J-147 ufa

April 2, 2021

J147 ndi mankhwala oyesera omwe ali ndi zotsatira zotsutsana ndi matenda a Alzheimer's komanso ukalamba mu zitsanzo za mbewa za ukalamba wofulumira. Ndiwochokera ku curcumin komanso wogwiritsa ntchito mankhwala amphamvu a neuroogenic ndi neuroprotective omwe adapangidwa poyamba kuti athe kuchiza matenda a neurodegenerative okhudzana ndi ukalamba omwe amakhudza njira zambiri zomwe zimakhudzidwa ndi matenda a shuga a neuropathy.


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 105kg / mwezi

J-147 ufa (1146963-51-0) kanema

 

J-147 ufa (1146963-51-0) Zolemba

Name mankhwala J-147 ufa
Mafananidwe J147; j 147; N-(2,4-Dimethylphenyl) -2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide
Nambala ya CAS 1146963-51-0
Kalasi ya Mankhwala Palibe deta yomwe ilipo
InChI Mfungulo HYMZAYGFKNNHDN-SSDVNMTOSA-N
MUZIKONDWERETSA CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)N=CC2=CC(=CC=C2)OC)C
Molecular Formula C18H17F3N2O2
Kulemera kwa maselo 350.341 g / mol
Misa ya Monoisotopic 350.124 g / mol
Melting Point Palibe deta yomwe ilipo
Malo otentha Palibe deta yomwe ilipo
Ekusiya theka la moyo Palibe deta yomwe ilipo
mtundu Yoyera mpaka wofiira
Kutupa DMSO (> 30 mg/ml) kapena EtOH (> 30 mg/ml)
Stempage temp refrigerate
ntchito mankhwala oyesera omwe ali ndi zotsatira zotsutsana ndi matenda a Alzheimer's komanso ukalamba m'mawonekedwe a mbewa a ukalamba wofulumira

 

Chidule cha J-147

J-147 ufa unayamba kukhala mu 2011 ku Cellular Neurobiology Laboratory ya Salk Institute. Chiyambireni kuyambika kwake, pakhala pali maphunziro ambiri omwe amatsimikizira kuti amagwira bwino ntchito pochiza matenda a Alzheimer's komanso kubwezeretsa ukalamba.

Dr. Dave Schubert ndi omwe adafufuza nawo ku Salk Institute adachita mbali yayikulu pophunzira za J-147 curcumin. Mu 2018, ma neurobiologists adafukula momwe J-147 imagwirira ntchito nootropic ndi gawo lake pakuwongolera matenda amitsempha.

Kafukufuku ndi kafukufuku wa mankhwalawa akukhazikika pa kufunikira kwake pakuwongolera matenda a Alzheimer's. Komabe, ogwiritsa ntchito athanzi akhala ndi chidwi ndi zabwino za J-147 monga kukulitsa kukumbukira, kukulitsa luso la kuphunzira, ndi kutsitsimuka kwa ma neuron.

Mu 2019, asayansi adayesa kuyesa mankhwala a J-147 Alzheimer's pa anthu.

 

Kodi Nootropic J-147 Powder ndi chiyani?

J-147 ufa umachokera ku curcumin ndi Cyclohexyl-Bisphenol A. Mankhwala osokoneza bongo ali ndi mphamvu zowonongeka komanso zowonongeka. Mosiyana ndi ma nootropics ambiri, J-147 anti-aging supplement imapangitsa kuzindikira popanda kukhudza acetylcholine kapena phosphodiesterase enzymes.

Curcumin ndi gawo lamtundu wa turmeric ndipo ndiwothandiza kuthana ndi matenda amanjenje. Komabe, polyphenol iyi sichidutsa chotchinga cha magazi ndi ubongo moyenera. Zotsatira zake, J-147 nootropic idakhala gawo lalikulu kwambiri pomwe imadutsa chotchinga cha magazi ndi ubongo mosavuta.

 

Kodi J-147 imagwira ntchito bwanji?

Mpaka 2018, mphamvu ya J-147 pa seloyo idakhalabe yosamvetsetseka mpaka Salk Institute Neurobiologists isanadziwe bwino. Mankhwalawa amagwira ntchito pomanga ATP synthase. Puloteni iyi ya mitochondrial imathandizira kupanga mphamvu zamagetsi, motero, kuwongolera ukalamba.

