Chenodeoxycholic Acid (CDCA) Powder

January 12, 2022

Chenodeoxycholic acid ufa ndi imodzi mwazinthu zazikulu za bile acid zomwe zimapangidwa kuchokera ku cholesterol m'chiwindi cha anthu ndi nyama. Itha kugwiritsidwa ntchito pochiza ndulu ndi cerebral tendon xanthoma.


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1100kg / mwezi

 

Chenodeoxycholic Acid Specifications

Name mankhwala Chenodeoxycholic acid
Mankhwala Name (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
Mawu ofanana Chenodeoxycholic acid;

Anthropodeoxycholic acid;

asidi anthropodesoxycholic;

CCRIS 2195;

Chendol;

chenic acid;

Chenix;

Chenodeoxycholic acid;

Chenodesoxycholic acid;

Chenodiol;

gallodesoxycholic acid;

NSC 657949;

Xenbilox

Nambala ya CAS 474-25-9
InChIKey RUDATBOHQWOJDD-BSWAIDMHSA-N
Maselo Fmphutsi C24H40O4
Maselo Wasanu ndi atatu 392.57
Misa ya Monoisotopic 392.29265975
Melting Point 165-167 °C (kuyatsa)
Kutentha Pmafuta  437.26 ° C (kulingalira kovuta)
kachulukidwe 0.9985 (kuyerekeza movutikira)
mtundu Yoyera mpaka yoyera
Kutupa  ZOSAsungunuka
yosungirako Tkutentha  chipinda cham'chipinda
ntchito Chenodeoxycholic acid yagwiritsidwa ntchito pofufuza kuti awone zotsatira zake ngati chithandizo chanthawi yayitali cha cerebrotendinous xanthomatosis (CTX). Amagwiritsidwanso ntchito pofufuza kuti afufuze zotsatira zake pa kuyamwa kwamatumbo ang'onoang'ono a bile acid kwa odwala omwe ali ndi ileostomies.
Ripoti Loyeserera Mukhozanso

 

Chenodeoxycholic Acid

Chenodeoxycholic acid, yomwe imadziwikanso kuti chenodiol, ndi mtundu wa bile acid womwe umapezeka mwachibadwa m'thupi la munthu ndipo umagwiritsidwanso ntchito kunja kwa chenodeoxycholic acid. Kugwiritsa ntchito bile acid iyi kumalimbikitsidwa pochiza matenda osiyanasiyana ndipo malingalirowa amathandizidwa ndi umboni wasayansi. The chenodeoxycholic acid mechanism of action yaphunziridwa mwatsatanetsatane, m'maphunziro osiyanasiyana osiyanasiyana, ndi cholinga chopeza ntchito, ubwino, ndi zotsatira za chenodiol.

 

Kodi Bile Acids Ndi Chiyani?

Bile acids, monga momwe dzinalo limafotokozera moyenera, ma steroidal acid omwe amapezeka mu ndulu yamunthu ndi ndulu ya nyama zina zoyamwitsa. Bile ndi madzi am'mimba omwe amapangidwa ndi chiwindi ndikusungidwa mu ndulu. Ambiri mwa ma bile acid amapangidwa m'chiwindi ndipo amatha kuphatikiza ndi ma amino acid; taurine ndi glycine, kupanga mchere wa bile.

Ma bile acid omwe amapangidwa ndi chiwindi amatchulidwa ngati ma bile acid oyambira ndipo amaphatikizanso colic acid ndi chenodeoxycholic acid. Asanatulutse ma bile acid oyambawa, amasinthidwa kukhala mchere wa bile. Ndi mchere uwu wa bile womwe umatulutsidwa, ndikufika m'matumbo aang'ono. Kamodzi mu duodenal gawo la matumbo aang'ono, ma amino acid omwe amaphatikizidwa ndi bile acid amachotsedwa ndi zomera za m'matumbo. Amasinthidwanso zina zomwe zimapangitsa kuti colic acid isinthe kukhala deoxycholic acid ndi chenodeoxycholic acid kukhala lithocholic acid. Deoxycholic ndi lithocholic acid ndi yachiwiri bile acid.

