L - (+) - Ergothioneine (EGT) (497-30-3)

March 15, 2020

Ergothioneine ndi amino acid mwachilengedwe ndipo ndimomwe amachokera ku thiourea wa histidine, wokhala ndi atomu ya sulfure pa …… ..


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

 

L - (+) - kanema wa Ergothioneine (EGT) (497-30-3)

L - (+) - Ergothioneine (EGT) ufa Szizindikiro

Name mankhwala L - (+) - Ergothioneine (EGT)
Mankhwala Name ERGOTHIONEINE;

L-Ergothioneine;

Chisomo;

L ergothioneine

Brand NAme N / A
Kalasi ya Mankhwala N / A
Nambala ya CAS 497-30-3
InChIKey Kufotokozera: SSISHJJTAXXQAX-ZETCQYMHSA-N
Maselo Fmphutsi C9H15N3O2S
Maselo Wasanu ndi atatu 229.3 g / mol
Misa ya Monoisotopic 229.088498 g / mol
Malo otentha  N / A
Fkubwezeretsanso Pmafuta N / A
Halimo Half-Life N / A
mtundu Zera kapena zoyera
Szovuta  Sungunuka m'madzi (mpaka 10 mg / ml)
Smazunzo Tkutentha  -20 ° C
Amalingaliro l ergothioneine ufa wagwiritsira ntchito zowonjezera thanzi

 

L - (+) - Ergothioneine (EGT) (497-30-3) Mwachidule

Ergothioneine ndi amino acid mwachilengedwe ndipo ndimachokera ku thiourea wa histidine, wokhala ndi atomu ya sulfure pamphete ya imidazole. Izi zimapangidwa ndi zinthu zochepa, makamaka Actinobacteria, Cyanobacteria, ndi bowa wina. Ergothioneine imafuna wonyamula, EGT, yemwenso amadziwika kuti OCTN1 (chizindikiro cha jini SLC22A4), kuti alowe m'maselo. Kufotokozera kwa EGT kwatsimikiziridwa m'mizere yamunthu ndi nyama ndipo kuthekera kwake kotenga ergothioneine kwatsimikiziridwa mu vivo.

L-ergothioneine ndi mwachilengedwe amino acid ndipo ndi thiol / thione yotengera histidine. L-ergothioneine imapezeka kwambiri pama bowa komanso mabakiteriya ndipo amachepetsa kwambiri muzakudya zina kuphatikiza mfumu nkhanu, ng'ombe, nkhumba, mwanawankhosa, ndi nkhuku.

Ngakhale kukhalapo kwa L-ergothioneine mu zakudya zomwe anthu amadya, biosynthesis yake imawonedwa mu mabakiteriya ena ndi bowa.

 

Kodi L - (+) - Ergothioneine (EGT) ?

L-Ergothioneine ndi amino acid yemwe amapezeka makamaka mu bowa, komanso King Crab, nyama ya nyama zomwe zadyera pa udzu wokhala ndi ergothioneine, ndi zakudya zina. Ma amino acid ndi mankhwala omwe amapanga mapuloteni. Ergothioneine amagwiritsidwa ntchito ngati mankhwala.

Anthu amatenga ergothioneine chifukwa cha kuwonongeka kwa chiwindi, ng'ala, matenda a Alzheimer's, matenda ashuga, ndi matenda amtima.

L - (+) - ERGOTHIO ndi chiral amino-acid antioxidant wachilengedwe wachilengedwe mwa mabacteria ena ndi fungi. Ndi phula lofunikira la bioactive lomwe lakhala likugwiritsidwa ntchito ngati scavenger yosalala, chosefera cha ray ya ultraviolet, chowongolera cha kusintha kwa oxidation-kuchepetsa komanso ma cell a bioenergetics, ndi cytoprotector ya thupi, ndi zina zambiri.

