Pyrroloquinoline quinone (PQQ) (72909-34-3)

March 11, 2019
SKU: 108-09-8
5.00 kuchokera 5 kutengera 1 kasitomala mlingo

Pyrroloquinoline quinone (PQQ), wotchedwanso methoxatin, ndi redox cofactor. Imapezeka mu dothi komanso zakudya monga kiwifruit, monga …… ..


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

Kanema wa Pyrroloquinoline quinone (PQQ) (72909-34-3)

Zambiri za Pyrroloquinoline quinone (PQQ) (72909-34-3)

Name mankhwala Pyrroloquinoline quinone (PQQ)
Mankhwala Name Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

Nambala ya CAS 72909-34-3
InChIKey MMXZSJMASHPLLR-UHFFFAOYSA-N
MUZIKONDWERETSA C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
Molecular Formula C14H6N2O8
Kulemera kwa maselo 330.21
Misa ya Monoisotopic 330.012415 g / mol
Boliing Point 1018.6 ± 65.0 ° C (Wonenedweratu)
Mowala 569.8 ° C (1,057.6 ° F; 842.9 K)
kachulukidwe 1.963 ± 0.06 g / cm3 (Zanenedweratu)
mtundu Orange-Red Solid
Kusunga temp 2-8 ° C
Kutupa Sungunulani m'madzi
ntchito PQQ imanenedwa kuti imagwira ntchito ngati madzi osungunuka a vitamini / cofactor komanso monga antioxidant. Amapangidwanso kuti azigwiritsa ntchito pazakudya zamagetsi, monga mphamvu, kusintha chakudya, ndi mipiringidzo yokhala ndi mipanda yolimba etc.

Kodi Pyrroloquinoline quinone(PQQ)?

Pyrroloquinoline quinone (PQQ), wotchedwanso methoxatin, ndi redox cofactor. Imapezeka mu dothi komanso zakudya monga kiwifruit, komanso mkaka wa m'mawere wa anthu. Pyrroloquinoline quinone ndi magulu a pyrroloquinoline okhala ndi magulu a oxo kumalo a 4- ndi 5-magulu ndi gulu la carboxy pamalo a 2-, 7- ndi 9. Ili ndi gawo ngati mavitamini osungunuka ndi madzi komanso cofactor. Ndipo, imagwiritsa ntchito ma protein a kinase omwe akukhudzidwa ndi kusiyanasiyana kwa maselo am'mimba. Kuthekera kwakukulu kwa kubwezeretsa kwa redox ya PQQ kungapatsenso gawo lazamankhwala kuteteza motsutsana ndi neurodegeneration ndi khansa. (Monga othandizanso wa redox, Pyrroloquinoline quinone ndi wokhazikika kwambiri ndipo amatha kutenga nawo gawo pazokambirana zambiri kuposa ma antioxidants ena, monga ascorbic acid, quercetin, ndi epratechin.

Pyrroloquinoline quinone ndi buku la biofactor, ndipo amadziwika kuti ndi cofactor wa enzyme m'mabakiteriya. Kafukufuku akuwonetsa kuti Pyrroloquinoline quinone atha kukhalapo ponseponse pakubadwa kwachidziwitso komanso chisinthiko. Monga chomera champhamvu chomera, chilli pakukula kwa nyama ndi anthu. Pyrroloquinoline quinone akuti amatenga nawo mbali zosiyanasiyana zamagulu okhala ndi phindu lodziwoneka kuti limapulumuka (mwachitsanzo, kukula kwamakono a neonatal ndi magwiridwe antchito) zolengedwa.

Komanso, Pyrroloquinoline quinone ali ndi zochita za antioxidant ndi B-vitamini, wokhala ndi zabwino zambiri muubongo ndi thupi. Imalimbikitsa thanzi labwino komanso kukumbukira pokumana ndi kukanika kwa mitochondrial ndikuteteza ma neurons kuti awonongeke. Kafukufuku wazachipatala mwa anthu awonetsa kuti Pyrroloquinoline quinone imathandizira kukumbukira kwakanthawi komanso chidwi, kusintha kagayidwe kake ka mphamvu ndi ukalamba wathanzi, ndikuchepetsa chizindikiro cha kutupa, komanso kukonza malingaliro akumunthu wabwino.

Kodi Pyrroloquinoline amachita bwanji quinone(PQQ) ntchito?

Kafukufuku wamtundu akuwonetsa kugwira bwino ntchito kwa Pyrroloquinoline quinone polimbikitsa mitochondrial biogeneis. Rat hepatocytes omwe aphatikizidwa ndi PQQ pa 10-30 μM pa 24- 48 h yowonetsedwa "kuchuluka kwa citrate synthase ndi cytochrome c oxidase zochita, Mitotracker Madingidwe, mitochondrial DNA, komanso kupuma kwa ma cell. Kuphatikizidwa kwa njirayi kunachitika kudzera mwa kuphatikiza mapuloteni othandizira a cAMP (CREB) ndi peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), njira yodziwika bwino yoyendetsera mitochondrial biojiais. ” M'maphunziro a vivo m'makoma amawonetsanso zopindulitsa kuchokera pazowonjezera zakudya ndi PQQ (2mg PQQ / kg ya chakudya). Izi zimaphatikizapo kuchepa kwa plasma triglycerides, kuchuluka kwa mphamvu yamagetsi (yolumikizidwa ndi hepatic mitochondrial nkhani), komanso kulolerana kwa mtima ndi ischemia / reperfusion. Mitundu yoyesera ya kuvulala kwam'mimba ndi kuvulala kwa chingwe chikuwonetsa kuti Pyrroloquinoline quinone imayambitsa kufa kwa maselo a neuronal, mwa gawo kudzera mwa Pyrroloquinoline quinone yoteteza ma N-methyl-d-aspartic acid (NMDA) receptors. Mitundu yamatenda a Parkinson imawonetsa kuti Pyrroloquinoline quinone supplementation imachepetsa kuchepa kwa mitsempha, imawonjezera kuthekera kwa mitundu ya okosijeni mothandizika, komanso kupatsanso mphamvu njira zina.