Popeza ma bile acid amapangidwa m'chiwindi kuchokera ku cholesterol, amakhala ndi mphete ya steroid monga maziko awo. Ichi ndi chimodzi mwa zifukwa zomwe bile acids amachita ngati mahomoni a steroid m'thupi ndipo amagwira ntchito yofunika kwambiri pakutulutsa ma sign. Komabe, ntchito yayikulu ya bile acid ndikuwongolera chimbudzi chamafuta ndi mafuta omwe amadyedwa, ndipo amatero pozungulira mafuta azakudya, ndikupanga micelle.

Micelle amapangidwa pamene lipids muzakudya amakutidwa ndikunyamulidwa m'gawo lopangidwa ndi mchere wa bile. Ndikoyenera kutchula kuti micelles imakhala ndi bile acid koma imapangidwa ndi mchere wa bile womwe umakhala pamadzi ndi mawonekedwe a lipid. Malo awo pamodzi ndi chikhalidwe chawo cha hydroponic ndi hydrophilic amalola mchere wa bile kupanga ma micelles pamalo oyenera. Ndikofunikira kudziwa kuti mapangidwe a micelle ndiye chofunikira pakuwonongeka kwamafuta ndi michere yofunikira.

Ma bile acids alinso ndi ntchito zina zofunika, imodzi mwazo ndikuchepetsa matumbo a m'matumbo, omwenso ndi ofunikira pakupanga kwachiwiri kwa bile acid. Kuchotsa cholesterol ndikuthandizira kuyamwa kwa Mavitamini osungunuka mafuta ndi zina mwa ntchito zina za bile acid. Amagwira ntchito yofunika kwambiri m'thupi la munthu ndipo china chake chaching'ono ngati kusintha kwa ndende kumatha kusintha thupi kwambiri.

 

Kodi Chenodeoxycholic Acid (CDCA) Powder ndi chiyani?

Chenodeoxycholic Acid Powder (474-25-9) kapena Chenodiol Powder ndi bile acid yomwe imatha

kudyedwa kuti akwaniritse zopindulitsa zomwe zimapezedwa kuchokera ku chenodiol yamkati. The ufa ntchito achire, makamaka zochizira ndulu, amene basi madipoziti wa anaumitsa bile mu ndulu. Chenodiol itha kugwiritsidwanso ntchito pochiza zovuta zina monga kaphatikizidwe ka bile ndi metabolism. Ndi mankhwala ovomerezeka a FDA omwe nthawi zambiri amaperekedwa ku zovuta za chiwindi zomwe, pachimake, zimachokera ku zovuta za bile.

 

Kodi Chenodeoxycholic Acid Powder Amachokera Kuti?

Chenodeoxycholic acid imapangidwa ndi maselo a chiwindi kuchokera ku cholesterol. The exogenous chenodiol ufa komabe amasiyanitsidwa ndi bile la swan, Cygnus melanocoryphus.

 

Kodi Chenodeoxycholic Acid Powder Imagwira Ntchito Motani?

Chenodioxycholic acid ufa makamaka amagwiritsidwa ntchito pochiza ndulu, zomwe zimagawidwa m'magulu awiri malinga ndi zomwe zili mkati ndi maonekedwe awo pa radiography. Chenodiol imatha kuchitira bwino ndulu yomwe imapangidwa ndi cholesterol ndipo imawoneka ngati ya radiolucent. Mitsempha yomwe ili ndi ma radiopaque kapena ngati ili ndi ma radiolucent koma opangidwa ndi bile pigment, samathandizidwa ndi ufa wa CDCA.

Chenodiol amachitira ndulu mwa kusungunula mafuta m'thupi mwawo zomwe ndi zotsatira za biliary cholesterol desaturation ndi CDCA ufa. Njira ya chenodeoxycholic acid powder of action ndi yosavuta, chifukwa imalepheretsa kaphatikizidwe ka cholesterol ndi colic acid m'chiwindi. Pakapita nthawi, imalowa m'malo mwa cholic acid ndi zotumphukira zake m'thupi. Kuchuluka kwa cholesterol kumachepa, kukakamiza miyala ya kolesterolini kupasuka kuti igwirizane ndi kuchuluka kwa cholesterol.

Ikatengedwa pakamwa, chenodiol imapita kumatumbo, komwe imatengedwa ndikutumizidwa ku chiwindi kuti igwirizane ndi zotsalira za taurine ndi glycine. Akalumikizidwa, kutanthauza kuti mchere wa bile wapangidwa, CDCA bile salt imatulutsidwa mu bile. Mchere wa CDCA wa bile umakhalabe mukuyenda kwa enterohepatic kutanthauza kuti milingo ya seramu kapena mkodzo wa CDCA sisintha kwambiri.

 

Kodi Chenodeoxycholic Acid Amagwiritsidwa Ntchito Bwanji?

Chenodeoxycolic acid ufa amagwiritsidwa ntchito:

  • Chithandizo cha ma radiolucent cholesterol gallstones, sichingachitike chifukwa cha kupezeka kwa zovuta zina zomwe zimapangitsa kuti opaleshoni ikhale yovuta.
  • Chithandizo cha cerebrotendineous xanthomatosis
  • Kupititsa patsogolo ntchito ya m'matumbo ndikuwongolera kudzimbidwa
  • Chithandizo cha zolakwa obadwa nawo kapena biliary mtengo
  • Kuwongolera kwa hyperlipidemia

 

Kodi Chenodeoxycholic Acid Imafunikira Chiyani Pakugaya chakudya?

Chenodeoxycholic acid ndiwothandiza makamaka pothandizira kugayidwa kwa lipid popanga ma micelles mozungulira mafuta acid omwe atengedwa kuchokera m'matumbo. Cholinga chopanga micelle mozungulira lipids ndikupangitsa kuti zisasungunuke m'madzi kuti zitha kubweretsa m'matumbo kuti zilowe bwino. Ma cell amapangidwa ndi mchere wa bile ndipo amakhala ndi bile acids monga chenodeoxycholic acid, zomwe zimapangitsa kuti izi zikhale zofunika kwambiri pothandizira kugayitsa kwa lipid m'thupi la munthu.

 

Kodi Ubwino & Zotsatira za Chenodeoxycholic Acid Powder?

Chenodeoxycholic acid ufa amavomerezedwa ndi FDA kuti agwiritsidwe ntchito poyang'anira ndulu ndi zovuta zina. Pali maubwino angapo a chenodiol omwe adanenedwa ndi ogwiritsa ntchito ndikutsimikiziridwa ndi chidziwitso cha sayansi. Zopindulitsazi ziyenera kuganiziridwa popereka ufa wa CDCA kuti muwonetsetse kuti zopindulitsa zimaposa zoopsa.

Kasamalidwe ka Gallstones ndiye gawo lalikulu la Chenodiol, komabe, imangoyang'anira ndikusamalira mtundu wina wa ndulu. Ngati nduluyo ilibe radiolucent ndipo ili ndi cholesterol, kugwiritsa ntchito ufa wa CDCA sikungakhale kokwanira pakusungunuka kwake. Kafukufuku wopangidwa ndi cholinga chofanizira njira zosiyanasiyana zochizira ndulu za cholesterol adapeza kugwiritsa ntchito chenodiol pamodzi ndi lithotripsy kukhala njira yabwino yopangira. Chenodiol imalimbikitsidwa makamaka ngati kuchotsa ndulu ya ndulu si njira yabwino.

Ubwino wa Chenodeoxycholic acid ufa umaphatikizansopo chithandizo chazovuta zama metabolic monga cerebrotendinous xanthomas. Vutoli limaphatikizapo kusintha kwa majini mu jini yomwe imayika enzyme yomwe imafunikira kuti cholesterol ikhale ya bile acid m'chiwindi. Kusowa kwa enzymeyi kumabweretsa kuchepa kwapang'onopang'ono kwa kaphatikizidwe ka bile acid komanso kuwonjezeka kwakukulu kwa cholesterol yomwe imadziunjikira m'magawo osiyanasiyana amthupi, motero, kupanga ma xanthomas. Kuchiza ndi exogenous bile acids monga chenodiol kumathandiza kuchepetsa mafuta m`thupi m`thupi ndi bwino zizindikiro za chibadwa matenda.

