Palmitoylethanolamide (Pea) mwachidule

Pali malipoti akuti Food and Drug Administration idavomereza kutumiza fomu yofunsira kukayezetsa matenda a COVID-19 pogwiritsa ntchito mankhwala omwe amatsanzira zomwe molekyulu yomwe imapezeka mu chamba.

Mankhwala opanga, otchedwa ultramicronized palmitoylethanolamide (micro PEA), amakhulupirira kuti ndi anti-yotupa. Palmitoylethanolamide (PEA) ndi "mafuta omwe amapezeka mwachilengedwe" ofanana ndi endocannabinoid, imodzi mwazolengedwa zomwe zimapezeka mu cannabis zomwe zimayang'ana ma CB2 receptors. Ma receptors a CB2 amalingaliridwa kuti amatha kusintha kutupa ndi kupweteka mthupi lonse la munthu.

Popeza [micro PEA] yakhala ikugwiritsidwa ntchito ku Europe kwazaka 20, othandizira ena aku Italy amalimbikitsa kugwiritsa ntchito Micro PEA kuchiritsa odwala a COVID-19 ndipo akupeza kupambana.

COVID-19 yamphamvu imadziwika ndi mayankho okwiya kwambiri omwe angayambitse mphepo yamkuntho ya cytokine. "PEA yaying'ono sikuti imapha ma virus, koma amakhulupirira kuti imatha kuchepetsa kuyankha kwamatenda, komwe kumatha kupha.

 

Kodi Palmitoylethanolamide (PEA) ndi chiyani?

Palmitoylethanolamide (PEA) ndi lipid yomwe imachitika mwachilengedwe mthupi lathu m'gulu la mafuta amide acid. Chifukwa chake ndi lipid yakale. Pea imapangidwanso mwachilengedwe m'mitundu ndi nyama.

Palmitoylethanolamide (PEA) imapezeka mzakudya monga mkaka, nyemba za soya, nandolo wam'munda, lecithin ya soya, nyama, mazira ndi mtedza.

Mphotho ya Nobel Mphotho Levi-Montalcini adazindikira Palmitoylethanolamide (PEA) ngati molekyulu yachilengedwe, pofotokoza kufunika kwake pochiza matenda opweteka ndi zowawa. Pambuyo popezeka izi, maphunziro asayansi mazana adachitika posonyeza kuti ndiwothandiza komanso otetezeka kugwiritsa ntchito. Palmitoylethanolamide (PEA) imafotokozedwa m'mabuku asayansi ngati a zowawa zachilengedwe.

 

Palmitoylethanolamide (Pea)

Palmitoylethanolamide zabwino - Kodi Palmitoylethanolamide ntchito?

Palmitoylethanolamide (PEA) ndi mafuta acid amide ndipo amapangidwa ndikuchita mkati mwa thupi lathu kuwongolera ntchito zosiyanasiyana. Ndi mafuta amkati amkati amidi, omwe ali mgulu la zida za nyukiliya. Palmitoylethanolamide (PEA) yakhala ikupezeka makamaka m'mitundu yambiri yotupa ya nyama, komanso m'mayeso angapo azachipatala.

Ndi mankhwala othetsa ululu achilengedwe ndipo amatha kugwiritsidwa ntchito popweteka komanso kutupa. Zimapindulitsanso zina monga neuropathic ache, fibromyalgia, sclerosis, kuvulala mobwerezabwereza, matenda am'mapapo, ndi zovuta zina zambiri.

Zina mwazotsatira zabwino za Palmitoylethanolamide zimaphatikizapo;

 

i. Imathandizira ubongo

Mapindu a Palmitoylethanolamide pakukulitsa thanzi laubongo amalumikizidwa ndi kuthekera kwake kolimbana ndi kutupa kwa neural komanso kukweza kwa maselo a neural akupulumuka. Izi zimadziwika kwambiri ndi anthu omwe ali ndi vuto la neurodegenerative ndi stroke.

