1. Kodi Degarelix ndi chiyani?
2. Kodi ufa wa Degarelix umagwiritsidwa ntchito ndi chiyani?
3. Degarelix ufa Mechanism of Action
4. Kuchita kwa Degarelix
5. Kodi pali chiopsezo chilichonse ngati ndaphonya muyezo wa Degarelix kapena mankhwala osokoneza bongo?
6. Kodi ndi Zotsatira Zipi Zochuluka ndi Machenjezo omwe Degarelix Angayambitse?
7. Kutsiliza
8. Zambiri

Metadescription

Kwambiri, khansa ya Prostate tsopano ndi imodzi mwazifo zomwe zimawopseza thanzi komanso thanzi la abambo. Kupewa koyambirira ndi chithandizo ndikofunikira pochiza matendawa. Degarelix ufa Ndi mankhwala othandiza kuchiza matenda a khansa ya prostate, ndipo tiyenera kuyesetsa kudziwa zambiri zokhudzana ndi izi kuti tizitha kuzigwiritsa ntchito moyenera komanso mosamala.

1. Kodi Degarelix ndi chiyani?Phcoker

Degarelix (214766-78-6) ndi mankhwala othandizira mahomoni omwe amachepetsa kuchuluka kwa mahomoni m'thupi, kuphatikizapo testosterone. Amayikidwa pansi pa gulu la mankhwala omwe amadziwika kuti gonadotropin-releasing hormone (GnRH) receptor antagonists. Mankhwala opangidwa ndi peptide iyi amapangidwa ndi dzina la mtundu "Firmagon". Izi ndi izi:

  • Gulu La Mankhwala Ovuta: GnRH Analogue; GnRH wotsutsa; Antigonadotropin
  • Fomu La Chemical: C82H103ClN18O16
  • Misa ya Molar: 1630.75 g / mol g · mol − 1
  • Bioavailability: 30-40%
  • Njira Zoyendetsera: Jekeseni wanjira
  • Chithandizo: Feces (70-80%), Urine (20-30%)
  • Kuthetsa Half-Life: masiku a 23-61

2. Kodi ufa wa Degarelix umagwiritsidwa ntchito ndi chiyani?Phcoker

Degarelix ufa umagwiritsidwa ntchito pochiza khansa yapamwamba ya prostate. FDA idavomereza mankhwalawa kuti athandizire khansa yapamwamba ya prostate kwa odwala aku US ku 24th Disembala, 2008. Pa 17th February, 2009, European Commission idatsata ndipo idavomereza mankhwala a Degarelix kuti agwiritsidwe ntchito kwa odwala amuna achikulire omwe ali ndi khansa ya Prostate.

Zindikirani kuti Jakisoni wa Degarelix amayenera kuthandizidwa ndi dokotala kapena namwino kuchipatala. Degarelix itha kugwiritsidwanso ntchito pazinthu zina. Ku Sweden, mwachitsanzo, mankhwalawa amaphunziridwa kuti agwiritse ntchito ngati mankhwala oponyera ena mankhwala kuti alowetsedwe mwa olakwa. Chithandizo cha khansa ya m'mawere cha Degarelix chikuwonedwanso ngati njira ina yothandizira khansa ya m'mawere mwa amuna.

Dokotala wanu angakulimbikitseni mankhwalawa pazinthu zina. Ngati simukudziwa chifukwa chomwe mumamwa mankhwalawa, ndikofunikira kuti mulankhule ndi dokotala. Monga ndi mankhwala ena, simuyenera kupatsa Degarelix kwa wina aliyense, ngakhale atakhala ndi zofanana ndi zanu. Izi ndichifukwa choti mankhwalawa amatha kukhala ovulaza ngati atengedwa popanda kunena kwa dokotala.

