Mafuta akuluakulu a Tadalafil (171596-29-5)

October 20, 2018
SKU: 171596-29-5
5.00 kuchokera 5 kutengera 1 kasitomala mlingo

Raw Tadalafil ufa pansi pa dzina la Cialis amagwiritsidwa ntchito pofuna kuchiza matenda osokonekera (kusabala) ndi zizindikiro za chosaopsa cha prostatic ………


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1190kg / mwezi

Tadalafil ufa video

Mfundo Zachidule

Name mankhwala Tadalafil powder
Mankhwala Name (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand NAme Cialis, Adcirca
Kalasi ya Mankhwala PAH, PDE-5 Inhibitors; Phosphodiesterase-5 Enzyme Inhibitors
Nambala ya CAS 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
Maselo Fmphutsi C22H19N3O4
Maselo Wasanu ndi atatu 389.4
Misa ya Monoisotopic 389.138 g / mol
Kusungunula Pmafuta 298-300 ° C
Fkubwezeretsanso Pmafuta 2 ℃
Halimo Half-Life hours 17.5
mtundu Yoyera mpaka Yoyera Yogwedeza Mpweya Wolimba
Szovuta Sungunulani mu DMSO (78 mg / ml pa 25 ° C), methanol, madzi (<1 mg / ml pa 25 ° C), dichloromethane, ndi ethanol (<1 mg / ml pa 25 ° C)
Smazunzo Tkutentha Sungani kutentha kutentha pakati pa 59 ° F ndi 86 ° F (15 ° C ndi 30 ° C). Musasunge mankhwala awa kumalo amvula kapena amchere.
Tadalafil Amalingaliro Mafuta akuluakulu a Tadalafil, mapepala ogonana, ma khofi akugonana, ndi zina zotero.

Kufotokozera

Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6] pyrido [3,4-B] Cialis), ndi mtundu wa PDE1,4 inhibitor ndi mankhwala omwe amalamulidwa ndi pakamwa. Ndi b-carboline yomwe imachokera ndipo imapangidwa mosiyana ndi vardenafil (Levitraw) ndi sildenafil (Viagraw), onse omwe ndi PDE5 inhibitors kutengera mtundu wophatikizidwa wa pyrimidine. Tadalafil ufa (CAS 5-171596-29) imachulukitsa magazi kulowa mu corpus cavernosum pomatsitsa minofu yamitsempha yamagazi, ndipo izi zimathandiza bambo kukwaniritsa erection. Tadalafil ufa wavomerezedwa ndi United States (US) Food and Drug Administration (FDA) ku 5 pochiza matenda osokoneza bongo (ED), ndipo adagulitsidwa padziko lonse lapansi pansi pa dzina la Cialis. Amagwiritsidwanso ntchito pochiza matenda am'mapapo komanso matenda oopsa a prostatic hyperplasia, komwe mchitidwe wa prostate umakulitsidwa, ndikupangitsa mavuto pokodza.

Mbali ya pharmacologic yosiyana ndi Tadalafil ndiyo yautali kwambiri (maola 17.5) poyerekeza ndi Viagra ndi Levitra (maola 4-5). Kutalika kwa theka la moyo kumakhalapo nthawi yaitali ndipo ndi mbali yodziwika ndi dzina lachidziwitso la "mapiritsi a mapeto a sabata." Kutalika kwa theka la moyo ndilo maziko a kafukufuku wamakono wa ntchito ya tadalafil mu mitsempha yowopsa kwambiri. mankhwala amodzi patsiku.

Njira yogwira ntchito

Penile erection pakukakamiza kugonana kumatheka chifukwa cha kumasuka kwa mitsempha ya penile ndi corpus cavernosal yosalala minofu, zomwe zimapangitsa kuwonjezeka kwa magazi ku limba. Kupumula uku kumapangitsa kuwonjezeka kwamagazi kudzera m'mitsempha ya penile, pamene magazi awa amadzaza zipinda ziwiri mkati mwa mbolo yotchedwa corpora cavernosa. Pamene zipinda zimadzaza magazi, mbolo imakula molimba. Kukonzekera kumathera pamene mgwirizano wa minofu ndi magazi ophatikizidwa amatha kutuluka mumtsempha wa penile.

