotide. M'malo mwake, iye amati amadziona kuti ndi wamng'ono. Mbalame zam'madzi ndi zam'madzi zimakhala zovuta kwambiri. Anapitiriza kunena kuti bambo ake, omwe ali ndi zaka makumi asanu ndi awiri zapitazi, amatenganso zina.

Kuwonjezera apo, Dr. Sinclair wakhala akugwiritsa ntchito mankhwalawa monga oyambirira ku Brigham ndi Women's Hospital. Ali ndi ndondomeko zowonjezeretsa kuyesa kwa okalamba omwe ali ndi thanzi labwino. Ngakhale kuti phunziro lake limodzi ndi lathunthu, adakalibe buku lovomerezeka. Sinclair adayamba gawo lachiwiri lachipatala ichi NMN supplement kafukufuku mu 2018.

chipatala Mayesero

Mu phunziro lachipatala lomwe liri chifukwa cha 1st June 2020, ofufuza akuyang'ana kuti asinthe kusintha kwa mphamvu ndi beta-selo ikugwira ntchito ndi NMN supplementation mwa anthu. Ophunzirawo akuchokera ku Sunivesite ya Washington University of Medicine ndi Keio University School of Medicine ku Tokyo.

Mu kuyesedwa kwaumunthu komwe kunayamba ku 2016 ku Keio University, akatswiriwa anali kuyang'ana kuti aone ngati NMN ndi otetezeka kwambiri. Mu gawo lachiŵiri lopitirira, bungwe lomwelo, lotsogoleredwa ndi Shin-Ichiro, likufufuza kafukufuku wa NMN wa nthawi yayitali. Zowonjezerapo, gululi likufuna kufufuza njira zokhudzana ndi matenda opatsirana pogonana, NMN kinetics, ndi mankhwala omwe amachititsa kuti shuga isamagwiritsidwe ntchito.

Mu phunziro lachipatala la 2017 ndi University of Washington, ophunzirawo anali ndi akazi a 50 a zaka 55 mpaka zaka 75. Gululi linaikidwa pa mlingo wa tsiku ndi tsiku wa 250mg wa NMN kwa masabata asanu ndi atatu. Ngakhale kuti anali a thanzi labwino, akaziwa anali ndi shuga kwambiri, triglyceride, ndi BMI. Phunziro silinamalire.

Monga pakalipano, palibe mabuku omwe amathandizira NMN kugwira ntchito kwa anthu. Komabe, muyenera kupachika chifukwa chinachake chikuphika ndipo mayesero a chipatala angakhale akulonjeza.


2019 Mankhwala Otsutsa Otsutsa Okalamba: Nicotinamide Mononucleotide (NMN)

6. Mmene Mungagwiritsire ntchito Nicotinamide Mononucleotide (NMN) Yotsutsa Kukula? aasraw

Ngati mukuyang'ana kugula nicotinamide mononucleotide, pali zinthu zingapo zomwe muyenera kudziwa.

Mungathe kutenga mankhwala monga chakudya chowonjezera chifukwa sanalandire mgwirizano womaliza wa FDA kukhala mankhwala osokoneza bongo.

Mlingo uli pakati pa 25mg ndi 300mg malingana ndi ubwino wa thanzi lomwe mukufuna kuti mukwaniritse. Komabe, anthu ena amavomereza kutenga 1000mg patsiku. Tenga Mwachitsanzo, Dr. Sinclair amatenga 750mg / tsiku. Kuphatikiza apo, akuwonjezera mphamvuyi ndi resveratrol ndi metformin.

Mu mayesero a chipatala a NMN, ambiri ofufuza adzaika maphunziro awo pamtundu wa 100mg kwa 250mg.

Mvetserani pamagulu osiyana

Ngati mukufuna kupititsa patsogolo mankhwalawa, muyenera kugula mapiritsi a Nicotinamide Mononucleotide kuti muwongolera. Kugwiritsa ntchito mankhwalawa kumachepetsa kuchepetsa ndalama zomwe zimalowa m'matumbo. Chifukwa chake n'chakuti imayambitsa matenda ndi kuchepa pamene imadutsa m'magazi ndi chiwindi.

