Nicotinamide riboside (NR) ndi nicotinamide riboside (Chloride)

Nicotinamide riboside (NR) mankhwala enaake ndi mtundu wa nicotinamide riboside (NR).

1.Kodi Nicotinamide Riboside (NR) ndi chiyani?

NR ndi mtundu wa vitamini B3 kapena niacin. Mgwirizanowu unapezedwa mzaka za m'ma 1940 ngati chinthu chokulirapo cha H. fuluwenza. Kumayambiriro kwa 21st zaka zana, kafukufuku wambiri atsimikizira kuti NR ndiyotsogola kwa NAD +. M'thupi la munthu, michere iyi imachepetsa cholesterol, imachepetsa chiopsezo cha matenda amtima, imathandizira magwiridwe antchito a ubongo, komanso imachepetsa nyamakazi.

Nicotinamide riboside (NR) ndi pyridine-nucleoside, yotsogola kwa NAD + (Nicotinamide adenine dinucleotide). NAD + imayatsa ntchito zambiri zachilengedwe kuphatikiza kukonza kwa DNA, kupanga mphamvu zamagetsi, kukhazikitsa thupi kwa thupi, ndi zina zambiri. Tsoka ilo, mamolekyu awa mwachilengedwe amatsika ndi senescence.

2.Kodi Nicotinamide Riboside (NR) Chloride ndi chiyani?

Nicotinamide Riboside (NR) mankhwala enaake (NIAGEN) ndi ochokera ku NR ndi chlorine. Kampaniyo imakulitsa milingo ya NAD + ndipo imayambitsa SIRT1 ndi SIRT3. Zimasinthira ukalamba powonjezera kagayidwe kazakudya kamene kamayambitsa matenda komanso kutsutsana ndi zovuta zamagetsi zokhudzana ndi zakudya.

Ku US, nicotinamide riboside mankhwala enaake amadziwika kuti ndi otetezeka. Chifukwa chake, ndichakudya chovomerezeka chogwiritsa ntchito mapuloteni kugwedezeka, madzi a vitamini, nkhama, ndi zina zotero zowonjezera.

3.Kutsiliza

Anthu akhala akulimbana ndi ukalamba poyang'ana khungu. Nthawi ina, muyenera kuti mwakumana ndi ena odana ndi ukalamba mafuta onunkhira nkhope makwinya, khungu lomwe likuthwanima komanso kufooka. Komabe, mankhwalawa ndi osasintha komanso osakhalitsa. Njira yotsimikizika yakukalamba mwabwino ndikukhazikitsa kusintha kwachilengedwe kumbuyo kwa senescence ndikuthana ndi zomwe zimayambitsa.

Ofufuzawo apeza kulumikizana pakati pamankhwala otsika a NAD + ndi matenda okhudzana ndi ukalamba. Kupeza kwakukulu kumeneku kwakhala kovuta pa keke pachipatala powonjezera mwayi wosintha ukalamba. Pachifukwa ichi, nicotinamide riboside mankhwala enaake ufa yakhala ikuyenda m'mayendedwe azachipatala azachipatala chifukwa chothandiza kuthana ndi nthawi.

The Chemical mfundo ya Nicotinamide Riboside (mankhwala enaake) ufa

Name mankhwala Nicotinamide riboside mankhwala enaake (NR-CL) (23111-00-4)
Mankhwala Name NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; Cotoride ya nitotinamide; 3-Carbamoyl-1- (β-D-ribofuranosyl) mankhwala a pyridinium chloride; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; Nicotinamide BD Riboside Chloride (WX900111); NR-CL;
Nambala ya CAS 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
MUZIKONDWERETSA C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
Molecular Formula C11H15ClN2O5
Kulemera kwa maselo 290.7002
Misa ya Monoisotopic 290.066949 g / mol
Melting Point N / A
mtundu woyera
Kusunga temp -20 ° C Freezer
ntchito zakudya zowonjezera zakudya, gawo la mankhwala

Nicotinamide riboside mankhwala enaake

Kudziwa Ubwino wa Nicotinamide riboside (NR), Kodi Ubwino wa Nicotinamide Riboside Chloride ndi uti?