Kupezeka kwa chowonjezera cha J-147 m'dongosolo laumunthu kumaletsa poizoni wokhudzana ndi zaka zomwe zimachokera ku mitochondria yosagwira ntchito komanso kuchulukitsa kwa ATP.

Njira ya J-147 yochitira zinthu idzawonjezeranso milingo ya ma neurotransmitters osiyanasiyana kuphatikiza NGF ndi BDNF. Kupatula apo, imagwira ntchito pamagulu a beta-amyloid, omwe nthawi zonse amakhala okwera pakati pa odwala omwe ali ndi Alzheimer's ndi dementia.

Zotsatira za J-147 zikuphatikizapo kuchepetsa kupitirira kwa Alzheimer's, kuteteza kukumbukira kukumbukira, komanso kupititsa patsogolo kupanga maselo a neuronal.

 

Ubwino Wotheka wa J-147

Kukulitsa Kuzindikira

Chowonjezera cha J-147 chimathandizira kukumbukira kwakanthawi ndi kukumbukira kwakanthawi. Mankhwalawa amasintha zolakwika pakati pa okalamba omwe ali ndi vuto lakuzindikira. J-147 yogulitsa imapezeka ngati chiwongola dzanja ndipo achinyamata akutenga kuti akalimbikitse kuphunzira.

Kutenga mankhwala oletsa kukalamba a J-147 kumathandizanso kukumbukira, masomphenya, ndi kumveka bwino m'maganizo.

 

Kusamalira Matenda a Alzheimer's

J-147 amapindulitsa odwala omwe ali ndi Alzheimer's pochepetsa kuchepa kwa vutoli. Mwachitsanzo, kutenga chowonjezeracho kumachepetsa kuchepa kwa beta-amyloid (Aβ), komwe kumabweretsa kusokonezeka kwa chidziwitso. Kuphatikiza apo, J-147 curcumin imathandizira kuwonetsa ma neurotrophin kutsimikizira kupulumuka kwa mitsempha, chifukwa chake, kukumbukira kukumbukira ndi kuzindikira.

Odwala omwe ali ndi AD amakhala ndi zochepa zochepa za neurotrophic. Komabe, kutenga J-147 Alzheimer's supplement kumalimbikitsa NGF ndi BDNF. Ma neurotransmitters awa amathandizira kupanga kukumbukira, kuphunzira, ndi magwiridwe antchito.

 

neuroprotection

J-147 nootropic imalepheretsa kufa kwa neuronal komwe kumachitika chifukwa cha kupsinjika kwa okosijeni.

Chowonjezera ichi chimaletsanso kuchepa kwa ma NMDA (N-Methyl-D-aspartate) receptors, omwe amachititsa kuti magazi asatuluke.

Kutenga mankhwala a J-147 kumakulitsa zinthu zomwe zimachokera muubongo (BDNF) komanso minyewa ikukula (NGF). Ma neurotransmitters awiriwa amayendetsa matenda amitsempha monga Alzheimer's ndi dementia. Kuphatikiza apo, BDNF ndiyofunika mu neurogeneis.

 

Kuwonjezera Ntchito ya Mitochondrial

Kutenga mankhwala a J-147 kungathetseretu milingo ya ATP polimbikitsa ntchito za mitochondrial.

Kukalamba kumayambitsa kuchepa kwa mitochondria chifukwa cha kusagwira ntchito bwino komanso kuwonjezeka kwa mitundu yogwira ntchito ya okosijeni. Komabe, chowonjezera cha J-147 chimalimbana ndi njirayi poletsa ATP5A synthase. Maphunziro osawerengeka amawerengera mankhwalawa kuti atalikitse moyo wamunthu.

 

J-147 ndi Anti-ukalamba

Malinga ndi Salk Researchers, J-147 zowonjezerapo kukalamba zimapangitsa kuti maselo okalamba awonekere achichepere.

Kusagwira ntchito kwa mitochondria kumathandizira kukalamba. Ma homeostasis amachepetsa, chifukwa chake, kuchepa kwa thupi. Kuphatikizanso apo, kuwonongeka kwa maselo ndi kuwonongeka kwa mitochondrial kudzachitika chifukwa cha kupanga ROS (mitundu yama oxygen yokhazikika). Kutenga ufa wa J-147 kuthana ndi izi, chifukwa chake, kuchepa kwa senescence.