Chenodeoxycholic acid, pamodzi ndi epimer, ursodeoxycholic acid, amakhulupirira kuti ali ndi antioxidant ndi anti-inflammatory properties, ngakhale kuti ubwino umenewu umawoneka kwambiri ndi ursodiol. Chenodiol imathandizanso pochiza zolakwika zobadwa nazo za kagayidwe kazakudya ndi matenda ena owopsa a chiwindi.

 

Momwe Mungatengere Chenodeoxycholic Acid Powder?

(1) Musanayambe kumwa ufa wa chenodiol

Musanayambe kumwa ufa wa chenodeoxycholic, ndi bwino kuti mudziwitse dokotala wamankhwala onse omwe alipo komanso am'mbuyomu mankhwala ndi thanzi kuti atsimikizire kuti palibe kuyanjana komwe kungabweretse zotsatira zakupha. Mwachitsanzo, ufa wa CDCA uli ndi zotsatira zingapo zomwe zimagwirizana mwachindunji ndi ntchito ya chiwindi chifukwa chake kugwiritsa ntchito mu matenda a chiwindi kumatsutsana. Ndikofunikiranso kudziwitsa dokotala za ziwengo zilizonse zomwe zili papiritsi ya chenodiol kapena ufa, kuonetsetsa kuti pamakhala chiopsezo chochepa cha zotsatirapo.

 

(2)Chenodeoxycholic amlingo wa cid ufa

Chenodiol ufa uyenera kutengedwa pakamwa, kaya ndi chakudya kapena popanda. Mlingo weniweni wa chenodeoxycholic acid ufa umadalira kulemera kwa munthu, matenda omwe akugwiritsidwa ntchito, komanso kuyankhidwa kwa mankhwala. Zomwe gawo lomaliza limatanthauza kuti mlingo woyambirira ndi kusunga mlingo wa chenodeoxycholic acid ufa ukhoza kusiyana kwambiri potengera momwe thupi limachitira bwino kapena moipa. Nthawi zambiri, kwa munthu wamkulu, mlingo umakhala pakati pa 13 mg ndi 16 mg pa kilogalamu ya kulemera.

Chenodiol ufa umagwiritsidwa ntchito makamaka pochiza ndulu, ndipo monga momwe angatengere nthawi yaitali kuti awonongeke ndi kutulutsa, ufa ukhoza kugwiritsidwa ntchito kwa zaka ziwiri. Komabe, pakatha zaka 2, kugwiritsa ntchito chenodeoxycholic acid kuyenera kuyimitsidwa chifukwa bile acid imakhala ndi zotsatira zoyipa za hepatotoxic. Komanso, zizindikiro za ndulu kapena matenda ena a biliary zingatenge mpaka chaka kuti ziwonongeke ndi kugwiritsa ntchito ufa wa CDCA.

 

(3)Ndikaphonya mlingo bwanji or overdose?

Ngati mlingo wa chenodiol ufa waphonya, ndi bwino kusiya izo ndi kutenga mlingo wotsatira pa nthawi yokhazikika. Kuchulukitsa kawiri kungayambitse bongo ndipo osavomerezeka. Ngakhale kuti palibe zambiri zomwe zanenedwa mopitirira muyeso ndi chenodiol ufa, pali ochepa omwe amafunikira chenjezo. Ngati kumwa mopitirira muyeso kumayembekezeredwa ndipo munthuyo akuvutika kupuma, chithandizo chamankhwala mwamsanga chiyenera kufunidwa.

 

(4)Kodi ndiyenera kupewa chiyani ndikamamwa chenodiol?

Kugwiritsa ntchito chenodeoxycholic acid ufa kumatsutsana muzochitika zina, monga:

  • chiwindi
  • Cirrhosis
  • Matenda a chiwindi
  • Matenda a kapamba
  • Kutsekereza m'matumbo
  • Hemolytic anemia kapena matenda ena kapena hemolysis
  • Kugwiritsa Ntchito Mowa pafupipafupi
  • uchidakwa
  • Pregnancy

Kugwiritsa ntchito chenodiol pa mimba kungakhale kwambiri teratogenic kwa mwana wosabadwayo ndipo mwamtheradi contraindicated. Panthawi yoyamwitsa, sizikudziwika ngati bile acid CDCA imalowa mu mkaka wa m'mawere chifukwa chake imatsutsana. Kufunsana ndi dokotala musanayambe kumwa ufa wa chenodeoxycholic acid pamene kuyamwitsa kumalangizidwa kwambiri.

 

Ndi Mankhwala Ena ati Angagwirizane ndi Chenodeoxycholic Acid?

Zomwe zanenedwapo za chenodeoxycholic acid zotsatira makamaka chifukwa cha zotsatira za bile acid mwachindunji, ndipo kawirikawiri chifukwa cha kugwirizana kwa ufa ndi mankhwala ena. Izi sizikutanthauza, komabe, kuti chenodeoxycholic acid ufa sichidzagwirizanitsa ndi mankhwala ena. Ngati chenodiol imatengedwa ndi mankhwala enieni a zitsamba kapena mankhwala, zotsatira za ufa zidzasintha kwambiri. Chiwopsezo chokhala ndi zotsatira zoyipa chidzawonjezekanso ndi kuyanjana uku.

Mankhwala enieni omwe alibe mphamvu yolumikizana ndi chenodeoxycholic acid ufa ndi awa:

  • Cholestyramine
  • Colestipol
  • Mapiritsi oletsa kubereka kapena mankhwala olowa m'malo mwa mahomoni
  • Maantacids omwe ali ndi aluminium monga zopangira zawo zazikulu monga Almacone, Gelusil, Maalox, Mag-al Plus, Mylanta, Rulox, ndi ena.
  • Ochepetsa magazi monga warfarin, Coumadin, Jantoven.

Cholestyramine ndi colestipol onse ndi bile acid sequestrants omwe amagwira ntchito m'mimba pogwira bile acid, motero, amalepheretsa kugwira ntchito kwawo. Kutenga ma sequestrants a bile acid okhala ndi bile acid kungapangitse kuti zotsalirazo zisakhalenso zambiri ndipo palibe phindu lomwe lingawonekere. M'malo mwake, matenda omwe chenodeoxycholic acid amalembedwa adzaipiraipira.

Ndikofunika kuti musatenge chenodiol ndi mitundu ina ya bile acid chifukwa izi zingapangitse chiopsezo cha zotsatirapo. Ndibwino kuti muyang'ane ndi dokotala ndikuwadziwitsa za mavitamini ena aliwonse kapena mankhwala omwe munthu angatenge, musanayambe chenodiol monga mankhwala ena angafunikire kuyimitsidwa asanayambe chenodeoxycholic acid. Osati zokhazo, kutchula mankhwala omwe agwiritsidwa ntchito posachedwapa ndikusiya kungakhale kopindulitsa chifukwa mankhwala ena amatha kukhala m'dongosolo kwa nthawi yaitali.

 

Kodi Pali Kusiyana Kotani Pakati pa Ursodeoxycholic Acid Powder Ndi Chenodeoxycholic Acid Powder?

Chenodeoxycholic acid powder ndi Ursodeoxycholic acid ufa ndi awiri mwazinthu zazikulu za bile acid zomwe zimaperekedwa ndikugwiritsidwa ntchito poyang'anira ndulu.

 

Ursodeoxycholic acid ufa

Ursodeoxycholic acid powder kapena ursodiol ndi yachiwiri bile acid m'thupi la munthu, yomwe imapangidwa kuchokera ku kusintha kwa mchere wa bile ndi zomera za m'matumbo. Mosiyana ndi chenodeoxycholic acid yomwe ndi bile acid yoyambirira komanso yopangidwa m'chiwindi, ursodiol imapangidwa m'matumbo ang'onoang'ono. Exogenous ursodeoxycholic acid ufa amapangidwa kuchokera ku cholic acid yomwe imachotsedwa mu bile ya bovine.