Kuyankha uku kumapangidwa ndikutulutsidwa kwa nitric oxide (NO) kumalo osungira mitsempha ndi maselo a endothelial, komwe kumalimbikitsa kapangidwe ka cGMP m'maselo osalala a minyewa ndikuwongolera kuchepa ndi kupindika kwa mitsempha yamagazi yomwe imanyamula magazi kupita ndi kuchokera ku mbolo. Cyclic GMP imayambitsa kupumula kwa minofu ndikuwonjezereka kwa magazi kulowa mu corpus cavernosum, ndipo imayipitsidwa ndi mtundu wa cGMP enieni wa phosphodiesterase 5 (PDE5) mu corpvern cavernosum yomwe ili kuzungulira mbolo. Tadalafil imalepheretsa PDE5 ndipo potero imakula ndikuwonjezera kuchuluka kwa cGMP. Tadalafil imayimitsa PDE5 kuti isawononge cGMP kenako ndikuwonjezera cGMP yomwe ikupezeka kuti igwire ntchito ndipo imapangitsa kuti erection ikhale kwa nthawi yayitali.

Komabe, pamene hafu ya moyo wa Tadalafil ndi yochepa, zotsatira zake zimatha patsiku la masiku 2 kupanga PDE5 kubwerera ndipo umoyo wanu wa kugonana - umakula. Mungafunike kutenga nthawi yaitali kuti mukwaniritse zomwe mumafuna, monga masiku amphamvu a Cialis 4-5 masiku a 4-5.

ntchito

  • Erectile kulephera (ED)
  • Kupanga mankhwala oopsa
  • Benign Prostatic hyperplasia
  • Analgesic
  • Kuzimitsa kwa Norepinephrine
  • Mu-opiod receptor agonist

Analimbikitsa Tadalafil powder Mlingo

Cialis imakhala ndi mapiritsi a chikasu, ovekedwa ndi mafilimu komanso amondi m'zigawo za 5, 10 ndi 20 milligram (mg). Ndalama yoyamba yoyamba ya Cialis ufa kuti igwiritsidwe ngati momwe osowa ambiri amagwiritsira ntchito ndi 10 mg, kutengedwa musanakhalepo kugonana.

Mlingo woyamba ndi ma XMUMX milligrams (mg) osachepera mphindi 10 musanayambe kugonana. Mlingowo ukhoza kuwonjezeka mpaka 30 mg kapena kuchepa kwa 20 mg, pogwiritsa ntchito mphamvu ndi kulekerera. Koma, chiwerengero chachikulu cha 5 mg ndi mlingo umodzi. Nthawi zambiri odwala ambiri amawadziwitsa nthawi zambiri patsiku. Sitiyenera kutenga mlingo umodzi pa maola 20. Odwala omwe amayembekezera kuti azigonana kamodzi pawiri pa sabata akhoza kutenga mlingo wa 24 mg, ndipo izi zikhoza kuchepetsedwa kukhala 5 mg kamodzi tsiku ndi tsiku, malingana ndi momwe akuchitira.

Cialis ufa wogwiritsidwa ntchito momwe amafunikira adawonetsedwa kuti azigwira bwino ntchito poyerekeza ndi placebo mpaka maola a 36 akutsatira dosing. Chifukwa chake, popereka malangizo kwa odwala pakugwiritsa ntchito bwino Cialis ufa, izi ziyenera kuganiziridwa.

Ndizofunikira kudziwa kuti erection sichingachitike pongotenga piritsi. Ndipo musatenge Cialis kukamwa ngati mukutenga Adcirca ya pulmonary arterial hypertension. Beside, Tadalafil ya kukanika kugwira ntchito imangogwiritsidwa ntchito ndi achikulire azaka za 18 ndi kupitilira apo.

ubwino

• Tadalafil powder akhoza kuthandiza kutulutsa minofu mu prostate yanu ndi chikhodzodzo. Izi zingathandize kusintha zizindikiro za BPH yanu.

• Kuonjezera zizindikiro za ED, ufa wa tadalafil umathandiza kuwonjezera magazi kupita ku mbolo. Izi zingakuthandizeni kupeza ndi kusunga erection. Kwa tadalafil powder kukuthandizani kuti mukhale ndi erection, muyenera kukwatira.