Ubwino wa nicotinamide riboside chloride vs nicotinamide riboside ndi ofanana chifukwa onse amagwira ntchito kuti apange ma protein a NAD ndi sirtuin 1.

Metabolism Yathanzi Yothetsera Kunenepa Kwambiri

Kafukufuku wambiri watsimikizira kufunika kwa nicotinamide riboside chloride pochepetsa kunenepa. Ogwiritsa ntchito atha kutaya mpaka 10% yamafuta amthupi lawo osaponderezedwa kapena kulimbitsa thupi.

Kumwa mankhwala kumathandiza kutsitsa cholesterol cha LDL kwinaku ukukweza mafuta m'thupi. Izi zimachitika zikalepheretsa michere yomwe imayambitsa kusakanikirana kwa ma triglycerides. Zotsatira zake, kupanga ma lipoprotein otsika kwambiri kumachepetsa.

Nicotinamide riboside chloride amapindulitsa odwala onenepa kwambiri omwe ali ndi matenda ashuga. Chowonjezeracho chimalimbitsa kagayidwe kake powongolera kusalolera kwa shuga

neuroprotection

Magulu a NAD akagwa pansi, mitsempha yanu komanso thanzi lanu lazidziwitso zitha kukhala pachiwopsezo. Tengani, mwachitsanzo, odwala omwe ali ndi matenda a Alzheimer's amawonetsa kuchepa kwa NAD + ndi kutayika kwa mitochondria.

Pakati pazogwiritsa ntchito mankhwala a nicotinamide riboside chloride, kasamalidwe kabwino ka minyewa yaukalamba pamwamba pamndandanda. Mankhwalawa amalephera kuwonongeka kwa ubongo, kupwetekedwa kwa mitsempha, kutupa kwa mitsempha, ndi kufa kwa mitsempha.

Zowonjezera Kukalamba

Chimodzi mwazinthu zofunikira kwambiri za Nicotinamide riboside chloride chimaphatikizapo kulimbikitsa athanzi kukalamba. Kampaniyi imabweretsa kuwonjezeka kwa kupanga kwa NAD, komwe kumachita gawo lalikulu m'chipindacho. Mwachitsanzo, imakweza mphamvu zamagulu mkati mwa minofu, chiwindi, ndi impso. Kuphatikiza apo, Nicotinamide riboside chloride imalepheretsa senescence powonjezera kufalikira kwa magazi m'magulu ofunikirawa.

Kukonza DNA

Nicotinamide riboside chloride imapindulitsa kapangidwe kake mwa kukonza DNA yakale komanso yowonongeka. Ngati kuchuluka kwa NAD kugwa, deoxyribonucleic acid yovulala imatha kuyambitsa mitundu yama oxygen, yomwe imayambitsa kupsinjika kwa oxidative, komanso kutenga khansa.

Nicotinamide riboside mankhwala enaake

Kodi Mungatani Kuti Nicotinamide Riboside Chloride Asinthe Ukalamba?

Pakukalamba, thupi limakumana ndikusintha kwakuthupi momwe ma cell amagwirira ntchito amabwerera mmbuyo. Mwachitsanzo, thupi limataya mapuloteni a NAD + ndi SIRT1 kuposa momwe angapangire. Kuchepetsa kwa ma coenzymes kumathandizira kufooka kwa magazi pomwe kumayambitsa zovuta zokhudzana ndi ukalamba monga matenda ashuga, matenda amtima, ndi kunenepa kwambiri.

Kutumiza nicotinamide riboside chloride amapindulitsa chitetezo chamthupi polimbikitsa mitsempha yamagazi, monga ma lymphocyte ndi leucocytes. Mgwirizanowu umagwiritsanso ntchito kaphatikizidwe ka NAD +, chifukwa chake, ikukweza milingo ya mapuloteni a SIRT1. Zotsatira zake, SIRT1 imachedwetsa ukalamba wam'mimba powonjezera magazi kupita ku mafupa, mafupa amtima, ndi minyewa yamitsempha.

Kuphatikiza apo, nicotinamide riboside chloride supplement amasintha ukalamba popanga ma NAD + ambiri othandizira kukonza ma DNA mkati mwa ma cell. Izi zimalepheretsa kupsyinjika kwa okosijeni

Kafukufuku amene alipo akutsimikiziranso kuti nicotinamide riboside chloride yowerengera kuchepa kwa mafupa, kuchepa kwa misozi, ndi fundus hypopigmentation. Zinthu zonsezi zili ponseponse pakati pa okalamba.

