Kuwunikira kwa PRL-8-53

Hype ya PRL-8-53 monga mankhwala osokoneza bongo omwe amapezeka koyambirira kwa ma 1970. Nikolaus Hansl, pulofesa ku yunivesite ya Creighton, mwachidziwikire adapeza nootropic pomwe akugwira aminoethyl meta benzoic acid esters.

Chiyambireni, chowonjezera ichi chakhala chikuchitika kafukufuku wamankhwala amodzi ndikuyesedwa kwamunthu. Kafukufuku wamankhwala anali umboni wotsimikizika kuti PRL-8-53 pophunzira imathandizira kukumbukira kwakanthawi kochepa komanso kusalankhula bwino. 

PRL-8-53 sinalandire kuvomerezedwa kwa FDA, koma ndizowonjezera zomwe sizikukonzedwa ku US. Mutha kupanga PRL-8-53 kugula ngati mankhwala osokoneza bongo.

 

Kodi PRL-8-53 ndi chiyani?

PRL-8-53 ndichokera ku benzoic acid ndi benzylamine. Mwasayansi, amadziwika kuti 3- (2- (benzyl (methyl) amino) ethyl) benzoate.

Kuyambira kumapeto kwa ma 1970, PRL-8-53 yakhala mkwiyo wonse ngati mankhwala osokoneza bongo opititsa patsogolo ubongo. Osachepera, pali kuyesa kwamunthu kopambana komwe kumatsimikizira kuyendetsa bwino kwake. Kuphatikiza apo, kuwunika kwa PRL-8-53 pa Reddit kumathandizira kuthandizira kowonjezera uku pakuthandizira kukumbukira ndi kuphunzira.

Pulofesa Hansl poyambirira adazindikira izi PRL-8-53 nootropic kumapangitsa kukumbukira kwakanthawi kochepa komanso kukumbukira mawu. Komabe, mankhwalawa amathandizanso kukhumudwa, kupsinjika, kuda nkhawa, komanso kutopa.

 

PRL-8-53 limagwirira kanthu

Chifukwa cha kafukufuku wosakwanira pa PRL-8-53, magwiridwe antchito ake enieni ndichinsinsi. Komabe, asayansi akuganiza kuti mankhwalawa amalimbikitsa ubongo kugwira ntchito m'njira zitatu.

PRL-8-53 nootropic imayendetsa kutulutsa kwa acetylcholine, yomwe ndi neurotransmitter yayikulu, yomwe imagwira ntchito kukumbukira ndi kuphunzira.

Mankhwala osokoneza bongo amagwiranso ntchito pamakina a dopaminergic posintha milingo yathanzi ya dopamine. Zowonjezera, kutenga Kukhumudwa kwa PRL-8-53 Mankhwala amalepheretsa kuchuluka kwa serotonin. Izi zimapangitsa kuti mukhale ndi nkhawa kuti muchepetse nkhawa, kusinthasintha kwamaganizidwe, komanso kugona tulo. 

 

Ubwino wa PRL-8-53

Kuchulukitsa Kutha KuphunziraPRL-8-53

PRL-8-53 ufa umatsimikizira kupititsa patsogolo kuzindikira ndi kutha kuphunzira. Zowonjezera zimayambitsa kukumbukira zambiri, mawu, ndi malingaliro osiyanasiyana. Chifukwa chake, yakhala mankhwala osokoneza bongo pakati pa ophunzira omwe akufuna kupyola mayeso ovuta.

PRL-8-53 yowerengera ingathandizenso kuyang'ana kwambiri, makamaka poyesera kumvetsetsa mfundo zatsopano. Akatswiri ena amisala amati kutenga mankhwala anzeruwa kumakusungani munjira, ndipo sizingakuvuteni polongosola zatsopano. Mapindu awa a PRL-8-53 atha kukhala mbandakucha watsopano wa anthu olimba mtima omwe akufuna mayeso ena ovuta a fizikiya kapena mayeso apakamwa.

 

Kupititsa patsogolo Chikumbutso

Chimodzi mwazinthu zazikulu za PRL-8-53 zimaphatikizapo kukulitsa kukumbukira. Nootropic imayambitsa acetylcholine ndi dopaminergic system, zomwe ndizofunikira pakuzindikira.

Pakuyesa kwamankhwala komwe kumakhudza maphunziro 47 azaumoyo, pulofesa Hansl adazindikira kuti omwe adatenga PRL-8-53 adachita bwino pamayeso okumbukira kuposa omwe adakhala pa placebo. Kuphatikiza apo, kukumbukira uku kumatha pafupifupi sabata.

Asanayesere maphunziro aumunthu, Hansl anali atazindikira kuti PRL-8-53 imathandizira kukumbukira zomwe makoswe amakumbukira. Zowonjezerazi zimapangitsa mtundu wa murine kukumbukira ndikugwirizanitsa yankho pazovuta. 

