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Mafuta aakulu a Flibanserin (167933-07-5)

(1 kasitomala review)

Mafuta akuluakulu a Flibanserin ndi mankhwala omwe amasonyeza kuti amachiza amayi omwe ali ndi chikhalidwe chogonana.


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1489kg / mwezi

Kufotokozera

Mawindo oda kwambiri a Flibanserin (167933-07-5)

Mafuta aakulu a Flibanserin (167933-07-5)

Mafuta akuluakulu a Flibanserin, ogulitsidwa pansi pa dzina la malonda Addyi, ndi ogwira ntchito ambiri omwe amagwiritsa ntchito serotonin agonist ndi otsutsa omwe amagwiritsidwa ntchito pochiza amayi omwe ali ndi vuto loyambitsa kugonana (HSDD). Mankhwalawa amachulukitsa chiwerengero cha zosangalatsa za kugonana mwezi uliwonse pafupi ndi theka la placebo kuyambira pachiyambi cha pafupifupi ziwiri kapena zitatu. Pa nthawi imodzimodziyo, ili ndi udindo monga serotonergic agonist, wotsutsa wa serotonergic komanso wodwala matenda oopsa.

Mafinya a Flibanserin (167933-07-5) Szizindikiro

Name mankhwala Mpweya wofiira wa Flibanserin
Mankhwala Name 1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one
Brand NAme Addyi
Kalasi ya Mankhwala Ogwira ntchito ambiri otchedwa serotonin agonist ndi otsutsa
Nambala ya CAS 167933-07-5
InChIKey PPRRDFIXUUSXRA-UHFFFAOYSA-N
Maselo Fmphutsi C20H21F3N4O
Maselo Wasanu ndi atatu 390.41 g / mol
Misa ya Monoisotopic 390.167 g / mol
Kusungunula Pmafuta 225 ° C
Malo otentha N / A
Halimo Half-Life ~ Maola 11
mtundu Yoyera kuti ikhale yachitsulo
Szovuta DMSO: soluble10mg / mL, momveka bwino
Smazunzo Tkutentha 2-8 ° C
Mpweya wofiira wa Flibanserin Amalingaliro Anapangidwe kuti azitha kuchiza matenda osokoneza bongo mwachisokonezo mwa amayi

Mafuta akuluakulu a Flibanserin (167933-07-5) Ndemanga

Flibanserin ufa ndiwo mankhwala oyamba omwe amavomerezedwa ku matenda okhudzana ndi chiwerewere (HSDD) omwe ali ndi amayi omwe amatsogoleredwa ndi a FDA mu August 2015. Poyamba anayamba kukhala mankhwala opatsirana pogwiritsidwa ntchito ndi Boehringer Ingelheim, koma anasonyeza kuti sanagwiritse ntchito bwino mayesero ndipo anapitanso patsogolo ngati mankhwala osokoneza bongo pogonana ndi Sprout Pharmaceuticals. Zochita za Flibanserin zimayesedwa kuti zimagwirizana kwambiri ndi 5-HTA1 ndi 5-HTA2 receptors, kuwonetsa ntchito za agonist pa 5-HTA1 ndi otsutsa pa 5-HTA2, zomwe zimapangitsa kutsikira kwa serotonin mu ubongo komanso kuwonjezera pa norepinephrine ndi dopamine neurotransmitters.

Flibanserin ufa (167933-07-5) Njira yogwira ntchito

Zochita za Flibanserin zimayesedwa kuti zimagwirizana kwambiri ndi 5-HTA1 ndi 5-HTA2 receptors, kuwonetsa ntchito za agonist pa 5-HTA1 ndi otsutsa pa 5-HTA2, zomwe zimapangitsa kutsikira kwa serotonin mu ubongo komanso kuwonjezera pa norepinephrine ndi dopamine neurotransmitters. Flibansetrin ili ndi mgwirizano wapamwamba kwa serotonin receptors mu ubongo: imakhala ngati agonist pa 5-HT1A komanso wotsutsa pa 5-HT2A. Mu vivo, flibanserin imamanga mofanana ndi 5-HT1A ndi 5-HT2A receptors. Komabe, m'magulu akuluakulu a ubongo 5-HT (mwachitsanzo, atapanikizika), flibanserin ikhoza kutenga 5-HT2A receptors mmwamba kuposa 5-HT (1A) receptors. Zingathenso kumenyana ndi D4 (dopamine) receptors ndi 5-HT2B ndi 5-HTB2C. Zomwe zimachitidwa pa mapuloteni a mphuno zimathandiza kuti kuchepa kwa serotonin kuwonjezereke komanso kuwonjezeka kwa dopamine ndi norepinephrine, zomwe zingakhale zolimbitsa mphoto. Flibanserin amagulitsidwa pansi pa dzina la malonda Addyi ndipo akuwonetsedwa kuti azisamalidwa ndi amayi omwe ali ndi chikhalidwe chogonana (HSDD) omwe amadziwika ndi chilakolako chogonana chomwe chimayambitsa mavuto aakulu.

Kugwiritsa ntchito Flibanserin ufa (167933-07-5)

Flibanserin ufa ndi wotsutsa wa 5-HT1A ndi 5-HT2A omwe amapangidwa kuti athetse vuto lachisokonezo chogonana pakati pa akazi (1,2).

Pothiridwa Flibanserin ufa (167933-07-5) Mlingo

100 mg mlomo kamodzi patsiku pogona

Nthawi ya mankhwala: Mankhwalawa ayenera kuchotsedwa pakatha masabata a 8 ngati wodwala sakunena kuti akukula bwino.

Ndemanga: Mankhwalawa samasonyezedwa kuti apititse patsogolo kugonana, ndipo sichiwonetsedwera kaamba ka mankhwala opatsirana pogonana kapena amuna.

Zotsatira za Flibanserin ufa (167933-07-5)

Zochitika zoipa ndizofala kwambiri pakati pa akazi kutenga flibanserin powder. Zambiri zovuta zinali zofatsa mpaka zochepa. Zomwe zimachitika nthawi zambiri zowonongeka ndizozunguza, kunyoza, kumva kutopa, kugona, ndi vuto logona.

Kumwa mowa panthawi ya flibanserin ufa kungayambitse kuthamanga kwa magazi (kuchepa kwa magazi komwe kunabweretsa zizindikiro pambuyo pa magetsi a 2 a vinyo ku 17%).


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1 review kwa Mafuta aakulu a Flibanserin (167933-07-5)

  1. phcoker -

    Ali ndi ufa wambiri wa Flibanserin kuti ayesedwe, zotsatira zowonetsera zimasonyeza kwambiri khalidwe labwino ndi chiyero!

Kuwonjezera ndemanga

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