Pyrroloquinoline quinone (PQQ) (72909-34-3)

March 11, 2019

Pyrroloquinoline quinone (PQQ), yotchedwanso methoxatin, ndi redox cofactor. Amapezeka m'nthaka ndi zakudya monga kiwifruit, monga …… ..

 


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

 

Kanema wa Pyrroloquinoline quinone (PQQ) (72909-34-3)

Zambiri za Pyrroloquinoline quinone (PQQ) (72909-34-3)

Name mankhwala Pyrroloquinoline quinone (PQQ)
Mankhwala Name Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

Nambala ya CAS 72909-34-3
InChIKey Gawo #: MMXZSJMASHPLLR-UHF
MUZIKONDWERETSA C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
Molecular Formula C14H6N2O8
Kulemera kwa maselo 330.21
Misa ya Monoisotopic 330.012415 g / mol
Malo Otsatira 1018.6 ± 65.0 ° C (Wonenedweratu)
Mowala 569.8 ° C (1,057.6 ° F; 842.9 K)
kachulukidwe 1.963 ± 0.06 g / cm3 (Zanenedweratu)
mtundu Olimba-Ofiira Olimba
Kusunga temp 2-8 ° C
Kutupa Sungunulani m'madzi
ntchito PQQ imanenedwa kuti imagwira ntchito ngati madzi osungunuka a vitamini / cofactor komanso monga antioxidant. Amapangidwanso kuti azigwiritsa ntchito pazakudya zamagetsi, monga mphamvu, kusintha chakudya, ndi mipiringidzo yokhala ndi mipanda yolimba etc.

 

Kodi Pyrroloquinoline quinone(PQQ)?

Pyrroloquinoline quinone (PQQ), wotchedwanso methoxatin, ndi redox cofactor. Imapezeka mu dothi komanso zakudya monga kiwifruit, komanso mkaka wa m'mawere wa anthu. Pyrroloquinoline quinone ndi magulu a pyrroloquinoline okhala ndi magulu a oxo kumalo a 4- ndi 5-magulu ndi gulu la carboxy pamalo a 2-, 7- ndi 9. Ili ndi gawo ngati mavitamini osungunuka ndi madzi komanso cofactor. Ndipo, imagwiritsa ntchito ma protein a kinase omwe akukhudzidwa ndi kusiyanasiyana kwa maselo am'mimba. Kuthekera kwakukulu kwa kubwezeretsa kwa redox ya PQQ kungapatsenso gawo lazamankhwala kuteteza motsutsana ndi neurodegeneration ndi khansa. (Monga othandizanso wa redox, Pyrroloquinoline quinone ndi wokhazikika kwambiri ndipo amatha kutenga nawo gawo pazokambirana zambiri kuposa ma antioxidants ena, monga ascorbic acid, quercetin, ndi epratechin.

Pyrroloquinoline quinone ndi buku la biofactor, ndipo amadziwika kuti ndi cofactor wa enzyme m'mabakiteriya. Kafukufuku akuwonetsa kuti Pyrroloquinoline quinone atha kukhalapo ponseponse pakubadwa kwachidziwitso komanso chisinthiko. Monga chomera champhamvu chomera, chilli pakukula kwa nyama ndi anthu. Pyrroloquinoline quinone akuti amatenga nawo mbali zosiyanasiyana zamagulu okhala ndi phindu lodziwoneka kuti limapulumuka (mwachitsanzo, kukula kwamakono a neonatal ndi magwiridwe antchito) zolengedwa.

Komanso, Pyrroloquinoline quinone ali ndi zochita za antioxidant ndi B-vitamini, wokhala ndi zabwino zambiri muubongo ndi thupi. Imalimbikitsa thanzi labwino komanso kukumbukira pokumana ndi kukanika kwa mitochondrial ndikuteteza ma neurons kuti awonongeke. Kafukufuku wazachipatala mwa anthu awonetsa kuti Pyrroloquinoline quinone imathandizira kukumbukira kwakanthawi komanso chidwi, kusintha kagayidwe kake ka mphamvu ndi ukalamba wathanzi, ndikuchepetsa chizindikiro cha kutupa, komanso kukonza malingaliro akumunthu wabwino.

 

Kodi Pyrroloquinoline amachita bwanji quinone(PQQ) ntchito?

Kafukufuku wamakoswe amawonetsa kugwira ntchito kwa Pyrroloquinoline quinone polimbikitsa mitochondrial biogenesis. Makoswe a hepatocyte omwe amakhala ndi PQQ pa 10-30 μM kwa 24-48 h adawonetsa "kuchuluka kwa citrate synthase ndi cytochrome c oxidase ntchito, Mitotracker kudetsa, DNA ya mitochondrial, komanso kupuma kwa ma oxygen. Kulowetsedwa kwa njirayi kudachitika poyambitsa puloteni yoletsa kuyankha kwa cAMP (CREB) ndi peroxisome proliferator-activated receptor-γ coactivator-1cy (PGC-1cy), njira yodziwika kuti ikuthandizira kusintha kwa mitochondrial biogenesis. ” M'maphunziro a vivo mu makoswe amawonetsanso zopindulitsa kuchokera ku zowonjezera zakudya ndi PQQ (2mg PQQ / kg ya chakudya). Izi zikuphatikiza kuchepa kwa plasma triglycerides, kuchuluka kwa mphamvu zamagetsi (zolumikizidwa ndi zomwe zili ndi hepatic mitochondrial), komanso kupirira kulolera kwa mtima ischemia / reperfusion. Zoyeserera zoyeserera za sitiroko ndi msana zikuwonetsa kuti Pyrroloquinoline quinone imachepetsa kufa kwa cell ya neuronal, mwa njira ina kudzera mwa Pyrroloquinoline quinone yoteteza ma N-methyl-d-aspartic acid (NMDA) receptors. Mitundu yamatenda a matenda a Parkinson ikuwonetsa kuti Pyrroloquinoline quinone supplementation imachepetsa kutaya kwa mitsempha, imawonjezera mitundu yama oksijeni yowonongeka, komanso imapereka chitetezo champhamvu kudzera munjira zina.

