Urolithin ufa

Phcoker imatha kupanga ndikupanga urolithin a, urolithin b ndi Urolithin A 8-Methyl Ether pansi pa cGMP.

Kodi Urolithin A ndi chiyani?

Urolithin A ndi mankhwala a metabolite omwe amabwera chifukwa cha kusintha kwa ellagitannins ndimatenda am'mimba. Zili m'gulu la mankhwala omwe amadziwika kuti benzo-coumarins kapena dibenzo-α-pyrones. Urolithin A yawonetsedwa kuti imalimbikitsa mitophagy ndikusintha thanzi la nyama mu nyama zakale komanso zitsanzo za ukalamba. Pakadali pano, awonetsanso kuti adutsa chotchinga chaubongo wamagazi, ndipo atha kukhala ndi zoteteza ku matenda a Alzheimer's.

Urolithin A ufa ndi mankhwala achilengedwe omwe ali ndi antiproliferative komanso antioxidant. Urolithin A imapangidwa ndimetabolism kuchokera ku polyphenols omwe amapezeka mtedza ndi zipatso, makamaka makangaza. Zoyambilira zake - ellagic acid ndi ellagitannins - ndizofala m'chilengedwe, kuphatikiza mbewu zodyedwa, monga makangaza, strawberries, raspberries, walnuts, tiyi ndi mphesa za muscat, komanso zipatso zambiri zam'malo otentha.

Kuyambira zaka za 2000, urolithin A yakhala ikuyang'aniridwa koyambirira kokhudza zomwe zingachitike pobadwa.

Kodi Urolithin A amagwira ntchito bwanji?

Urolithin A ndi urolithin, microbial human metabolite wazakudya zotengera ellagic acid (monga ellagic acid). M'matumbo am'mimba mwa mabakiteriya, ellagitannin ndi ellagic acid amatsogolera pakupanga Ma urolithins A, B, C ndi D. Amodzi mwa iwo, urolithin A (UA) ndiye m'mimba kwambiri wogwira mtima komanso wothandiza m'matumbo, omwe angagwiritsidwe ntchito ngati anti anti -kutupa ndi antioxidant.

M'maphunziro a labotale, zawonetsedwa kuti urolithin A imathandizira mitochondria, yomwe ndiyo njira yosinthira mitochondria kudzera pa autophagy. Autophagy ndi njira yochotsera mitochondria yolakwika pambuyo povulala kapena kupsinjika, ndipo imagwira bwino ntchito mukakalamba. m'munsi ndi pansi. Izi zawonetsedwa mumitundu yosiyanasiyana ya nyama (maselo a mammalian, makoswe ndi ma Caenorhabditis elegans).

Komabe, chifukwa gwero la ellagitannin ndi losiyana, kapangidwe ka gulu lirilonse la bakiteriya lidzakhalanso losiyana, chifukwa chake kutembenuka kwa urolithin A ndikosiyana kwambiri mwa anthu, ndipo anthu ena sangasinthe.

Urolithin A maubwino

Urolithin A (UA) ndi chakudya chachilengedwe, metabolite yomwe imachokera pagulu laling'ono. Ili ndi maubwino osiyanasiyana azaumoyo, kuphatikiza kuchepa kwa ma signin yotupa, zotsutsana ndi khansa komanso kuletsa kudzikundikira kwa lipid.

Urolithin A (UA) amatha kukhala anti-inflammatory and antioxidant. Ikhozanso kulimbikitsa mitochondrial phagocytosis m'zinyama zakale ndi mitundu yakukalamba ya ukalamba ndikuthandizira kukhala wathanzi.

Kodi Urolithin A ingagwiritsidwe ntchito ngati zowonjezera?

Mu 2018, US Food and Drug Administration idasankha urolithin A ngati chotchinjiriza pachakudya kapena zinthu zowonjezera zakudya, ndi ndalama zochokera ku 250 milligrams mpaka 1 gram pakatumikira.

Kodi pali zovuta zina za Urolithin A?

Kafukufuku wachitetezo mwa okalamba awonetsa kuti urolithin A imaloledwa bwino. M'maphunziro a vivo sanazindikire ngati pali poizoni kapena zovuta zina pazakudya za urolitin A kudya.

