Ganglioside GT1b (59247-13-1)

March 15, 2020

Dzinalo Ganglioside linagwiritsidwa ntchito koyamba ndi wasayansi waku Germany Ernst Klenk mu 1942 kwa lipids omwe anali atangotalikirana kumene ndi magulu am'magazi am'magazi ...

 


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

 

Ganglioside GT1b (59247-13-1) kanema

Ganglioside GT1b Szizindikiro

Name mankhwala Zovuta za GT1b
Mankhwala Name GANGLIOSIDE GT1B TRISODIUM Mchere; Zamgululi GT1B-GANGLIOSIDE; GT3B (NH1 + Mchere); kuphulika, gt1; (ganglioside gt4B) kuchokera ku ubongo wa ziweto; trisialoganglioside-gt1b kuchokera ku ubongo wa ziweto; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH1 + mchere)
Nambala ya CAS 59247-13-1
InChIKey Ndemanga: SDFCIPGOAFIMPG-VLTFPFDUSA-N
Molecular Formula C95H162N5Na3O47
Kulemera kwa maselo 2158.4 g / mol
Misa ya Monoisotopic 2157.119189 g / mol
Melting Point N / A
Stempage temp -20 ° C
Kutupa DMSO: sungunuka
ntchito Mankhwala; chromatography;

 

Kodi Ganglioside GT1b?

Dzinalo Ganglioside adagwiritsidwa ntchito koyamba ndi wasayansi waku Germany a Ernst Klenk ku 1942 kwa lipids omwe anali atangotalikirana kumene ndi magulu am'magazi am'magazi. Ndi molekyulu yopangidwa ndi glycosphingolipids (ceramides ndi oligosaccharides) ndi sialic acid imodzi kapena zingapo yolumikizidwa ndi unyolo wa shuga. Ndi gawo limodzi la cytoplasmic nembanemba yomwe imayang'anira zochitika zamagetsi zamagetsi. Mitundu yopitilira 60 ya zigawenga zimadziwika, ndipo kusiyana kwakukulu pakati pawo ndi malo ndi kuchuluka kwa zotsalira za NANA.

Ganglioside GT1b ndi imodzi mwazigawenga zambiri ndipo ndi trisialic ganglioside yokhala ndi zotsalira ziwiri za asidi zomwe zimalumikizidwa ndi chipinda chamkati cha galactose. Zimakhudza kwambiri chitetezo chamthupi. Pa 0.1-10 μM, imatha kulepheretsa kupanga kwa IgG, IgM ndi IgA ndim'magazi am'magazi am'magazi a mononuclear. Ganglioside GT1b yakhala ikufunsidwanso ngati cholandirira ma cell a Merkel cell polyoma virus komanso ngati njira yothandizira kuyambitsa matenda omwe amayambitsa Merkel cell carcinoma.

Ganglioside GT1b idakhudzidwanso mu khansa zingapo zama neuronal ndipo imawerengedwa kuti ndi ganglioside yolumikizidwa ndi metastases yaubongo. Kafukufuku wapeza kuti GM1, GD1a, ndi GT1b ali ndi zovuta zoletsa zomwe zimapangitsa kuti khungu lizikula komanso chizindikiritso komanso kusamukira kwa keratinocyte, ndipo kupezeka kwawo kungakhale kothandiza pakuwunika ubongo metastatic.

Ganglioside GT1b imakhudzanso chitetezo chamthupi. Ganglioside GT1b imalepheretsa chitetezo chamthupi cha munthu ndipo imalepheretsa ma immunoglobulins opangidwa ndi zotumphukira zamagazi zama mononuclear. Pali umboni kuti GD1b, GT1b, ndi GQ1b zitha kupititsa patsogolo kupanga ma cytokines a Th1 poletsa ntchito ya adenylate cyclase, poletsa kupanga Th2.

Monga receptor yomwe imazindikira mitundu ingapo ya poizoni wake wa oligosaccharide, ganglioside GT1b imalandirira momwe Clostridium botulinum bacterium botulinum neurotoxin imalowa m'maselo a mitsempha. Kafukufuku wasonyeza kuti poizoni wa tetanus amalowa m'mitsempha ya mitsempha pothandizidwa ndi GT1b ndi ma gangliosides ena, amalepheretsa kutulutsidwa kwa ma neurotransmitters mkati mwa dongosolo lamanjenje, ndikuyambitsa ziwengo zam'mimba. Mitundu ya botulinum C ya neurotoxin yolowa mu mitsempha yafufuza momwe mphamvu ya apoptotic imapangidwira maselo opangidwa ndi ganglioside GT1b omanga ku neuroblastoma.