L-Ergothioneine nthawi zina amagwiritsidwa ntchito mwachindunji pakhungu pofuna kupewa makwinya, kuchepetsa khungu la ukalamba, komanso kuchepetsa kuwonongeka kwa dzuwa.

 

L - (+) - maubwino a Ergothioneine (EGT)

L-ergothioneine ndiyopadera mwakuti imatha kufikira pakati penipeni pa maselo ena monga erythrocyte, mosiyana ndi ma antioxidants ena apamwamba monga mavitamini C ndi E. Alidi ndi jini yomwe imakhala ndi mapuloteni onyamula, ndikuwathandizira kuti atenge kumanja mtima wamaselo. Chifukwa chake ili ndi antioxidant wamphamvu kwambiri, wofunika monga L-glutathione. Kuphatikiza apo, adawonetsedwanso kuti ndi chelator wamphamvu, amathandizira kuti amange zitsulo zoopsa, pomwe amateteza maselo am'magazi kuti asawonongeke.

Polimbikitsidwa ndi katundu wake wa antioxidant, ofufuza adafufuza zotsatira zake zotsutsa, popeza ergothioneine amachita, pakati pa ena, pro-yotupa ya cytokine, interleukin. L - (+) - Ergothioneine (EGT) kotero ali ndi malo ambiri ogwira ntchito mthupi la munthu:

  • bongo limagwira ma molekyulu a oxygen (ma radicals aulere), potero kuthana ndi kupsinjika kwa oxidative ndikuchepetsa kuwonongeka kwa mitochondrial DNA, makutidwe ndi okosijeni a mapuloteni ndi lipid peroxidation;
  • Chelates - kapena misampha - zida zosiyanasiyana zachitsulo;
  • Amatha kuyambitsa ma enzyme a antioxidant monga glutathione peroxidase kapena SOD, kwinaku akuletsa ma enzyme omwe amapanga superoxide kwakukulu;
  • Amachepetsa makutidwe ndi okosijeni amitundu yambiri ya haemoprotein monga hemoglobin ndi myoglobin;
  • Kuteteza mitochondria;
  • L-ergothioneinereducer zovulaza zazing'onoting'ono za UV, monga zoteteza ku Khungu Lathu.
  • Amasunga ndikuwonetsetsa kuti ma antioxidants ena monga mavitamini C ndi E, glutathione ndi SOD;
  • Chimateteza ubongo ku ma neurotoxins motero umagwira gawo lopewa kuchepa kwamphamvu;
  • Imalimbikitsa kupuma kwam'magazi ndi lipolysis yamafuta, motero imawonjezera mphamvu ndi nyonga zolimbitsa thupi;
  • Akaphatikizidwa ndi hyaluronic acid, glucosamine, collagen, adawonetsedwa kuti amachepetsa kwambiri kupweteka kwamalumikizidwe ndikuwonjezera kuyenda molumikizana, komwe kumalumikizidwa makamaka ndi zizolowezi zoyipa zapambuyo pake, patatha milungu isanu ndi umodzi yokha.

 

L - (+) - Ergothioneine (EGT) chitetezo

Ngakhale l-ergothioneine amagawana dzina ndipo amatha kubwera kuchokera ku bowa wa ergot, siowopsa m'njira iliyonse.

European Union ili ndi miyezo yolimbikitsira kuposa United States ndipo yatsimikiza kuti l-ergothioneine zowonjezera zimakhala zotetezeka ndipo sizikukuyambitsa mavuto akulu mwa ana ndi ana opitilira apo.

Panel on Dietetic Products for the European Food Safety Authority ipeza kuti malire otetezeka tsiku ndi tsiku a 2.82 mg / kg ya kulemera kwa thupi kwa makanda, 3.39 mg / kg kwa ana aang'ono, ndi 1.31 mg / kg kwa akuluakulu, kuphatikizapo amayi oyembekezera komanso oyamwitsa.

