Lifiyamu orotate (5266-20-6)

March 9, 2020

Lithium orotate ndi mchere wopangidwa ndi lithiamu (alkali chitsulo) ndi orotic acid (chopangidwa mwachilengedwe mthupi) …….

 


Chikhalidwe: Mu Kupanga Misa
Zokonzedwa ndi Zokonzedweratu Zopezeka
mphamvu: 1277kg / mwezi

 

Lithium orotate (5266-20-6) kanema

Lifiyamu orotate (5266-20-6) zofunika

Name mankhwala Lifiyamu orotate
Mankhwala Name orotic acid lithiamu mchere monohydrate ; lithiamu; 2,4-dioxo-1H-pyrimidine-6-carboxylate; Lithiiorotasmonohydricum; UNII-L2N7Z24B30;
Nambala ya CAS 5266-20-6
InChIKey IZJGDPULXXNWJP-UHFFFAOYSA-M
MUZIKONDWERETSA [Li +]. C1 = C (NC (= O) NC1 = O) C (= O) [O-]
Molecular Formula C5H5LiN2O5
Kulemera kwa maselo 180.04
Misa ya Monoisotopic 162.025285 g / mol
Melting Point ≥300 ° C
Malo otentha N / A
mtundu woyera
ntchito ver-the-counter lithiamu orotate imalimbikitsidwa ngati chowonjezera chaumoyo chogwiritsidwa ntchito ngati gwero la lithiamu lotsika; itha kugwiritsidwa ntchito kwa mankhwala ochepetsa mphamvu ya lithiamu orotate pochiza matenda osokoneza bongo, migraines, ndi kuvutika maganizo komwe kumachitika chifukwa cha kupuma kwamatenda.

 

Kodi Lithium orotate ndi chiyani?

Lithium orotate ndi mchere womwe umakhala ndi lithiamu (chitsulo cha alkali) ndi orotic acid (chopangidwa mwachilengedwe m'thupi). M'chigawochi, lithiamu siyokhazikika pamtundu wa orotate ion, m'malo mwa carbonate kapena ion ina, ndipo monga mchere wina, imasiyanitsa kuti ipange ma lithiamu ions aulere. Ambiri mwa ma lithiamu orotate omwe amagulitsidwa amaperekedwa ngati mavitamini, monga mankhwala achilengedwe amtundu wambiri wamavuto amisala, ngakhale kuti sanafufuzidwe pakati pa 1973-1986 kuti athetse matenda ena, monga uchidakwa ndi matenda a Alzheimer's .

Monga njira ina yothandizira, lithiamu orotate imatha kusintha lithiamu ndikugwiritsidwa ntchito pochiza komanso kupewa ma episode a mania mwa anthu omwe ali ndi vuto la kupuma. Lithium akuti amathandizira komanso kupewa ma epicode a manic pochepetsa kuchepa kwa ubongo.

Ngakhale kuti orotic acid nthawi zina amatchedwa vitamini B13, satengedwa ngati vitamini. Thupi la munthu, orotic acid imatha kupangidwa kuchokera kuzinthu zazing'ono zomwe zimapezeka m'matumbo. Kuphatikiza apo, imagwiritsanso ntchito zabwino zambiri muubongo ndi thupi.

 

Kodi Lithium orotate imagwira ntchito bwanji?

Mafuta a lithiamu a orotic acid (lithiamu orotate) amasintha zotsatira zenizeni za lifiyamu yambiri poonjezera kugwiritsidwa ntchito kwa lifiyamu. The orotates imayendetsa lifiyamu kupita kumtundu wa mitochondria, lysosomes ndi maselo a glia. Lithium orotate imakhazikitsa michere ya lysosomal ndikuletsa ma enzyme zochita zomwe zimayambitsa kutsika kwa sodium komanso kusowa kwamadzi mu zina za mchere wa lithiamu.

 

Mapindu a Lithium orotate

Lithium orotate amagwiritsidwa ntchito pochiza matenda owopsa kapena kuvutika mtima kwa odwala omwe ali ndi vuto la kupuma, komanso kupewa kutenganso kubwereza kwa ma epicode a manic. Itha kupindulitsanso iwo omwe ali ndi nkhawa kwambiri kuchokera ku PTSD ndipo angathandize ngati chikhazikitso cha mantha.

Pakati pa 80s kafukufuku wamowa adachitika ndipo adapeza kuti mankhwala a Lithium orotate tsiku lililonse amathandizira oledzera paulendo wawo kuti asiye kumwa. Omwe ali ndi vuto la OCD komanso matenda oonera amatha kupindula nawo. Kuphatikiza apo, Lithium orotate samangogwiritsa ntchito chithandizo chaupangiri, komanso amathandizanso kupirira pakukonzanso.

Komanso, Lithium orotate imathandizanso poteteza ubongo. Lithium orotate amateteza ubongo poletsa kutayika kwa maselo aubongo ndikupanga maselo atsopano aubongo. Zawonetsa kusintha kwa Parkinson, matenda a Alzheimer's ndi dementia. Zinyama zimaphunzira lithiamu orotate idawonetsa kusintha pakuvulala koopsa kwa ubongo ndi zikwapu. Zitha kukhalanso zothandiza ngati chodzitetezera pakatikati pamanjenje chifukwa cha matenda a Lyme komanso chingateteze ku kufinya kwa ubongo.