Mwachitsanzo, pakafukufuku wa anthu 250 omwe akudwala sitiroko, palmitoylethanolamide supplement yothandizidwa ndi luteolin idapezeka kuti ithandizanso kuchira. PEA idapezeka kuti ikuthandizira kukumbukira, thanzi laubongo komanso magwiridwe antchito tsiku ndi tsiku. Zotsatirazi za palmitoylethanolamide powder zidawonedwa masiku 30 atatha kuwonjezera ndikuwonjezeka kupitirira mwezi umodzi.

 

ii. Pewani zowawa zingapo ndi Kutupa

Asayansi amatipatsa maumboni ambiri owonjezera amtundu wa Palmitoylethanolamide. Zowonadi zake, Palmitoylethanolamide imapereka mpumulo wamapweteka ku mitundu yosiyanasiyana ya ululu ndi kutupa. Maphunziro ena omwe akuwonetsa katundu wa zopweteka za Palmitoylethanolamide ndi;

Pakafukufuku wokhudza nyama, palmitoylethanolamide zowonjezerazo pamodzi ndi quercetin anapezeka akupereka mpumulo ku zowawa zamagulu komanso kukonza magwiridwe antchito ndi kuteteza khungu kuti lisawonongeke.

Kafukufuku woyambirira amawonetsa kuti PEA ikhoza kuthandizira kuchepetsa kupweteka kwa mitsempha mwa odwala matenda ashuga (matenda ashuga).

Pakufufuza kwina ndi anthu 12, muyezo wa Palmitoylethanolamide wa 300 ndi 1,200 mg / tsiku loperekedwa pafupifupi masabata atatu mpaka asanu ndi atatu amapezeka kuti amachepetsa mphamvu ya kupweteka kwapakati komanso neuropathic.

Kafukufuku wokhudza odwala 80 omwe akudwala Fibromyalgia syndrome adazindikira kuti PEA kuwonjezera pa mankhwala ena omwe ali ndi vutoli amatha kuchepetsa ululu.

Kupitilira apo, maphunziro ena angapo akuwonetsa mpumulo wa Palmitoylethanolamide kuphatikiza ululu wamkati, kupweteka kwammbuyo, kupweteka kumbuyo, kupweteka khansa pakati pa ena.

 

iii. Zimathandizira kuchepetsa zizindikilo za kukhumudwa

PEA imakhudza molakwika amalandila omwe amachititsa kuti azisangalala. Kafukufuku wina akuwonetsa kupumula kwa nkhawa ya palmitoylethanolamide ngati gawo lofunikira polimbana ndi kukhumudwa.

Pakufufuza kwa odwala 58 omwe ali ndi vuto lakukhumudwa, Palmitoylethanolamide yowonjezera pa 1200 mg / tsiku limodzi ndi mankhwala a antidepressant (citalopram) omwe amaperekedwa kwa masabata a 6 anapezeka kuti amathandizira kwambiri kusintha kwa mitsempha komanso zizindikiro zapafupipafupi.

 

iv. Zimachepetsa chimfine

Palmitoylethanolamide imapindula polimbana ndi chimfine chomwe chimapezeka pakutha kwake kuwononga kachilombo komwe kamayambitsa chimfine. Modabwitsa, chimfine chofala chimafala kwambiri ndipo chimakhudza pafupifupi aliyense makamaka anthu omwe ali ndi chitetezo chamthupi.

Kafukufuku wokhala ndi anyamata achichepere 900 adawonetsa kuti muyezo wa Palmitoylethanolamide wa 1200 mg patsiku amachepetsa nthawi yomwe amatenga nawo mbali kuti achiritse kuzizira komanso zodziwikiratu monga kupweteka mutu, kutentha thupi komanso zilonda zapakhosi.

Palmitoylethanolamide (Pea)

v. Amachepetsa zizindikilo za insular (multiple) sclerosis

Ndi mankhwala a anti-yotupa a Palmitoylethanolamide otsimikizika, mosakayikira ndi oyenera kuchitira matenda ambiri.

Pakufufuza kwa odwala 29 omwe ali ndi matenda opha ziwalo zambiri, a PeA adawonjezera muyezo wa interferon IFN-β1a adapezeka kuti amachepetsa ululu komanso amathandizira moyo wa odwala.

