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Msosialotetrahexosylganglioside Sodium (GM1) ubongo wa nkhumba (37758-47-7)

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Gulu la GM1 lagwiritsidwa ntchito kwambiri pochiza nthenda ya ubongo ya hypoon-ischemic ubongo, matenda a Parkinson ...


Chikhalidwe: Mu Kupanga Misa
Zokonzedwa ndi Zokonzedweratu Zopezeka
mphamvu: 1277kg / mwezi

Kufotokozera

Msosialotetrahexosylganglioside Sodium (GM1) ubongo wa nkhumba (37758-47-7) kanema

Msosialotetrahexosylganglioside Sodium (GM1) ubongo wa nkhumba (37758-47-7) Ndemanga

Ubongo wa monosialotetrahexosylganglioside (GM1) wa ubongo wa nkhumba (37758-47-7), dzina lalifupi lingakhale GM1, lochotsedwa mu ubongo wa nkhumba ndipo ndi membala wa gangliosides omwe ali ndi malo amodzi a asidiic acid.

GMl ingalimbikitse matenda a ubongo pambuyo povulaza dongosolo lalikulu la mitsempha la zifukwa zosiyanasiyana, kulimbikitsanso kuti thupi likhale lopanda mphamvu. Zofufuza zimasonyeza kuwonongeka kwa ubongo wa GMl, ubongo wosokoneza ubongo kuti ubwezeretse maselo a mitsempha m'mimba ya msana umatetezera komanso kumalimbikitsa gawo la selo.

Poyesa ndondomeko yachiwiri yachipatala yowonetsa, ikhoza kuchepetsa nthenda yotchedwa oxaliplatin-induced neurotoxicity (OIN). Koma sizinayesedwe ndi mayesero a III. Chiyeso chachitatu chimayesedwa kuti afufuze zotsatira ndi chitetezo cha mnosialotetrahexosylganglioside Sodium Injection pofuna kupewa HIV ku khansa ya m'mimba.

Msosialotetrahexosylganglioside Sodium (GM1) ubongo wa nkhumba (37758-47-7) Specifizolemba

Name mankhwala Msosialotetrahexosylganglioside Sodium (GM1) ubongo wa nkhumba
Mankhwala Name Msosialotetrahexosylganglioside Sodium (Porcine ubongo)