NMN yamagulu amodzi mwachindunji alowa mwazi popanda zitsulo zilizonse. Kuchuluka kwake kwa njira iyi yobereka ndi pafupifupi kasanu kuposa kulamulira komlomo. Pachifukwa ichi, mufunika kuwonjezera mlingo kuti mupange choyamba chamagetsi pachiwindi. Tiyerekeze kuti mukufufuza, mungafunikire ufa wochuluka wa nicotinamide mononucleotide kuti mutsirize phunzirolo.

7. Zotsatira Zake za Nicotinamide Mononucleotide Muyenera Kudziwa aasraw

Zophiphiritsira zimagwirizana ndi zomwe zikuwonetsedwa ndi niacinamide ndi zina vitamini B3 compoundnicotinamide zotsatira zowonongeka s. Komabe, anthu ambiri samawadziwa konse. Mwachitsanzo, mkulu wa sayansi ya kafukufuku wa Harvard University adavomereza kutenga NMN, koma sanazindikire zotsatira zake.

Pakalipano, mu Nicotinamide Mononucleotide yomwe ilipo ikugwira ntchito pa mbewa, palibe deta yomwe imasonyeza kuti pali zotsatirapo zina zomwe zimayambitsa maonekedwe a murine. Palibe wofufuza amene adalemba chizindikiro choipa pafupipafupi komanso kwa nthawi yaitali NMN administration.

Anthu ena amatha kuona zotsatirazi zoipa;

  • nseru
  • kusanza
  • chizungulire
  • Mimba imakhumudwitsidwa
  • kutsekula
  • Zomwe zimayambitsa matendawa monga itchiness, mng'oma, kapena misampha

Nthawi zambiri, zotsatira za nicotinamide mononucleotide zikhoza kukhala zovuta kwambiri kuti mufunse kufufuza mwamsanga. Kutchula zochepa, zovuta kupuma, kupweteka mtima kwa mtima, kusanza kosalekeza, khungu la chikasu, ndi kusowa kwa njala ndi zina mwa zizindikiro zovuta.

Contraindications

Pakadali pano, mayesero a zachipatala amangokhala akuluakulu okalamba mu zaka za 45 mpaka zaka 75. Pa chifukwa ichi, magulu otsatirawa ayenera kukhala osamala asanayambe kuwonjezera zowonjezera kupirira kwa NMN.

  • Amayi oyembekezera ndi oyamwitsa
  • Anthu omwe ali ndi mbiri ya hypersensitivity kwa NMN
  • Odwala amamwa mankhwala odwala matenda aakulu

8. Kodi Ndingapeze Kuti Mankhwala Osokoneza Bongo-Nicotinamide Mononucleotide (NMN)? aasraw

(1) NMN Zakudya Zakudya

Mwinamwake mukukangana kuti ndi chifukwa chiyani muyenera kugula Nicotinamide Mononucleotide pamene mungapeze mosavuta zakudya zina. Ndiloleni ndikufotokozere mwachidule chifukwa chake izi zowonjezera ndizofunikira.

Monga NAD + imachepa m'thupi chifukwa cha kukalamba, maselo sangathe kulimbana ndi zotsatira zake. Panthawi imeneyi, kusankha kwanu kokha kungakhale kugwiritsa ntchito NMN supplements. Madokotala amakulimbikitsani kutenga zakudya za NMN monga broccoli, bowa, edamame, kapena shrimp. Komabe, zakudya izi zidzangopereka zosakwana 5% za zomwe thupi lanu limafuna.

FDA ikuvomereza kuti munthu aliyense akusowa pafupifupi 560mg ya NMN patsiku. Tiyerekeze kuti mutenga mafuta kuchokera ku broccoli, mudzadya mapepala a 1500 ofanana.

(2) Zotsatira za NMN

The nicotinamide mononucleotide ufa wambiri ilipo kugulitsidwa m'masitolo ambiri a mankhwala ndi mankhwala kapena ma laboratories. Ngati mukufuna zina pa kafukufuku wanu, mukhoza kupanga ndondomeko yowonjezera, yomwe imabwera ndi mitengo yotsika mtengo ndi zoperekera pazitsamba zotsatsira.

Kupanga malonda a pa NMN pa intaneti kumangopulumutsa nthawi yanu komanso kumapereka nsanja yabwino poyerekeza mitengo yosiyana. Ngati simuli wofufuza, mukhoza kugula Nicotinamide Mononucleotide zowonjezera kuti mugwiritse ntchito. Musanayambe dongosolo, onetsetsani kuti ndi zakudya zamakono.