 

Kufananiza mapindu ndi ntchito

Ursodiol ndi Chenodiol amagwiritsidwa ntchito posungunula ndulu, komabe, ntchito zina za ziwirizi sizofanana. Ursodiol imagwiritsidwanso ntchito pochiza matenda a biliary cholangitis ndi sclerosing cholangitis. Chifukwa chachitetezo chake chokwera, ursodiol ndi bile acid wosankhidwa pochiza intrahepatic cholestasis yapakati.

 

Kusiyana Kwakukulu

Kusiyanitsa kwakukulu pakati pa chenodeoxycholic acid powder ndi ursodeoxycholic acid powder ndikuti chotsiriziracho si hepatotoxic ndipo chingagwiritsidwe ntchito momasuka pamene yoyamba ndi hepatotoxic ndipo ingayambitse matenda a chiwindi omwe angakhale oopsa. Chenodiol ndi pulayimale ya bile acid ndipo Ursodiol ndi yachiwiri bile acid limodzi ndi epimer ya chenodiol.

Kafukufuku waposachedwapa omwe anachitidwa ndi cholinga chofanizira ursodiol ndi chenodiol anapeza kuti UDCA inali yothandiza kwambiri kuchepetsa kukula kwa ndulu pa mwezi wa 3 ndi mwezi wa 6. Komabe, patatha miyezi 12 mphamvu ya chenodiol ndi ursodiol inali yokwanira ndipo panalibe kusiyana kwakukulu pakati pa awiriwa. Kuphatikiza apo, zidapezeka kuti Ursodiol imatha kulunjika ndikuchiza ndulu zazikulu ndi zazing'ono pawiri, Mlingo waukulu komanso wochepera. Chenodiol, kumbali ina, inali yothandiza pochepetsa kukula kwa miyala yaying'ono ya ndulu pamilingo yayikulu.

Malingana ndi kafukufuku wosiyana, chenodiol pa mlingo wochepa unagwirizanitsidwa ndi kuwonjezeka kwa cholecystectomy.

 

Kodi Zotsatira Zake Zomwe Zingakhalepo za Chenodeoxycholic Acid Ndi Chiyani?

Pamene chenodeoxycholic acid atchulidwa, ndi bwino kutsatira ndi wodwalayo pafupipafupi. Ulendo uliwonse wotsatira uyenera kuphatikizapo kuyezetsa magazi komwe kumayang'ana kwambiri ma enzyme a chiwindi. Izi ndichifukwa cha hepatotoxic chikhalidwe cha chenodeoxycholic acid. Zotsatira za chenodeoxycholic acid zitha kugawidwa m'magulu asanu, kutengera dongosolo la ziwalo lomwe limakhudzidwa kwambiri ndi zotsatira zake:

 

Zotsatira za Hematologic

Nthawi zingapo za zotsatira za hematologic zanenedwa, ndi anthu onse omwe akhudzidwawo akunena za kuchepa kwakukulu kwa maselo oyera a magazi. Kukhazikika sikunatsike pansi pa 3000 ndipo ngakhale kuchepa uku, mankhwalawa adaloledwa bwino. Chigamulo chosiya ufa wa CDCA sichinapangidwe kwa odwala onsewa chifukwa chotsatira ichi sichinabweretse nkhawa zazikulu za thanzi.

 

Zotsatira zoyipa kwa chiwindi

Chenodeoxycholic acid ufa ndi hepatotoxic chifukwa chake ntchito yake imatsutsana ndi matenda a chiwindi. Komanso, hepatotoxicity ya ufa wa CDCA ukhoza kukhala wovuta kwambiri moti kuyang'anitsitsa nthawi zonse kwa michere ya chiwindi n'kofunika kwambiri pamene mankhwala ayamba. Zotsatira zoyipazi sizimawonedwa nthawi zambiri ngati njira zodzitetezera monga kuwunika momwe chiwindi chimagwirira ntchito zimatengedwa. Kugwiritsiridwa ntchito kwa ufa wa chenodiol popanda kuyang'ana pa mayesero a chiwindi kungayambitse kulephera kwa chiwindi ndi matenda.

