Ganglioside GT1b (59247-13-1)

March 15, 2020
SKU: 167933-07-5

Ganglioside idagwiritsidwa ntchito koyamba ndi wasayansi waku Germany, Ernst Klenk mu 1942, kukhala ngati ma lipid ochokera ku ma cell a ganglion cell… ..


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

Ganglioside GT1b (59247-13-1) kanema

Ganglioside GT1b S.zizindikiro

Name mankhwala Ganglioside GT1b
Mankhwala Name GANGLIOSIDE GT1B TRISODIUM SALT; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) kuchokera ku ubongo wa bovine; trisialoganglioside-gt1b kuchokera ku ubongo wa bovine; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + mchere)
Nambala ya CAS 59247-13-1
InChIKey Ndemanga: SDFCIPGOAFIMPG-VLTFPFDUSA-N
Molecular Formula C95H162N5Na3O47
Kulemera kwa maselo 2158.4 g / mol
Misa ya Monoisotopic 2157.119189 g / mol
Melting Point N / A
Stempage temp -20 ° C
Kutupa DMSO: sungunuka
ntchito Mankhwala; chromatography;

Kodi Ganglioside GT1b?

Ganglioside adagwiritsidwa ntchito koyamba ndi wasayansi waku Germany, Ernst Klenk mu 1942, kukhala ndi ma lipids omwe anali atangotuluka kumene kuchokera ku ma cell a ganglion cell. Ndi molekyulu yopangidwa ndi glycosphingolipids (ceramides ndi oligosaccharides) ndi asidi amodzi kapena angapo a saalic omwe amalumikizidwa ndi unyolo wa shuga. Ndi gawo limodzi la nembanemba ya cytoplasmic yomwe imayang'anira zochitika zapa cellular trans. Mitundu yoposa 60 ya ma gangliosides amadziwika, ndipo kusiyana kwakukulu pakati pawo ndi malo ndi kuchuluka kwa zotsalira za NANA.

Ganglioside GT1b ndi amodzi mwa ma ganglioside ambiri ndipo ndi trisialic ganglioside wokhala ndi zotsalira ziwiri za sialic acid zolumikizidwa ndi gulu lamkati la galactose. Imakhala ndi yolepheretsa kuyankha kwamphamvu kwa thupi. Pa 0.1-10 μM, imatha kulepheretsa kupangika kwa IgG, IgM ndi IgA ndi maselo amitsempha a m'magazi. Ganglioside GT1b yafunsidwanso ngati host cell receptor ya Merkel cell polyoma virus komanso ngati njira yomwe ingayambitse matenda omwe amayambitsa Merkel cell carcinoma.

Ganglioside GT1b idakhudzidwanso mu khansa zingapo zama neuronal ndipo imawerengedwa kuti ndi ganglioside yolumikizidwa ndi metastases yaubongo. Kafukufuku wapeza kuti GM1, GD1a, ndi GT1b ali ndi zovuta zoletsa zomwe zimapangitsa kuti khungu lizikula komanso chizindikiritso komanso kusamukira kwa keratinocyte, ndipo kupezeka kwawo kungakhale kothandiza pakuwunika ubongo metastatic.

Ganglioside GT1b imakhudzanso chitetezo cha mthupi. Ganglioside GT1b imakhala ndi zolepheretsa kuyipa kwa chitetezo cha mthupi la munthu komanso imalepheretsa ma immunoglobulin opangidwa ndi ma cell a cell a cell a cell a cell. Pali umboni kuti GD1b, GT1b, ndi GQ1b ikhoza kupititsa patsogolo kupanga ma cytokines a Th1 poletsa ntchito ya adenylate cyclase, pomwe ikulepheretsa kupanga kwa Th2.

Monga receptor yomwe imazindikira mitundu ingapo ya poizoni wake wa oligosaccharide, ganglioside GT1b imalandirira momwe Clostridium botulinum bacterium botulinum neurotoxin imalowa m'maselo a mitsempha. Kafukufuku wasonyeza kuti poizoni wa tetanus amalowa m'mitsempha ya mitsempha pothandizidwa ndi GT1b ndi ma gangliosides ena, amalepheretsa kutulutsidwa kwa ma neurotransmitters mkati mwa dongosolo lamanjenje, ndikuyambitsa ziwengo zam'mimba. Mitundu ya botulinum C ya neurotoxin yolowa mu mitsempha yafufuza momwe mphamvu ya apoptotic imapangidwira maselo opangidwa ndi ganglioside GT1b omanga ku neuroblastoma.