• Kwa PAH, ufa wa tadalafil umayesetsa kukonzanso luso lanu lochita masewera olimbitsa thupi m'mapapo anu. Izi zimapangitsa magazi kuyenda.

Zotsatira zoyipa

Pamodzi ndi zotsatira zake zofunikira, mankhwala akhoza kuchititsa zina zosayenera. Ngakhale kuti zovuta zonsezi sizitha kuchitika, ngati zikuchitika zimakhala zofunikira kuchipatala. Chonde onani zotsatira zotsatirazi za tadalafil powder:

Zotsatira zofala

▪ kumutu

▪ amadwala m'mimba

▪ ululu wammbuyo

▪ minofu ya minofu

▪ kusamba (khungu lofiira)

▪ zonyansa kapena mphuno

▪ m'mimba

Zotsatira zoopsa koma zoopsa

Erection yaitali yomwe ingabweretse kuwonongeka kwa mbolo, mavuto a masomphenya, ndi kutaya kwa kumva.

Ngati zotsatirazi ndi zofewa, zimatha kutha masiku angapo kapena masabata angapo. Ngati ali ovuta kwambiri kapena osapitako, lankhulani ndi dokotala kapena wamankhwala.

Anthu omwe ali ndi zifukwa izi sayenera kutenga Cialis pokhapokha ngati dokotala akugwirizana:

Matenda a mtima, angina, kapena mtundu uliwonse wa matenda a mtima

Kuthamanga kwapamwamba kapena kutsika kwa magazi

Kusintha mtima kwa mtima kapena kupweteka kwa miyezi mkati mwa miyezi yotsiriza ya 6, kapena matenda a myocardial mkati mwa miyezi yotsiriza ya 3

Matenda a maselo a matenda, matenda ena a myeloma, hemophilia, khansa ya m'magazi, kapena matenda ena a magazi

Matenda a chiwindi kapena impso

Chilonda cha m'mimba

Retinitis pigmentosa

Kuwonongeka kwa chiwalo cha mbolo, monga matenda a Peyronie

Matenda aliwonse omwe adalangizidwa kuti asagone nawo

Kugwirizana kwa Tadalafil

Mukamagwiritsa ntchito tadalafil, pangakhale mankhwala ena omwe angakhudze mankhwala, omwe angapangitse zotsatirapo. Kugwiritsa ntchito mankhwala osokoneza bongo kungasinthe momwe mankhwala anu amagwiritsira ntchito kapena kuwonjezera chiopsezo chanu chowopsa.

Tadalafil ali ndi mphamvu zochepa zowonjezera kuchepetsa kuchepetsa kuthamanga kwa magazi. Tadalafil ingayambitse kuchepa kwa magazi pamene ikugwiritsidwa ntchito ndi nitrates, zomwe zingayambitse chizungulire, kutaya mtima, komanso kudwala matenda osokonezeka mtima. Musagwiritse ntchito tadalafil ndi zina mwa izi: mankhwala ena ogwiritsidwa ntchito pochizira chifuwa / angina (nitrates monga nitroglycerin, isosorbide), mankhwala osangalatsa omwe amatchedwa "poppers" omwe ali ndi amyl kapena butyl nitrite.

Ngati mukugwiritsanso ntchito mankhwala a alpha blocker (monga doxazosin, tamsulosin) kuti muzitha kutulutsa prostate / BPH yothamanga kapena kuthamanga kwa magazi, kuthamanga kwa magazi kungakhale kotsika kwambiri komwe kungachititse kuti mukhale ndi chizungulire kapena kutaya. Dokotala wanu angayambe kulandira chithandizo ndi mankhwala ochepa a tadalafil kapena kusintha mankhwala anu ochepetsa mankhwala a alpha kuti muchepetse chiopsezo cha kutsika kwa magazi.