Zizindikiro za matenda a chiwindi zomwe zimatha kukhala ndi hepatotoxicity ya chenodiol ndi:

  • Maso achikasu
  • Khungu lachikaso
  • Mtsuko wakuda
  • Kutopa kosazolowereka komanso kutopa
  • Ululu waukulu wamimba
  • Mseru ndi kusanza komwe sikuthetsa

 

Zotsatira za m'mimba

Zotsatira zoyipazi zimatha kuwonekera nthawi iliyonse panthawi yamankhwala, komabe, zimawonedwa nthawi zambiri pamene chithandizo chayamba. Izi ndizochitika wamba chifukwa mankhwala ambiri akagwiritsidwa ntchito koyamba, amatha kuyambitsa kukwiya pang'ono kwa m'mimba. Pafupifupi 30 peresenti mpaka 40 peresenti ya anthu omwe amatenga chenodiol amafotokoza kutsekula m'mimba komwe kumaloledwa bwino komanso osati kwakukulu. Okwana 15 peresenti yokha ya omwe akudwala matenda otsekula m'mimba chifukwa cha mlingo anafunika kuchepetsa mlingo. Ena adanenanso za kusintha kwa zizindikiro pambuyo pa kugwiritsa ntchito mankhwala oletsa kutsekula m'mimba.

Kawirikawiri, kusiya chenodiol kumafunika pamene kutsekula m'mimba kuli koopsa ndipo kumayendera limodzi ndi kupweteka kwa m'mimba. Musanasiye mankhwala, ndikofunika kusiyanitsa pakati pa kutsekula m'mimba kuchokera ku colicky, kupweteka kwa m'mimba komwe kungakhalepo ndi ndulu. Kusokoneza komaliza ndi ufa wa CDCA wakale komanso wosiya kumatha kuwononga thanzi lonse.

 

Zina mwazotsatira zoyipa za m'mimba ndi monga,

  • Nsowa ndi kusanza
  • Mitengo
  • Kuthamangitsani
  • kudzimbidwa
  • Dyspepsia
  • Kupweteka kwa m'mimba mokhazikika
  • Flatulence
  • Anorexia

 

Kukhazikika kwa Cholesterol

Pafupifupi 10 peresenti yowonjezera kuchuluka kwa mafuta a kolesterolini ndi mafuta oipa, LDL, akhoza kuwonedwa ndi kugwiritsa ntchito chenodeoxycholic acid powder. Azimayi ochepa omwe amamwa bile acid adanenanso kuti kuchuluka kwa triglycerides kumawonjezeka, komanso kuchuluka kwa cholesterol ndi LDL. Palibe kusintha kwa HDL kapena mafuta abwino omwe adanenedwa.

 

Kuchotsa ndulu kapena cholecystectomy mitengo

Anthu omwe ali ndi ndulu ndi mbiri ya ululu wa biliary nthawi zambiri amafunikira njira ya cholecystectomy monga chithandizo cha ndulu zawo. Komanso, odwalawa sanathenso kulekerera mlingo waukulu wa chenodeoxycholic acid ufa ndipo anapatsidwa mlingo wochepa m'malo mwake. Kulephera kulekerera mlingo waukulu wa CDCA ufa, motero, wakhala akugwirizanitsidwa ndi kuchuluka kwa cholecystectomy mitengo.

Ndi Njira Zotani Zomwe Akutengedwera Kuti Awonetsetse Kugwiritsa Ntchito Motetezedwa Ndi Bwino Kwa Chenodeoxycholic Acid?

Ogwira ntchito zachipatala ndi madokotala ambiri amayendera maulendo otsatila kuti ayang'ane mwachidwi zotsatira za chenodeoxycholic acid powder kuti zitsimikizire chitetezo chake ndi mphamvu yonse ya ufa.

