Oleoylethanolamide (OEA) (111-58-0)

March 11, 2020
SKU: 16589-24-5
5.00 kuchokera 5 kutengera 1 kasitomala mlingo

Oleoylethanolamide (OEA) ndi endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Ndi …… ..


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

Oleoylethanolamide (OEA) (111-58-0) kanema

Mafotokozedwe a Oleoylethanolamide (OEA) (111-58-0)

Name mankhwala Oleoylethanolamide (OEA) ufa
Mankhwala Name n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

Nambala ya CAS 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
MUZIKONDWERETSA CCCCCCCCC = CCCCCCCCC (= O) NCCO
Molecular Formula C20H39NO2
Kulemera kwa maselo 325.5 g / mol
Misa ya Monoisotopic 325.537 g · mol-1
Melting Point 59-60 ° C (138-140 ° F; 332-333 K)
Malo otentha 496.4 ± 38.0 ° C (Wonenedweratu)
kachulukidwe 0.915 ± 0.06 g / cm3 (Zanenedweratu)
mtundu White powder
Stempage temp -20 ° C
Solubility mu ethanol ndi DMSO Sungunuka
ntchito Munda wa phamaceutical; ma suppl;

mwachidule

Oleoylethanolamide (OEA) kapena N-Oleoylethanolamide (OEA) ndi molekyu yopangidwa m'thupi, yomwe imapezeka m'matumbo. Umboni wowonjezereka ukusonyeza kuti OEA imatha kukhala ngati gawo la amkati am'mimba komanso kutenga nawo gawo pakuwongolera machitidwe okhudzana ndi mphotho. Komanso adanenedwa ngati othandizira pokhapokha omwe amachepetsa kudya komanso kuchuluka kwa thupi.

Kodi Oleoylethanolamide (OEA) ndi chiyani?

Oleoylethanolamide (OEA) ndi endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Ndi glycolamide lipid mwachilengedwe omwe ali ndi mawonekedwe osiyanasiyana apadera a homeostasis monga kulakalaka kudya, ntchito yotsutsa-kutupa, kukondoweza kwa lipolysis ndi mafuta oxidation. Oleoylethanolamide imatha kutengedwa ngati mahomoni am'matumbo a ubongo. Oatmeal, mtedza, ndi ufa wa cocoa ndizinthu zazikulu zakudya za Oleoylethanolamide muzakudya. Komabe, kuchuluka kwa Oleoylethanolamide omwe amapezeka mu zakudya izi ndizotsika (ochepera 2 µg / g).

Monga biologically yogwira lipid sing'anga, oleylethanolamide (OEA) imapangidwa m'matumbo ndi ziwalo zina, ndipo imakhudzidwa ndimalamulo yamagetsi yamagetsi yamagetsi, kuwongolera zakudya zomwe zimadya komanso lipid metabolism, monga momwe imatha kuyendetsa chakudya cha Vertebrate ndi kulemera kwa thupi. Oleoylethanolamide ndi mafuta acid ethanolamide (FAE), analog ya monounsaturated analog ya endocannabinoid arachidonic acid ethanolamide (anandamide), ndiogwira ntchito wotsutsana ndi anandamide. Ndikofunikira kudziwa kuti Oleoylethanolamide ndi yosiyana ndi anandamide, imayima yokha pa cannabinoid receptor, ndipo imagwira ntchito yake yachilengedwe kudzera munjira zina, kuyang'anira ntchito ya PPAR-α kuti ipangitse lipolysis. Oleoylethanolamide ndi mankhwala omwe angathe kuthana ndi kunenepa kwambiri omwe amaloza m'malo mwa CB1.

Kafukufuku wam'mbuyomu wasonyeza kuti Oleoylethanolamide ndiwothandiza komanso odana ndi yotupa komanso antioxidant. Exo native makonzedwe a Oleoylethanolamide amalepheretsa moyenera kuphatikiza TLR4-yolumikizira proinflammatory cascades, potero amachepetsa kutulutsa kwa proinfigueatory cytokines ndi chemokines, oxidative and nitrosative stress, ndipo pamapeto pake amalepheretsa kuwonongeka kwa mitsempha kutsogolo kwamakolo.

Source of Oleoylethanolamide (OEA)

Pali magawo awiri olandila Oleoylethanolamide (OEA), imodzi ndi yochokera kuzomera zachilengedwe, ndipo ina imapangidwa mu labu.