 

Phindu la Pyrroloquinoline quinone(PQQ) maubwino

Mu ubongo ndi thupi, PQQ ili ndi maubwino osiyanasiyana.

- PQQ imachirikiza ntchito yoyenera ya mitochondrial

Mitochondria ndi omwe amapanga mphamvu m'maselo athu ndipo amatenga gawo lofunikira mu thanzi lathunthu. PQQ poteteza mitochondria yomwe ilipo ndikulimbikitsa m'badwo wa mitochondrial, chifukwa chake lipangeni ATP (Energy). Zambiri zogwira ntchito mitochondria, mphamvu zambiri.

- PQQ imathandizira kukula kwa mitsempha

PQQ imathandizira kupanga Nerve Kukula Factor (NGF.), Imateteza ndikubwezeretsa maselo owonongeka muubongo ndi mitsempha, motero imalepheretsa kuchepa kwamtunduwu (kuiwala kukumbukira, kuvuta kuphunzira, ndi zina zambiri) chifukwa cha ukalamba, sitiroko kapena vuto la neurodegenerative, ndikulimbikitsa chitetezo cha m'thupi komanso antioxidant ntchito, ndi kutetezedwa ku zochitika zamtima ndi zamanjenje.

- PQQ imalepheretsa kupsyinjika kwa okosijeni

PQQ imapereka chitetezo champhamvu cha antioxidant, chimateteza maselo mthupi kuchokera ku kuwonongeka kwa oxidative komanso kuwononga ma radicals aulere. Imathandizira kagayidwe ka mphamvu ndi ukalamba wathanzi, ndikuyang'ana buku la cofactor lomwe lili ndi antioxidant ndi B zochita ngati.

Kupatula apo, PQQ ikhoza kukhalanso ndi kupewa ndikuchiza kuwonongeka kwa chiwindi komanso ntchito yolimba ya anticancer.

Kugwiritsa / ntchito kwa Pyrroloquinoline quinone(PQQ)

Pakafukufuku wa 2009 wofalitsidwa mu magazini ya zamankhwala a Food kale, Pyrroloquinoline Quinone adawonetsedwa kuti ali ndi kuthekera kothandiza kuteteza. Itha kugwiritsidwa ntchito pochiza kuchepa kwamkati (kukumbukira kukumbukira, kuvuta kuphunzira, ndi zina) chifukwa cha ukalamba, matenda a stroko kapena minyewa ya m'mitsempha, komanso kutetezedwa ku zochitika zamtima ndi mitsempha ya ischemic. Zotsatira zofananazi zidafotokozedwa mu kafukufuku wotsatira wa 2011 momwe Pyrroloquinoline Quinone adaperekedwanso mwachindunji ngati zowonjezera pazakudya, monga zakumwa zozikidwa mkaka zokhala ndi mkaka.

 

Momwe mungakwaniritsire Pyrroloquinoline quinone(PQQ)?

Mmoyo, mutha kupeza PQQ kuchokera pazakudya zina sourse, mwachilengedwe zimapezeka mu zakudya ndi zakumwa zosiyanasiyana, kuphatikiza tsabola wobiriwira, parsley, tiyi kapena kiwifruit ndi zina zambiri. Komabe, ngati muwerenga kuchuluka kwa chakudya chomwe munthu amadya tsiku lililonse, ambiri aife sitingapeze PQQ yokwanira pazakudya zathu za tsiku ndi tsiku. Chifukwa chake, ngati mukufuna zabwino zambiri, mutha kupeza PQQ yochulukirapo m'njira zina, monga PQQ zowonjezera zakudya.

 

Tsamba:

  • Kukhetsa, Kelsey (12 February 2017). "Antioxidant Yachilengedwe Ikhoza Kuletsa Matenda A chiwindi". msn.com. Kubwezeretsedwa 14 February 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "Pyrroloquinoline quinone: chimbudzi cha methylotrophs ndikukula kwa kukula kwa tizilombo". BioFactors. 1 (1): 51–3. PMID 2855583.
  • Felton LM, Anthony C (2005). "Sayansi yamankhwala am'madzi: gawo la PQQ ngati cofactor wa mammalian enzyme?". Chilengedwe. 433 (7025): E10, kukambirana E11–2. onetsani: 10.1038 / nature03322. MAFUNSO OTHANDIZA:
  • Westerling J, Frank J, Duine JA (1979). "Gulu lopangira methanol dehydrogenase lochokera ku Hyphomicrobium X: umboni wa electron spin resonance wa kapangidwe ka quinone". Chilengedwe Biophys Res Commun. 87 (3): 719–24. onetsani: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline quinone-based dehydrogenases of acetic acid bacteria.Appl Microbiol Biotechnol. 2018 Nov; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.