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Dihydromyricetin (DHM) (27200-12-0)

Dihydromyricetin (kapena DHM) ndi gawo kuchokera ku Japan Raisin Tree lomwe lakhala likugwiritsidwa ntchito kwazaka zambiri ngati anti-alcohol ……….


Chikhalidwe: Mu Kupanga Misa
Zokonzedwa ndi Zokonzedweratu Zopezeka
mphamvu: 1277kg / mwezi

Kufotokozera

Dihydromyricetin Szizindikiro

Name mankhwala Dihydromyricetin (DHM)
Mankhwala Name Ampelopsin
Ampeloptin
(+) - Dihydromyricetin
Name Brand N / A
Kalasi ya Mankhwala phytochemical; mayendedwe ochokera ku mankhwala azitsamba achi China (TCM);
Nambala ya CAS 27200-12-0
InChIKey KJXSIXMJHKAJOD-LSDHHAIUSA-N
Maselo Fmphutsi C15H12O8
Maselo Wasanu ndi atatu 320.25 g / mol
Misa ya Monoisotopic 320.053217 g / mol
Malo otentha 780.7 ± 60.0 ° C (Wonenedweratu)
Fkubwezeretsanso Pmafuta N / A
Halimo Half-Life N / A
mtundu zoyera kuti zikhale
Szovuta DMSO: ≥5mg / mL (kwatenthetsa)
Smazunzo Tkutentha <+ 8 ° C
Amalingaliro 1. Yogwiritsidwa ntchito m'makampani opanga zakudya, dihydromyricetin ufa wogwiritsidwa ntchito ngati zopangira;
2. Yogwiritsidwa ntchito pazopatsa thanzi, dihydromyricetin ufa wogwiritsidwa ntchito ngati zida zopangira chitetezo chathupi;
3. Ikugwiritsidwa ntchito m'munda wopanga mankhwala, dihydromyricetin ufa wotuluka ngati makapisozi kapena mapiritsi pochizira matenda am'mapapo komanso kuteteza chiwindi.

Mbiri ya Dihydromyricetin

Dihydromyricetin (kapena DHM) ndiwomwe amachokera ku mtengo wa ku Japan wa Raisin womwe wakhala ukugwiritsidwa ntchito kwazaka zambiri ngati mankhwala othana ndi mowa komanso matenda a hangover ku mankhwala achikhalidwe aku Korea komanso ku China. Kafukufuku waposachedwa akusonyeza kuti DHM ikhoza kutsitsa magazi anu ndikuteteza chiwindi chanu ku zowonongeka ndi matenda.

DHM ndi flavonoid yomwe imachotsedwa ku tiyi wa Vine koma amathanso kuuchotsa ku makungwa a mtengo wa Holvenia Dulcis. Ndipo koposa zonse, Dihydromyricetin ali ndi mbiri yayitali yotengedwa mwachindunji pofuna kuchiza matenda am'mutu komanso ma hangovers.

Kodi Dihydromyricetin ndi chiyani?

Dihydromyricetin, yemwenso amadziwika kuti Ampelopsin, ndi flavanonol, mtundu wa flavonoid. Amapezeka mu Ampelopsis mitundu japonica, megalophylla, ndi grossedentata; Cercidiphyllum japonicum; Hovenia dulcis; Rhododendron cinnabarinum; mitundu ina ya Pinus; ndi mitundu ina ya Cedrus, komanso Salix sachalinensis.

Dihydromyricetin Tingafinye ufa, chophatikiza chachikulu ndicho ma flavonoids. Ndi ntchito zokulitsa ufulu ma radicals, ma antioxidants, antithrombotic, Tumor, anti-yotupa ndi zina zapadera; Dihydromyricetin ndi padera lapadera la flavonoid. Kuphatikiza pazomwe zimachitika mu flavonoids, imakhalanso ndi mphamvu yotsitsa poizoni wa mowa, kupewa chiwindi cha mowa, chiwindi chamafuta, komanso ma cell a chiwindi. Kuchepetsa ndi kuchepetsa zochitika za khansa ya chiwindi. Ndi chinthu chabwino kuteteza chiwindi ndi hangover.