M'maphunziro azachipatala, kuyankha kwakukulu kunanenedwa mpaka 36 h pambuyo pobweretsa mankhwala. Tadalafil imapangidwa makamaka mu chiwindi ndi CYP3A4 ku mabungwe omwe sagwira ntchito motsutsana ndi PDE5 ndipo amachotsa makamaka monga metabolites mu ndowe ndi mkodzo. Ma pharmacokinetics a tadalafil samayang'aniridwa ndi zinthu monga kudya zakudya ndi mowa, zaka, kupezeka kwa matenda ashuga, komanso kufatsa kapena kufatsa pang'ono kwa hepatic. Zochitika zovuta kwambiri zokhudzana ndi mankhwala osokoneza bongo ndi mutu, kupweteka kwa msana, dyspepsia, ndi myalgia. Pa Mlingo wa 10 ndi 20 mg, Tadalafil ilibe gawo lalikulu kuthamanga kwa magazi komanso kuthamanga kwa mtima ndipo sizimapangitsa kuchuluka kwa kuphwanya kwa myocardial. Malipoti osinthika amtundu wotalikirapo kuposa 4 h ndi chidziwitso chapamwamba adadziwika pogwiritsa ntchito tadalafil. Kuika patsogolo zinthu, ngati sikumagwiritsidwa ntchito moyenera, kumatha kuwononga minofu. Odwala omwe ali ndi erection yayitali kuposa 4 h amalangizidwa kuti apite kuchipatala mwadzidzidzi. Mwa odwala matenda ashuga, kusintha kwa ntchito ndi tadalafil sikutanthauza mtundu wa shuga ndi mtundu wa mankhwala a shuga.

Mankhwala ena akhoza kuthandizira kuchotsa tadalafil m'thupi lanu, zomwe zingakhudze momwe tadalafil imagwirira ntchito. Zitsanzo zimaphatikizapo mankhwala a azole (monga itraconazole, ketoconazole), macrolide antibiotics (monga clarithromycin, erythromycin), HIV protease inhibitors (monga fosamprenavir, ritonavir), kachirombo ka hepatitis C protease inhibitors (monga boceprevir, telaprevir), rifampin .

Osamamwa mankhwalawa ndi mankhwala ena aliwonse omwe ali ndi tadalafil kapena mankhwala ena ofanana ndi omwe amagwiritsidwa ntchito pochiza matenda osokoneza bongo-mapiritsi a pulmonary (monga sildenafil, vardenafil).

Ponena za kugonana kwa tadalafil ndi mankhwala ena ali ndi zochuluka kwambiri, ngati mukufuna kugwiritsa ntchito mankhwala ndi tadalafil powder (CAS 171596-29-5), choyamba kumbukirani kukaonana ndi dokotala ndipo adzakupatsa uphungu komanso wodalirika malangizo.

Dziwani zambiri

Tadalafil ufa, sildenafil powder, ndi vardenafil powder onse amachita mwa kuletsa puloteni PDE5, koma mankhwalawa amalepheretsanso mitundu ya PDE michere 6, 1, ndi 11 mosiyanasiyana. Mwachitsanzo, Sildenafil ndi vardenafil amalepheretsa PDE6, nyamayi yomwe imapezeka mu diso, kuposa tadalafil. Owerenga ena a sildenafil amatha kuona bluish tinge ndipo amakhala ndi mphamvu zowonjezera chifukwa cha PDE6. Kuwonjezera apo, Sildenafil ndi vardenafil amalepheretsanso PDE1 kuposa tadalafil. PDE1 imapezeka mu ubongo, mtima, ndi minofu yosalala. Zimaganiziridwa kuti kutetezedwa kwa PDE1 ndi sildenafil ndi vardenafil kumatsogolera ku vasodilation, flushing, ndi tachycardia.

Poyerekeza ndi machitidwe a PDE6 ndi PDE1, tadalafil inkagwira ntchito kwambiri pa PDE11. PDE11 imasonyezedwa minofu ya chifuwa, prostate, chiwindi, impso, chifuwa cha pituitary, ndi mayesero. Komabe, zotsatira za thupi loletsa PDE11 sizidziwika.

KULAMBIRA NDI KUSINTHA:

Nkhaniyi Ikagulitsidwa Kugwiritsa Ntchito Kafukufuku kokha. Migwirizano Yogulitsa. Osati Zongogwiritsa Ntchito Anthu, kapena Zamankhwala, Zoweta Zanyama, kapena Zogwiritsa Ntchito Panyumba.