 

Bwino Chilimbikitso ndi Kuchepetsa KutopaPRL-8-53

PRL-8-53 kukhumudwa kwa mankhwala osokoneza bongo kumawonetsera zida za dopaminergic. Pawiriyo imakulitsa zochitika za dopamine, mankhwala amubongo omwe amakhudza chidwi, kukulitsa malingaliro, ndikuchepetsa kutopa. Chifukwa chake, imalimbikitsa thanzi lamaganizidwe, kuthekera kothana ndi zovuta zamaganizidwe monga ADHD ndi schizophrenia.

Ngakhale zabwino za PRL-8-53, simuyenera kugwiritsa ntchito nootropic ngati gawo la mankhwala anu. Izi sizimapangidwira kuchiza kapena kuchiza matenda.

 

Momwe mungatengere PRL-8-53?

Zomwezo Mlingo wa PRL-8-53 pafupifupi 5mg patsiku, amatengedwa ngati chowonjezera pakamwa. Ngakhale pali kafukufuku wochepa wokhazikitsa mlingo woyenera kwambiri, kuyesa koyambirira kwa anthu kunagwiritsa ntchito 5mg. Kuwonetsa zina mwa ndemanga za PRL-8-53 kumatsimikizira kuti ogwiritsa ntchito ena mwakhama amatenga 10mg mpaka 20mg ya chowonjezera.

Ngati mukupereka chowonjezera kuti chikumbukire kwakanthawi kochepa, monga mukamayesa mayeso, onetsetsani kuti mukugwiritsa ntchito maola awiri musanachite masewera olimbitsa thupi.

PRL-8-53 nootropic imapezeka mu ufa, mapiritsi, ndi mawonekedwe amadzimadzi. Mutha kusankha kumeza piritsi kapena kuwonjezera pakumwa kwanu; zilizonse zomwe zili zoyenera kwa inu. Ngakhale mutha kusankha kuyang'anira zinenero zing'onozing'ono, njirayi ikhoza kusokoneza lilime lanu. Ogwiritsa ntchito ambiri angasankhe kutenga PRL-8-53 pakamwa.

 

Katundu wa PRL-8-53

Pakadali pano, palibe malingaliro oyenera a PRL-8-53. Kulumikizana kotheka kwa chigawo ichi ndi mankhwala ena osokoneza bongo sikudziwika. Kuphatikiza apo, PRL-8-53 ili ndi potency yayikulu, chifukwa chake, sikofunikira kuyiphatikiza ndi ma nootropics ena olimbikitsa kukumbukira. 

Sitikulangiza kapena kulimbikitsa aliyense Katundu wa PRL-8-53. Osachepera, zingakhale bwino ngati simungayerekeze ndi mankhwala anzeru omwe amakhala ndi zovuta zofananira. Ngakhale panali chenjezo lamphamvuli, ogwiritsa ntchito ena m'magulu azamisala amavomereza kuti kusungunula ufa wa PRL-8-53 ndi Alpha-GPC, piracetam, IDRA-21, ndi theanine kumawapatsa mwayi wothandizirapo kwambiri.

 

Kodi pali zovuta zina za PRL-8-53?

Pakadali pano, palibe zotsatirapo za PRL-8-53. Zida zokhazokha zomwe zidapezeka zidachokera ku 1970s panthawi yazachipatala komanso zoyeserera zamankhwala a nootropic. Phunziro laumunthu, ophunzirawo sanasonyeze zizindikiritso zoyipa pamlingo wa 5mg patsiku.

Ngakhale kulibe zovuta zamankhwala PRL-8-53 zoyipa zomwe zalembedwa, onetsetsani kuti mulibe mankhwala ochepa. Malinga ndi kafukufuku wamakoswe, kuchuluka kwa zowonjezera izi kumawononga mayendedwe.

PRL-8-53

Zokumana Nazo

Pali zochitika zambiri zogwiritsa ntchito pa sitolo ya Reddit ndi Amazon zokhudzana ndi zotsatira za Kuda nkhawa kwa PRL-8-53 nootropic.