 

vi. Palmitoylethanolamide bwino kagayidwe

Palmitoylethanolamide (PEA) imatha kumangiriza ku PPAR- α, wolandila yemwe amachititsa kuti thupi likhale ndi metabolism, njala, kuonda ndi mafuta oyaka. PPAR- α receptor ikakulimbikitsani mumakhala ndi mphamvu zamagetsi zomwe zimathandiza thupi kuwotcha mafuta ochulukirapo pakuchita masewera olimbitsa thupi motero mumatha kulemera.

 

vii. Palmitoylethanolamide ikhoza kuchepetsa chidwi chanu chofuna kudya

Kuchepetsa thupi kwa Palmitoylethanolamide kumawonetsedwa pakukhudza kwake chidwi chanu. Zofanana ndi kupititsa patsogolo kagayidwe, pamene PPAR- α receptor imayendetsedwa kumayambitsa kumverera kwodzaza mukamadya motero kumakuthandizani kuyang'anira kuchuluka kwa zopatsa mphamvu.

Kupitilira apo, PEA imawonedwa ngati mafuta acid ethanolamides omwe amathandiza kwambiri pakudya. Pakufufuza kwa makoswe ochulukirapo omwe ali ndi kulemera kwakukulu, zakudya zowonjezera za PEA pa 30 mg / kg thupi kwa masabata 5 zinapezeka kuti zimachepetsa kwambiri kudya kwawo, mafuta ochuluka motero kulemera kwa thupi.

 

viii. Palmitoylethanolamide odana ndi kutupa zotsatira zolimbitsa thupi

Wina akhoza kumva kupweteka ndi kutupa panthawi komanso pambuyo pake chifukwa chakulemera kwambiri. Zowonjezera za PEA zitha kuteteza izi polimbikitsa ntchito zotsutsana ndi zotupa za PPAR- α receptor. Palmitoylethanolamide ikhozanso kulepheretsa kutulutsa kwa michere yotupa mu minofu ya anthu ya adipose.

 

Ndani ayenera kutenga supplement wa Palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) yowonjezera imakhala yoyenera kwa onse omwe ali ndi ululu wosakwiya kapena kutupa komanso aliyense amene ali ndi chidwi chofuna kuchepetsa thupi ngakhale pakumwa mankhwala kapena ayi. PeA yawonedwa kuti ikulimbikitsa mphamvu ya mankhwala ena. Ndi njira kwa iwo omwe samapeza mpumulo pakugwiritsa ntchito omwe akupha ululu.

Palmitoylethanolamide mpumulo wa nkhawa Ndilo lingaliro labwino kwambiri kuti aliyense amene ali pachiwopsezo cha kukhumudwa kapena kukhumudwa atenge PEA.

Kuphatikiza apo, wina atuta zambiri za PEA kuchokera ku zowonjezera chifukwa opanga amafuna mapangidwe omwe amawonjezera Palmitoylethanolamide bioavailability m'thupi lanu.

 

Kodi PEA imachokera kuti?

Pea imapangidwa mwachilengedwe m'matupi athu komanso nyama ndi zomera. Komabe, kwa anthu omwe ali ndi ululu wambiri kapena kutupa, PEA imachitika mosakwanira motero kufunikira kwa zowonjezera za PEA.

Palmitoylethanolamide itha kupezeka kuchokera kuzakudya zomwe zili ndi mapuloteni ambiri monga mkaka, nyama, nyemba za soya, lecithin ya soya, mtedza ndi nandolo wam'munda pakati pa ena. Komabe, a PEA omwe amapezeka kuchokera kuzakudya ndi ochepa. Izi zimapangitsa kupanga palmitoylethanolamide kochuluka kofunikira kuthana ndi zosowazi.

 

Kodi PEA imakukwezani?

Phenethylamine ndi Palmitoylethanolamide onse amatha kuyitanitsa PEA, koma ndi zinthu zosiyanasiyana.

Phenethylamine (PEA) ndi organic organic, monoamine alkaloid, ndikutsata amine, yemwe amakhala ngati chapakati cha mitsempha yolimbikitsa mwa anthu. Phenethylamine imalimbikitsa thupi kupanga mankhwala ena omwe amathandizira pakukhumudwa komanso matenda ena amisala.