Kuphatikiza apo, ganglioside GT1b imayendetsa bwino kayendedwe ka maselo, kulowetsedwa, komanso kudziphatika kwa fibronectin (FN) kudzera pamasewera olimbana ndi α5 subunit ya α5β1, kupezako komwe kungagwiritsidwe ntchito kukulitsa njira zochizira khansa. Kuphatikizika kwa GT1b ndi MAG pamtundu wa neurons kumatha kuwongolera kuyanjana kwa GT1b mu membrane wa plasma wa neurons, zomwe zimapangitsa kuyambitsa kukula kwa mitsempha.

Ubwino wa Ganglioside GT1b

Ganglioside GT1b ndi acidic glycosphingolipid yomwe imapanga ma lipid rafts mu neuronal cell a chapakati mantha dongosolo ndipo imathandizira kutalika kwa maselo, kusiyanitsa, kuphatikiza, kusintha kwa chizindikiro, kugwirizanitsa kwa ma cell, ma cell ndi tumastasis.

Kuyankha kwa Autoimmune ku gangliosides kumatha kudzetsa Guillain-Barre syndrome. Ganglioside GT1b imapangitsa dopaminergic neuron kufooka, zomwe zimatha kuyambitsa kapena kukulitsa matenda a Parkinson.

Ganglioside GT1b ndi scavenger ya • OH ma free radicals, yomwe imateteza bongo kuti lisawonongeke mtDNA, kugwidwa ndi lipid peroxidation yoyambitsidwa ndi opanga ma oxygen ophatikizika.

Zotupa za Ehrlich zimatulutsa ganglioside GT1b, ndipo anti-GT1b ali ndi kuthekera kwakukulu kwa khansa iyi. Mgulu la zigawenga limaphatikizidwanso ndi Miller Fisher syndrome.

Zotsatira za Ganglioside GT1b

Gangliosides amatha kumangiriza ku lectins, kugwira ngati maselo omata komanso maselo omatira .

Kuchuluka kwa ganglioside GT1b kwalumikizidwa ndi matenda angapo kuphatikiza matenda a Thai-Sachs ndi matenda a Sandhof.

Ganglioside GT1b imalepheretsa antigen kapena mitogen-ikiwayambitsa kuchuluka kwa maselo ndipo yatchulidwa ngati botulinum receptor, mankhwala osokoneza bongo omwe amakhala ndi zotsatira zovuta za thupi.

Ganglioside GT1b imapezeka pafupifupi m'maselo am'mitsempha ndipo imawonetsedwa pa adventitia. GT1b imathandizira kusiyanitsa kwa neuronal ndi mapangidwe a dendritic, omwe amapanga khalidwe losautsa komanso limathandizira hyperalgesia ndi allodynia.

Ganglioside GT1b imatha kusokoneza chitetezo cha mthupi. Imakhala ndi cholepheretsa kusintha kwamphamvu kwa chitetezo cha mthupi la munthu ndipo imalepheretsa immunoglobulin yopangidwa ndi ma cell a cell a cell a cell.

Kuphatikiza apo, Ganglioside GT1b imayenderana ndi matenda otsatirawa: fuluwenza, matenda a guillain-garré, cholera, kafumbata, botulism, khate komanso kunenepa kwambiri.

Tsamba:

  • Erickson, KD, Garcea, RL, ndi Tsai, B. Ganglioside GT1b ndi malo ochitirako khungu a Merkel cell polyomavirus. Journal of Virology 83 (19), 10275-10279 (2009).
  • Kanda, N., ndi Tamaki, K. Ganglioside GT1b amathandizira kupanga ma immunoglobulin opangidwa ndi ma cell a cell a cell a cell a cell. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, ndi Ringler, NJ Binding wa botulinum ndi tetanus neurotoxins ku ganglioside GT1b ndi zotumphukira zake. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Gangliosides, kapangidwe, zopezeka, zamoyo ndi kuwunika ”. Library ya Lipid. American American Chemists 'Society. Zosungidwa kuyambira zoyamba pa 2009-12-17.
  • Nicole Gaude, Journal of Biological Chemistry, Vol. 279: 33 mas. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, etc. Biosynthesis of the main gangliosides GD1a and GT1b. Glycobiology, Gawo 22, Kutulutsa 10, Okutobala 2012, masamba 1289-