Dihydromyricetin ubwino

ZOPHUNZITSA ANTI-HANGOVER

Phindu lalikulu la DHM ndikuletsa ndikuchepetsa ma hangovers, kuti muteteze chiwindi chanu ndi ubongo wanu. Izi zimatheka ndi kuwonjezeka kwa mowa dehydrogenase (ADH) ndi acetaldehyde dehydrogenase (ALDH), omwe ndi michere yofunika kugwetsa mowa ndi acetaldehyde mkati mwa thupi.

Acetaldehyde makamaka ndi mankhwala oopsa ndipo ndi imodzi mwazomwe zimayambitsa ma hangovers. Ma enzesowa akakulimbikitsidwa, mowa ndi acetaldehyde zitha kuthyoledwa mwachangu kuposa zabwinobwino.

MTIMA WABODZA

DHM ili ndi zinthu zambiri zam'magazi zomwe zimapangitsa kuti pakhale thanzi labwino. Izi zimachitika chifukwa DHM imalimbikitsa heme-oxygenase-1 (HO-1), enzyme yomwe imathandizira kuwonongeka kwa heme ndikuwunikira katundu wama cell. Dihydromyricetin amathanso kulimbikitsa thanzi la chiwindi.

Ma dihydromyricetin ena amapindula

1) Dihydromyricetin imatha Kuyeretsa zotsalira m'thupi ndi antioxidation

2) Dihydromyricetin imatha Antibiotic Action

3) Dihydromyricetin imatha Kuteteza Chiwindi: Dihydromyricetin ili ndi mphamvu yolimbana ndi ALT ndi AST m'mwazi wa Serum. Itha kutsitsa bilirubin yathunthu mu seramu yamagazi. Chifukwa chake ili ndi chochita champhamvu chotsitsa aminotransferase ndi jaundice.

4) Dihydromyricetin Itha Kuchepetsa kuchuluka kwa shuga m'magazi ndi mafuta am'magazi: Dihydromyricetin imatha kuchepetsa kuchuluka kwamafuta amwazi mu mbewa. Zimatha kuchepetsa kuwonongeka kwa maselo a chiwindi omwe amayamba chifukwa cha kuchuluka kwa mafuta m'magazi ndikuwongolera kuthekera kwa antioxidation. Nthawi yomweyo, imatha kutsitsa shuga wambiri.

5) Dihydromyricetin imatha Anti-kutupa

6) Dihydromyricetin imatha Anti-chotupa: Dihydromyricetin ufa wotulutsa umalepheretsa kuchuluka kwa maselo a chotupa.

Zotsatira zoyipa za Dihydromyricetin.

Pafupifupi pali maphunziro ochepa pofika pano omwe akuyang'ana pa mbiri ya DHMs athari ndipo pakadali pano palibe mavuto onse omwe adanenedwa.

Kufufuza mwachangu ku Amazon kuwonetsa ndemanga zikwizikwi. Kuyang'ana pa iwo, pali malipoti ena a kusakhazikika kwam'mimba, mseru, ndi m'mimba. Komabe, palibe makasitomala ambiri omwe amafotokoza zotsatirazi.

Dihydromyricetin amagwiritsa ntchito

Amagwiritsa ntchito:

  1. Dihydromyricetin ufa wogwiritsidwa ntchito kuteteza chiwindi;
  2. Dihydromyricetin ufa womwe umagwiritsidwa ntchito kuwongolera mafuta a shuga m'magazi;
  3. Dihydromyricetin ufa uli ndi mphamvu zowonjezera chitetezo chathupi;
  4. Dihydromyricetin ufa ndi ntchito ya antioxidant ndi anti-cancer;
  5. Dihydromyricetin ufa womwe amagwiritsidwa ntchito kuteteza matenda, kutsokomola, kupweteka komanso kuthetsa utsi wa utsi.
  6. Dihydromyricetin ili ndi chiyembekezo chotsogola pakukonzekera zopangidwa ndi mankhwala osamalira khungu kapena mankhwala othandizira kupewetsa kapena kuchiritsa ovulala pakhungu.

ntchito

  1. Yogwiritsidwa ntchito m'makampani opereka zakudya, dihydromyricetin ufa wogwiritsidwa ntchito ngati zopangira;
  2. Yogwiritsidwa ntchito pazopatsa thanzi, dihydromyricetin ufa wogwiritsidwa ntchito ngati zida zopangira chitetezo cha m'thupi;
  3. Ikugwiritsidwa ntchito m'munda wopanga mankhwala, dihydromyricetin imachotsa ufa womwe umagwiritsidwa ntchito ngati mapiritsi kapena mapiritsi pochizira matenda amtundu wa kupuma komanso kuteteza chiwindi.

