α-ketoglutaric

Phcoker ali ndi kuthekera kochulukitsa ndikupereka Calcium 2-oxoglutarate ndi Alpha-Ketoglutaric Acid pansi pa cGMP.

Ndi mayina ena ati omwe al-ketgoglutaric acide amadziwika nawo?

A-cétoglutarate, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alfa-Cétoglutarate, Alfa-Cétoglutarate d'Arginine Defaine, Alfa-Dongolonga, , Alpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Keto Glutaric Acid, Alpha Ketoglutarate, Alfa Ketoglutaric Acid, Alfa KG, Alfa KG, Alfa KG, Alpha KG, Alfa KG, Al-KG, Al KG, Al KG, Alpha KG -Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate, 2-Oxoganodic Acid.

Kodi Alpha-Ketoglutaric acid ndi chiyani?

Alpha-ketoglutaric (AKG) ndi organic acid yomwe ndiyofunika pakupanga kagayidwe koyenera kwama amino acid onse komanso kusamutsa mphamvu yamagetsi mumtsinje wa citric acid. Ndichotsogola cha glutamic acid, amino acid wosafunikira womwe umakhudzidwa ndi kaphatikizidwe ka mapuloteni komanso kuwongolera magazi m'magazi. Kuphatikiza ndi L-glutamate, AKG imatha kuchepetsa kuchuluka kwa ammonia wopangidwa muubongo, minofu ndi impso, komanso kuthandizira kuchepetsa thupi la nayitrogeni wamthupi ndikupewa kuchuluka kwa nayitrogeni m'matumba ndi madzi. Anthu omwe amadya kwambiri mapuloteni, matenda a bakiteriya, kapena m'mimba m'mimba dysbiosis atha kupindula ndi zowonjezera za AKG kuti zithandizire kuchuluka kwa ammonia komanso kuteteza minofu.

Anthu ena amatenga alpha-ketoglutarate kuti apititse patsogolo masewera othamanga. Omwe amapereka masewera othamanga amadzinenera kuti alpha-ketoglutaric acid atha kukhala chinthu chofunikira kuwonjezera pa chakudya choyenera komanso maphunziro kwa othamanga omwe akufuna kuchita bwino kwambiri. Amayambitsa izi pamaphunziro omwe amawonetsa kuti ammonia wowonjezera m'thupi amatha kuphatikiza ndi alpha-ketoglutarate kuti muchepetse mavuto omwe amapezeka ndi ammonia wambiri (ammonia toxicity). Koma, pakadali pano, maphunziro okhawo omwe akuwonetsa alpha-ketoglutarate angachepetse poizoni wa ammonia omwe adachitika mwa odwala a hemodialysis.

Opereka chithandizo chamankhwala nthawi zina amapereka alpha-ketoglutarate kudzera m'mitsempha (ya IV) popewa kuvulala kwa mtima komwe kumachitika chifukwa chamavuto am'magazi panthawi yochitidwa opaleshoni yamtima komanso kupewa kuwonongeka kwa minofu mutachitidwa opaleshoni kapena kukhumudwa.

Njira zogwirira ntchito za Alpha-Ketoglutaric acid

Njira zenizeni zogwirira ntchito za α-Ketoglutarate sizinafotokozeredwe. Zina mwa zochita za α-Ketoglutarate zimaphatikizapo kuchita kayendedwe ka Krebs monga wapakatikati, kusintha kwa kusintha kwa kagayidwe kake ka amino acid, kupanga glutamic acid pophatikiza ndi ammonia, ndikuchepetsa nayitrogeni pophatikizanso. Ponena za zochita za α-Ketoglutarate ndi ammonia, akuti α-Ketoglutarate itha kuthandiza odwala omwe ali ndi propionic academia omwe ali ndi ammonia komanso kuchuluka kwa glutamine / glutamate m'magazi awo. Chifukwa chakuti glutamate / glutamine yokhazikika imapangidwa kuchokera ku α-Ketoglutarate, odwala a propionic acidemia ali ndi vuto lopanga α-Ketoglutarate ndikuwonjezera kwa α-Ketoglutarate iyenera kukonza zikhalidwe za odwalawa. Kafukufuku wina wambiri awonetsanso kuti kuyang'anira α-Ketoglutarate mu zakudya za makolo zomwe zimaperekedwa kwa odwala pambuyo pa opereshoni zathandizira kuchepetsa kuchepa kwamapuloteni am'mimba omwe nthawi zambiri amawoneka atachitidwa opaleshoni. Kuchepetsa kuchepa kwa minyewa kumanenedwa kuti kumachitika chifukwa chotsika kwambiri kwa α-Ketoglutarate.

Alpha ketoglutaric acid (AKG) supplement - Kodi maubwino a Alpha ketoglutaric acid ndi ati?