 

L - (+) - ufa wa Ergothioneine (EGT) ntchito ndi kugwiritsa ntchito

Zakudya zoyenera ndi / kapena zakudya zophatikizidwa kuphatikiza mavitamini okhala ndi moyo wautali monga L-ergothioneine yowonjezera kungachepetse chiwopsezo chachikulu cha matenda osatha komanso kukalamba msanga.

L-ergothioneine ufa ndi njira yabwino yothandizira kukalamba wathanzi, zakudya zopatsa thanzi.

Kafukufuku akuwonetsa kuti antioxidant ya EGT imagwira ntchito ngati anti-yoteteza kuti iziteteze ma cell ku matenda amthupi ndi neurodegenerative.

  1. Kutupa

Kafukufuku akuwonetsa kuti monga antioxidant, EGT ikhoza kuteteza motsutsana ndi kutupa.

Rheumatoid nyamakazi ndi vuto la autoimmune lomwe limadziwika chifukwa cha kutupa kwambiri (ndipo nthawi zambiri sikumafotokozedwa).

Ndizotheka kuti EGT ichepetse kutupa kwa odwala omwe ali ndi nyamakazi.

  1. Matenda a Neurodegenerative

Monga cytoprotectant, EGT ndiwowonjezera wodziwika pakati pa odwala a Alzheimer's and Parkinson.

EGT imathandizira chitetezo chamthupi cha thupi lanu ndipo imatha kuteteza ma cell am'magazi ku zipsyinjo zowononga komanso kupsinjika kwa zopitilira muyeso zaulere.

Poteteza maselo a muubongo, njira yake yolepheretsa kufera kwa ma cell muubongo ndi kuteteza ku matenda a neurodegenerative.

  1. Matenda a Chiwindi

Chifukwa cha cytoprotectant ndi antioxidant, EGT ndimakonda amino acid mwa odwala matenda a chiwindi.

  1. Ukalamba Wokalamba

Nthawi zambiri mumapeza EGT muzinthu zambiri zosamalira khungu chifukwa cha cytoprotectant ndi antioxidant - yomwe ingateteze khungu la khungu kuwonongeka kwa okosijeni.

Zowonongeka zaulere zamavuto ndi kupsinjika kwa oxidative ndizomwe zimathandizira kukalamba msanga, khungu lotupa, ndi makwinya.

  1. Matenda Aakulu

Dipatimenti Yachitetezo ku US idapereka ndalama zokwanira $ 1.34 miliyoni kwa ofufuza ku Yunivesite ya Colorado kuti aphunzire njira ya antioxidant ya EGT yolimbana ndi matenda am'mapapu polimbana ndi ma veterans.

 

Reference:

  • Oumari M, et al. Kusintha kwa ergothioneine pambuyo pochita ndi singlet oxygen. Free Radic Biol Med. 2019 Apr; 134: 498-504.
  • Cheah, LK, Halliwell, B. Ergothioneine; antioxidant angathe, zokhudza thupi ntchito ndi udindo matenda, Biochim. Ma biophys. Acta 2012; (5): 784-793.
  • Genghof, DS Biosynthesis wa Ergothioneine ndi Hercynine wa. Fungi ndi Actinomycetales, J. Bacteriol., 1970; 103 (2): 475-478.
  • Refine, JE, Elkins, ND Zotsatira za ergothioneine pa kuvulala kwam'mapapo komanso kutupa m'matumbo a cytokine osagwirizana, Prev. Med. 2012; (54): S79-S82.
  • Gulu la EFSA pa Zakudya Zamadzimadzi, Zakudya Zabwino ndi Ziwengo (2017). "Chidziwitso chachitetezo cha l-ergothioneine ngati chakudya chatsopano - zowonjezerapo zakudya komanso kuwunika kwa chitetezo kwa makanda ndi ana aang'ono, amayi apakati ndi oyamwitsa". Zolemba za EFSA. 15 (11): 5060. onetsani: 10.2903 / j.efsa.2017.5060.