Kukalamba kumalumikizidwanso ndi kuchepa kwa chidziwitso komanso kusokonezeka kwa neurodegenerative. Komabe, zochitika zingapo za J-147 zimatsimikizira mphamvu ya mankhwalawa pobwezeretsa kukumbukira kukumbukira, kupititsa patsogolo luso lachidziwitso, komanso kuchiza matenda a dementia, Alzheimer's, ndi matenda ena okhudzana ndi ukalamba.

 

Mlingo Wokhazikika wa J-147

(1) Mlingo wokhazikika

Mlingo watsiku ndi tsiku wa J-147 umakhala pakati pa 5mg ndi 30mg. Mutha kugawa mlingo wa J-147 pawiri. Makamaka, mlingo wanu uyenera kukhala wocheperako ndikukulitsa kutengera kulekerera kwa thupi lanu.

Chowonjezera ichi chimagwira pakamwa. Muyenera kupewa kutenga madzulo kapena usiku chifukwa ena J-147 amawunikiranso kuti atha kusokoneza mawonekedwe anu ogona.

 

(2) Mlingo wodwala

Ofufuza adagwiritsa ntchito 10mg/kg ya mlingo wa J-147 pochiza matenda a Alzheimer mumitundu ya mbewa.

Komabe, mlingo wanu uyenera kudalira momwe mulili. Tengani, mwachitsanzo, ngati mutatha kupititsa patsogolo kuzindikira kwanu, muyenera kuonetsetsa kuti mumamwa 5mg mpaka 15mg. Mosiyana ndi izi, poteteza minyewa ndikuwongolera zovuta zama neurodegenerative, mutha kukulitsa mlingowu kukhala pafupifupi 20mg ndi 30mg.

M'mayesero azachipatala a J-147, ophunzirawo amatha kumwa mankhwalawa atangotsala pang'ono kusala kudya kwa maola 8.

 

Kusiyanitsa pakati pa J-147 ndi T-006

T-006 ndichotengera cha J-147 nootropic. Chipindacho chidapangidwa posintha gulu la methoxyphenyl la J-147 curcumin ufa ndi tetramethylpyrazine.

Kuonjezera ndi T-006 kwa miyezi pafupifupi itatu kumachepetsa chifunga cha muubongo ndikuwonjezera mphamvu zonse. Kuonjezera apo, ufawo umawonjezera mphamvu ya mawu ndikupangitsa wogwiritsa ntchito kukhala wodekha. Mosiyana ndi izi, zochitika za J-147 zimaphatikizapo kukumbukira bwino, masomphenya, ndi kununkhiza.

Ngakhale pali kusiyana kochepa kotereku, zowonjezera ziwirizi zimakhala ndi zotsatirapo zofanana.

 

Kodi J-147 ndiyotetezeka mukamagwiritsa ntchito?

Mankhwala a J-147 ndi otetezeka. Wapambana mayeso a poizoni m'mayesero a nyama monga amafunira a Food and Drug Administration (FDA). Kuphatikiza apo, mayesero azachipatala a J-147 akhala akuchitika kwakanthawi.

Palibe zolembedwa za zoyipa za J-147 pamayesero am'mbuyomu komanso aumunthu.

 

J-147 mayesero azachipatala

Gawo loyambirira la mayeso azachipatala a J-147 adayamba koyambirira kwa 2019 monga adathandizidwa ndi Abrexa Pharmaceuticals, Inc. Cholinga cha phunziroli chinali kuyesa chitetezo ndi kulolerana kotenga nootropic, ndi zida zake zama pharmacokinetic m'mitu yathanzi.

Kafukufuku wamankhwala anali okhudzana ndi achinyamata komanso achikulire. Gulu lofufuzirali lidasinthidwa mosiyanasiyana, khungu kawiri, ndikuwongoleredwa ndi ma placebo ndimlingo umodzi wokwera.

Pamapeto pa kuyesedwa kwaumunthu, asayansi akuyenera kukhazikitsa zotsatira zake potengera zotsatira zoyipa, kugunda kwa mtima ndi kamvekedwe, kusintha kwa thupi, ndi mapindu a J-147 pa dongosolo la mitsempha.

 

Ndemanga za ogwiritsa ntchito / zokumana nazo atagwiritsa ntchito J-147

Nawa ena mwa ndemanga za J-147;

Capybara akuti;

“… Pakhoza kukhalanso ndikumverera kwa mphamvu zambiri koyambirira. Osati mphamvu ya caffeine kapena amphetamine, koma mphamvu yowonjezera. Ndidasangalala gawo ili popeza ndimatha kuganiza zopanga zina monga kukwera njinga, ndikuzichita mosazengereza kapena kudzitsimikizira kuti ndiyamba. Kulimbikitsana ndekha kunali kopanda ntchito. Izi zidatha patatha milungu ingapo, ndipo pomwe ndidasangalala ndikumverera kotere, enanso sangatero, motero ndikulemba izi ngati zomwe zingachitike. ”

F5fireworks akuti;

“Zikuwoneka ngati nootropic yosangalatsa komanso yolonjeza. Zikuwoneka kuti ku US adachita kafukufuku wazachipatala chaka chatha. ”

Wogwiritsa wina akuti;

“Chabwino, ndalandira dzulo ndipo ndamwa kale 10mg ya mankhwala atatu. Ndinazitenga mozama ndipo zidasungunuka bwino kwambiri. Sililawa zoipa. Zotsatira zanga zidayamba mwachangu kwambiri kwa ine. Masomphenya anga ndi malingaliro anga zimawoneka zakuthwa mwanjira ina, koma atha kukhala malowa chabe. Zikuwoneka kuti sizikhala ndi vuto lililonse, koma ndi molawirira kwambiri kuti ndinene… Ndidamva zonse kukhala bwino ndikulimbikitsidwa tsiku lonse ndi 3 mg wina m'mawa pafupifupi 10 koloko m'mawa. ”

Fafner55 akuti;

"Ndikupitiliza kumwa J147 popanda phindu lililonse kupatula kufupika kwa kutupa ndi kutupa kotchulidwa kale."

 

Wopanga ufa wa J-147 - Kodi tingagule kuti ufa wa J-147?

Zovomerezeka za nootropic iyi ikadali fupa la mikangano koma sikudzakulepheretsani kupeza zinthu zovomerezeka. Kupatula apo, mayeso azachipatala a J-147 Alzheimer akuchitika. Mutha kugula ufawo m'masitolo apaintaneti mukamapeza mwayi wofananiza mitengo ya J-147 kwa ogulitsa osiyanasiyana. Komabe, muyenera kuwonetsetsa kuti mumagula kuchokera kwa ogulitsa omwe ali ndi mayeso odziyimira pawokha a labotale.

Ngati mukufuna zina za J-147 zogulitsa, fufuzani ndi kampani yathu. Timapereka ma nootropics ambiri pansi paulamuliro wabwino. Mutha kugula zambiri kapena kugula kamodzi kutengera cholinga chanu cha psychonautic. Chonde dziwani kuti mtengo wa J-147 ndi wochezeka pokhapokha mutagula malonda.

 

Zothandizira

  1. Lapchak, AP, Bombien, R., and Rajput, SP (2013). J-147 ndi Novel Hydrazide Lead Compound to Chithandizo cha Neurodegeneration: Ceetox TM Safety and Genotoxicity Analysis. Zolemba za Neurology ndi Neurophysiology.
  2. M'mbuyomu, M., et al. (2013). Neurotrophic Compound J147 Imasinthiratu Kuwonongeka Kwazidziwitso mu Matenda Aakulu a Alzheimer's. Kafukufuku & Chithandizo cha Alzheimer's.
  3. Mankhwala Osokoneza bongo a Alzheimer Amatembenuziranso Clock mu Powerhouse Cell. Salk Institute.January 8, 2018.
  4. Qi, Chen., Et al. (2011). Mankhwala Osokoneza Bongo a Kulimbikitsanso Kuzindikira ndi Matenda a Alzheimer's. Laibulale Yapagulu la Sayansi.
  5. Daugherty, DJ, ndi al. (2017). Chotulutsa cha Novel Curcumin Chithandizo cha matenda ashuga Neuropathy.
  6. Lejing, Lian., et al. (2018). Zotsatira za Anti-depressant-like za Novel Curcumin Derivative J147: Kuphatikizidwa kwa 5-HT1A Neuropharmacology.