Phindu la Pyrroloquinoline quinone(PQQ) maubwino

Mu ubongo ndi thupi, PQQ ili ndi maubwino osiyanasiyana.

- PQQ imachirikiza ntchito yoyenera ya mitochondrial

Mitochondria ndi omwe amapanga mphamvu m'maselo athu ndipo amatenga gawo lofunikira mu thanzi lathunthu. PQQ poteteza mitochondria yomwe ilipo ndikulimbikitsa m'badwo wa mitochondrial, chifukwa chake lipangeni ATP (Energy). Zambiri zogwira ntchito mitochondria, mphamvu zambiri.

- PQQ imathandizira kukula kwa mitsempha

PQQ imathandizira kupanga Nerve Kukula Factor (NGF.), Imateteza ndikubwezeretsa maselo owonongeka muubongo ndi mitsempha, motero imalepheretsa kuchepa kwamtunduwu (kuiwala kukumbukira, kuvuta kuphunzira, ndi zina zambiri) chifukwa cha ukalamba, sitiroko kapena vuto la neurodegenerative, ndikulimbikitsa chitetezo cha m'thupi komanso antioxidant ntchito, ndi kutetezedwa ku zochitika zamtima ndi zamanjenje.

- PQQ imaletsa kupsinjika kwa oxidative

PQQ imapereka chitetezo champhamvu cha antioxidant, chimateteza maselo mthupi kuchokera ku kuwonongeka kwa oxidative komanso kuwononga ma radicals aulere. Imathandizira kagayidwe ka mphamvu ndi ukalamba wathanzi, ndikuyang'ana buku la cofactor lomwe lili ndi antioxidant ndi B zochita ngati.

Kupatula apo, PQQ ikhoza kukhalanso ndi kupewa ndikuchiza kuwonongeka kwa chiwindi komanso ntchito yolimba ya anticancer.

Kugwiritsa / ntchito kwa Pyrroloquinoline quinone(PQQ)

Pakafukufuku wa 2009 wofalitsidwa mu magazini ya zamankhwala a Food kale, Pyrroloquinoline Quinone adawonetsedwa kuti ali ndi kuthekera kothandiza kuteteza. Itha kugwiritsidwa ntchito pochiza kuchepa kwamkati (kukumbukira kukumbukira, kuvuta kuphunzira, ndi zina) chifukwa cha ukalamba, matenda a stroko kapena minyewa ya m'mitsempha, komanso kutetezedwa ku zochitika zamtima ndi mitsempha ya ischemic. Zotsatira zofananazi zidafotokozedwa mu kafukufuku wotsatira wa 2011 momwe Pyrroloquinoline Quinone adaperekedwanso mwachindunji ngati zowonjezera pazakudya, monga zakumwa zozikidwa mkaka zokhala ndi mkaka.

Momwe mungakwaniritsire Pyrroloquinoline quinone(PQQ)?

M'moyo, mutha kupeza PQQ kuchokera ku zakudya zina zowawidwa, zimakhalapo mwachilengedwe mu zakudya ndi zakumwa zingapo, kuphatikizapo tsabola wobiriwira, parsley, tiyi kapena kiwifruit etc. Komabe, ngati muwerenge kuchuluka kwa chakudya chomwe munthu amadya tsiku lililonse, ambiri a ife sitingapeze PQQ yokwanira kuchokera ku chakudya chathu chatsiku ndi tsiku. Chifukwa chake, ngati mukufuna maubwino ambiri, mutha kupeza zambiri za PQQ mwa njira zina, monga PQQ yowonjezera zakudya.

Tsamba:

  • Drain, Kelsey (12 February 2017). "Antioxidant Wachilengedwe Amatha Kupewa Matenda A chiwindi". msn.com. Zabwezedwa 14 February 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "Pyrroloquinoline quinone: chimbudzi cha methylotrophs ndikukula kwa kukula kwa tizilombo". BioFactors. 1 (1): 51–3. PMID 2855583.
  • Felton LM, Anthony C (2005). "Biochemistry: Gawo la PQQ monga mamiliyoni enzyme cofactor?". Zachilengedwe. 433 (7025): E10, kukambirana E11-2. doi: 10.1038 / nature03322. PMID 15689995.
  • Westerling J, Frank J, Duine JA (1979). "Gulu lopangira ma methanol dehydrogenase kuchokera ku Hyphomicrobium X: umboni wa ma resonance a" quinone ". Biochem Biophys Res Commun. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline quinone-based dehydrogenases of acetic acid bacteria.Appl Microbiol Biotechnol. 2018 Nov; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.

KULAMBIRA NDI KUSINTHA:

Nkhaniyi Ikagulitsidwa Kugwiritsa Ntchito Kafukufuku kokha. Migwirizano Yogulitsa. Osati Zongogwiritsa Ntchito Anthu, kapena Zamankhwala, Zoweta Zanyama, kapena Zogwiritsa Ntchito Panyumba.