Alpha-Ketoglutarate (AKG) ngati Athletic Performance Supplement
Alpha ketoglutaric acid, kapena Alpha-ketoglutarate ndi mankhwala a mitochondria ndipo imathandiza kwambiri pakusandutsa chakudya kukhala mphamvu. Komanso ndi gwero la glutamine ndi glutamate. Mu minofu, glutamine ndi glutamate zimalepheretsa kuwonongeka kwa mapuloteni ndikuwonjezera mapuloteni.

Alpha-ketoglutarate imathandizira kupanga mafupa. Imayang'anira kaphatikizidwe ka kolajeni mwina powonjezera kuchuluka kwa mamolekyulu omwe amapezeka kuti asakanikirane. Collagen ndi gawo lalikulu la mafupa.

Alpha-ketoglutarate imathandizira kupanga insulin ngati kukula-1 ndi kukula kwa hormone. Awa onse ndi mahomoni omwe amawongolera kukonzanso kwa mafupa ndikupanga minofu yatsopano.

alpha ketoglutaric acid amapindulitsa ukalamba
Kafukufuku akuwonetsa kuti AKG imatha kuthana ndi zovuta zingapo ikatengedwa monga momwe yauzira.

Komabe, pali zisonyezero zina zomwe Alpha-Ketoglutarate (AKG) itha kuthandiza pazinthu zotsutsana ndi ukalamba.

Kafukufuku wina wamkulu wopangidwa ku Buck Institute for Research on Aging limodzi ndi Ponce de Leon Health adapeza thanzi labwino kuposa 60% pamaphunziro awo a mammalian.

α-ketoglutaric
AKG imakulitsa moyo wa munthu wamkulu wa C. elegans. (A) AKG imakulitsa kutalika kwa nyongolotsi zazikulu. (B) Mlingo woyankha wa mlingo wa AKG pakukhalitsa.
Kuphatikiza apo, a Ponce De Lon Health (PDL) adatulutsa lipoti loyeserera, lipotilo likuwonetsa kuti patadutsa theka la chaka, zaka zakulimbikira kwa nkhanizo zidachepa pafupifupi zaka 8.5 atatenga alpha-ketoglutarate (AKG) yomwe ili mkampani.

Mankhwala ena, monga mankhwala ochepetsa ukalamba rapamycin ndi metformin yothandizira matenda ashuga, awonetsanso zomwezo poyesa mbewa. Koma AKG mwachilengedwe imapangidwa ndi mbewa komanso matupi athu, ndipo zimawerengedwa kuti ndi zotheka kudyedwa ndi owongolera.

Zinthu zomwe tifunikira kuzisamalira ndikuti alpha ketoglutaric acid ndiwosavuta kwambiri komanso wosavuta kudya. Zowonjezera zolimbitsa thupi pamsika zimawonjezedwa ndi arginine-α-ketoglutarate (AAKG), gawo lalikulu la arginine, pomwe Ponce De Lon Health imagwiritsa ntchito calcium α-ketoglutarate calcium.

Alpha-ketoglutarate imakhalanso ndi mphamvu zolimbitsa thupi
AKG imatchedwanso kuti michere yothandizira mthupi ndipo imagwira ntchito yofunika kwambiri m'thupi. Zimadziwika kale kuti AKG ndi gwero lofunikira la glutamine ndi glutamate, limatchedwa glutamine homologue komanso yotengera. Thupi, limasandulika kukhala glutamine. Glutamine imatha kukulitsa magulu oyera am'magazi (macrophages ndi neutrophils) .AKG monga glutamine homologue imakhala ndi mphamvu zoteteza thupi, imatha kusunga zotchingira m'matumbo, imawonjezera ma cell amthupi komanso ntchito ya neutrophils ndi phagocytosis, amachepetsa kusintha kwa bakiteriya mu vivo.

Tsamba:

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  3. Blomqvist BI, Hammarqvist F, von der Decken A, Wernerman J. Glutamine ndi alpha-ketoglutarate amalepheretsa kuchepa kwa mitsempha ya glutamine yopanda minofu ndikukhala ndi mapuloteni pambuyo poti chiuno chatha. Metabolism 1995; 44: 1215-22.
  4. Hammarqvist F, Wernerman J, von der Decken A, Vinnars E. Alpha-ketoglutarate amateteza kaphatikizidwe ka protein komanso glutamine yaulere m'mitsempha yamafupa pambuyo pochitidwa opaleshoni. Opaleshoni. 1991; 109: 28-36.
  5. Zhang W, Qu J, Liu GH, ndi al. Epigenome yokalamba komanso kukonzanso kwake [J]. Zowunikira Zachilengedwe Biology Yama cell, 2020, 21 (3).
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  7. Alpha-Ketoglutarate, Metabolite Yokhazikika, Amakulitsa Moyo Wonse ndipo Amapanikizika ndi Matenda Okalamba. Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ.