NADH 2Na (606-68-8)

March 15, 2020

NADH ndi mtundu wa michere ya nicotinamide adenine dinucleotide (NAD), mtundu wa coenzyme wophatikizika ndi vitamini B3 ……….

 


Chikhalidwe: Mu Kupanga Misa
Zokonzedwa ndi Zokonzedweratu Zopezeka
mphamvu: 1277kg / mwezi

Kanema wa NADH 2Na (606-68-8)

Zambiri za Beta-Nicotinamide adenine dinucleotide disodium salt (NADH 2Na)

Name mankhwala Beta-Nicotinamide adenine dinucleotide disodium mchere (NADH 2Na)
Mankhwala Name NADH (mchere wa disodium); Disodium nicotinamide adenine dinucleotide; eta-d-ribofuranosyl-3-pyridinecarboxamide, disodiumsalt; beta-NADH Disodium salt; Nicotinamide adenine dinucleotide, yafupika;
Nambala ya CAS 606-68-8
InChIKey Gawo #: QRGNQKGQENGQSE-WUEGHLCSSA-L
MUZIKONDWERETSA C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O.[Na+].[Na+]
Molecular Formula C21H27N7Na2O14P2
Kulemera kwa maselo 709.4
Misa ya Monoisotopic 709.088661 g / mol
Melting Point 140-142 ℃
mtundu Yellow
Stempage temp 2-8 ℃
Kutupa H2O: 50 mg / mL, momveka bwino, wachikasu
ntchito Mankhwala; zakudya ndi zakudya zopatsa thanzi;

 

Kodi Beta-Nicotinamide adenine dinucleotide disodium salt (NADH 2Na) ndi chiyani?

NADH ndi mtundu wa enzyme ya nicotinamide adenine dinucleotide (NAD), mtundu wa coenzyme wophatikizira ndi vitamini B3. NADH (b-Nicotinamide adenine dinucleotide) Mchere wa Disodium, wotsika, womwe umadziwikanso kuti Nicotinamide adenine dinucleotide, ndi coenzyme pamachitidwe a redox. Amagwira ntchito ngati wobwezeretsanso wopereka ma elekitironi muzinthu zamagulu monga glycolysis, β-oxidation ndi citric acid cycle (Krebs cycle, TCA cycle). Mchere wa NADH disodium umatenganso nawo gawo pakuwonetsa zochitika zam'maselo, mwachitsanzo ngati gawo la poly (ADP-ribose) polymerases (PARPs) pakuyankha kwa kuwonongeka kwa DNA. Monga mchere wa disodium wa NADH, umagwiritsidwa ntchito pazakudya ndi zowonjezera zakudya pochiza matenda a Parkinson, matenda otopa kwambiri, matenda a Alzheimer's ndi matenda amtima.

 

Beta-Nicotinamide adenine dinucleotide disodium mchere (NADH 2Na) maubwino

Monga coenzyme ya oxidoreductases, mchere wa NADH disodium umagwira gawo lofunikira pakupanga mphamvu zamthupi.

- NADH disodium salt itha kubweretsa kumvetsetsa kwamaganizidwe, kukhala tcheru, kusinkhasinkha, ndi kukumbukira. Ikhoza kukulitsa mphamvu zamaganizidwe ndipo imatha kukulitsa malingaliro. Itha kukulitsa mphamvu zamagetsi mthupi ndikusintha kagayidwe kake, mphamvu zamaubongo ndi kupirira.

- Thandizani anthu omwe ali ndi vuto lachipatala, kuthamanga kwa magazi kapena cholesterol;

- Sinthani magwiridwe antchito;

- Kuchepetsa ukalamba ndikusunga umphumphu wa maselo amitsempha kuti athandizire dongosolo lamanjenje;

- Angathe kuchiza matenda a Parkinson, kukonza magwiridwe antchito a ma neurotransmitters muubongo wa odwala omwe ali ndi matenda a Parkinson, kuchepetsa kulumala ndi zosowa zamankhwala;

- Kuchiza matenda otopa (CFS), matenda a Alzheimer ndi matenda amtima;

- Tetezani zotsatira zoyipa za mankhwala a Edzi otchedwa zidovudine (AZT);

- Tsutsani zotsatira za mowa pachiwindi;

- Kutopa kwapaulendo wandege

 

Beta-Nicotinamide adenine dinucleotide disodium mchere (NADH 2Na) mavuto:

Pakadali pano, mchere wa NADH disodium umawoneka wotetezeka kwa anthu ambiri akagwiritsidwa ntchito moyenera komanso mwachidule, mpaka sabata 12. Anthu ambiri samakumana ndi vuto lililonse akamamwa mankhwala omwe tsiku lililonse ndi 10 mg.

Komabe, palibe nkhokwe zokwanira zamagwiritsidwe ntchito ka mchere wa NADH disodium panthawi ya pakati komanso poyamwitsa., Chifukwa chake ayenera kukhala kumbali yotetezeka ndikupewa kugwiritsidwa ntchito.

 

Tsamba:

  • Birkmayer JG, Vrecko C, Volc D, Birkmayer W. Nicotinamide adenine dinucleotide (NADH) - njira yatsopano yothandizira matenda a Parkinson. Kuyerekeza kugwiritsa ntchito pakamwa ndi kulera. Acta Neurol Scand Suppl 1993; 146: 32-5 (Pamasamba)
  • Budavari S, mkonzi. Mndandanda wa Merck. Wolemba 12. Whitehouse Station, NJ: Merck & Co., Inc., 1996.
  • Bushehri N, Jarrell ST, Lieberman S, et al. Oral yafupika ya B-nicotinamide adenine dinucleotide (NADH) imakhudza kuthamanga kwa magazi, lipid peroxidation, ndi mbiri ya lipid mu makoswe oopsa (SHR). Geriatr Nephrol Urol 1998; 8: 95-100.
  • Bushehri N, Jarrell ST, Lieberman S, et al. Oral yafupika ya B-nicotinamide adenine dinucleotide (NADH) imakhudza kuthamanga kwa magazi, lipid peroxidation, ndi mbiri ya lipid mu makoswe oopsa (SHR). Geriatr Nephrol Urol 1998; 8: 95-100.
  • Castro-Marrero J, Cordero MD, Segundo MJ, et al. Kodi pakamwa coenzyme Q10 kuphatikiza NADH yowonjezera kumatha kutopa ndi magawo amomwe am'magazi mu kutopa kwamatenda? Antioxid Redox Signal 2015; 22 (8): 679-85.
  • Dizdar N, Kagedal B, Lindvall B. Chithandizo cha matenda a Parkinson ndi NADH. Acta Neurol Scand 1994; 90: 345-7.