Onani zina mwa ndemanga za PRL-8-53;

 

Kuphunzira ndi Kukumbukira kuwongolera

Chrico031 akuti;

"Ndimagwiritsa ntchito PRL-8-53 kwambiri ndikakhala ndi nkhani zoloweza pamtima. Zimathandiza kwambiri kudziwa kuti ndimaloweza msanga zinthuzo. ”

Inmy325xi akuti;

"Ndazindikira kuti kulankhulalankhula ndikulankhula ndi PRL. Bukuli limandithandiza kwambiri pophunzira ndi caffeine. ”

 

Mlingo wa PRL-8-53

Baliflipper akuti;

“Ndinayamba ndi mankhwala ochepa ndipo ndinkayesetsa kwambiri. Ndikumvadi kuti 10mg ndiyabwino kwambiri tsiku lililonse ... Komabe, ndidaganiza zoyesa 20mg Lachisanu kuti ndiyesere mayeso a Neuroscience ndipo ndidadabwitsidwa ndikuthandizira kukumbukira ... Ndidawona kuti kuchuluka kwake kwakukulu kudathandiziranso kukumbukira ndipo kunathandiza kwambiri pakuyesa . ” 

 

PRL-8-53 okwana

Lifehole akuti;

"Ndimamwa m'mawa ndikadzuka (11am) ndi Noopept, L-theanine, bupropion, vortioxetine, ndi tianeptine ... Ndizosatheka kuzindikira zomwe zikuchita ndi mankhwala ochuluka chonchi malinga ndi zikondwerero za zomwenso…"

Chrico031 akuti;

"Pano ndikuchita IDRA-21 ndi PRL-8-53 tsiku lililonse. Ndikusangalala ndi makondomu, ndipo zimapangitsa kuti kuloweza ndi kumvetsa mfundo zatsopano kuzikhala kosavuta. ”

 

Kulawa kwa PRL-8-53

Baliflipper akuti;

"Monga zilankhulo zina zambiri, imakoma kwambiri. Komabe, sikuti ndi yoyipa ngati Noopept… ikuthandizanso kuti lilime lako liziziririka nthawi yoyamba… Ubwino wake umaposadi kukoma. ”

 

PRL-8-53 Zotsatira zoyipa

Omniavocado akuti;

"Ndidakumbukiranso pang'ono pambuyo poti zotsatira zake zidafooka ngakhale pang'ono. Nditamwa mankhwala omalizira, ndinali ndi vuto losaneneka, losakhala bwino kwenikweni. ”

Wosadziwika dzina akuti;

"Nditamwa mankhwala opitirira 30mg pakamwa komanso 15mg pang'ono, ndimadwala mutu ndipo zimandidabwitsa chifukwa cha masomphenya anga."

 

Kutsiliza

PRL-8-53 ufa ndi nootropic yodalirika yomwe imakhalabe yosadziwika mu sayansi. Umboni wokhawo wowoneka bwino wa magwiridwe ake ndichaka makumi asanu. Komabe, okonda ma neurohackers amakhala banki ngati cholimbikitsira chokumbukira chokhala ndi zovuta zochepa za PRL-8-53.

Zowonjezerazo ndizabwino kukumbukira kwakanthawi kochepa. Zomwe adapeza kuchokera kwa ogwiritsa ntchito odziwa zambiri komanso kafukufuku yemwe akupezeka amafufuza Kuda nkhawa kwa PRL-8-53 Mankhwalawa amakumbutsa kukumbukira mpaka 200%.

Kuyanjana kwa nootropic iyi ndi mankhwala ena akadali chinsinsi. Chifukwa chake, chitetezo chake ndi kulolerana sikudziwika. Chifukwa chake, kuyesa PRL-8-53 stack sikungakhalenso njira ina. Funsani dokotala musanatenge PRL-8-53 limodzi ndi mankhwala ena akuchipatala.

Mutha kupanga PRL-8-53 kugula mu ufa kapena mawonekedwe apiritsi ngati supplementary nootropic.

 

Zothandizira
  1. Hansl, NR, & Mead, BT (1978). PRL-8-53: Kupititsa patsogolo kuphunzira ndikusungidwa mwa anthu chifukwa chakuchepa kwamkamwa kwa wothandizila watsopano wa psychotropic. Psychopharmacology (Berl).
  2. Hansl, NR (1974). Wolemba spasmolytic ndi CNS wothandizila: 3- (2-benzylmethylamino ethyl) benzoic acid methyl ester hydrochloride.
  3. McGaugh, JL, & Petrinovich, LF (1965). Zotsatira za mankhwala osokoneza bongo pakuphunzira ndi kukumbukira. Ndemanga yapadziko lonse lapansi ya Neurobiology.
  4. Kornetsky, C., Williams, JE, & Mbalame, M. (1990). Zosangalatsa komanso zolimbikitsa za mankhwala osokoneza bongo. NIDA Kafukufuku.
  5. Giurgea, C. (1972). Pharmacology yothandizira kuphatikiza kwa ubongo. Kuyesera lingaliro la nootropic mu psychopharmacology. Zoona Pharmacol (Paris).
  6. Hindmarch, I. (1980). Psychomotor ntchito ndi mankhwala osokoneza bongo. Briteni Journal of Clinical Pharmacology.
  7. Yaiwisi PRL-8-53 ufa (51352-87-5)

 

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