(1) Muyenera kudziwa china chowonjezera musanatenge Degarelix

Izi ndi zina zofunika kudziwa musanamwe mankhwalawa:

  • Degarelix imatha kubala amuna. Ngati mukuyembekezera kukhala bambo mtsogolo, ndikofunikira kuti mulankhule ndi dokotala. Mungafune kulingalira za kusunga umuna musanayambe chithandizo.
  • Mankhwalawa sakuvomerezeka kuti agwiritsidwe ntchito ndi akazi. Amayi oyembekezera sayenera kugwiritsa ntchito mankhwalawa. Izi ndichifukwa choti mankhwalawa amatha kuvulaza mwana wosabadwa. Amayi oyamwitsa, kapena omwe akufuna kubereka ana, ayeneranso kupewa kugwiritsa ntchito mankhwalawa. M'malo mwake, azimayi ambiri sayenera kugwiritsa ntchito Degarelix.
  • Sichabwino kutenga Degarelix ngati mukudwala. Onetsetsani kuti mwadziwitsa dokotala wanu ngati muli ndi matenda a QT aatali, omwe ndi vuto la mtima lomwe limatha kupangitsa kukomoka, kugunda kwamtima kosagwirizana, kapena kufa mwadzidzidzi. Muyeneranso kudziwitsa dokotala wanu ngati muli ndi mtima, impso, kapena matenda a chiwindi. Onaninso dokotala wanu ngati muli ndi sodium yayikulu, magnesium, potaziyamu, kapena calcium m'magazi anu.
  • Ndikofunikanso kuuza dokotala wanu wamankhwala kapena dokotala ngati mukusowa mankhwala kapena zosakaniza zina. Izi ziwathandiza kudziwa ngati simunayamwa jakisoni wa juzi ya Degarelix.

(2) Mlingo wa jekeseni wa Degarelix

Degarelix amabwera m'mitundu iwiri:

  • 120 mg vial: Vial iliyonse yogwiritsira ntchito imakhala ndi 120 mg ya Degarelix ufa monga Degarelix acetate.
  • 80 mg vial: Vial iliyonse yogwiritsira ntchito imakhala ndi 80 mg wa Degarelix ufa monga Degarelix acetate.

Degarelix amabwera mu mawonekedwe a ufa, omwe amayenera kukhala osakanikirana ndi amadzimadzi ndikulowetsedwa pansi pa khungu m'dera lam'mimba, kwinakwake pakati pa nthiti ndi m'chiuno. Nthawi yoyamba yomwe mumalandira mankhwalawa, mudzapatsidwa jakisoni awiri a Degarelix. Mutatha kumwa jakisoni woyamba wa Degarelix, mudzalandira jakisoni kamodzi pakubwera kotsatira kwanu mwezi uliwonse.

Mlingo woyambirira nthawi zambiri amakhala Degarelix 240 mg kutumikiridwa ngati jakisoni wothandizila wa 2 wa Degarelix 120 mg aliyense pamsasa wa 40 mg / mL. Mutatha kumwa koyamba, mudzalandira jekeseni imodzi yokha ya 80 mg pa nthawi ya 20 mg / mL tsiku lililonse la 28.

Mukafuna kulandira jakisoni wa Degarelix, muyenera kupewa kuvala zovala zolimba, chiuno kapena lamba kuzungulira m'mimba mwanu komwe jakayo idzaperekedwako. Mukalandira jakisoni wa Degarelix, onetsetsani kuti chiuno chanu kapena lamba wanu sichikukakamiza kuderalo. Muyenera kupewa kupopera kapena kukwapula komwe mankhwalawo alowa.

Kuchepetsa zizindikiro za khansa ya Prostate yomwe imadalira testosterone pakukula kumafuna kuchuluka kosalekeza kwa mahomoni. Kuti izi zitheke, ndikofunikira kuti Degarelix acetate iyenera kutumikiridwa ndendende monga adalimbikitsa adokotala.