9. Chidule aasraw

Zikumveka zosamveka kunena kuti NMN imawonjezera nthawi ya moyo wa anthu. Komabe, izi zikutsimikiziridwa. Chifukwa cha imfa pakati pa okalamba ndi chifukwa cha matenda omwe amachititsa zaka zambiri, zomwe zimachitika chifukwa cha ntchito zamagulu osauka.

The Nicotinamide Mononucleotide yotsutsa-kukalamba imangoyamba kuwongolera mafuta opangira mavitamini komanso kuwonjezera mphamvu za maselo. Zimagwira ntchito polepheretsa NAD +, yomwe imayamba kuchepa ngati ifeyo tikukalamba.

Kugwiritsira ntchito mankhwala okalamba, kusungunuka, dzuwa, kapena kuchita masewera olimbitsa thupi pa zakudya zabwino kungangosintha nkhope yanu. Komabe, muyenera kumvetsa chomwe chimayambitsa mavuto okalamba omwe angawachitire. Nicotinamide mononucleotide imasintha ukalamba pokonzanso DNA yowonongeka, kuteteza ubongo, mapulogalamu a mtima, kupangitsa minofu kugwira ntchito, ndi kuwonjezera chipiriro.

Ngati mukufuna nicotinamide mononucleotide ufa wambiri, fufuzani ndi ife ndipo muzisangalala ndi mtengo wabwino.

Zothandizira

  1. Mphero, KF, Yoshino, J., Yoshida, S., et al. (2016). Kulamulira kwa Nthaŵi Zakale za Nicotinamide Mononucleotide Zimasintha Mitengo ya Kusagwirizana Kwambiri M'magulu. Cell Metabolism.
  2. Yoshino, J., Mills, KF, Imai, SI, ndi Yoon, MJ (2011). Nicotinamide Mononucleotide, chofunika kwambiri cha NAD + Chokhazikika, Amachiza Pathophysiology Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chamakono Cell Metabolism.
  3. Yamamoto, T., Byun, J., Zhai P., Ikeda, Y., Oka, S., ndi Sadoshima, J. (2014). Nicotinamide Mononucleotide, Wopakatikati wa NAD + Synthesis, Amateteza Mtima ku Ischemia ndi Reperfusion.
  4. Sinclair, DA, Uddin, GM, Youngson, NA, ndi Morris, MJ (2016). Mutu kupita ku Mutu Kufanizitsa Chithandizo cha Nthawi Yachidule ndi Chotsutsa NAD + Chotsatira Nicotinamide Mononucleotide (NMN) ndi Ma sabata asanu ndi limodzi a Kuchita Zozizira M'magulu Okazi Amuna.
  5. Imai, S., Yoshino, J., Mills, KF, Grozio, A., et al. (2019) Slc12a8 ndi Nicotinamide Mononucleotide Transporter. Chilengedwe cha Metabolism.
  6. De Picciotto, NE, Mills, KF, Imai, S., Gano, LB, et al. (2016). Nicotinamide Mononucleotide Amatsitsimutsa Matenda Osavuta ndi Mavuto Osokoneza Bongo ndi Amphawi Okalamba.
  7. Yao, Z., Gao, Z., Yang, W., ndi Jia, P. (2017). Nicotinamide Mononucleotide Imaletsa JNK Kukonzekera Kuti Muthane ndi Matenda a Alzheimer.
  8. Hou, Y., Wang, Y., Zhang, Y., Lautrup, S., et al. (2018). NAD + Zowonjezeretsa Zomwe Zimapangitsa Makhalidwe Aakulu a Alzheimer ndi DNA Kuwonongeka Mayankho mu New AD Mouse Model ndi Kutulutsidwa DNA Kukonza Kufooka.

Kusiya ndemanga

Shangke Chemical ndi makampani apamwamba kwambiri omwe amagwiritsa ntchito mankhwala omwe amathandiza kwambiri. Pofuna kuyendetsa khalidweli panthawi yopanga, akatswiri ambiri odziwa bwino ntchito, makina oyambirira kupanga zipangizo komanso ma laboratori ndi mfundo zofunika kwambiri.

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