Otsatira a NAD⁺: Nicotinamide Riboside Chloride vs Nicotinamide Mononucleotide

Pali zowonjezera zisanu za NAD + koma pakadali pano, titha kusintha chidwi chathu kukhala nicotinamide riboside chloride vs nicotinamide mononucleotide (NMN).

Zipangizo ziwirizi zimakulitsa milingo ya NAD + mthupi kuti ipangitse magwiridwe antchito am'manja ndikuchepetsa kuchepa kwa mphamvu.

Chomwe chimasiyanitsa awiriwa ndikuti NMN si mtundu wa vitamini B3. Mankhwalawa samalowerera mu selo mpaka atasandulika kukhala nicotinamide riboside. Cholinga chake ndikuti kukula kwake kwa ma molekyulu ndikokulirapo kuposa nikotinamide riboside chloride powder. Chifukwa cha malowa, kupezeka kwa NMN ndikuyembekeza kuyambitsa milingo ya NAD + kwakhala fupa lokangana m'malo ofufuzira.

Malingana ndi Dr. Sinclair, katswiri wa zamoyo ku yunivesite ya Harvard, momwe ntchito ya NMN ilili silingafanane. Amavomereza kugwiritsa ntchito izi kuwonjezera. Sinclair ikufanana ndi mphamvu ya NMN kuyendetsa makina opondera. Wasayansiyo adati imathandizira kuyendetsa bwino magazi, imalimbikitsa kupilira kwa minofu, komanso kagayidwe kabwino ka kagayidwe.

Mofananamo, Nicotinamide riboside chloride imagwidwa mwachindunji ndi selo. Molekyu ndi njira ina ya vitamini B3. Ikulitsa milingo ya NAD + kupitilira 60% m'thupi la munthu. Mosiyana ndi ambiri Otsatira a NAD, zomwe zili pamndandanda wamawonekedwe a FDA, nicotinamide riboside (NR) chloride ili m'gulu lovomerezeka la zakudya za GRAS (Zomwe Zimadziwika Kuti Zotetezeka).

Bwanji osatenga ufa wa NAD mwachindunji? Nicotinamide Riboside Chloride vs Nicotinamide Adenine Dinucleotide (NAD)

Popeza cholinga chathu ndikukweza NAD mthupi, mwina mukufunsa chifukwa chake mumakangana pa nicotinamide riboside chloride. Simukuyenera kuyang'anira NAD molunjika m'dongosolo lanu m'malo mopyola pamavuto ogwiritsa ntchito apakatikati monga NIAGEN, NR, kapena NMN? Ndiloleni ndikufotokozereni mwachidule za nicotinamide riboside chloride vs nicotinamide adenine dinucleotide.

Chifukwa chachikulu chomwe simuyenera kutenga NAD mwachindunji ndikuti biomarker siyingagwire selo.

Kuphatikiza kwa kugwiritsa ntchito nicotinamide riboside chloride vs nicotinamide adenine dinucleotide ndikuti choyambacho chimatha kulowa mu nembanemba ya plasmic. Kuchuluka kwake kwa mayikidwe ake kumakhala kwakukulu kwambiri kudzera m'thupi, mpaka m'magazi, ndipo pamapeto pake kupita kuubongo.

Nicotinamide riboside mankhwala enaake

Nicotinamide riboside (NR) Mlingo wa Chloride: Momwe Mungagwiritsire Ntchito?

Mu 2016, chowonjezera cha nicotinamide riboside chloride chidapambana mwayi wa GRAS. Chaka chimodzi m'mbuyomo, a FDA adavomereza kuti ndi gwero la niacin komanso chopangira zakudya tsiku lililonse la 180mg.

Pakadali pano, mulingo wokwanira wa nicotinamide riboside chloride mlingo wofika 300mg patsiku. Komabe, m'mayesero ena aumunthu, omverawo amatha kumwa mpaka 2000mg ya mankhwalawa. Muyenera kuzindikira kuti kupitirira 500mg kumatha kubweretsa zotsatira zoyipa za nicotinamide riboside.