Komanso, chitetezo cha nthawi yayitali chowonjezera Urolithin A ndi makangaza sichidziwika, ngakhale chithandizo chanthawi yayitali chotsitsa makangaza ndichabwino.

Kodi Urolithin B ndi chiyani? Urolithin B ufa?

Urolithin B ufa (CAS NO: 1139-83-9) ndi urolithin, mtundu wa mankhwala a phenolic omwe amapangidwa m'matumbo mwa anthu atamwa chakudya cha ellagitannins monga makangaza, strawberries, raspberries wofiira, walnuts kapena vinyo wofiira wachikulire . Urolithin B imapezeka mumkodzo ngati urolithin B glucuronide.

Urolithin B imachepetsa kuwonongeka kwa mapuloteni ndipo imapangitsa kuti thupi likhale ndi hypertrophy. Urolithin B imaletsa ntchito ya aromatase, michere yomwe imasinthitsa estrogen ndi testosterone.

Urolithin B ndi mankhwala achilengedwe omwe ali ndi antiproliferative ndi antioxidant. Urolithin B yawonetsedwa kuti idutsa chotchinga chaubongo wamagazi, ndipo itha kukhala ndi zoteteza ku matenda a Alzheimer's.

Urolithin B ndi ofunikira am'mimba ochepa a ellagitannis ndikuwonetsa zochitika zothandizira anti-oxidant ndi pro-oxidant kutengera dongosolo ndi momwe zinthu zilili. Urolithin B amathanso kuwonetsa ntchito ya estrogenic ndi / kapena anti-estrogenic.

Kodi ntchito Urolithin B? Ubwino wa Urolithin B (UB)

Ubwino wa Urolithin B:

Imalimbikitsa Mapuloteni A Minofu

Amachepetsa Mapuloteni a Minofu

Mutha Kukhala Ndi Zotsatira Zoteteza Pamisempha

Mutha Kukhala Ndi Katundu Wotsutsa-Aromatase

Urolithin B ya minofu

Urolithin B imatha kuchepetsa kuwonongeka kwa minofu yomwe imakhalapo pakuchita masewera olimbitsa thupi komanso kuteteza minofu yolimbana ndi nkhawa zomwe zimayambitsidwa ndi zakudya zamafuta kwambiri. Kafukufuku wokhudzana ndi matenda a Urolithin B mu mbewa adazindikira kuti amathandizira kukula kwa myotubes ndi kusiyanitsa ndikuwonjezera kaphatikizidwe kakapuloteni. Zinaonetsa kuthekera koteteza ubiquitin-proteinasome pathway (UPP), njira yofunika kwambiri yothandizira mapuloteni. Inathandizanso kupanikizika kwa minofu ndikuchepetsa mphamvu ya minofu.

Poyerekeza ndi testosterone, Urolithin B pamene amatengedwa ku 15 M adakulitsa zochitika za androgen receptor ndi 90% pomwe testosterone imatha kukwaniritsa kuchuluka kwa receptor kwa 50% ku 100uM. Izi zikutanthauza kuti zimatengera Urolithin B wocheperako kuti achulukitse zochitika za androgen mokulira ndiye kuchuluka kwa testosteronewhich kumawonjezera ntchito ya androgen mothandizika.

Komanso, 15uM yothandiza kwambiri ya Urolithin B ikuluikulu ya mapuloteni kudzera pa 96% poyerekeza ndi 100uM ya insulin, yomwe mapuloteni akuluakulu a minyewa amaphatikizira mwa 61% onse. Chikhulupiriro ndichakuti zimatenga nthawi yayitali kwambiri kuti Urolithin B awonjezere kuphatikiza kwa mapuloteni am'mimba kwambiri.

Kafukufukuyu akuwonetsa kuti Urolithin B ikhoza kulepheretsa mapuloteni ena kuphatikiza munthawi yomweyo kumawonjezera kaphatikizidwe kazakudya, ndiye kapangidwe kazachilengedwe kamene kamathandizanso kupanga minofu yotsika pomwe kumaletsa kusweka kwa minofu.

Urolithin B ndi amodzi mwamatumbo a michere ya ellagitannins, ndipo ali ndi zotsutsana ndi zotupa komanso zoteteza ku antioxidant. Urolithin B imalepheretsa zochitika za NF-κB pochepetsa phosphorylation ndikuwonongeka kwa I VerBcy, ndikupondereza phosphorylation ya JNK, ERK, ndi Akt, ndikukweza phosphorylation ya AMPK. Urolithin B imakhalanso wolamulira mafupa a minofu.