 

Mlingo wa lithium orotate

Chifukwa cha kuphatikiza kwakukulu kwa lithiamu orotate, mankhwala othandizira ndi ocheperako kuposa mawonekedwe a lithiamu. Pali mapindu ambiri otenga lithiamu orotate pamiyeso yotsika.

Mankhwalawa amakhala pakati pa 20 ndi 250 mg. Atha kuperekanso mawonekedwe amadzi, makamaka mozungulira XNUMXmcg. Pa mlingo uwu, si poizoni.

Panthawi yakukhumudwa kwambiri, mankhwala othandizira a lithiamu orotate ndi 150 mg / tsiku. Izi zikufanizidwa ndi 900-1800 mg wa mitundu yomwe mumalandira. Munthawi iyi ya lithiamu orotate, palibenso zoyipa za ma lithiamu zomwe zimachitika komanso osafunikira kuwunika miyezo ya seramu.

Kugwiritsa ntchito kwa Lithium orotate

Monga chowonjezera pazakudya, Lithium orotate itha kugwiritsidwa ntchito pang'ono pochiza matenda monga kupsinjika kwa manic, uchidakwa, ADHD ndi ADD, kukhumudwa, nkhanza, PTSD, Matenda a Alzheimer's komanso kusamalira kupsinjika.

Mankhwala ena, lithiamu orotate angagwiritsidwe ntchito pochiza komanso kupewa zinthu zotsatirazi:

nkhawa

Matenda a bipolar

Mutu wamutu

Kusokonezeka maganizo

Glaucoma

kusowa tulo

Migraine

matenda Parkinson

Matenda osokoneza bongo

Komanso, lithiamu orotate imagwiritsidwanso ntchito pokonzanso kukumbukira, kuthetsa ululu komanso kuchepetsa nkhawa.

 

Lithium orotate zotsatira zoyipa

Kuphatikiza pamapindu omwe ali pamwambapa, lithiamu orotate imayambitsanso mavuto ena mthupi, monga beow:

Lipoti la 2007 lofalitsidwa mu Journal of Medical Toxicology limachenjeza kuti lithiamu orotate itha kukhala ndi zowopsa, kugwiritsa ntchito lithiamu orotate nthawi zambiri kumatha kuyambitsa mseru komanso kunjenjemera. Pamodzi ndi nseru ndi kusanza, zimayambitsanso matenda amtima komanso mavuto amitsempha. Palinso nkhawa zina kuti kugwiritsa ntchito lithiamu orotate kumachepetsa kugwira ntchito kwa impso.

Komanso, lithiamu orotate amatha kuyanjana ndi mankhwala ena. monga ACE inhibitors, anticonvulsants, antidepressants, calcium channel blockers, dextromethorphan, loop diuretics, meperidine, methyldopa, ndi monoamine oxidase inhibitors (MAOIs), etc.

Poganizira zoopsa zaumoyo zomwe zimakhudzana ndi poizoni wa thium, muyenera kuyezetsa magazi pafupipafupi kuti muwonetsetse kuti mankhwalawa a mankhwalawa sakupezeka mukamagwiritsa ntchito lithiamu orotate.

 

Tsamba:

  • ACOG Committee on Exercise Bulletins — Obstetrics. ACOG Practice Bulletin: Maupangiri aupangiri wama kachipatala a maopaleshoni-gynecologists okwana 92, Epulo 2008 (alowa m'malo mwa zipolopolo 87, Novembala 2007). Kugwiritsa ntchito mankhwala amisala pa nthawi ya pakati komanso mkaka wa m`mawere. Obstet Gynecol. 2008; 111: 1001-1020.18378767.
  • Balon R. Zowopsa zomwe zingachitike pa "zowonjezera zakudya" lithiamu orotate. Ann Chipatala. 2013; 25 (1): 71.23376874.
  • Barkins R. Low-dose lithiamu ndi zotsatira zake zathanzi. Zotsatira za Nutr. 2016; 39 (3): 32-34.
  • Heim W, Oelschläger H, Kreuter J, Müller-Oerlinghausen B. kumasulidwa kwa lifiyamu kuchokera pakukonzekera kosasunthika. Faniziro la zilembo zisanu ndi ziwirizi. Mankhwala. 1994; 27 (1): 27-31.8159780.
  • Nieper, Hans Alfred (1973), "Kugwiritsa ntchito kwa lithiamu orotate. Kafukufuku wazaka ziwiri ”, Agressologie, 14 (6): 407–11, PMID 4607169.
  • Gong R, Wang P, Dworkin L. Zomwe tiyenera kudziwa pokhudzana ndi lifiyamu pa impso. Ndine J Physiol Renal Physiol. 2016; 311 (6): F1168-F1171.27122541.
  • lithiamu orotate