Mlingo wa niacin umangogwira ntchito pa athanzi Akuluakulu, kuphatikiza amayi oyembekezera ndi amayi oyamwa.

Zotsatira za Nicotinamide Riboside Chloride: Kodi Ndizotetezeka Kugwiritsa Ntchito Chowonjezera cha Nicotinamide Riboside Chloride?

Nicotinamide riboside chloride powder ndiotetezeka ndipo imakhala ndi gawo lokhumbidwa kwambiri la zinthu za GRAS. Izi sizitanthauza kuti kampaniyo ilibe zisonyezo zoyipa. Kupatula apo, madzi ndi moyo komanso amakoka zovuta zina mukawazunza. Pofuna kuthana ndi zotsatirapo, onetsetsani kuti mlingo wanu wa Nicotinamide riboside chloride ndiwotsika kwambiri.

Zina mwazovuta zomwe zimachitika ndi monga;

  • Mimba imakhumudwitsidwa
  • nseru
  • kusanza
  • kutsekula
  • Khungu zimachitikira monga zidzolo ndi kuchulukitsa kuvulala

Kuphatikiza pa zomwe zili pamwambapa za nicotinamide riboside chloride zoyipa, muyeneranso kukumana nazo kuwonda. Komabe, zotsatirazi ndi dalitso pobisalira makamaka ngati muli onenepa kwambiri, kunenepa kwambiri, kapena mukuyesera kuchepetsa kulemera kwanu.

Kodi Mungagule Kuti (NR) Nicotinamide Riboside Chloride mu Bulk?

Mutha kupanga nicotinamide riboside chloride kugula pa sitolo yapaintaneti. Kaya mukufuna ufa wamagulu ambiri kapena owonjezera owerengera chakudya, onetsetsani kuti mukuyang'ana omwe akupatsirani zowona. Kuphatikiza kwakanthawi kogula ndikuti mutha kufananiza mitengo ndikuwona mayankho enieni a makasitomala. Komabe, mukuyeneranso kugwera zachinyengo.

Ndife mtundu wodalirika ndipo zogulitsa zathu zonse zimatsata njira zowongolera zabwino. Timagwiritsa ntchito mankhwala osiyanasiyana ndipo zowonjezera zakudya. Tiuzeni ife za oda yanu ndi ogwidwawo wochezeka.

Zothandizira
    1. Conze, D., Brenner, C., & Kruger, CL (2019). Chitetezo ndi kagayidwe kabwino ka kayendetsedwe ka nthawi yayitali ya NIAGEN (Nicotinamide Riboside Chloride) mu Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Healthy Onenepa Akuluakulu. Scientific Reports.
    2. Bogan, KL & Brenner, C. (2008). Nicotinic Acid, Nicotinamide, ndi Nicotinamide Riboside: Kuunika Kwakukulu kwa Mavitamini a NAD + omwe amatsogolera mavitamini mu Nutrition ya Anthu. Kukambirana Kwapachaka pa Zakudya Zabwino.
    3. Mehmel, M., Jovanovic, N., & Spitz, U. (2020). Nicotinamide Riboside - The Current State of Research and Therapeutic Usees.
    4. Turck, D., Castenimiller, J., ndi al. (2019). Chitetezo cha Nicotinamide Riboside Chloride ngati Novel Food Potsatira Malamulo (EU) 2015/2283 ndi Bioavailability ya Nicotinamide kuchokera ku Gwero ili, mu Context of Directive 2002/46 / EC. Zolemba za EFSA.
    5. Elhassan, YS ndi al. (2019). Nicotinamide Riboside Imawonjezera Ukalamba Wamunthu Wamisala NAD + Metabolome ndipo Imapangitsa Zisindikizo za Transcriptomic ndi Anti-Inflammatory. Malipoti a Cell.
    6. Aman, Y., Qiu, Y., Tao, J., & Fang, EF (2018). Othandizira Othandizira Kulimbikitsa NAD + mu Ukalamba ndi Matenda Okhudzana ndi Ukalamba. Mankhwala Otanthauzira Okalamba.
    7. RAW NICOTINAMIDE MONONUCLEOTIDE (NMN) PODA (1094-61-7)
    8. Yaiwisi LORCASERIN HCL ufa (846589-98-8)

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