Kutengedwa muyezo wa 500mg-1.5g pa mlingo, maola angapo aliwonse, PEA imapatsa wogwiritsa ntchito chisangalalo, mphamvu, kukondoweza, ndikukhala bwino.

Komabe, chonde onani kuti Phenethylamine (PEA) si Palmitoylethanolamide (PEA). Mankhwala a phenethylamine sanavomerezedwe ndi a FDA kuti azigwiritsa ntchito mankhwala. Palmitoylethanolamide (PEA) ndi chinthu chachilengedwe chomwe chimapangidwa ndi thupi; Ndizothandiza komanso zotetezeka kugwiritsa ntchito ngati chowonjezera cha ululu ndi kutupa.

 

Kodi PEA zowonjezera otetezeka?

Palmitoylethanolamide (PEA) ndi chinthu chachilengedwe chomwe chimapangidwa ndi thupi; Ndizothandiza kwambiri komanso zotetezeka kugwiritsa ntchito ngati chowonjezera cha ululu ndi kutupa. Palibe zovuta zoyipa za palmitoylethanolamide zomwe zidanenedwapo komanso kuti sipangakhale kuyanjana ndi mankhwala ena.

 

Kodi zotsatira zoyipa za PEA ndi ziti?

Palibe zovuta zoyipa kapena kulumikizana ndi mankhwala osokoneza bongo komwe kwanenedwa pakadali pano. Palmitoylethanolamide akhoza kumwedwa pamodzi ndi chinthu china chilichonse. Zimathandizira kupweteka kwamphamvu kwa ma analgesics achikale ndi anti-inflammatories.

 

Kodi Palmitoylethanolamide ali ndi pathupi pabwino?

Osagwiritsidwe ntchito ndi amayi apakati.

Palmitoylethanolamide itha kuthandizira kuthana ndi kutupa komanso kupweteka kwakanthawi.

Ziyenera kutengedwa moyang'aniridwa ndi azachipatala.

 

Palmitoylethanolamide theka lamoyo - Zimatenga nthawi yayitali bwanji kuti mtola uzigwira ntchito?

Palmitoylethanolamide (PEA) itha kumwedwa limodzi ndi mankhwala ena opweteka kapena payekha, monga walangizidwa ndi akatswiri azachipatala, kuti athandizire kupumula.

Kuchita bwino pakumva kupweteka ndi 8 hr

Zotsatira zimasiyanasiyana; zotsatira mkati mwa 48 hr mwa anthu ena, koma gwiritsani ntchito masabata a 8 pazotsatira zabwino, atha kugwiritsidwa ntchito kwakanthawi kwakanthawi kupweteka kwamitsempha.

 

Kodi PEA imagwira ntchito bwanji kupweteka?

Kafukufuku wasonyeza kuti PEA ili ndi zida zotsutsana ndi zotupa komanso zotsutsana ndi nociceptive ndipo kuzigwiritsa ntchito pafupipafupi kumathandizira kuti thupi lanu lizitha kumva zowawa pochepetsa kuyankha kwamaselo amanjenje omwe amachititsa ululu.

Palmitoylethanolamide imagwiranso ntchito molunjika kuti ipangitse zochitika za ena olandila monga ma cannabinoid receptors. PEA imalimbikitsa molakwika ma cannabinoid receptors (CB1 ndi CB2) pochita ngati enzyme (FAAH-fatty acid amide hydrolase) yomwe ikukhudzidwa pakuwonongeka kwa cannabinoid anandamide. Izi zimathandizira kukweza milingo ya anandamide mthupi lathu, lomwe limafunikira kupumula ndikuthana ndi ululu.

 

Kodi PEA ndi chiyani kuti muchepetse ululu?

Palmitoylethanolamide (PEA) ndi chinthu chachilengedwe chomwe chimapangidwa ndi thupi; Ndi mafuta amkati amkati amkati, omwe ali mgulu la zida za zida za nyukiliya, ndipo atha kugwiritsidwa ntchito ngati chowonjezera chothandizira kupweteka ndi kutupa. PEA ndimolekyulu yachilengedwe, yoteteza, yamafuta yopangidwa mthupi lathu, kuthandiza kuthandizira mitsempha ya myelin kuti igwire ntchito yamitsempha.