Achyranthes Aspera, wobadwira ku India, China ndi mayiko ena ambiri aku Asia, akuti ali ndi Oleoylethanolamide OEA. Vuto la Oleoylethanolamide wachilengedwe wobiriwira wachilengedwe ndilakuti pali gawo lokhalo lomwe limapezeka, 15: 1 ndiwodziwika kwambiri, ndipo si wamphamvu monga makasitomala kapena opanga omwe akuyembekeza. Zachidziwikire, zitha kukhala zapamwamba, koma mtengo wake udzakhala wokwera kwambiri, motero sizothandiza kwambiri kupanga zachilengedwe Oleoylethanolamide OEA zochuluka.

Gwero lalikulu la Oleoylethanolamide limapangidwa kuchokera ku oleic acid, limagwiritsidwa ntchito ngati wotsogola wa N-oleoyl-phosphatidylethanolamine, pomwepo amakonzedwa ndi N-acyl-phosphatidylethanolamine-kusankha phospholipase D (PLD) kuti amasule Oleoylethanolamide OEA.

Oleoylethanolamide ndi metabolite wachilengedwe wa oleic acid. Chifukwa chake, zakudya zotsutsana ndi oleic acid ndizomwe zimachokera ku OEA.

Kodi Oleoylethanolamide (OEA) amagwira ntchito bwanji?

Mwa anthu onenepa kwambiri, OEA imatha kuyendetsa mphamvu homeostasis ndikulakalaka makamaka mwa kugwira ntchito kwa ma receptor osiyanasiyana kuphatikiza proximal proliferator-activated receptor-α (PPAR-α), G-protein-couped receptor 119 (GPR119) ndi preptent receptor angathe kuchepa kwa chingwe pang'onopang'ono V (TRPV1). Zowonadi, OEA imayendetsa ma receptor awa ndikuchedwa kuyambitsa kudya, imachepetsa kukula kwa chakudya, imachepetsa magawo pakati pa chakudya ndipo pamapeto pake imasintha thupi.

Kuphatikiza apo, kafukufuku wina woyesera akuwonetsa kuti OEA imapondanso kufotokozera kwa IL-6, interleukin-8 (IL-8), ma cell adularion adhesion molecule-1 (ICAM-1) ndi ma cell cell adhesion molecule-1 (VCAM-1) ku TNF -Ikuchititsa kutupa kwa ma umbilical vein endothelial maselo kudzera mwa kugwira ntchito kwa zotupa zolandilira. OEA idalepheretsanso njira yanyukiliya ya kappa-B (NF-kB) m'thupi. Pakafukufuku wa YT et al, OEA (50 µmol / L) adaletsa TNF-α inachititsa kuti VCAM-1 ichitike ku HUVEC.

Phindu la Oleoylethanolamide (OEA)

Oleoylethanolamide (OEA) ufa ndibwino kuti muchepetse thupi ngati munthu wofuna kudya ndipo amathandizira kuchuluka kwa cholesterol mwa akulu.

Oleoylethanolamide (OEA) monga Wopondera chakudya

Kuchepetsa chilakolako chofuna kudya ndikuchepetsa chakudya chambiri ndi njira yokhayo yolimbikitsira mphamvu komanso kuchuluka kwa thupi. Popeza chilimbikitso chofuna kudya ndizofunikira kwambiri pakudya (mphamvu) ya chakudya, kusamalira chilakiko ndikofunikira pakulamulira kunenepa kwambiri kwamthupi, makamaka mukaphatikizidwa ndi zisankho zathanzi zomwe zimaphatikizapo chidwi ndi kudya bwino, zakudya zowonjezera, komanso masewera olimbitsa thupi.

Oleoylethanolamide yowonjezera imathandizira kuyendetsa metabolism ya lipid, imathandizira kuthetsa njala potumiza mauthenga olimbitsa thupi ku ubongo ndipo awonetsedwa kuti amathandizira kuchepetsa ma triglyceride ndi kuchuluka kwa cholesterol yamagazi.

Oleoylethanolamide kwa Thupi lamafuta mafuta

OEA ndi njira yotetezeka yolowera chilimbikitso ndi kugwiritsa ntchito mphamvu.

Zotsatira za OEA zidaphunziridwa koyamba chifukwa zimagawana zofanana ndi mankhwala ena, cannabinoid omwe amadziwika kuti anandamide. Ma Cannabinoids ndi okhudzana ndi chomera Cannabis, ndipo anandamides omwe amapezeka mu chomera (ndi chamba) amatha kukulitsa chidwi cha munthu chofuna kuzimitsa chakudya posowetsa yankho pakudya. Malinga ndi Wikipedia, Oleoylethanolamide ndi analogue ya monocsaturated ya endocannabinoid anandamide. Ngakhale OEA ili ndi kapangidwe ka mankhwala omwe ali ofanana ndi anandamide, zomwe zimapangitsa pakudya ndi kasamalidwe kaukolo ndizosiyana. Mosiyana ndi anandamide, OEA imachita mosadalira njira ya cannabinoid, kuwongolera zochitika za PPAR-α kuti ilimbikitse lipolysis.