Kuti muwonetsetse kuti mankhwala a Degarelix akuthandiza mkhalidwe wanu, mungafunike kukayezetsa magazi pafupipafupi. Onetsetsani kuti mukusungira nthawi yonse yomwe mwalandira ndi adokotala.

Muyeneranso kudziwa kuti jakisoni wa Degarelix angakhudze zotsatira za mayeso ena azachipatala. Mukakhala kuti mukumwa mankhwalawa, onetsetsani kuti mwawauza dokotala kuti mwalandira mankhwala mukamayesedwa pambuyo pake.

Peptide Degarelix Mankhwala Ovuta Kugwiritsa Ntchito Cancer Prostate

3. Degarelix ufa Mechanism of ActionPhcoker

Testosterone wamwamuna akuti amathandizira kukula kwa maselo a khansa mu Prostate. Mankhwala omwe amalepheretsa testes kutulutsa testosterone amadziwika kuti amachepetsa kapena kuletsa kukula kwa maselo a khansa mu Prostate. Palinso mankhwala omwe amatseka machitidwe a testosterone poletsa kupezeka kwa mahomoni achimuna kupita ku maselo a khansa.

Degarelix ufa (214766-78-6) imagwira ntchito pochepetsa kuchuluka kwa testosterone yomwe imapangidwa mwachilengedwe ndi thupi. Zimachita izi poletsa gnRH receptors mu pituitary gland mu ubongo. Izi zimalepheretsa kupanga mahomoni a luiteinising, motero amalepheretsa ma testeswo kupanga testosterone.

4. Kuchita kwa DegarelixPhcoker

Monga mankhwala ena a khansa, Degarelix amatha kuyanjana ndi mankhwala ena ndi mankhwala azitsamba. Izi ndi zina mwa mitundu ya mankhwala omwe angayambitse kuyanjana akagwiritsidwa ntchito limodzi ndi Degarelix:

  • Anti-psychotic
  • Mankhwala ochepetsa matenda a emetic
  • Mapuloteni ena a proteinasease
  • Tricyclic antidepressants
  • Antifunglas
  • Mankhwala othandizira a Macrolide
  • Kusankha Serotonin Reuptake Inhibitors
  • Alfuzosin
  • Amiodarone
  • Buprenorphine
  • Chloral hydrate
  • Chloroquine ndi
  • Disopyramide, pakati pa ena.

Mukagwiritsidwa ntchito limodzi ndi Degarelix, mankhwala ena amatha kukulitsa chiopsezo cha mtundu wamtundu wamwano womwe umadziwika ndi dzina la QT. Muli pachiwopsezo chowopsa chotere komanso mavuto ake ngati mungathe:

  • Kodi ndi okalamba (65 wazaka ndi akulu)
  • Khalani ndi mbiri yabanja yokhala ndi mitsempha yodwala ya mtima kapena matenda a mtima
  • Khalani ndi mbiri ya kufa kwadzidzidzi kwamtima
  • Khalani ndi kugunda pang'onopang'ono kapena kugunda kwamtima
  • Khalani ndi kutalika kwa nthawi ya QT
  • Amadwala matenda ashuga
  • Wakhala ndi stroke
  • Khalani ndi calcium yochepa, magnesium, kapena potaziyamu

Ngati muli ndi zina mwazomwe zili pamwambazi, kapena mukumwa mankhwala ena kuti muthane ndi thanzi lililonse, ndikofunikira kuti muuzeko dokotala musanagwiritse ntchito mankhwala a Degarelix. Onetsetsani kuti mwauza dokotala wanu za zamankhwala kapena zamankhwala zamankhwala, mankhwala othandizira odwala, zakudya zopatsa thanzi, mankhwala azitsamba ndi mavitamini omwe mukumwa kapena mukukonzekera. Izi zikuthandizani kuti mupewe mankhwala omwe angayambitse kulumikizana kwa Degarelix.

