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Mkaka wa YK-11 (431579-34-9)

(1 kasitomala review)

YK-11 ufa ndilo gulu la androgen receptor modulators (SARMs). Kwenikweni, zomwe YK11 imachita posankha ......


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1470kg / mwezi

Kufotokozera

Mawonekedwe a YK-11 powder (431579-34-9)

Mphungu YK-11 ufa (431579-34-9) Ndemanga

YK11, yomwe imatchedwanso Myostine, imatengedwa kuti ndiyo imodzi mwa ma ARV amphamvu kwambiri pamsika. Ndizopanga steroidal kusankha androgen receptor modulator. Mankhwalawa ali ndi ntchito ya anabolic mu vitro mu C2C12 myoblasts ndipo amasonyeza kwambiri mphamvu kuposa dihydrotestosterone (DHT) pankhaniyi. YK11 nayenso ndi Myostatin inhibitor. Angakuthandizeni kupeza minofu ndi kutaya mafuta.

Mkaka wa YK-11 (431579-34-9) Szizindikiro

Name mankhwala Mkaka wa YK-11
Mankhwala Name YK11, (17a, 20E) -17,20 - [(1-Methoxyethylidene) bis (oxy)] - 3-oxo-19-norpregna- 4,20-diene-21-carboxylic Acid Methyl Ester; YK11 ((17A, 20E) -17,20 - [(1-methoxyethylidene) bis- (oxy)] - 3-oxo-; DNA (Terrabacter kupsyinjika YK11 16S rRNA jini mpukutu); GenBank AB070463
Brand NAme Palibe deta yopezeka
Kalasi ya Mankhwala Ma ARV
Nambala ya CAS 431579-34-9
InChIKey KCQHQCDHFVGNMK-DEIKBOPOSA-N
Maselo Fmphutsi C25H34O6
Maselo Wasanu ndi atatu 430.53386
Misa ya Monoisotopic 430.236 g / mol
Kusungunula Pmafuta 190-200 ° C
Fkubwezeretsanso Pmafuta Palibe deta yopezeka
Halimo Half-Life Maola 6-10, malinga ndi munthu
mtundu White olimba
Szovuta Propylene Glycol, DMSO, Mowa
Smazunzo Tkutentha Kutentha kwapakati
Mkaka wa YK-11 Amalingaliro Selective Androgen Receptor Modulator, Myostatin Inhibitor

Mafuta akuluakulu YK-11 ufa (431579-34-9) Ndemanga

Ogwiritsa ntchito ambiri amaganiza kuti YK11 ndilofunika kwambiri kuti atsegule zonse zomwe thupi limapindula ndikukwaniritsa zovuta za minofu ndi zotsatira zochepa. YK11 ikuwoneka kuti ndi SARM yopambana kuchokera pa ndemanga, pamene kwenikweni, mankhwalawa sali ngati SARM. Nkhaniyi ikutsutsana ndi sayansi ndi ndemanga kuti ikuuzeni bwino zomwe mungayembekezere ku SARM-steroid hybrid, ndi zoopsa ndi zotsatira.

Ananenanso kuti YK11 ikhoza kuchepetsa ntchito ya myostatin, yopanga myostatin inhibitor. YK-11 sarm ndi imodzi mwa mphamvu kwambiri kunja uko. Simungathe kuyerekeza YK ndi LGD-4033 kapena SARM ina iliyonse chifukwa cha mphamvu yake.

Komabe, ngakhale YK-11 ufa wofiira ndi wamphamvu kwambiri ndikumbukira kuti pangokhala maphunziro owerengeka okha omwe anachita ndi chigawo ichi. Ichi ndi chifukwa chachikulu chomwe anthu ambiri amawonekera kuti apite ndi SARM monga Ostamuscle, RAD-140 kapena GW-501516.