Kodi Urolithin A 8-Methyl Ether ndi chiyani?

Urolithins ndi metabolites yachiwiri ya ellagic acid yochokera ku ellagitannins. Mwa anthu ellagitannins amasinthidwa ndimatumbo a microflora kukhala ellagic acid omwe amasinthidwanso kukhala urolithins A, urolithin B, urolithin C ndi urolithin D m'matumbo akulu.

Urolithin A 8-Methyl Ether ndiye chinthu chapakatikati pa kapangidwe ka Urolithin A. Ndi yofunika yachiwiri ya metabolite ya ellagitannin ndipo ili ndi antioxidant komanso anti-yotupa katundu.

Kodi Urolithin A 8-Methyl Ether imagwira ntchito bwanji?

(1) Katemera wa antioxidant

Urolithin A 8-Methyl Ether imakhala ndi antioxidant pochepetsa kuchepa kwaulere, makamaka kuchepetsa kuchuluka kwa mitundu yama oxygen (ROS) m'maselo, ndikuletsa ma lipid peroxidation m'mitundu ina.

(2) Zida zotsutsana ndi zotupa

Urolithin A 8-Methyl Ether ili ndi zinthu zotsutsana ndi zotupa poletsa kupanga nitric oxide. Amalepheretsa kutulutsa mapuloteni a nitric oxide synthase (iNOS) ndi mRNA omwe amachititsa kutupa.

Urolithin A 8-Methyl Ether amapindula

Urolithin A 8-Methyl Ether ndi chinthu chapakatikati pakupanga kwa Urolithin A, komanso metabolite wofunikira wa ellagitannin, wokhala ndi antioxidant ndi anti-inflammatory properties. Monga metabolite wa Urolithin A, itha kukhalanso ndi phindu la Urolithin A:

(1) Itha kutalikitsa moyo;
(2) Thandizani kupewa khansa;
(3) Kupititsa patsogolo kuzindikira;
(4) Zotheka kuchepetsa thupi

Ntchito za Urolithin A 8-Methyl Ether zowonjezera?

Zowonjezera za Urolithin A zimapezeka mosavuta mumsika ngati zakudya zowonjezera ellagitannin. Monga mankhwala opangira kagayidwe kake ka Urolithin A, Urolithin A 8-Methyl Ether ingagwiritsidwenso ntchito pazowonjezera.

Komabe, palibe madata ambiri pazambiri zake zowonjezera, ndipo kafukufuku wina amafunika.

Tsamba:

  1. Garcia-Munoz, Cristina; Vaillant, Fabrice (2014-12-02). "Thupi la Metabolic la Ellagitannins: Zokhudza Zaumoyo, ndi Kafukufuku Wokhudzana ndi Zakudya Zopindulitsa". Ndemanga Zoyipa mu Science Science ndi Zakudya Zabwino. 54 (12): 1584–1598. onetsani: 10.1080 / 10408398.2011.644643. Kufotokozera: ISSN 1040-8398. MAFUNSO OTHANDIZA: PMID 24580560.
  2. Ryu, D. et al. Urolithin A imathandizira kusintha kwa mitophagy ndikuchulukitsa moyo wa C. elegans ndikuwonjezera kugwira ntchito kwa makoswe. Nat. Med. 22, 879-888 (2016).
  3. "Chidziwitso cha FDA GRAS GRN Na. 791: urolithin A". Ulamuliro wa Zakudya ndi Mankhwala ku US. 20 Disembala 2018. Chotsatira 25 August 2020.
  4. Singh, A .; Andreux, P .; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). "Urolithin A wothandizidwa pakamwa ndiwotetezeka ndipo amasintha ma biomarker a minofu ndi mitochondrial okalamba". Kukalamba mu Ukalamba. 1 (suppl_1): 1223-1224.
  5. Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Kuunika chitetezo cha urolithin A, metabolite wopangidwa ndi m'matumbo a microbiota pakudya zakudya zamasamba zotengera ellagitannins ndi ellagic acid". Chakudya ndi Chemical Toxicology. 108 (Pt A): 289–297. onetsani: 10.1016 / j.fct.2017.07.050. MAFUNSO OTHANDIZA: