Ursodeoxycholic acid (UDCA) ufa

January 12, 2022

Ursodeoxycholic acid (UDCA kapena Ursodiol) ndi yachiwiri ya bile acid yopangidwa ndi mabakiteriya am'matumbo m'thupi la munthu ndi mitundu ina yambiri. Amagwiritsidwa ntchito pochiza ndulu yaing'ono mwa anthu omwe sangathe kuchitidwa opaleshoni ya ndulu, komanso kuteteza ndulu mwa odwala onenepa kwambiri omwe amawonda mwachangu.


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1100kg / mwezi

 

Ursodeoxycholic Acid Powder (128-13-2) Zofotokozera

Name mankhwala Ursodeoxycholic acid
Mankhwala Name (R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
Mawu ofanana UDCA;

Ursodiol;

Tauroursodiol, Urosodeoxycholic Acid;

Ursodeoxycholic acid (micronized);

URSODEOXYCHOLIC ACID;

URSODESOXYCHOLIC ACID;

URSODEOXYCHOLOC ACID;

Nambala ya CAS 128-13-2
InChIKey RUDATBOHQWOJDD-UZVSRGJWSA-N
Maselo Fmphutsi C24H40O4
Maselo Wasanu ndi atatu 392.57
Misa ya Monoisotopic 392.29265975
Melting Point 203-204 °C (kuyatsa)
Kutentha Pmafuta  437.26 ° C (kulingalira kovuta)
kachulukidwe 0.9985 (kuyerekeza movutikira)
mtundu Choyera - pafupifupi choyera
Kutupa  ethanol: 50 mg/mL, momveka
yosungirako Tkutentha  2-8 ° C
ntchito Ursodeoxycholic acid (UDCS) ndi chitetezo cha maselo chomwe chimagwiritsidwa ntchito kwambiri pochepetsa matenda a chiwindi ndi biliary. Ursodeoxycholic acid angagwiritsidwe ntchito pofufuza zochitika zake zenizeni zomwe zimachokera ku kuchepetsa kuyamwa kwa mafuta m'thupi, kusungunuka kwa cholesterol m'magazi mpaka kupondereza kuyankha kwa chitetezo cha mthupi.
Ripoti Loyeserera Mukhozanso

 

Ursodeoxycholic acid (UDCA), yomwe imadziwikanso kuti Ursodiol, ndi bile acid yomwe imatulutsidwa mumadzi a bile. Anapezeka koyamba mu ndulu ya zimbalangondo. Ngakhale kuti si bile acid yayikulu mwa anthu, yapezeka kuti ili ndi mphamvu zochizira. Mbiri yakugwiritsa ntchito kwa UDCA mwa anthu imachokera ku China.

 

Pakadali pano, UDCA yachilendo imagwiritsidwa ntchito padziko lonse lapansi pochiza ndikuwongolera matenda osiyanasiyana a hepatobiliary, monga matenda a ndulu (cholelithiasis), cholangitis yapachiyambi, ndi sclerosing cholangitis.

Chifukwa chiyani muyenera kumwa ursodeoxycholic acid (ursodiol)?

Ursodeoxycholic acid (ursodiol) imateteza hepatocytes ndi cholangiocytes ndikuletsa kuwonongeka kwina kulikonse kwa iwo. UDCA ufa wasonyezedwanso kuti ukhale ndi moyo wathanzi kwa odwala m'matenda osiyanasiyana a hepatobiliary.

 

Kodi Ursodeoxycholic Acid (UDCA) Powder ndi chiyani?

Monga tafotokozera pamwambapa, ufa wa Ursodeoxycholic acid ndi mawonekedwe a UDCA omwe amagwiritsidwa ntchito pochiza odwala matenda osiyanasiyana a hepatobiliary. Ursodeoxycholic acid ufa wapezeka kuti ukugwira ntchito mu Primary Biliary Cirrhosis ndipo wasonyezedwa kuti apititse patsogolo kupulumuka kwa odwala. Kuti mupeze ufa wabwino kwambiri wa Ursodeoxycholic acid ndikupeza mtengo wabwino, mwinamwake mukufunikira kugula Ursodeoxycholic acid powder yogulitsa.

 

Physicochemical katundu wa Ursodeoxycholic Acid

UDCA (3α, 7β-dihydroxy5β-cholanoic acid) ndi asidi yachiwiri ya bile. Iwo aumbike pambuyo enzymatic zochita za matumbo tizilombo pa pulayimale ya ndulu zidulo. Ma asidi a bile amayambanso, amapangidwa kuchokera ku enzymatic hydroxylation reaction ya cholesterol.

UDCA ufa wasonyezedwa kuti uli ndi hepato-protective properties. Nthawi zambiri, ma acid ambiri oyambira ndi achiwiri amapangidwa ndi hydrophobic. Kumbali inayi, Ursodeoxycholic acid powderis hydrophilic ndipo amachepetsa kuwonongeka kwa okosijeni komwe kumachitika chifukwa cha hydrophobic acid. The hydrophilic katundu wa Ursodeoxycholic acid ufa ndi maziko a oral UDCA therapy, yomwe ili yabwino komanso yosavuta.

Pambuyo kutenga exogenous UDCA pakamwa, mayamwidwe kumachitika makamaka m`matumbo aang`ono ndi kungokhala chabe sanali ionic kufalikira. UDCA imaphwanyidwa mu proximal jejunum pamene imasakanikirana ndi ma micelles a endogenous bile acids. Pambuyo polowa m'chiwindi, kugwirizanitsa kwa UDCA kumachitika. Kenako UDCA imalumikizidwa ndi glycine komanso pang'ono ndi taurine. Kenako imatulutsidwa mwachangu mu bile kudzera mukuyenda kwa enterohepatic.

Ursodeoxycholic acid conjugates motero amapangidwa amatengedwa makamaka kuchokera ku distal ileum. Nonabsorbed UDCA imadutsa m'matumbo ndipo imasinthidwa ndi mabakiteriya am'mimba kukhala lithocholic acid. Asidi ya Lithopolis nthawi zambiri imasungunuka ndipo imatulutsidwa mu ndowe. Gawo laling'ono la lithocholic acid limatengedwa. Kenako amathiridwa ndi sulphate m’chiŵindi, n’kutulutsidwa m’matumbo, ndipo pamapeto pake amatuluka m’chimbudzi.

 

Ursodeoxycholic Acid/Ursodiol Powder Mechanism of Action

Ursodeoxycholic acid ufa wasonyeza kuti uli ndi njira zambiri zogwirira ntchito, ndipo palinso njira zomwe zikuphunziridwa.

Ursodeoxycholic acid ufa wasonyeza kuti ndi wothandiza kwambiri poteteza cholangiocyte kuvulala kwa poizoni wa bile acids, kukondoweza kwa biliary secretion yomwe yawonongeka kale, kukondoweza mu ndondomeko ya detoxification motsutsana ndi hydrophobic bile acids, kapena kuletsa apoptosis, mwachitsanzo, selo lodzipangira mankhwala. kufa kwa hepatocytes.

Sizikudziwikabe kuti ndi iti mwa njirazi yomwe imayang'anira phindu la UDCA. Kupatula apo, kuchuluka kwa phindu lochokera ku UDCA kumadaliranso momwe munthuyo alili komanso gawo la matenda.

 

Kodi Magwero Akuluakulu a Ursodeoxycholic acid powder Pamsika Ndi Chiyani?

Ngakhale kuti anthu amapanga UDCA, ndiyotsika kwambiri kuposa ma bile acid ena opangidwa. Choncho, kufufuza kwina kwina kukuchitikabe. Mpaka pano, kupanga ufa wa ursodeoxycholic acid mu zimbalangondo kwakhala kochuluka kwambiri.

Popeza pali zokhudzidwa ndi ufulu wa zinyama komanso chiopsezo chopha nyama, njira zina zikuyang'aniridwa. Pakati pawo, bovine UDCA ufa wasonyeza zotsatira zabwino. Magwero ena monga yisiti ndi algae akuyang'aniridwa. Kupanga kopanga kwa UDCA kuchokera ku mamolekyu am'mbuyo ndikosangalatsanso kwambiri. Komabe, zokhuza mtengo zimaganiziridwanso. Zomwe zachitika posachedwa m'derali zikuyang'ana magwero a zomera ngati njira ina. Pali zambiri zopangira ursodeoxycholic acid ufa zogulitsa, pezani gwero lenileni la ursodeoxycholic acid powder supplier, muyenera kumvetsera kwambiri. Ndipo zowonjezera za ursodeoxycholic acid zilipo pa intaneti.

 

Ubwino & Zotsatira za Ursodeoxycholic Acid Powder

Kodi ursodeoxycholic acid ndi chiyani? Ufa wa UDCA wawonetsa kusintha kwakukulu ndipo umangokhala ndi matenda osiyanasiyana a hepatobiliary. Amagwiritsidwa ntchito pochiza ndi kusamalira matenda osiyanasiyana a hepatobiliary, monga matenda a ndulu (cholelithiasis), cholangitis yapachiyambi, ndi sclerosing cholangitis.

Zawonetsedwa kuti zimakhudza kwambiri chitetezo chamthupi, kuchepetsa cholesterol, kusungunula miyala ya ndulu, kuteteza chiwindi, ndikuchepetsa kuchuluka kwa lipids m'magazi kutchula ochepa. Ngakhale kuti njira yeniyeni yomwe UDCA imachitira akadali malo ofufuza, njira zodziwika zakhala zikukambidwa kale pamwambapa.

 

Kodi Ursodeoxycholic acid powder ndi chiyani Zogwiritsidwa ntchito?

Ursodeoxycholic acid (ursodiol) amagwiritsidwa ntchito kwambiri komanso mozama pa matenda osiyanasiyana a chiwindi ndi bile. Komabe, kugwiritsidwa ntchito kwake sikumangokhalira ku hepatobiliary pa se. Kupyolera muzaka zofufuza mwamphamvu, zotsatira zabwino za UDCA pochiza matenda osiyanasiyana zatsimikiziridwa. Izi zikuphatikiza kusungunula miyala ya ndulu ndi kuteteza ndi kuchiza ndulu ya cholesterol. UDCA ufa umagwiritsidwanso ntchito ngati mankhwala a anionic pofufuza kafukufuku wa biochemical, anti-cholelithiasis agent, anticonvulsant, ndi cytoprotective agent. Kugwiritsiridwa ntchito kwina kwa ursodeoxycholic acid ufa akadali malo okhudzidwa ndi kafukufuku wosiyanasiyana wopitilira komanso mayesero achipatala.

 

Momwe Mungatengere Ursodeoxycholic Acid Powder?

Ursodeoxycholic acid supplement nthawi zambiri samagulitsidwa pa kauntala ndipo, nthawi zambiri amafuna kuuzidwa ndi dokotala. Musanagwiritse ntchito UDCA, ndikofunikira kukambirana za chiopsezo chomwe chingakhalepo motsutsana ndi phindu ndi dokotala wanu. Dokotala nthawi zambiri amakambirana za mbiri yakale yachipatala, makamaka matenda a hepatobiliary komanso mbiri yakale. Ngakhale kuti UDCA imagwiritsidwa ntchito pa matenda a hepatobiliary, pali matenda ena a hepatobiliary omwe ayenera kusamala.

Choncho, kukambirana kwambiri ndi dokotala n'kofunika kwambiri ndipo makamaka ngati muli ndi mbiri yakale yachipatala yomwe ili pamzere wa ascites (madzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimutsana), kutuluka magazi (mitsempha yomwe imakula ndi kutuluka magazi), hepatic encephalopathy (ubongo). matenda chifukwa cha kulephera kwa chiwindi), kuwonongeka kwa chiwindi m'mbuyomu, kuyika chiwindi, kutsekeka kwa biliary thirakiti, vuto la biliary, ndi kapamba.

Zokambirana zonse zikapanda kuwopsa, UDCA nthawi zambiri imalembedwa motere:

 

Kwa matenda a gallstone:

Akuluakulu ndi ana a zaka za 12 ndi kupitirira-Mlingo wa ursodeoxycholic acid nthawi zambiri ndi 8 mpaka 10 milligrams (mg) pa kilogalamu (kg) ya kulemera kwa thupi patsiku, kugawidwa muwiri kapena katatu.

Ana osakwana zaka 12 - Izi zimatsimikiziridwa ndi dokotala.

 

Kwa primary biliary cirrhosis:

Akuluakulu-Mlingo wake nthawi zambiri ndi 13 mpaka 15 milligrams (mg) pa kilogalamu (kg) ya kulemera kwa thupi patsiku, kugawidwa m'magulu awiri kapena anayi. Dokotala wanu akhoza kusintha mlingo wanu ngati mukufunikira.

Ana - Izi zimatsimikiziridwa ndi dokotala

 

Pofuna kupewa gallstones pakuwonda mwachangu:

Akuluakulu-Mlingo wa ursodeoxycholic acid nthawi zambiri ndi 300 milligrams (mg) kawiri pa tsiku.

Ana osakwana zaka 12- Izi zimatsimikiziridwa ndi dokotala.

Nthawi zambiri, ngati mlingo umodzi waphonya, kutenga mlingo womwe unaphonya posachedwa kumalangizidwa ngati nthawi yochokera ku mlingo wotsiriza inali yosapitirira maola 4. Mlingo wambiri wophonya, kukaonana ndi dokotala ndikofunikira.

UDCA iyenera kutengedwa motsatira malangizo a dokotala. Pankhani ya overdose, ndizokayikitsa kuti mlingo umodzi wowonjezera ungayambitse vuto. Komabe, mukakhala ndi vuto lalikulu, ndibwino kuti muwone dokotala kapena kupita kuchipatala chapafupi.

Monga mankhwala aliwonse, nthawi zonse pamakhala zotsatira zake pamlingo wina. Ndi bwino kukaonana ndi dokotala kapena chipatala chapafupi ngati zotsatira za ursodeoxycholic acid zotsatirazi zikuwonekera:

 

Zizindikiro zofala

Kupweteka kwa chikhodzodzo, mkodzo wamagazi kapena wamtambo, kukodza kowawa kapena kupweteka, chizungulire, kugunda kwa mtima, kulakalaka kukodza pafupipafupi, kusanza, kupweteka m'munsi kapena m'mbali, nseru, totupa pakhungu kapena kuyabwa thupi lonse, kupweteka m'mimba, kusanza, kufooka.

 

Zizindikiro zochepa

Chimbudzi chakuda ndi chochedwa, kupweteka pachifuwa, kuzizira kapena kutentha thupi, chifuwa, mawanga ofiira pakhungu, kupweteka kwambiri kapena kosalekeza m'mimba, zilonda zapakhosi kapena zotupa zotupa, zilonda kapena zilonda kapena mawanga oyera pamilomo kapena mkamwa, kutuluka magazi kwachilendo kapena kuvulala, kutopa kwachilendo kapena kufooka.

Kupumula kwachidziwitso kwachidziwitso kwawonetsedwa kuti kukuwonekera mkati mwa masabata a 3-6 kuyambira chithandizo ndi ufa wa UDCA. Kutalika kwa nthawi ya chithandizo kumasiyanasiyana munthu ndi munthu. Dokotala wolembera amawunika momwe zinthu ziliri nthawi ndi nthawi. Chifukwa chake, kutsata nthawi yake ndikofunikira. Ursodeoxycholic acid ufa wapezeka kuti ndi wotetezeka kwa anthu omwe akhala akuutenga mpaka miyezi 6 ndipo ngakhale mwa anthu omwe atenga miyezi 48. Choncho, ndibwino kunena kuti ufa wa UDCA ndi wotetezeka kuti ugwiritsidwe ntchito kwa nthawi yaitali, pokhapokha ngati pali nthawi yotsatiridwa komanso kuyesedwa kwa chiwindi nthawi zonse kumachitika panthawi yake.

 

Kodi Mankhwala Abwino Kwambiri Othandizira Matenda a Chiwindi Ndi Chiyani?

Palibe njira yabwino yothetsera matenda onse a chiwindi kapena kuwombera kamodzi kokha. Ursodeoxycholic acid ufa, komabe, ndi wothandiza komanso wosagwirizana ndi mitundu yosiyanasiyana ya hepatobiliary, monga matenda a ndulu (cholelithiasis), cholangitis chachikulu cha biliary, ndi primary sclerosing cholangitis.

 

Kodi Ndingamwe Ursodiol/Ursodeoxycholic Acid Ndi Mankhwala Ena?

UDCA ndi mankhwala otetezeka. Komabe, chenjezo liyenera kugwiritsidwa ntchito ngati mankhwala ena aliwonse omwe ali ndi cholestyramine, colestimide, colestipol, aluminium hydroxide, ndi smectite akutengedwa pamodzi ndi UDCA chifukwa mayamwidwe a UDCA amawonongeka ndi iwo. Kuyanjana kwa mankhwala a metabolic ndi mankhwala opangidwa ndi cytochrome P4503A amawoneka pamodzi ndi mankhwala ena monga cyclosporin, nitrendipine, ndi dapsone.

 

Kodi Ursodeoxycholic Acid Powder Ndi Yabwino Pachiwindi?

Ursodeoxycholic Acid Powder ndi yabwino kwa chiwindi chifukwa cha zochita zake zotetezera pa cholangiocytes ndi hepatocytes, kuteteza kuvulaza ku zotsatira za poizoni za bile acid, kukondoweza kwa biliary secretion, ndi kukondoweza mu ndondomeko ya detoxification motsutsana ndi hydrophobic bile acid ndi kuletsa apoptosis, mwachitsanzo. , maselo odzipangira okha amafa a hepatocytes.

UDCA kapena Udiliv(dzina lazamalonda) lagwiritsidwanso ntchito kuthana ndi matenda a chiwindi chamafuta, makamaka Non-alcoholic steatohepatitis(NASH), ndi zotulukapo zabwino kwambiri. Komabe, kufufuza kwina ndi kusanthula kwa meta ndikofunikira kuti zikhale zowona.

 

Kodi Pali Kusiyana Kotani Pakati pa Ursodeoxycholic Acid(UDCA) Ndi Chenodeoxycholic Acid(CDCA)?

UDCA ndi CDCA onse ndi bile acid. Mwa anthu, onse UDCA ndi Chenodeoxycholic Acid (CDCA) amapangidwa. Komabe, CDCA imapangidwa mokulirapo. Onse a UDCA ndi CDCA ndizinthu zowononga cholesterol, poyambira. CDCA ndi bile acid yoyambirira, mwachitsanzo, imapangidwa makamaka ndi chiwindi kuchokera ku cholesterol, pomwe UDCA imapangidwa chifukwa cha kuwonongeka kwa enzymatic ndi mabakiteriya m'matumbo.

Momwemonso, pankhani ya matenda a gallstone, Ursodeoxycholic Acid (UDCA) inali yothandiza kwambiri kuposa CDCA m'maboma apansi ndi apamwamba.

 

kugula Ursodeoxycholic Acid ufa wochuluka? | | Kodi kupeza bwino Ursodeoxycholic Acid wopanga ufa?

Ursodeoxycholic acid ufa wochuluka ungagulidwe pa intaneti kudzera pamasamba osiyanasiyana. Komabe, muyenera kusamala ponena za zowona ndi mtundu wa chinthucho. A cheke mwatsatanetsatane wa yogwira zosakaniza ndi ndende ayenera kuchitidwa choyamba. Phcoker ndiye wopanga ufa wabwino kwambiri wa ursodeoxycholic acid.

 

Ursodeoxycholic Acid: The Ultimate FAQ Guide

Kodi ursodiol imagwira ntchito?

Inde. Ursodiol yasonyeza kuti ndi yothandiza pochiza matenda osiyanasiyana a hepatobiliary, pokhapokha ngati atadziwika msanga, ndipo chithandizocho chimayambika mwamsanga.

 

Ndi mankhwala ati omwe amasungunula matope a ndulu?

Ufa wa UDCA watsimikiziridwa kuti ndi wothandiza pakusungunula matope a ndulu.

 

Kodi ursodiol ingayambitse kulemera?

UDCA ufa ukhoza kuyambitsa kulemera, makamaka m'miyezi yoyamba ya 12 ya mankhwala.

 

Kodi ursodiol ndi steroid?

Steroids ndi magulu amitundu yosiyanasiyana. Ma steroid ndi bile acid onse amapangidwa kapena ndi zinthu za metabolic za cholesterol. Kafukufuku wina wawonetsa momwe ma steroid amafanana ndi bile acid pakuwongolera magwiridwe antchito a tsiku ndi tsiku. Komabe, kafukufuku wochulukirapo m'mundawu akufunika kuti akhale ndi umboni wokwanira.

 

Kodi ursodiol ndi immunosuppressant?

UDCA yapezeka kuti ili ndi zinthu zina zochepetsera thupi.

 

Kodi ursodiol imachepetsa bile acid?

UDCA yawonetsa kuti ndi yothandiza polimbikitsa kutulutsa poizoni motsutsana ndi ma hydrophobic acid. Ursodeoxycholic acid ufa wasonyezedwanso kuchepetsa hydrophobic acid. Komabe, kufufuza kwina n’kofunikabe.

 

Kodi ursodiol imathandizira ma enzymes a chiwindi?

UDCA yatsimikiziridwa kuti ndiyothandiza pakuwongolera ma enzymes a chiwindi m'matenda osiyanasiyana a chiwindi.

 

Ndi ursodeoxycholic acid ufa zabwino kwa impso?

Kafukufuku wopangidwa pa makoswe sanasonyeze kuvulaza ndi ufa wa UDCA. Komabe, kafukufuku wambiri wokhudza anthu akupitilirabe.

 

Kodi ursodiol imathandizira chiwindi chamafuta?

UDCA imathandiza m'chiwindi chamafuta. Komabe, mayesero opangidwa mosamala akali mkati mwa mutu womwewo.

 

Kodi ursodiol imachepetsa triglycerides?

UDCA yapezeka kuti imatsitsa Low-density lipoproteins (LDL) ndi Very Low-Density Lipoproteins (VLDL). Komabe, mlingo wonse wa triglyceride ulibe kusintha kwakukulu potsatira chithandizo ndi UDCA powder.

 

Kodi pali njira ina ya ursodiol?

Pali njira ina yothandizira UDCA. Komabe, mphamvu ndi mphamvu za othandizirawa akhala akukangana. Kufunsana ndi dokotala za njirayo ndi zomwe zili zabwino kwa inu zingakhale zothandiza.

 

Kodi ursocol ndi antibiotic?

Ayi, ursocol si mankhwala. Ndi mankhwala omwe ali ndi ntchito zosiyanasiyana koma makamaka amateteza hepatocytes ndikuthandizira kuwonongeka kwa ndulu.

 

Kodi cholestasis ndi matenda a chiwindi?

Cholestasis amangotanthauza kuti ndulu imasiya kuyenda motsatira mtengo wa biliary kapena kutuluka kwapang'onopang'ono. Kutsekereza kwa bile kungayambitse kuvulala kwa chiwindi ndi matenda.

 

Kodi ursodeoxycholic acid ndi yothandiza bwanji?

UDCA imagwira ntchito pochiza matenda osiyanasiyana a hepatobiliary komanso matenda ena.

 

Kodi ursodiol ndi mankhwala otani?

UDCA ndi yachiwiri bile acid. Ndikofunikira kwambiri poteteza cholangiocyte kuvulala kwa poizoni wa bile acid, kukondoweza kwa biliary secretion yomwe idasokonekera kale, kukondoweza mu njira yochotsera hydrophobic bile acid, kapena kuletsa apoptosis mwachitsanzo, kufa kwa cell ya hepatocyte.

 

Kodi ursodiol imachepetsa cholesterol?

Kafukufuku amasonyeza kuti Ursodeoxycholic acid ufa ukhoza kuchepetsa mafuta a kolesterolini.

 

Kodi ursodiol ikhoza kuyambitsa kapamba?

Pancreatitis yogwiritsidwa ntchito ndi UDCA sizofala. UDCA yagwiritsidwa ntchito pochiza kapamba.

 

Kodi ursodiol imakupangitsani kugona?

Kutopa ndi kufooka ndi zina mwazovuta zomwe zimachitika ndi UDCA.

 

Zothandizira

  1. Kugwiritsa ntchito ursodeoxycholic acid mu matenda a chiwindi. D Kumar, RK Tandon.J Gastroenterol Hepatol. 2001 Jan;16(1):3-14. doi: 10.1046/j.1440-1746.2001.02376.x.PMID: 11206313
  1. Ursodeoxycholic acid mu cholestatic chiwindi matenda: njira zochita ndi achire ntchito revisited.Gustav Paumgartner , Ulrich Beuers.PMID: 12198643 DOI: 10.1053/jhep.2002.36088 Hepatology. 2002 Sep; 36 (3): 525-31.
  1. Njira zochita ndi achire lapamwamba ursodeoxycholic asidi mu cholestatic chiwindi matenda.Gustav Paumgartner, Ulrich Beuers.PMID: 15062194 DOI: 10.1016/S1089-3261(03) 00135-1. 2004 Feb;8(1):67-81, vi.
  1. Mawonekedwe a Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, The Most Hydrophilic Bile Acid, in the Heart.Noorul Izzati Hanafi, Anis Syamimi Mohamed, Siti Hamimah Sheikh Abdul Kadir, Mohd Hafiz Dzarfan Othman.PMID: 30486474 P6316857 P10.3390 P8040159D: P2018 P27D: P8DZD: 4/biom159 XNUMX Nov XNUMX;XNUMX(XNUMX):XNUMX.
  1. Ursodeoxycholic Acid Response Is Associated With Reduced Mortality in Primary Biliary Cholangitis With Compensated Cirrhosis.Binu V John, Nidah S Khakoo, Kaley B Schwartz, Gabriella Aitchenson, Cynthia Levy, Bassam Dahman, Yangyang Deng, David S Goldberg Kaplan Martin, David S Goldberg, Paul Martin , Tamar H Taddei.PMID: 33989225 PMCID: PMC8410631 (ikupezeka pa 2022-09-01) DOI: 10.14309/ajg.0000000000001280 Am J Gastroenterol. 2021 Sep 1; 116 (9): 1913-1923.
  1. Kodi chithandizo cha nthawi yayitali cha ursodeoxycholic acid ndi chiyani kwa odwala omwe ali ndi biliary cirrhosis?Virginia C Clark, Cynthia Levy.PMID: 17290236 DOI: 10.1038/ncpgasthep0741 Nat Clin Pract Gastroenterol Hepatol. 2007 Apr; 4(4):188-9.
  1. Kukula kwaposachedwa mu kaphatikizidwe ka ursodeoxycholic acid (UDCA): kuwunika kofunikira. Fabio Tonin ndi Isabel WCE Arendsothandizira wolemba.PMCID: PMC5827811 PMID: 29520309 doi: 10.3762/bjoc.14.33 Beilstein J Org Chem. 2018; 14: 470–483 .
  1. Chimbalangondo cha ndulu: vuto lakugwiritsa ntchito mankhwala azikhalidwe komanso kuteteza nyama. Yibin Feng, wolemba wogwirizana Kayu Siu,Ning Wang,Kwan-Ming Ng, Sai-Wah Tsao, Tadashi Nagamatsu, and Yao Tong.PMCID: PMC2630947 PMID: 19138420 doi: 10.1186/1746-4269-Ethnomed-5. 2; 2009: 5.
  1. Ursodeoxycholic acid: chinthu chotetezeka komanso chothandiza pakusungunula ndulu ya cholesterol.GS Tint, G Salen, A Colalillo, D Graber, D Verga, J Speck, S Shefer.PMID: 7051912 doi: 10.7326/0003-4819-97-3-351 . Ann Intern Med. 1982 Sep;97(3):351-6.
  1. Gallstone dissolution therapy ndi ursodiol. Kuchita bwino ndi chitetezo. G Salen.PMID: 2689115 DOI: 10.1007/BF01536661 Dig Dis Sci. 1989 Dec;34(12 Suppl):39S-43S.
  1. Ursodeoxycholic acid - zotsatira zoyipa ndi kuyanjana kwa mankhwala. Hempling, K. Dilger, U. Beuers
  2. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial.Keith D. Lindor,Kris V. Kowdley,E. Jenny Heathcote, M. Edwyn Harrison,Roberta Jorgensen,Paul Angulo,James F. Lymp,Lawrence Burgart,Patrick Colin
  1. Mlingo waukulu wa ursodeoxycholic acid therapy ya nonalcoholic steatohepatitis: mayesero akhungu, osasintha, oyendetsedwa ndi placebo†.Ulrich FH Leuschner,Birgit Lindenthal,Günter Herrmann,Joachim C. Arnold,Martin Rössle,Hans-Jörg Cordes,Stefan Zem Hein, Thomas Berg, Gulu Lophunzira la NASH
  1. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial.Keith D. Lindor,Kris V. Kowdley,E. Jenny Heathcote, M. Edwyn Harrison,Roberta Jorgensen,Paul Angulo,James F. Lymp,Lawrence Burgart,Patrick Colin
  1. Udindo wa ursodeoxycholic acid mu steatohepatitis yopanda mowa: kuwunika mwadongosolo.Zun Xiang, Yi-peng Chen, Kui-fen Ma, Yue-fang Ye, Lin Zheng, Yi-da Yang, You-ming Li, Xi Jin.PMID : 24053454 PMCID: PMC3848865 DOI: 10.1186/1471-230X-13-140 BMC Gastroenterol. 2013 Sep 23; 13:140.
  1. Ursodeoxycholic acid vs. chenodeoxycholic acid as cholesterol gallstone-dissolving agents: a comparative randomized study.E Roda, F Bazzoli, AM Labate, G Mazzella, A Roda, C Sama, D Festi, R Aldini, F Taroni, L Barbara.PMID: 7141392 DOI: 10.1002/hep.1840020611 Hepatology. Nov-Dec 1982;2(6):804-10.