PEA ndi asidi wamafuta omwe amapezeka pama cell osiyanasiyana mu kutupa ndi kupweteka kwakanthawi, ndipo awonetsedwa kuti ali ndi neuroprotective, anti-inflammatory, anti-nociceptive (anti-pain) komanso anti-convulsant. Amachepetsanso kufalikira kwa m'mimba komanso kufalikira kwa khansa, komanso kuteteza mitsempha ya endothelium mumtima wama ischemic. Nthawi zambiri kwa anthu omwe ali ndi matenda osachiritsika, thupi silimatulutsa PEA yokwanira, potenga PEA kuti iwonjezere kuchepa kwa thupi kumatha kukhala kothandiza kuthana ndi izi.

 

Kodi mtola ndi wotsutsana ndi zotupa?

Palmitoylethanolamide (PEA) ndichinthu chosangalatsa chotsutsana ndi zotupa komanso chitha kukhala ndi chiyembekezo chambiri chothandizira matenda a (auto) angapo amthupi, kuphatikiza matumbo opatsirana ndi matenda opweteka a CNS.

 

Kodi mtola ndi wabwino kwa nyamakazi?

Palmitoylethanolamide (PEA) imapindulitsanso nyamakazi pochepetsa kukula ndi kusamalira ululu wopweteka komanso kuthandizira kuchepetsa kupita patsogolo kwa chiwonongeko chokhudzana ndi nyamakazi.

 

Kodi opweteka kwambiri ndi otani a ululu wamitsempha?

PEA (palmitoylethanolamide) yakhalapo kuyambira zaka za m'ma 1970 koma ikudziwika kuti ndi njira yatsopano yothandizira kutupa ndi kupweteka. Palibe kuyanjana kwa mankhwala kapena zovuta zoyipa zomwe zadziwika.

PEA yawonetsa kuthekera kwa kupweteka kwakanthawi kwamitundu ingapo komwe kumakhudzana ndi zovuta zambiri, makamaka ndi ululu wamitsempha ya m'mitsempha, ululu wopweteka komanso kupweteka kwa visceral monga endometriosis ndi interstitial cystitis.

 

Kodi ndingathandize bwanji kupweteka kwamitsempha kunyumba?

PEA ndi molekyulu yamafuta yomwe imathandizira kuthandizira mitsempha ya myelin kuti igwire bwino ntchito yamitsempha.

Kuperewera kwa mavitamini kuchokera ku gulu la B sikungangobweretsa kupweteka kwamitsempha, komanso kumawonjezera.

Zizindikiro zina zosasangalatsa zitha kuchitika, monga kugwedezeka, kugwedezeka ndi kuluma kwa manja ndi mapazi, kumverera ngati kuti wina akuyenda pa waya wokuta kapena ubweya wa thonje kapena ngakhale dzanzi la

manja ndi mapazi.

Vitamini B1 yocheperako imabweretsa chisokonezo pakugwira ntchito kwa mitsempha ndipo chifukwa cha matenda amitsempha ndi ululu wamitsempha. Powonjezera vitamini B1, kupweteka kumachepa ndipo ntchito yamitsempha imakula. Vitamini B1 imatha kutengedwa limodzi ndi PEA, izi zimapereka chithandizo chokwanira pakumagwira kwa mitsempha, zimalepheretsa kupweteka kwa mitsempha kapena kuwawa kwakukulira. Kafukufuku waposachedwa awonetsa kuti anthu ambiri omwe ali ndi ululu wosatha, okalamba komanso odwala matenda ashuga samakhala ndi mavitamini okwanira m'magazi awo. Ichi ndi chimodzi mwazifukwa zomwe anthuwa sangathandiziridwe ndi mankhwala othetsa ululu okha; amafunikira

zoposa pamenepo. Mavitamini a PEA kuphatikiza B amathandizira chitetezo chamanjenje komanso chitetezo chamthupi pakamva kupweteka kwamitsempha.

