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N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

NACET (N-Acetylcysteine ​​ethyl ester) ndi lipophilic cell-permeable cysteine ​​yotengeka yachilendo ndi yapadera ya pharmacokinetic komanso zodabwitsa… ..


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

Kufotokozera

Zambiri za NACET (59587-09-6)

Name mankhwala NACET (59587-09-6)
Mankhwala Name R) -ethyl 2-acetamido-3-mercaptopropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-Acetylcysteine ​​ethylester;
Nambala ya CAS 59587-09-6
InChIKey MSMRAGNKRYVTCX-LURJTMIESA-N
MUZIKONDWERETSA CCOC (= O) C (CS) NC (= O) C
Molecular Formula C7H13NO3S
Kulemera kwa maselo 191.25
Misa ya Monoisotopic 191.061614 g / mol
Melting Point 44.1-44.5 ° C
Malo otentha 337.6 ± 32.0 ° C (Wonenedweratu)
kachulukidwe 1.138 ± 0.06 g / cm3 (Zanenedweratu)
mtundu Kuchoka poyera
ntchito Nootropics ndi mankhwala anzeru, angagwiritsidwe ntchito kukulitsa kukumbukira, kuyang'ana, kukhazikitsa, luntha komanso kusonkhezera. Itha kugwiritsidwanso ntchito ngati chakudya chowonjezera.

Kodi NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) ndi lipophilic cell-permeable cysteine ​​yotengedwa ndi mawonekedwe achilendo a pharmacokinetic ndi mwayi wodabwitsa wa antioxidant. NACET imakhala ndi mkamwa kwambiri. Ndi wolimba antioxidant komanso wolemera wotsogola wa GSH, womwe umagwirizana ndi acid yake ya N-acetyl -L yaulere imasiyana ndi -cysteine ​​(NAC). NACET ndi ufa woyera pamawonekedwe otentha ndipo umasungunuka momasuka m'madzi ndi ma organic sol sol.

NAC imachokera ku cysteine. Kuyambira mu 1970s, yakhala ikugwiritsidwa ntchito pochiza odwala omwe ali ndi acetaminophen overdose ndi mitsempha, ndipo amamugulitsa ngati mankhwala komanso zakudya zopatsa thanzi. Poyerekeza ndi NAC, NACET imakhala ndi lipophilicity yapamwamba komanso imatha kuchita mankhwala. Ili ndi mwayi wogwirizira Nac ya pharmacological, ngati othandizira a mucolytic, antioxidant, othandizira a GSH, paracetamol antidote, ndipo osachepera Donor of gaseous transmitter H 2 S ndi othandizira oteteza UV.

Kuphatikiza apo, mphamvu ya nucleophilicity ndikuchepetsa mphamvu ya NACET yatsimikizidwanso m'maselo ofiira a anthu. Zapezeka kuti zimadziunjikira m'magazi ofiira amtundu wa anthu, motsutsana ndi kuwonongeka kwa oxidative chifukwa cha hydroperoxides. Chifukwa chake, kuthekera kwa NACET monga anti-nitrite-ikiwaletsa antioxidant ndikokulira kuposa kwa NAC methemoglobinemia ndi ma oxidant ena amphamvu. Kafukufuku mu makoswe apeza kuti NACET imakhudzidwa mwachangu kwambiri kuposa NAC pamene NACET imayang'aniridwa pakamwa. Imatha kulowa m'maselo ndikutulutsa NAC ndi cysteine, zomwe zimawonjezera hydrogen sulfide (H (2) S) potulutsa. Ndiwofunika kusankha pakamwa ngati wopanga H (2) S,

Ubwino wa NACET (N-Acetylcysteine ​​ethyl ester)

Monga antioxidant wamphamvu, NACET imakhala ndi phindu lalikulu pa thanzi la munthu.

- Sinthani mikhalidwe yambiri yazaumoyo ndikuchepetsa zizindikiro za matenda amisala;

- Chithandizo cha acetaminophen bongo, kuteteza impso ndi chiwindi;

- Imakweza ntchito yam'mapapo mwa kuchepetsa kutupa ndi kuthyola ntchofu, potero kumachepetsa matenda opumira.

- Limbikitsani thanzi laubongo poyang'anira glutamate ndikuwonjezera glutathione, angagwiritsidwe ntchito pochiza matenda monga matenda a Alzheimer's ndi matenda a Parkinson;

- Sinthani chonde mwa abambo ndi amayi

- Athandize kukonza chitetezo cha mthupi m'matenda ambiri, kupewa makulidwe a oxidative pamtima, ndikuchepetsa chiopsezo cha matenda a mtima.

- Tithandizire Kukhala Ndi Magazi Atsitsi Mwa Kuchepetsa Kutupa mu Maselo A mafuta

Mapulogalamu a NAECT (N-Acetylcysteine ​​ethyl ester)

Chifukwa NACET yawonetsa zotsatira zabwino pamatenda amisala, matenda opumira kwambiri komanso matenda amisala, amagwiritsidwa ntchito ngati mankhwala komanso zakudya kuti ateteze ubongo, kukonza magwiridwe antchito am'mutu komanso mthupi, kuti apititse patsogolo kukumbukira, kuzindikira komanso kuchita masewera othamanga.

Tsamba:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): buku lotchedwa lipophilic cell-permeable cysteine ​​lotengedwa ndi mawonekedwe achilendo a pharmacokinetic ndi kuthekera kodabwitsa kwa antioxidant. Biochem Pharmacol. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) ndi N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine ​​wokhala ndi mankhwala osokoneza bongo omwe ali ndi mbiri yapadera yamankhwala ogwiritsira ntchito pakamwa ngati O, H2S ndi othandizira a GSH ndi monga antioxidants: Zotsatira ndi kuwunika mwachidule. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Kubwereza. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester monga GSH chothandizira mu maselo akulu a endothelial a anthu: Kafukufuku wofanizira ndi mankhwala ena. 2018 Oct; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) ndi N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine ​​wokhala ndi mankhwala osokoneza bongo omwe ali ndi mbiri yapadera yamankhwala ogwiritsira ntchito pakamwa ngati O, H2S ndi othandizira a GSH ndi monga antioxidants: Zotsatira ndi kuwunika mwachidule. Zolemba Za Kafukufuku Wamankhwala. Gawo 8, Kutulutsa 1, Ogasiti 2018, masamba 1-9.

KULAMBIRA NDI KUSINTHA:

Nkhaniyi Ikagulitsidwa Kugwiritsa Ntchito Kafukufuku kokha. Migwirizano Yogulitsa. Osati Zongogwiritsa Ntchito Anthu, kapena Zamankhwala, Zoweta Zanyama, kapena Zogwiritsa Ntchito Panyumba.


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Kanema wa NACET (59587-09-6)

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Mafotokozedwe ndi zolemba zamagulu

Shangke Chemical ndi makampani apamwamba kwambiri omwe amagwiritsa ntchito mankhwala omwe amathandiza kwambiri. Pofuna kuyendetsa khalidweli panthawi yopanga, akatswiri ambiri odziwa bwino ntchito, makina oyambirira kupanga zipangizo komanso ma laboratori ndi mfundo zofunika kwambiri.

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