Kupanga thupi kwa Oleoylethanolamide

Aliyense amafuna thanzi kudzera pakupanga masewera olimbitsa thupi. OEA imadziwika kwambiri ndi omanga thupi. M'magawo othandizira othandizira, TTA (tetradecylthioacetic acid) imagwiritsidwa ntchito nthawi zambiri synergistically ndi oleoylethanolamide (OEA), zonsezi zimathandizanso kutentha mafuta komanso kuchepetsa njala. TTA ikhoza kukhalanso yolimbikitsa pakati pa othandizira mafuta, chifukwa imawoneka ngati ikutentha mafuta osachita zolimbitsa thupi; Zotsatira zoyambirira zikusonyeza kuti thupi limangowoneka ngati "likuchotsa" mafuta mmalo mongofunika kuti liwotchedwe ndi masewera olimbitsa thupi.

Oleoylethanolamide (OEA) amachepetsa triglycerides ndi cholesterol, ndipo, wophatikizana ndi cannabinoid wotsutsana naye, amatseka kulemera kwa thupi ndikuwongolera dyslipidaemia mu zitsanzo za nyama.

Kuphatikiza apo, makina a oleoylethanolamide apezeka kuti azisintha shuga homeostasis, komanso kutulutsidwa kwa insulini komanso ma insulin posonyeza ma hepatocytes ndi adipocytes.

Ma rereearch ena akuwonetsa kuti owoylethanolamide yowonjezera ali ndi zotsatira zabwino pa nkhawa, ndipo njira zambiri ndi umboni ndizofunikira kuti zithandizire.

Momwe mungagwiritsire ntchito Oleoylethanolamide OEA

Oleoylethanolamide mavuto

Oleoylethanolamide OEA ndiyatsopano pamsika wowonjezera, ndipo palibe zovuta zoyipa zomwe zanenedwapo. US Food and Drug Administration (FDA) idalibe nkhawa zokhudzana ndi chitetezo cha OEA. M'moyo watsiku ndi tsiku, oleoylethanolamide ndi njira ina yotetezeka yolemetsa, yomwe imagwiritsidwa ntchito poyesa kuchuluka kwa catabolism m'mimba ya m'mimba, ndikuthandizira kuchepetsa mafuta popanda zovuta zoyipa.

Oleoylethanolamide mlingo

Palibe mulingo wovomerezeka pagulu wa oleoylethanolamide popeza zowonjezera za oleoylethanolamide sizidatchuka kwambiri komanso poyambira. RiduZone anali ufa woyamba wa OEA kutchulidwa mu 2015.

Mlingo wovomerezeka wa oleoylethanolamide ndi kapisozi imodzi 200mg mukamamwa popanda kuphatikiza

Kafukufuku akuwonetsa kuti muthanso kutsitsa kapena kuwonjezera kuchuluka kwa tsiku lililonse malinga ndi thupi lanu.

100mg kwa munthu wa 150lb

145mg kwa munthu wa 200lb

180mg kwa munthu wa 250lb

Kugwiritsa ntchito Oleoylethanolamide (OEA)

Oleoylethanolamide ufa wagwiritsa ntchito mu Healthcare supplement, wopangidwa mu Hard kaputule kapena piritsi la kuwonda.

Tsamba:

  • Gaetani S, Oveisi F, Piomelli D (2003). "Kusintha kwa mawonekedwe a ufa muzole wa anorexic lipid mediator oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.

  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Kawongoleredwe kazakudya za oleoylethanolamine". Selo. Mol. Life Sci. 62 (6): 708-16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.

  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hick & Dani Piomelli (2005-12-22). "Kuchulukitsa kwaprostial wa oleoylethanolamine m'matumbo ochepa a Burmese python (Python molurus)". Ndine J Physiol Regul Integr Comp Physiol. 290 (5): R1407-R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.

  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Seputembara 2008). "Ntchito za endocannabinoids ndi kufananizira kwake kunenepa kwambiri ndi zovuta za kudya". Idyani Chakudya Cholemetsa. 13 (3): e42-8. PMID 19011363.

  • Serrano A, et al. Oleoylethanolamide: zomwe zimayambitsa ma hypothalamic transmitters ndi ma gut peptides okhazikitsa zakudya. Neuropharmacology. (2011)