 

Palmitoylethanolamide (Pea)

Kodi Palmitoylethanolamide ndi cannabinoid?

CBD (Cannabidiol) ndi mankhwala omwe amachotsedwa ku hemp ndi chamba. Ngakhale thupi limapanga cannabinoids mwachilengedwe, CBD yathandizidwa kuti ikwaniritse zosowa.

Cannabinoids ndi mankhwala achilengedwe omwe amapanga thupi omwe amachititsa kukumbukira, kupweteka, kusilira komanso kuyenda. Asayansi akuganiza kuti cannabinoids imatha kukhala yopindulitsa pakuchepetsa kutupa ndi nkhawa, kuwononga maselo a khansa, kupereka mpumulo m'misempha komanso kumathandizanso kulakalaka.

PEA ndi mafuta acid amide omwe amapangidwanso m'thupi ndipo amatha kutchedwa cannabimimetic. Izi zikutanthauza kuti zimatsimikizira ntchito za CBD mthupi lanu.

Onse CBD ndi PEA amachita mosaletseka poletsa mafuta acid amide hydrolase (FAAH), omwe nthawi zambiri amawononga anandamide ndikufooketsa. Izi zimapangitsa kuchuluka kwa anandamide. Anandamide imasewera gawo lalikulu pamalingaliro komanso chilimbikitso. Kuchuluka kwa anandamide kumathandizira dongosolo la endocannabinoid.

Pea yatchuka komanso kupikisana ndi CBD. PEA imadziwika kuti ndi njira ina yotetezeka ku CBD chifukwa cha zovuta zamilandu zomwe zimayang'anizidwa komanso chifukwa chakuti anthu ambiri sangathe kulekerera 'mwala' womwe umabwera ndi CBD.

Komanso, PEA ndi yotchipa kwambiri kuposa CBD. Komabe, PEA itha kugwiritsidwa ntchito kuphatikiza pa CBD kuti ikwaniritse zotsatira zake.

 

Kodi Pea ndi endocannabinoid?

AYI, Palmitoylethanolamide (PEA) ndi endocannabinoid-ngati lipid mkhalapakati wokhala ndi mankhwala a analgesic ndi anti-inflammatory. PEA imathandizira ECS kudzera pakukonzekera ma endocannabinoid signaling komanso kuyambitsa njira zolandirira cannabinoid.

Endocannabinoid system (ECS) ndichinthu chofunikira kwambiri chachilengedwe chomwe chimayang'anira ndikuwunika zochitika zosiyanasiyana zakuthupi mthupi. Kafukufuku wa ECS watsogolera kuzindikiritsa osati ma endocannabinoids okha monga anandamide (AEA) ndi 2-arachidonoylglycerol (2-AG), komanso oyimira lipid endabannabinoid ngati lipid monga palmitoylethanolamide (PEA). Mankhwala oterewa omwe amakhala ndi endocannabinoid nthawi zambiri amagawana njira zofananira zama endocannabinoids koma alibe mgwirizano wogwirizana ndi mtundu wakale wa cannabinoid receptor 1 ndi mtundu 2 (CB1 ndi CB2).

 

Palmitoylethanolamide (PEA) ndi Anandamide

Palmitoylethanolamide ndi anandamide ndizogwirizana chifukwa onsewa ndi amkati wamafuta acid amide opangidwa m'thupi.

PEA ndi anandamide amanenedwa kuti amathandizira pakumva kupweteka komanso amalimbikitsa opha opweteka omwe amagwiritsidwa ntchito.

Amaphwanyidwenso ndi michere yamafuta acid hydrolase mthupi, chifukwa chake zotsatira zomwe zimagwiritsidwa ntchito palimodzi ndizoposa zomwe zimagwiritsidwa ntchito pazowonjezera zamankhwala.

 

Palmitoylethanolamide VS Phenylethylamine

Phenethylamine ndi mankhwala omwe amapangidwa mwachilengedwe ndi thupi. Amagwiritsidwa ntchito kwambiri pakupititsa patsogolo masewera othamanga komanso amathanso kuthandiza kuchepetsa kukhumudwa, kuthandizira kuchepa thupi komanso kuwonjezera kusintha kwamphamvu.