Kuphatikiza apo, ganglioside GT1b imayendetsa bwino kayendedwe ka maselo, kulowetsedwa, komanso kudziphatika kwa fibronectin (FN) kudzera pamasewera olimbana ndi α5 subunit ya α5β1, kupezako komwe kungagwiritsidwe ntchito kukulitsa njira zochizira khansa. Kuphatikizika kwa GT1b ndi MAG pamtundu wa neurons kumatha kuwongolera kuyanjana kwa GT1b mu membrane wa plasma wa neurons, zomwe zimapangitsa kuyambitsa kukula kwa mitsempha.

 

Ubwino wa Ganglioside GT1b

Ganglioside GT1b ndi acidic glycosphingolipid yomwe imapanga ma lipid rafts mu neuronal cell a chapakati mantha dongosolo ndipo imathandizira kutalika kwa maselo, kusiyanitsa, kuphatikiza, kusintha kwa chizindikiro, kugwirizanitsa kwa ma cell, ma cell ndi tumastasis.

Mayankho omwe amadzipangitsa okha pama gangliosides atha kubweretsa matenda a Guillain-Barre. Ganglioside GT1b imapangitsa kuchepa kwa dopaminergic neuron, komwe kumathandizira kuyambitsa kapena kukulitsa matenda a Parkinson.

Ganglioside GT1b ndi scavenger ya • OH ma free radicals, yomwe imateteza bongo kuti lisawonongeke mtDNA, kugwidwa ndi lipid peroxidation yoyambitsidwa ndi opanga ma oxygen ophatikizika.

Zotupa za Ehrlich zimatulutsa ganglioside GT1b, ndipo anti-GT1b ali ndi kuthekera kwakukulu kwa khansa iyi. Mgulu la zigawenga limaphatikizidwanso ndi Miller Fisher syndrome.

 

Zotsatira za Ganglioside GT1b

Gangliosides amatha kumangiriza ku lectins, kugwira ngati maselo omata komanso maselo omatira .

Kuchuluka kwa ganglioside GT1b kwalumikizidwa ndi matenda angapo kuphatikiza matenda a Thai-Sachs ndi matenda a Sandhof.

Ganglioside GT1b imaletsa kuyankha kwa antigen kapena mitogen-komwe kumayambitsa mayankho a T cell ndipo amadziwika kuti ndi botulinum toxin receptor, poizoni wosowa wokhala ndi zovuta m'thupi.

Ganglioside GT1b amapezeka pafupifupi m'maselo amitsempha ndipo amawonetsedwa pa adventitia. GT1b imalimbikitsa kusiyanitsa kwamitsempha ndi mapangidwe a dendritic, omwe amapanga machitidwe owopsa ndikuwonjezera hyperalgesia ndi allodynia.

Ganglioside GT1b imatha kusokoneza chitetezo chamthupi. Imakhala ndi mphamvu yoletsa chitetezo chamthupi chamunthu ndikulepheretsa immunoglobulin yopangidwa ndi zotumphukira zamagazi zamagulu am'magazi.

Kuphatikiza apo, Ganglioside GT1b ndiyofanana ndi matenda otsatirawa: fuluwenza, guillain-garré syndrome, kolera, kafumbata, botulism, khate ndi kunenepa kwambiri.

 

Tsamba:

  • Erickson, KD, Garcea, RL, ndi Tsai, B. Ganglioside GT1b ndi malo ochitirako khungu a Merkel cell polyomavirus. Journal of Virology 83 (19), 10275-10279 (2009).
  • Kanda, N., ndi Tamaki, K. Ganglioside GT1b amathandizira kupanga ma immunoglobulin opangidwa ndi ma cell a cell a cell a cell a cell. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, ndi Ringler, NJ Binding wa botulinum ndi tetanus neurotoxins ku ganglioside GT1b ndi zotumphukira zake. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Magalasi, mapangidwe, zochitika, biology ndi kusanthula ". Laibulale ya Lipid. Bungwe la American Chemists 'Society. Zosungidwa kuchokera pachiyambi pa 2009-12-17.
  • Nicole Gaude, Journal of Biological Chemistry, Vol. 279: 33 mas. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, etc. Biosynthesis yamagulu akuluakulu am'magazi a GD1a ndi GT1b. Glycobiology, Voliyumu 22, Nkhani 10, Okutobala 2012, masamba 1289–