Ndikofunika kukambirana ndi dokotala za matenda anu azachipatala komanso mankhwala omwe mungakhale mukutenga pazifukwa zingapo. Choyamba, zithandiza adotolo kukambirana nanu momwe kugwiritsa ntchito mankhwalawa ndimankhwala ena kungakhudzire thanzi lanu. Dokotala wanu akudziwitsaninso momwe matenda anu amakhudzira dosing, komanso luso la Degarelix. Dokotala wanu akudziwitsaninso ngati kuwunika kulikonse kudzakhala kofunikira.

5. Kodi pali chiopsezo chilichonse ngati ndaphonya muyezo wa Degarelix kapena mankhwala osokoneza bongo?Phcoker

Palibe zokuchitikirani zachipatala zokhudzana ndi zoopsa zomwe zimachitika chifukwa chakusowa kapena kugwiritsidwa ntchito mopitirira muyezo pa Degarelix. Komabe, simuyenera kusiya kumwa mankhwalawa popanda kufunsa dokotala. Ngati mungaphonye mwayi wokhala ndi jakisoni wa Degarelix, itanani dokotala kuti akupatseni malangizo.

Popeza Degarelix acetate iyenera kuperekedwa ndi dokotala, ndizosowa kwambiri kuti mankhwala osokoneza bongo amatha kuchitika. Pakachitika vuto la bongo la Degarelix, komabe, ndikofunikira kuti muziyimbira foni malo anu othandizira poyizoni kapena kupita kuchipatala msanga. Khalani okonzeka kuwonetsa kapena kunena zomwe mwatenga, kuchuluka kwa zomwe mudatenga, ndi pamene mudatenga.

Peptide Degarelix ufa Ndi Mankhwala Oona Omwe Amagwiritsidwa Ntchito Khansa ya Prostate

6. Kodi ndi Zotsatira Zipi Zochuluka ndi Machenjezo omwe Degarelix Angayambitse?Phcoker

Monga ndi mankhwala ena ambiri, Degarelix angayambitse mavuto osiyanasiyana. Zotsatira zoyipa za Degarelix zimatha kukhala zofatsa kapena zowopsa, ndipo zimathanso kukhala zosakhalitsa kapena zokhazikika. Otsatirawa ndiofala Zotsatira zoyipa za Degarelix, omwe ambiri sazindikira ndi aliyense omwe amamwa mankhwalawa:

  • Ululu wammbuyo
  • Chills
  • kudzimbidwa
  • Kuchepetsa libido
  • Kusokonekera kwa Erectile
  • Kukula kwa ma testicles
  • kutsekula
  • chizungulire
  • Kuchulukitsa kukufuna kukodza pafupipafupi
  • mutu
  • Kutentha kumatentha
  • nseru
  • Kuthamanga mobwerezabwereza
  • Zochita pakhungu pamalowo jakisoni, monga ululu, kufiira, kuuma, kutupa
  • Kukwapula
  • kutopa
  • kusowa tulo
  • Kufooka
  • kulemera phindu

Ngakhale zambiri zoyipa za Degerelix pamwambazi sizili zazikulu, zimatha kubweretsa mavuto akulu ngati apitilira nthawi yayitali. Ndikofunika kuti mupeze chithandizo chamankhwala kuti muzindikire zotsatirazi zomwe zimapezeka kawirikawiri, koma zoyipa:

  • Kutupa kwachilendo
  • Mafupa amapweteketsa kapena kupweteka
  • Kupweteka kwamabele ndi kutupa
  • Zizindikiro monga chimfine, monga chifuwa, kutentha thupi, kupweteka m'mimba
  • Spike mu magazi cholesterol
  • Spike mu magazi

Popeza Degarelix amachepetsa kupanga testosterone, ikhoza kuyambitsa maselo ofiira am'magazi, mkhalidwe womwe umadziwika kuti magazi m'thupi. Zizindikiro za kuchepa kwa magazi zimaphatikizapo chizungulire, khungu lotumbulika, kutopa kosazolowereka komanso / kapena kufupika, ndikofunikira kuti mulumikizane ndi dokotala wanu nthawi yomweyo. Dokotala wanu azichita kuyezetsa magazi nthawi ndi nthawi kuti aziona kuchuluka kwa maselo ofiira m'magazi anu.