Kapena GM1

Zotsatira /
Brand NAme Shenjie
Kalasi ya Mankhwala Sphingolipids
Nambala ya CAS 37758-47-7
InChIKey GTTLZSUWCRJZRC-CRQBLQEMSA-N
Maselo Fmphutsi C73H134N4O31
Maselo Wasanu ndi atatu 1563.85
Misa ya Monoisotopic 1563.85
Kusungunula Pmafuta N / A
Halimo Half-Life /
mtundu Kutsekemera kofiira kofiira
Kutupa chloroform / methanol (9: 1): 10 mg / mL, yoyera, yopanda mtundu
yosungirako Tkutentha -20 ° C
Amalingaliro Zilonda zamtundu wa poizoni za kolera zomwe zimaphatikiza mu ubongo kumapeto kwa infantile lipidosis.
Zinthu zoyesera Mu Nyumba Makhalidwe Abwino
Character Powera woyera kapena woyera; zokoma pang'ono, zopanda pake; yonyowa. Chomerachi chimasungunuka m'madzi, chimasungunuka pang'ono mu methanol, pafupifupi chosasungunuka mu anhydrous ethanol.
Chizindikiro
Zithunzi zomasulira mtundu 1 Tengani mayeso njira 0.2ml pansi okhutira mtima, kuwonjezera madzi 2ml, ndipo onjezerani ndi Hydroquinone hydrochloric asidi njira (hydroquinone 0.2g, kuwonjezera madzi 10ml kusungunuka, kuwonjezera hydrochloric asidi 90ml, kuwonjezera 0.1mol / L Mkuwa sulphate yankho 0.25ml, firiji Kutetezeredwa) 2ml, Kutentha kwa madzi kwa 15 Mphindi, yankho la buluu ndi lofiirira, ndi Ne mowa 5ml Kuchotsa mitsempha, ndi mowa wosanjikiza ndi buluu.
Zithunzi zomasulira mtundu 2 Tengani mankhwala za 20mg, kuwonjezera glacial acetic asidi 1ml, madzi otentha kusamba Kutentha kusungunuka kwathunthu, kuwonjezera atatu ferric mankhwala enaake mayeso madzimadzi 1 madontho, mu madzi osamba otentha khoma chitoliro pang'onopang'ono kuwonjezera asidi sulfuric 1ml, kotero kuti njira mu zigawo ziwiri , mawonekedwe awiriwa ayenera kukhala bulauni
Sodium salt Zomwe zimadziwika kuti ndi zotani za sodium mchere mu mankhwalawa (Chinese Pharmacopoeia edition 2015 four 0301).
Zamadzimadzi otchedwa chromatography (LC) Mu graph chromatographic yomwe ili pansi pa zomwe zilipo, nthawi yosungirako chiwerengero chachikulu cha mayesero ayenera kuyenderana ndi nthawi yosungirako nsonga yaikulu ya njira yothetsera.
Kuwonetseratu zolaula Mapu owonetserako magetsi a mankhwalawa ayenera kukhala ogwirizana ndi mapu a mankhwala (China Pharmacopoeia 2015 edition 0402).
Yambani
PH 5.0 ~ 6.5
Kuyera ndi mtundu wa yankho Ayenera kufotokozedwa opanda mtundu; ngati ndi mitambo, sizingakhale zowonjezereka kuposa momwe zimakhalira ndi nkhanza No. 1th; Ngati kutembenuza kwa mtundu sikuyenera kukhala kozama kuposa yankho la Yellow No. 1th colorimetric.
Kuthamanga kwakukulu Yomaliza njirayi iyenera kukhala yoyera ndi yoonekera pambuyo papamwamba kutentha, palibe mkaka kuwala, palibe mpweya
Chinthu chodziwitsira (Zophatikiza mapuloteni) ≤50000
Total Sialic acid Malinga ndi mankhwala ouma, mabala omwe ali ndi asidi ayenera kukhala 19.0 ~ 21.0%
Zinthu zina Sialic acid ≤0.3%; GD3, GD1a, zonyansa zosadziwika ndi ≤ 0.5%; zosafunika ndi ≤2.0%
mapuloteni ≤1.0%
Pamwamba molecular kulemera zosafunika ≤0.5%
Zosungunuka zowonjezera Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤0.003%
Water ≤4.0%
Mafuta otsala ≤5.0%
Chitsulo cholemera ≤20ppm
Zoopsa zachilendo Tsatirani Malamulo
Zinthu zolimbana ndi matenda Ziyenera kukhala molingana ndi malamulo (zochuluka zamakonzedwe)
Purojeni Ziyenera kukhala molingana ndi malamulo (zochuluka zamakonzedwe)
Malire a microbial Mawerengero a mabakiteriya aerobic ayenera <100cfu / g, ndipo chiwerengero cha nkhungu ndi yisiti chiyenera kukhala <50cfu / g
Mwachindunji ≥98.0%

yaiwisi MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) ufa (37758-47-7) Ndemanga

Sodium Monosialotetrahexosylganglioside (37758-47-7), dzina lalifupi lingakhale GM1, lochotsedwa mu ubongo wa nkhumba ndipo ndi membala wa gangliosides omwe ali ndi ziwalo limodzi za asidiic acid.