YK11 ikupeza chidwi kuchokera kwa omanga thupi chifukwa cha kukhoza kwawo kumanga minofu mwamsanga ndi zotsatira zochepa, mofanana ndi ma ARV osiyanasiyana. Makhalidwe a YK11 ndi apadera. Malolekiti a YK amagawana mofanana ndi steroids kuposa SARM, ngakhale kuti nthawi zambiri amaikidwa molakwika mu chidebe chomwecho monga SARM zina zonse zomwe sizochita.

Chiwerengero chimodzi cha pulogalamuyi chikusonyeza kuti YK11 imawonjezera minofu ya minofu. Ochita kafukufuku anapeza kuti imapangitsa mapuloteni follistatin (a myostatin inhibitor).

YK11 ingathandizenso thanzi la mafupa. Pa kafukufuku pa maselo a mafupa, YK11 inachulukitsa magulu a mapuloteni omanga mafupa.

Anthu ena opanga thupi omwe ayesa YK11 amafotokoza kulemera kwa minofu ndi kuwonongeka kwa mafuta ndi zotsatira zochepa. Komabe, pakali pano palibe zinyama kapena maphunziro a anthu a YK11 ndipo chitetezo chake sichidziwika.

Mkaka wa YK-11 (431579-34-9) Njira yogwira ntchito

YK11 ili ndi mankhwala ofanana ndi a DHT ndipo izi zikuwonetsedwa mwa njira yomwe imamangirizira ndi androgen receptors. Thupi limapanga DHT mwachilengedwe pofuna kulimbikitsa thanzi la prostate, kukula kwa tsitsi, komanso kukula kwa msinkhu.

Tikadakhala m'kalasi YK11 ngati SARM ndiye kuti idzakhala yoyenera kwambiri komanso yotchuka kwambiri pamsika. Ndi chifukwa chakuti zimangowonjezera zokhazokha ndi torogen zizindikiro, zomwe zimayambitsa ntchito zowopsya komanso zowombera kupyola padenga. Komanso, YK11 imadziwika ngati myostatin inhibitor.

Ochita kafukufuku anachita kafukufuku wa selo kuti apeze momwe zimagwirira ntchito kumanga minofu. Zotsatira zimasonyeza kuti zimangofuna kuwonjezera ma follistatin. Follistatin ndi mtundu wina wa mapuloteni m'thupi la munthu womwe umathandiza kusunga myostatin. Myostatin ndi hormone yomwe ntchito yake ndi yowononga minofu yopanda mphamvu.

Pakalipano, YK11 yekha yaiwisi yakuda ikhoza kuletsa myostatin.

Umboni winanso umasonyeza kuti YK11 ingalimbikitsenso kukula kwa mafupa polepheretsa chipata chomwe chimagwira ntchito ngati DHT.

ubwino ya phala YK11 (431579-34-9)

Kuwonjezera Kukula kwa Minofu

Ngakhale YK11 si SARM payekha, ili ndi mphamvu zodabwitsa zowonjezera minofu kukula. Zimanenedwa kuti ndizolimba monga S23.

Ndi chifukwa chakuti mwachibadwa kumawonjezera follistatin zomwe zimathandizanso thupi lanu kuti likhale ndi maselo a minofu. Follistatin imathandizanso kuchotsa myostatin, ndikukutsegulira kuti mutha kukula kwa minofu. Koma ngati zotsatira za follistatin zilibe njira iliyonse, ndiye kuti myostatin inhibition sichikhoza kuchitika, zomwe zingapangitse YK11 kukhala yopanda ntchito.

Osati kumveka ngati mbiri yosweka koma palibe phunziro laumunthu kapena zinyama kubwezeretsa deta pamzerewu.

Zonse zomwe tiri nazo ndi umboni wosakayika wochokera ku ndemanga zowonongeka pamasewera a pa intaneti. Chimene amatiuza ndikuti adatha kuchepetsa kuchepa kwa mafuta komanso ma 15 lbs of minofu amapindula pang'onopang'ono.