Degarelix amatinso amawonjezera ngozi ya matenda ashuga. Ngati muli ndi matenda ashuga, ndikofunikira kuti mumayezetsa pafupipafupi kuti muwone ngati ali ndi shuga.

Degarelix amanenanso kuti amawonjezera ngozi ya mafupa. Zitha kupangitsa kuti fupa lichepetse ndikusweka mosavuta. Ngati muli kale ndi mafupa am'mimba, ndikofunikira kuti mudziwitse dokotala kuti adziwe momwe matenda anu angakhudzire dgare.

Odwala ena atha kukhala ndi zovuta zina za Degarelix kupatula zomwe zidatchulidwa pamwambapa. Mukakumana ndi chisonyezo chilichonse chomwe chimakupangitsani kukhala opanda nkhawa kapena chodetsa nkhawa, ndibwino kuti muwonane ndi dokotala mosachedwa.

Dokotala angakulangizeni kuti musiye jakisoni wa Degarelix ngati mungakumane ndi vuto la mtima. Zizindikirozi zimatha kuphatikizira kupweteka pachifuwa, kuwawa kwakumbuyo kumbuyo kwanu, kumva kukakamiza kapena kutsinitsa chifuwa, nseru yayikulu, kusanza, thukuta, komanso / kapena nkhawa.

Dokotala angakulangizeninso kuti musiye kugwiritsa ntchito Degarelix ngati mungakhale ndi vuto lalikulu. Zizindikirozi zimatha kuphatikizira angioedema, yomwe imadziwika ndi mng'oma, kupuma movutikira, ndi kutupa kwa nkhope, pakamwa, manja ndi / kapena mapazi.

Pali zosiyanasiyana Chenjezo la Degarelix kukumbukira. Chimodzi mwazo ndikuti mankhwalawa amatha kudutsa madzi amthupi (masanzi, mkodzo, thukuta, ndowe). Chifukwa chake, muyenera kupewa kulola madzi amthupi anu kukumana ndi manja anu kapena khungu la munthu wina komanso ma surfes ena osachepera maola a 48 atalandira jakisoni wa Degarelix.

Osamalira amalangizidwa kuti avale magolovesi oteteza pakumayeretsa madzi amthupi a wodwala komanso mukamachapa zovala kapena zodukiza. Zovala zodetsedwa ndi zofewa ziyeneranso kutsukidwa mosiyana ndi zovala zina.

Ngakhale pali zovuta zina za Degarelix zomwe mungadandaule nazo, palinso maubwino ena a Degarelix omwe mungayang'ane nawo mukamagwiritsa ntchito mankhwalawa. M'maphunziro azachipatala, zawonetsedwa kuti jekeseni ya Degarelix imathandizira kuchepetsa mwachangu miyezo ya testosterone kuposa njira zina zodziwonera zamahomoni othandizira. Mankhwalawa nthawi zambiri samayambitsa ma testosterone oyamba omwe amachititsa kufupika kwa zizindikiro.

Ubwino wina wa Degarelix ndikuti mankhwalawa nthawi zambiri amalekeredwa bwino, kupatula Kafukufuku adawonetsa kuti mayankho omwe amapezeka jakisoni amapezeka mu 40 peresenti ya mavesi a gulu la Degarelix <1 peresenti ya gulu la leuprolide. Izi zimachitika modekha kapena zolimbitsa thupi, ndipo zidachitika makamaka jakisoni woyamba.

