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Mafuta aakulu a AICAR (2627-69-2)

Nkhumba ya AICAR, yomwe imadziwikanso ngati AICA, yomwe ili ndi chinsalu choyambitsa purine ndi mankhwala omwe amachititsa antinoplastic ntchito ndi activator ya AMP-activated ...... ..


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1277kg / mwezi

Kufotokozera

Mavidiyo akuluakulu a AICAR (2627-69-2)

Mafuta aakulu a AICAR (2627-69-2) Ndemanga

Mafuta a AICAR omwe amadziwikanso kuti ZMP ndi analog ya AMP yomwe imatha kulimbikitsa ntchito ya protein kinase (AMPK) yodalira AMP. Mafuta akulu a AICAR ali pakati pa m'badwo wa inosine monophosphate. Mafuta akulu a AICAR akugwiritsidwa ntchito pochiza ndi kuteteza kupweteka kwa mtima kusachimake, kungalowetse maselo a mtima kuti ateteze adenosine kinase ndi adenosine deaminase. Zimapangitsa mlingo wa nucleotide kubwezeretsanso kukula kwa adenosine m'gulu la adenosine monophosphate pokhapokha pazochitika za myocardial ischemia. Mafuta a AICAR akuwonjezera kuyambitsa glucose pogwiritsa ntchito translocation ya GLUT4 ndi / kapena poyambitsa njira ya P38 MAPK. Pakalipano, mankhwalawa akuwonetsedwanso kuti akhoza kuchiza matenda a shuga mwa kuwonjezera ntchito yodetsa matenda ya tizilombo powasintha maonekedwe a minofu.

Mafuta aakulu a AICAR (2627-69-2) Szizindikiro

Name mankhwala Mafuta aakulu a AICAR
Mankhwala Name 1-ribosyl-4-carboxamido-5-aminoimidazole, ARA 100, ARA-100, ARA100, GP 1 110, 5-aminoimidazole-4-carboxamide 1-ribofuranoside, 5-aminoimidazole-4-carboxamide riboside, acadesine, AICA ribofuranoside, AICA kumtunda, aminoimidazole carboxamide ribonucleoside, arasine, Z-riboside
Brand NAme Palibe deta yopezeka
Kalasi ya Mankhwala SAR
Nambala ya CAS 2627-69-2
InChIKey RTRQQBHATOEIAF-UUOKFMHZSA-N
Maselo Fmphutsi C9H14N4O5
Maselo Wasanu ndi atatu 258.23
Misa ya Monoisotopic 258.096 g / mol
Kusungunula Pmafuta 214-215 ° C
Fkubwezeretsanso Pmafuta 214 ° C
Halimo Half-Life Mfupi kwambiri
mtundu Satana
Szovuta H2O:> 10 mg / mL
Smazunzo Tkutentha -20 ° C
Mafuta aakulu a AICAR Amalingaliro AMPK activator

Mafuta aakulu a AICAR (2627-69-2)

Mafuta akulu a AICAR omwe amadziwikanso kuti ZMP ndi analog ya AMP, ndi ovomerezeka ndi Cell, omwe amachititsa kuti pulogalamu ya AMP-activated kinase (AMPK). Zimatha kulimbikitsa ntchito ya protein kinase (AMPK) yowonjezera AMP, kuyambitsa kuchulukitsa, kusiyanitsa komanso kuchepetsa mphamvu za maselo odwala MC3T3-EI komanso kuchepetsa kuwonetseratu za psychoinine za proinflammatory cytokines ndi iNOS mu astrocytes.

Mafuta akulu a AICAR ali pakati pa m'badwo wa inosine monophosphate. Mafuta akulu a AICAR akugwiritsidwa ntchito pochiza ndi kuteteza kupweteka kwa mtima kusachimake, kungalowetse maselo a mtima kuti ateteze adenosine kinase ndi adenosine deaminase. Zimapangitsa mlingo wa nucleotide kubwezeretsanso kukula kwa adenosine m'gulu la adenosine monophosphate pokhapokha pazochitika za myocardial ischemia. Mafuta a AICAR akuwonjezera kuyambitsa glucose pogwiritsa ntchito translocation ya GLUT4 ndi / kapena poyambitsa njira ya P38 MAPK. Pakalipano, mankhwalawa akuwonetsedwanso kuti akhoza kuchiza matenda a shuga mwa kuwonjezera ntchito yodetsa matenda ya tizilombo powasintha maonekedwe a minofu.