Amalimbitsa Mitsinje

Mahomoni ogonana ndi ofunikira kuti akhale ndi mafupa amphamvu ndi abwino. Umboni ulipo umasonyeza kuti ufa wa YK11 ukhoza kuwonjezera nyonga ya fupa mwa kudziyika yokha ku torogen receptors, zomwe ziri zofanana ndi zomwe ma SAR ambiri amachita.

YK11 ikhozanso kuonjezera kuchuluka kwa PKB (puloteni kinase B) yomwe ilipo m'maselo a thupi omwe amachititsa kukula kwa maselo a mafupa.

Tisaiwale kuti mukufuna kukhala ndi minofu ndi mafupa amphamvu kuti muthetse fractures. Zitha kuthandizanso pazinthu izi chifukwa zimathandiza kumanga minofu, kuthandizira matenda a mafupa ndi kuchepetsa zotsatira za fupa la fupa.

Yopangira YK-11 powder (431579-34-9) Mlingo

Omwe amagwiritsa ntchito YK11 ufa wofiira amanena kuti kutenga mankhwala mu 10 kwa 15 mg pa tsiku kumawachitira zabwino. Ena awonetsa zotsatira zabwino pa 5 mg tsiku. Ambiri ogwiritsa ntchito amayendetsa pa 4 kwa masabata a 8. Mudzapezanso ogwiritsa ntchito omwe amasunga SAM zosiyana.

Zotsatira zoyipa Wowonjezera wa YK-11 powder (431579-34-9)

▲ Pakalipano, maphunziro okhawo apangidwa pa YK11.

Palibe umboni wamagulu kapena maphunziro a zinyama kuti abwezeretse zifukwa zomwe zimapangidwa za mankhwala.

Izi ziyenera kukupangitsani kulingalira kawiri kafukufuku ndi chigawo ichi. Mwina muyenera kufufuza mankhwala osiyanasiyana monga Ostarine ndi Ligandrol. Iwo ali ndi zambiri zambiri ndi kufufuza komwe kulipo.

Zimanenedwa kuti YK11 ikhoza kukhala poizoni kwa chiwindi. Kuyankhula mwakuya, kungakhudze tsitsi kukula, chingwe, mawu a prostate ndi ziwalo zina zofunika m'thupi.


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Mafotokozedwe ndi zolemba zamagulu

Zotsatira za YK-11 ndi Zokumana nazo kuchokera kwa Ogwiritsa Ntchito

Zothandizira

  1. Thevis, M., Piper, T., Dib, J., Lagojda, A., Kühne, D., Packschies, L., ... & Schänzer, W. (2017). Kuwonetsera masewera a masewera a androgen receptor modulator (SARM) YK-11 pofuna kukonza njira zowononga doping. Rapid Communications mu Mass Spectrometry, 31(14), 1175-1183.
  2. Kanno, Y., Ota, R., Someya, K., Kusakabe, T., Kato, K., & Inouye, Y. (2013). Kusankha ndirorogen receptor modulator, YK11, imayambitsa kusiyana kwa myogenic kwa ma C2C12 myoblasts ndi mawu a follistatin. Tizilombo toyambitsa matenda ndi mankhwala, 36(9), 1460-1465.
  3. Piper, T., Dib, J., Putz, M., Fusshöller, G., Pop, V., Lagojda, A., ... & Thevis, M. (2018). Zofukufuku pa vivvo kagayidwe kake ka SARM Y1K11: Kuzindikiritsa ndi kupangidwira kwa metabolites zomwe zingakhale zothandiza poletsa kuyendetsa doping. Kuyeza mankhwala ndi kusanthula, 10(11-12), 1646-1656.

1 review kwa Mkaka wa YK-11 (431579-34-9)

  1. Phcoker -

    Muli ndi YK-11 powder kuti muyesedwe, zotsatira zowonetsera zimasonyeza bwino kwambiri ndi chiyero!

Kuwonjezera ndemanga

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