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Oleoylethanolamide (OEA) (111-58-0)

Oleoylethanolamide (OEA) ndi endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Ndi …… ..


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

Kufotokozera

Mafotokozedwe a Oleoylethanolamide (OEA) (111-58-0)

Name mankhwala Oleoylethanolamide (OEA)
Mankhwala Name n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

Nambala ya CAS 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
MUZIKONDWERETSA CCCCCCCCC = CCCCCCCCC (= O) NCCO
Molecular Formula C20H39NO2
Kulemera kwa maselo 325.5 g / mol
Misa ya Monoisotopic 325.537 g · mol-1
Melting Point 59-60 ° C (138-140 ° F; 332-333 K)
Malo otentha 496.4 ± 38.0 ° C (Wonenedweratu)
kachulukidwe 0.915 ± 0.06 g / cm3 (Zanenedweratu)
mtundu White
Stempage temp -20 ° C
Solubility mu ethanol ndi DMSO Sungunuka
ntchito Munda wa phamaceutical; ma suppl;

Kodi Oleoylethanolamide (OEA) ndi chiyani?

Oleoylethanolamide (OEA) ndi endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Ndi glycolamide lipid mwachilengedwe omwe ali ndi mawonekedwe osiyanasiyana apadera a homeostasis monga kulakalaka kudya, ntchito yotsutsa-kutupa, kukondoweza kwa lipolysis ndi mafuta oxidation. Oleoylethanolamide imatha kutengedwa ngati mahomoni am'matumbo a ubongo. Oatmeal, mtedza, ndi ufa wa cocoa ndizinthu zazikulu zakudya za Oleoylethanolamide muzakudya. Komabe, kuchuluka kwa Oleoylethanolamide omwe amapezeka mu zakudya izi ndizotsika (ochepera 2 µg / g).

Monga biologically yogwira lipid sing'anga, oleylethanolamide (OEA) imapangidwa m'matumbo ndi ziwalo zina, ndipo imakhudzidwa ndimalamulo yamagetsi yamagetsi yamagetsi, kuwongolera zakudya zomwe zimadya komanso lipid metabolism, monga momwe imatha kuyendetsa chakudya cha Vertebrate ndi kulemera kwa thupi. Oleoylethanolamide ndi mafuta acid ethanolamide (FAE), analog ya monounsaturated analog ya endocannabinoid arachidonic acid ethanolamide (anandamide), ndiogwira ntchito wotsutsana ndi anandamide. Ndikofunikira kudziwa kuti Oleoylethanolamide ndi yosiyana ndi anandamide, imayima yokha pa cannabinoid receptor, ndipo imagwira ntchito yake yachilengedwe kudzera munjira zina, kuyang'anira ntchito ya PPAR-α kuti ipangitse lipolysis. Oleoylethanolamide ndi mankhwala omwe angathe kuthana ndi kunenepa kwambiri omwe amaloza m'malo mwa CB1.

Kafukufuku wam'mbuyomu wasonyeza kuti Oleoylethanolamide ndiwothandiza komanso odana ndi yotupa komanso antioxidant. Exo native makonzedwe a Oleoylethanolamide amalepheretsa moyenera kuphatikiza TLR4-yolumikizira proinflammatory cascades, potero amachepetsa kutulutsa kwa proinfigueatory cytokines ndi chemokines, oxidative and nitrosative stress, ndipo pamapeto pake amalepheretsa kuwonongeka kwa mitsempha kutsogolo kwamakolo.

Kodi Oleoylethanolamide (OEA) amagwira ntchito bwanji?

Mwa anthu onenepa kwambiri, OEA imatha kuyendetsa mphamvu homeostasis ndikulakalaka makamaka mwa kugwira ntchito kwa ma receptor osiyanasiyana kuphatikiza proximal proliferator-activated receptor-α (PPAR-α), G-protein-couped receptor 119 (GPR119) ndi preptent receptor angathe kuchepa kwa chingwe pang'onopang'ono V (TRPV1). Zowonadi, OEA imayendetsa ma receptor awa ndikuchedwa kuyambitsa kudya, imachepetsa kukula kwa chakudya, imachepetsa magawo pakati pa chakudya ndipo pamapeto pake imasintha thupi.

Kuphatikiza apo, kafukufuku wina woyesera akuwonetsa kuti OEA imapondanso kufotokozera kwa IL-6, interleukin-8 (IL-8), ma cell adularion adhesion molecule-1 (ICAM-1) ndi ma cell cell adhesion molecule-1 (VCAM-1) ku TNF -Ikuchititsa kutupa kwa ma umbilical vein endothelial maselo kudzera mwa kugwira ntchito kwa zotupa zolandilira. OEA idalepheretsanso njira yanyukiliya ya kappa-B (NF-kB) m'thupi. Pakafukufuku wa YT et al, OEA (50 µmol / L) adaletsa TNF-α inachititsa kuti VCAM-1 ichitike ku HUVEC.

Phindu la Oleoylethanolamide (OEA)

Monga ceramidase inhibitor, agoist endo native wa GPR119 receptor, Oleoylethanolamide imagwira ntchito pothana ndi matenda a neurodegenerative, anti-atherosulinosis, apoptosis, kupumula kwa ululu, metabolid lipid yolimbikitsidwa, ndi maselo pama cell a islet β. Chitetezo ndi matenda ena a metabolic ali ndi chitetezo chabwino. Kuphatikiza apo, imatha kuchepetsa mafuta m'thupi mwakuwongolera kudya, kuwongolera kunenepa, ndikukwaniritsa kunenepa. Oleoylethanolamide ilinso ndi mphamvu yochepetsera kutupa ndi kuchepa kwa cholesterol.

Ntchito za Oleoylethanolamide (OEA)

  • Phamaceutical munda chakudya cham'malo
  • Gaetani S, Oveisi F, Piomelli D (2003). "Kusintha kwa mawonekedwe a ufa muzole wa anorexic lipid mediator oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Kawongoleredwe kazakudya za oleoylethanolamine". Selo. Mol. Life Sci. 62 (6): 708-16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hick & Dani Piomelli (2005-12-22). "Kuchulukitsa kwaprostial wa oleoylethanolamine m'matumbo ochepa a Burmese python (Python molurus)". Ndine J Physiol Regul Integr Comp Physiol. 290 (5): R1407-R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.
  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Seputembara 2008). "Ntchito za endocannabinoids ndi kufananizira kwake kunenepa kwambiri ndi zovuta za kudya". Idyani Chakudya Cholemetsa. 13 (3): e42-8. PMID 19011363.
  • Serrano A, et al. Oleoylethanolamide: zomwe zimayambitsa ma hypothalamic transmitters ndi ma gut peptides okhazikitsa zakudya. Neuropharmacology. (2011)

KULAMBIRA NDI KUSINTHA:

Nkhaniyi Ikagulitsidwa Kugwiritsa Ntchito Kafukufuku kokha. Migwirizano Yogulitsa. Osati Zongogwiritsa Ntchito Anthu, kapena Zamankhwala, Zoweta Zanyama, kapena Zogwiritsa Ntchito Panyumba.


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