AICAR ndiwotetezera purine ndi ntchito yoteteza thupi. Ndikofunika pochiza matenda opatsirana pogwiritsa ntchito mtundu wa 2 shuga komanso momwe mungathere mankhwala osiyanasiyana a kansa.

AICAR ufa (2627-69-2) Njira yogwira ntchito

Fomu ya nucleoside ya AICAR, acadesine, ndi nthano ya adenosine yomwe imalowa m'maselo a mtima kuti iletse adenosine kinase ndi adenosine deaminase. Zimapangitsa mlingo wa nucleotide kubwezeretsanso kukula kwa adenosine m'gulu la adenosine monophosphate pokhapokha pazochitika za myocardial ischemia. Mu myocyte wa mtima, acadesine ndi phosphorylated ku AICAR kuti ayambitse AMPK popanda kusintha miyeso ya nucleotides. AICAR ikhoza kulowa njira yopangira adenosine kaphatikizidwe pofuna kulepheretsa adenosine deaminase kuwonjezera kuwonjezeka kwa ma ATP ndi ma adenosine.

Kugwiritsa ntchito ufa wa AICAR (2627-69-2)

▪ Kuteteza thupi

▪ Kugwiritsa ntchito mankhwala osokoneza bongo

▪ Kutsegula kwa shuga kumathandiza

▪ AMPK activator

▪ Matenda amadzimadzi

▪ Matenda a m'magazi amphamvu kwambiri

akulimbikitsidwa Pulogalamu ya AICAR (2627-69-2) Mlingo

Mlingo wa AICAR ukhoza kuwonjezeka kuchokera ku 150 mg tsiku lililonse, ngati umagwiritsa ntchito GW, mpaka 500 mg tsiku patsiku. Botolo lirilonse limalowa m'zigawo za 50 mg, kotero zikuwoneka mtengo. Pachifukwa ichi, ndizomveka kuzigwiritsa ntchito pamasabata anayi asanafike tsiku la mpikisano.

ubwino AICAR ufa (2627-69-2)

♦ AICAR ndiwotetezera purine ndi ntchito yoteteza thupi. Ndikofunika pochiza matenda opatsirana pogwiritsa ntchito mtundu wa 2 shuga komanso momwe mungathere mankhwala osiyanasiyana a kansa.

♦ AICAR ntchito yochiza matenda amadzimadzi.

• AICAR ili ndi mphamvu zothetsera matenda opatsirana pogonana pamene microglia yowonongeka ikugwira ntchito.

♦ AICAR ikuthandizira kukonza galimoto, kukumbukira ntchito ndi ubongo

♦ AICAR imagwiritsidwa ntchito bwino ngati kuphatikizidwa ku phokoso lopirira. Othamanga amaigwiritsanso ntchito kuti ntchito ikhale yopambana m'maseŵera kumene amafunika kupirira.

♦ AICAR ndi nucleoside analogue yomwe imatha kulowa m'madzi a nucleoside ndipo imatha kuonjezera kwambiri adenosine panthawi ya kuwonongeka kwa ATP. Adenosine-regulating agents (ARAs) akhala akudziwika kuti angathe kuchiritsidwa mu myocardial ischemia.

• AICAR imagwiritsidwa ntchito pochiza matenda oopsa a khansa ya m'magazi ndipo imapezeka kuti ili ndi zotsatira za mtima.

KULAMBIRA NDI KUSINTHA:

Nkhaniyi Ikagulitsidwa Kugwiritsa Ntchito Kafukufuku kokha. Migwirizano Yogulitsa. Osati Zongogwiritsa Ntchito Anthu, kapena Zamankhwala, Zoweta Zanyama, kapena Zogwiritsa Ntchito Panyumba.


Shangke Chemical ndi makampani apamwamba kwambiri omwe amagwiritsa ntchito mankhwala omwe amathandiza kwambiri. Pofuna kuyendetsa khalidweli panthawi yopanga, akatswiri ambiri odziwa bwino ntchito, makina oyambirira kupanga zipangizo komanso ma laboratori ndi mfundo zofunika kwambiri.

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