Dihydromyricetin kafukufuku in Anti Cancer

M'malo mwake, pali kafukufuku wina wokakamiza wosonyeza kuti dihydromyricetin itha kuthandiza ndi vuto losagwirizana ndi mowa lotchedwa Hepatocellular carcinoma (HCC). HCC ndi chikhalidwe chomwe chimawonetsa chimodzi mwazovuta kwambiri zodwala ndi kufa padziko lonse lapansi, ndikuwonetsa anthu ambiri odwala khansa ya chiwindi. Momwe DHM imawonetsera kuteteza chiwindi (ndi hepatprotective) zotsatira zake zidawonetsa kuti zidalepheretsa kuchuluka kwa maselo ndikutsitsa apoptosis m'mizere ya cell ya HCC, zomwe zikuwonetsa kuti DHM ndiwopereka chiyembekezo chamankhwala a HCC.

Reference:

Dihydromyricetin imathetsa vuto la doxorubicin polimbikitsa kuletsa kwa NLRP3 poyambitsa SIRT1. Dzuwa Z, Lu W, Lin N, Lin H, Zhang J, Ni T, Meng L, Zhang C, Guo H. Biochem Pharmacol. 2020 Feb 26: 113888. doi: 10.1016 / j.bcp.2020.113888. [Epub patsogolo posindikiza]

Metabolomics of the Protential Effect of Ampelopsis grossedentata ndi Major Active Compound Dihydromyricetin pa chiwindi cha High-Fat Diet Hamster. Fan L, Qu X, Yi T, Peng Y, Jiang M, Miao J, Xiao P. Evid based Complement Alternat Med. 2020 Jan 28; 2020: 3472578. doi: 10.1155 / 2020/3472578. eCollection 2020.

Kukhazikitsa ma siginolo a Ampelopsin (Dihydromyricetin) mu njira zosiyanasiyana: kuwunika misewu yayikulu ndi njira zina zochepa zomwe amayenda. Fayyaz S, Qureshi MZ, Alhewairini SS, Avnioglu S, Attar R, Sabitaliyevich UY, Buha A, Salahuddin H, Adylova A, Tahir F, Pawlak-Adamska E. Cell Mol Biol (Noisy-le-grand). 2019 Sep 30; 65 (7): 15-20.

Golgi imasinthanso ndikukhazikitsa mapuloteni 65 kutsika kwake kumafunika popewa khansa zotsatira za dihydromyricetin pama cell a khansa yamchiberekero cha anthu. Wang F, Chen X, Yuan D, Yi Y, Luo Y.

Mmodzi wa PloS Mmodzi. 2019 Nov 26; 14 (11): e0225450. doi: 10.1371 / journal.pone.0225450. eCollection 2019.

KULAMBIRA NDI KUSINTHA:

Nkhaniyi Ikagulitsidwa Kugwiritsa Ntchito Kafukufuku kokha. Migwirizano Yogulitsa. Osati Zongogwiritsa Ntchito Anthu, kapena Zamankhwala, Zoweta Zanyama, kapena Zogwiritsa Ntchito Panyumba.


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Dihydromyricetin (27200-12-0) kanema

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Mafotokozedwe ndi zolemba zamagulu

Shangke Chemical ndi makampani apamwamba kwambiri omwe amagwiritsa ntchito mankhwala omwe amathandiza kwambiri. Pofuna kuyendetsa khalidweli panthawi yopanga, akatswiri ambiri odziwa bwino ntchito, makina oyambirira kupanga zipangizo komanso ma laboratori ndi mfundo zofunika kwambiri.

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