GM1 ingalimbikitse kuchiza kwa matenda a ubongo pambuyo povulazidwa ndi dongosolo lalikulu la mitsempha la zifukwa zosiyanasiyana, kulimbikitsa matenda opatsirana. Zofufuza zimasonyeza kuvulala kwa ubongo wa GM1, ubongo wosokoneza kubwezeretsa maselo a mitsempha mu kuvulala kwa msana wamtunduwu kumateteza komanso kumalimbikitsa gawo la selo.

Poyesa ndondomeko yachiwiri yachipatala yowonetsa, ikhoza kuchepetsa nthenda yotchedwa oxaliplatin-induced neurotoxicity (OIN). Koma sizinayesedwe ndi mayesero a III. Chiyeso chachitatu chimayesedwa kuti afufuze zotsatira ndi chitetezo cha mnosialotetrahexosylganglioside Sodium Injection pofuna kupewa HIV ku khansa ya m'mimba.

MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) ufa (37758-47-7) Njira ya zochita?

GM1 (monosialotetrahexosylganglioside) ndi "prototype" ganglioside, ndi membala wa gangliosides omwe ali ndi malo ochepa a asidiic acid. GM1 ili ndi zofunikira za thupi ndi zovuta zapulasitiki ndi njira zowonongeka, komanso kutulutsidwa kwa ubongo m'maganizo. Kuphatikiza pa ntchito yake mu thupi la ubongo, GM1 imakhala ngati malo omanga poizoni ndi E. coli kutentha kwapadera (Traveler's diarrhea).

ubwino of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) ufa (37758-47-7)

Ganglioside GM1 ndi membala wa banja la ganglioside limene lagwiritsidwa ntchito m'mayiko ambiri ndipo limagwiritsidwa ntchito ngati njira yodalirika yothandizira kupewa matenda angapo a mitsempha, kuphatikizapo kuvulala kwachisipha. Zotsatira za mankhwala a GM1 zatsimikiziridwa kuti ndizophatikizapo anthu akuluakulu komanso akuluakulu omwe amatsatira chisokonezo cha ubongo.

akulimbikitsidwa MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Mlingo

Mankhwala ankagwiritsidwa ntchito pa mlingo wa 20-40 mg tsiku ndi tsiku kudzera mu jekeseni yowopsa kapena yopanda pang'onopang'ono mogwirizana ndi malangizo a dokotala. Pazigawo zovuta za kusintha kwa matenda: Matenda amagwiritsidwa ntchito pa mlingo wa 100 mg tsiku ndi jekeseni; Pambuyo pa masabata a 2-3, nthawi zambiri amasunga kuchuluka kwa 20-40 tsiku lililonse kwa milungu isanu ndi umodzi, mlingo woyamba wa 500-1000 mg umayendetsedwa ndi kupweteka kwa matenda a Parkinson; Kuyambira tsiku lachiwiri, mankhwala ogwiritsira ntchito mankhwalawa amagwiritsidwa ntchito ndi mlingo wa 200 mg tsiku ndi tsiku ndi jekeseni, mkati mwa jekeseni kapena m'mimba mwa masabata a 18 nthawi zambiri. pamene mankhwalawa akugwiritsidwa ntchito ndi jekeseni ya subcutaneous kapena intravenous, ayenera kupasuka ndi kuchepetsedwa m'madzi kwa jekeseni mpaka ku 10 mg / ml pa: Pamene kutayira kwa intravenous, mankhwala osakondedwa ndi osakanizidwa mu 0.9% sodium chloride jekeseni kapena 5% jekeseni jekeseni.

Zotsatira zoyipa of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7)

Mbali ya pamtundu wa GM1 ufa imakhala makamaka kuthamanga kwamtunduwu atagwiritsidwa ntchito.


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1 review kwa Msosialotetrahexosylganglioside Sodium (GM1) ubongo wa nkhumba (37758-47-7)

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    Ali ndi Monosialotetrahexosylganglioside Sodium (GM1) ubongo wa nkhumba (37758-47-7) kuyesa, zotsatira za kuyesa zimasonyeza khalidwe labwino kwambiri ndi chiyero!

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