 

Kodi Ndingapeze Kuti Zambiri Paza ufa wa Chenodeoxycholic Acid Ogulitsidwa?

Kuti mudziwe zambiri pa malonda a ufa wa chenodeoxycholic acid wambiri, mungagwiritse ntchito zipangizo zapaintaneti monga mawebusaiti osiyanasiyana opanga ufa wa chenodeoxycholic acid kapena fakitale.

 

Kafukufuku Wambiri Wokhudza Chenodeoxycholic Acid

Chenodeoxycholic acid pakali pano akuphunziridwa kuti agwiritse ntchito zina za pawiri, kupatulapo ntchito zake za biliary. Kampani ina yaku Australia ya biotechnology pano ikuphunzira chenodiol kuphatikiza ndi mankhwala ochepetsa lipid, bezafibrate pochiza matenda a Hepatitis C.

 

Mafunso Ofunsidwa Kawirikawiri

(1)Chifukwa chiyani chenodeoxycholic acid (chenodiol) kwa anthu osankhidwa okha?

Chenodiol ndi bile acid wamphamvu yemwe amathandizira kuchiza ndulu. Komabe, imakhalanso ndi hepatotoxic ndipo ingayambitse matenda aakulu a chiwindi. Ichi ndichifukwa chake sikuvomerezeka kwa omwe ali ndi matenda a chiwindi chifukwa zizindikiro za matendawa zimatha kukokomeza ndi bile acid.

 

(2)Kodi ndingatenge Chenodal (chenodiol) ngati ndili ndi pakati?

Kugwiritsa ntchito chenodiol ali osavomerezeka pa mimba chifukwa teratogenic mphamvu ya mankhwala.

 

(3)Ndiyenera kutenga Chenodal nthawi yayitali bwanji?chenodeoxycholic acid)

Chenodal ikhoza kutengedwa kwa zaka ziwiri panthawi imodzi, ndipo ikhoza kutenga chenodeoxycholic acid CDCA ufa mpaka chaka kuti muchepetse zizindikiro ndikuchiza matendawa. Pambuyo pogwiritsira ntchito ufa wa CDCA kwa zaka ziwiri, ndikofunika kuti mupume.

 

(4)Chifukwa chiyani ndimafunsidwa kuti ndiziwonana ndi wothandizira wanga nthawi ndi nthawi kuti andiyeze?

Wothandizira wanu akuyesa ma enzymes a chiwindi ndi mafuta a kolesterolini kuti atsimikizire kuti zonse zili bwino, ndipo chenodiol sichinakhudze thanzi lanu lonse. Chifukwa cha chikhalidwe cha hepatotoxic cha CDCA ufa komanso mphamvu yake yoyambitsa matenda a chiwindi m'malo mofulumira, chenodeoxycholic acid wothandizira wanu adzakufunsani nthawi ndi nthawi kuti muyesedwe. Miyezo ya cholesterol yapezekanso kuti ikuchulukirachulukira pogwiritsa ntchito chenodiol, chomwe ndi mayeso ena omwe wopereka wanu adzakufunsani.

 

(5)Ndi mankhwala ati omwe ndiyenera kupewa ndikamamwa Chenodal (chenodiol)?

Mukatenga Chenodiol, muyenera kupewa zotsalira za bile acid monga cholestyramine ndi colestipol monga momwe zimakhalira ndi ufa wa CDCA ndikupangitsa kuti ntchito yake ikhale yovuta. Sitikulimbikitsidwa kumwa anticoagulants monga warfarin ndi coumadin, mapiritsi oletsa kubadwa ndi estrogen mmenemo, kapena maantacids ndi mankhwala ena okhala ndi aluminiyamu. Ngati mutenga mavitamini owonjezera, zowonjezera zitsamba, ndi tiyi wa zitsamba, kapena mwangosiya kumwa mankhwala, muyenera kudziwitsa dokotala wanu kuti atsimikizire kuti palibe mankhwala omwe alipo kapena atsopano omwe akugwirizana ndi chenodiol.

 

Reference

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