Zambiri zoyambirira kuchokera ku kafukufuku wazachipatala zingapo zikuwonetsa kuti poyerekeza ndi a LHRH agonists, Degarelix adalumikizidwa kupulumuka kwambiri mkati mwa 1st chaka cha chithandizo. Zowona kuti mwayi wothana ndi khansa ya prostate ndiwokwera kwambiri pogwiritsa ntchito mankhwalawa ndi imodzi mwazabwino za Degarelix zomwe zimapangitsa kuti mankhwalawa akhale oyesera.

Degarelix ndi mowa

Kumwa mowa wochepa kumawoneka kuti sikukhudza phindu kapena chitetezo cha degarelix. Komabe, muyenera kupewa kumwa mowa wambiri mukamamwa mankhwalawa.

7. KutsilizaPhcoker

Ngati inu kapena wokondedwa wanu ali ndi khansa ya Prostate, mosakayikira Degarelix chemotherapy ndi njira imodzi yabwino kwambiri yomwe mungasankhe. Chifukwa chokhacho chomwe mungaganizire kuti musankhe maopaleshoni kuposa chithandizo cha mahomoni ngati Degarelix zingakhale mtengo. Komabe, kusiyana kulikonse kwa mitengo kumaphimbidwa ndi maubwino a Degarelix.

8. ZowonjezerekaPhcoker

Muyenera kuti mukudandaula za mtengo wa Degarelix. Mtengo wapakati pachithandizo ndi Degarelix uli pafupifupi $ 4,400. Izi zikugwirizana ndi mtengo wamankhwala ena omwe amapezeka a khansa ya prostate yapamwamba. Mtengo wa jakisoni wa Degarelix wa jakisoni wa 80 mg uli pakati $ $ 519 kuti uwapatse ufa umodzi wa jakisoni. Mtengo wake umatanthauzanso mankhwala omwe mumawachezera.

Mutha kudutsanso “Degarelix mugule pa intanetiKutsatsa. Muyenera kusamala kwambiri mukamagula mankhwala pa intaneti. Onetsetsani kuti mumayang'ana moyenera zotsatira zake ndikuyesetsa mwachangu musanayitanitse mankhwala kwa ogulitsa pa intaneti. Onetsetsani kuti ogulitsa kapena mankhwala ogulitsa pa intaneti ndi ovomerezeka komanso kuti zomwe akugulitsa ndi zovomerezeka komanso zovomerezeka za mankhwalawo.

Degarelix iyenera kusungidwa kutentha. Onetsetsani kuti mwateteza mankhwalawa ku kuwala ndi chinyezi. Monga ndimankhwala ena, mupewe Degarelix kufikira ana.

Osataya ufa wa Degarelix mu zinyalala zam'nyumba kapena m'madzi otaika, mwachitsanzo kuchimbudzi kapena pansi pa kumira. Funsani dokotala kapena wamankhwala momwe mungatayire mankhwala omwe atha ntchito kapena osagwiritsanso ntchito.

Zothandizira

  1. Van Poppel H, Tombal B, et al (October 2008). Degarelix: buku lotchedwa gonadotropin-releasing hormone (GnRH) receptor blocker - limapezeka mchaka chimodzi, chamitundu yambiri, chosasinthika, gawo lachiwiri la kafukufuku wopeza khansa ya prostate. EUR. Uroli. 54: 805-13.
  2. US National Library of Medicine National Institutes of Health, Kuwunika kosagwiritsa ntchito mtengo wa degarelix pochiza khansa yapamwamba yodalira ma prostate ku United Kingdom, Lee D1, Porter J, Brereton N, Nielsen SK, 2014 Apr; 17 (4 (233) ): 47-XNUMX.
  3. Gittelman M, Pommerville PJ, Persson BE, et al (2008). Chaka cha 1, cholembera chotseguka, osankha gawo la II lomwe limapeza kuphunzira kwa Refarelix pochiza khansa ya Prostate ku North America. J. Urol. 180: 1986-92.