Palmitoylethanolamide mbali inayo ndi acid acid amide yomwe imadziwika kwambiri chifukwa cha kupweteka komanso kutupa.

Zophatikiza ziwiri izi sizikugwirizana. Chokhacho chomwe chimalumikiza iwo ndikuti onsewa ndi achidule ngati PEA.

 

Kodi ndimatenga bwanji supplement ya Palmitoylethanolamide (PEA)?

Pomwe tidatsimikiza za phindu la kuthana ndi kutupa kwa Palmitoylethanolamide pazopindulitsa zina, ndikofunikira kuti mudziwe zambiri za PEA. Pea imapezeka m'ma tinthu tambiri ndipo imagwiritsidwa ntchito m'madzi, izi zimapangitsa Palmitoylethanolamide bioavailability ndi mayamwidwe ochepa.

Nkhani yabwino, komabe, ndikuti opanga amafunafuna njira zomwe zimapangisa kuti peititlelethanolamide bioavailability azigwiritsa ntchito kwambiri m'thupi lanu. Kwa izi, Pea ufa amapezeka mu mawonekedwe abwinobwino wa ufa ndi mawonekedwe a micromized powder.

 

Mungagule kuti ufa wa Palmitoylethanolamide (PEA)?

Tili munthawi yosangalatsa pomwe masitolo apaintaneti akhala malo amodzi ogulitsira chilichonse kuphatikiza palmitoylethanolamide chochuluka. Ngati mungaganize zokatenga PEA, fufuzani zambiri kwa opanga opanga zowonjezera za palmitoylethanolamide. Ogwiritsa ntchito ambiri a palmitoylethanolamide amagula m'masitolo apaintaneti ndipo ayenera kuganizira ndemanga zawo za ufa wabwino kwambiri wa PEA pamsika.

 

achidule

AEA: Anandamide

CB1: Mtundu wa Cannabinoid wolandila

CB2: Cannabinoid mtundu wachiwiri wolandila

PAKATI: Cochrane Central Register ya Mayeso Olamulidwa

FAAH: Mafuta-acid amide hydrolase

NAAA: N-acylethanolamine hydrolyzing acid amidase

NAE: N-acylethanolamines

PEA: Palmitoylethanolamid

PPARα: Peroxisome proliferator-activated receptor alpha

PRISMA-P: Zinthu Zosankhika Zofotokozera Zowunika Mwadongosolo ndi Ma Meta-Analysis Protocols

VAS Pain: Scale Analog Scale for Pain

ECS: dongosolo la endocannabinoid

 

Tsamba:

[1] Artukoglu BB, Beyer C, Zuloff-Shani A, ndi al. Kuchita bwino kwa palmitoylethanolamide pamavuto: kuwunika meta. Dokotala Wopweteka 2017; 20 (5): 353-362.

[2] Schifilliti C, Cucinotta L, Fedele V, ndi al. Micronized palmitoylethanolamide amachepetsa zizindikilo za kupweteka kwa mitsempha mwa odwala matenda ashuga. Chithandizo Cha Zowawa 2014; 2014: 849623.

[3] Keppel Hasselink JM, Hekker TA. Chithandizo cha palmitoylethanolamide pochiza ululu wamitsempha yokhudzana ndi zovuta zosiyanasiyana zamatenda: mndandanda wamilandu. J Pain Res 2012; 5: 437-442. (Adasankhidwa)

[4] Keppel Hasselink JM, Kopsky DJ. Udindo wa palmitoylethanolamide, autacoid, pochiza matenda am'mimba: malipoti atatu ndikuwunikanso mabuku. J Nkhani Yachipatala 2016; 6 (3).

[5] Costa B, Colombo A, Bettoni I, Bresciani E, Torsello A, Comelli F. The endogenous ligand palmitoylethanolamide imachepetsa kupweteka kwa mitsempha kudzera pa cell cell ndi microglia modulation. Msonkhano wapachaka wa 21st Wa International Cannabinoid Research Society. St. Charles, Il. Usa: Pheasant Kuthamanga; 2011.

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