Mphungu Yaikulu 7P ufa (1890208-58-8)

December 29, 2018

Phulusa la 7p linapangidwa ngati imodzi mwazinthu zingapo ndi cholinga chodziwitsa thromboxane wapawiri ...


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1145kg / mwezi

Pulogalamu Yaikulu 7P powder (1890208-58-8) kanema

 

Mphungu Yaikulu 7P ufa (1890208-58-8) Kufotokozera

Mphungu Yaikulu 7P ufa umene umalimbikitsa mphulupulu za neuroni zam'mwamba zomwe zimachokera ku hippocampus, cerebral cortex, ndi retina. Pogwiritsa ntchito mankhwala a mitsempha ya mitsempha, Raw Compound 7P ufa ankawonetseredwa kuti apange kukula kwa zitsulo zabwino za 43, zomwe zimasonyeza kuti ntchito yowonjezereka ya Raw Compound 7P ufa imatanthawuza kuti kusinthika kwa axon kukonzanso mu vivo.further optimization of Mabala akuluakulu 7P ufa ndi kuwunika njira zomwe zimapangidwira kukhazikitsidwa kwa axon mu vivo zidzatsimikizira kuti padzakhala njira zowonjezereka zowonjezera njira zothandizira.

yaiwisi 2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (4-methoxy-3-pyridinyl) acetamide (Compound 7P) ufa (1890208-58-8) Szizindikiro

Name mankhwala 2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (4-methoxy-3-pyridinyl) acetamide (Raw Compound 7P ufa)
Mankhwala Name 2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (4-methoxy-3-pyridinyl) acetamide (Raw Compound 7P ufa)
Brand NAme Mphungu Yaikulu 7P ufa
Kalasi ya Mankhwala Mankhwala a Nootropic
Nambala ya CAS 1890208-58-8
InChIKey NAXWKPFXCOBXLE-UHFFFAOYSA-N
Maselo Fmphutsi C22H23N3O5S
Maselo Wasanu ndi atatu 441.508g
Misa ya Monoisotopic 440g / mol
Mfundo yosungunula N / A
Fkubwezeretsanso Pmafuta N / A
Halimo Half-Life N / A
mtundu White powder
Szovuta  pang'ono sungunuka m'madzi ndi mowa.
Smazunzo Tkutentha  Sungani kutentha kutentha, mu chidebe chosindikizidwa, pewani kutentha kwakukulu ndi kuwala.
Amalingaliro • Kuwonjezera kugwirizana
• Kuwongolera maganizo
• Thandizani kulimbana ndi kutopa
• Amaletsa okosijeni mkati mwa ubongo
• Amamwa mowa wokhudzana ndi ubongo

 

yaiwisi Chigawo 7P ufa (1890208-58-8) Ndemanga

Kakhungu Kakang'ono 7P (2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (4-methoxy-3-pyridinyl) acetamide) ufa womwe umalimbikitsa kutuluka kwa mitsempha yoyambilira yam'mimba yochokera ku hippocampus , kotekisi ya ubongo, ndi diso. mu mtundu wa nyama wa kuvulala kwamitsempha yamafuta, ufa wa Raw 7P ufa udawonetsedwa kuti upangitse kukula kwa mipata-43 ma axon abwino, kuwonetsa kuti mu vitro neurite kutuluka kwa ntchito ya Raw Compound 7P ufa kumamasulira kukonzanso kwa axon mu vivo. Mafuta Opakidwa 7P ufa ndi kuwunikira njira zomwe zimapangitsa kuti axon ikhazikitsidwe mu vivo ipereka maziko olingalira pazoyeserera zamtsogolo zothandizira njira zamankhwala.

Kugwiritsira ntchito Pulogalamu 7P ufa (1890208-58-8)

Pulogalamu 7p (2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (4-methoxy-3-pyridinyl) acetamide) inasonyeza ntchito yopambana ya maselo a khansa ya chiberekero. Mu nude mbewa xenograft model inoculated ndi maselo a HeLa, 7p inasonyeza kuti amadwala matenda a chiberekero. Kufufuza kwake kwapadera kwa zida zogometsa zokhudzana ndi zotupa kunasonyeza kuti 7p imayambitsa microstructure mudongosolo lodalira mlingo. Pulogalamu 7p inalinso kuchuluka kwa maselo a HeLa mu G0 / G1 ndi gawo la S ndipo anachepetsa kwambiri gawo la G2 / M. Zotsatira za 7p pa C-caspase-3, C-caspase-9, Bcl-2 ndi mawu a Bax m'maselo a HeLa anatsimikiziranso.

Tubulin polymerization kuyesera, maphunziro a immunofluorescence, kufufuza kwa maselo ndi mpikisano wa tubulin-binding assay anatsimikizira kwambiri kuti 7p ndi colchicine yomwe imamanga malo oletsa tubulin.

ubwino of Chigawo 7P ufa (1890208-58-8)

Pulogalamu 7p imalimbikitsa kukonzanso kwa optic yosweka

Konzani mitsempha ya mutu

akulimbikitsidwa Chigawo 7P ufa (1890208-58-8) Mlingo

Pulogalamu 7p inachititsa kuti 100% iwononge matenda a mthupi pa tsiku 4 pa mlingo waukulu (100, 50, ndi 25 mg / kg) yoperekedwa kwa masiku anayi otsatira, koma pa 100 mg / kg, mbewa zonse zidapulumuka ndipo zinachiritsidwa, panthawi ya 50 mg / makilogalamu atatu, asanu ndi atatu adapulumuka ndipo makoswe awiri adachiritsidwa, ndipo pa 25 mg / kg, palibe mbewa zomwe zidapulumuka