5a-hydroxy laxogenin ufa

January 10, 2022

5a-hydroxy laxogenin ufa uli ndi anabolic / androgenic chiŵerengero chofanana ndi Anavar ufa, koma popanda zotsatirapo kapena chiwindi toxicity.Mphamvu idzawonjezeka m'masiku a 3-5, ndipo minofu yowonda imawonjezeka mu masabata a 3-4. 5a-hydroxy-laxogenin ndi steroidal sapinogen. Mayesero adawonetsa kuti kaphatikizidwe ka mapuloteni kamawonjezeka ndi 200%, chinsinsi cha kukula kwa minofu ndi kukonzanso mofulumira.

 


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1050kg / mwezi

 

Zambiri zamakina a 5a-hydroxy laxogenin ufa

Name mankhwala 5a-hydroxy laxogenin ufa
Mafananidwe 5 alpha-Hydroxy laxogenin; 5-alpha-Hydroxy-laxogenin; 5 alpha hydroxy laxogenin; 5-alpha hydroxy laxogenin; 5-alpha-hydroxy laxogenin; 5a hydroxy laxogenin; 5a-hydroxy Laxogenin
Zosakaniza Purity = 99%
Nambala ya CAS 56786-63-1
Kalasi ya Mankhwala spirostani analogue ya brassinosteroid
InChI Mfungulo Chithunzi cha HCRGPOQBVFMZFY-PPCFKNSFSA-N
MUZIKONDWERETSA CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC(=O)C6(C5(CCC(C6)O)C)O)C)C)OC1
Molecular Formula C27H42O5
Kulemera kwa maselo 446.6
Misa ya Monoisotopic 446.30322444
Melting Point 247-250 ° C
Malo otentha 578.4 ± 50.0 ° C (Wonenedweratu)
Ekusiya theka la moyo hours 6-8
mtundu White powder
Kutupa DMF: 15mg/mL; DMSO: 10mg/mL
Stempage temp Osindikizidwa muuma, Kutentha Kwapachipinda
ntchito Zowonjezera; kumanga thupi; kupeza minofu

Omanga thupi ndi othamanga nthawi zambiri amayang'ana njira zowonjezera minofu yowonda popanda kuwonjezera mafuta m'thupi. Imodzi mwa njira zosavuta zopezera izi ndi kugwiritsa ntchito anabolic steroids, koma kugwiritsidwa ntchito kwa nthawi yaitali kwa steroids kumakhala ndi zotsatira zina zomwe zingakhale zovuta kwa ambiri.

Kafukufuku waposachedwa apeza chochokera ku chomera chomwe asayansi amakhulupirira kuti chimakhala ndi zotsatira zofanana ndi anabolic steroids, komabe, popanda zotsatira zoyipa za ma steroid.

Mankhwalawa amadziwika kuti 5a hydroxy laxogenin nthawi zambiri kapena ndi dzina lasayansi, 5-alpha-hydroxy laxogenin. 5a hydroxy laxogenin ufa ikugulitsidwa ndi ambiri a 5a hydroxy laxogenin operekera ufa monga chowonjezera chomanga thupi chifukwa cha ubwino wambiri wa mankhwalawa.

 

Kodi 5a-hydroxy laxogenin ndi chiyani?

5a-hydroxy laxogenin, ndi yochokera ku laxogenin, mankhwala opezeka m'chilengedwe, m'zomera. Laxogenin kapena 3beta-hydroxy-25D,5alpha-spirostan-6-one, ndi chomera chochokera ku anabolic steroid chomwe chadziwika pakati pa othamanga ndi omanga thupi chifukwa cha mphamvu zake zolimbitsa minofu.

Chifukwa chakuchulukirachulukira kwa Laxogenins ndi gawo lawo muzomera. Ndi mahomoni akumera, omwe amadziwikanso kuti brassinosteroids omwe amapangidwa mwadongosolo komanso magwiridwe antchito, ofanana kwambiri ndi mahomoni amtundu wa nyama ndi anthu. Chifukwa cha izi, akusintha anabolic steroids.

Laxogenins atha kupezedwa kuchokera ku anyezi aku China kapena pansi panthambi za chomera cha ku Asia, Smilax sieboldii. Laxogenins, mu zowonjezera zambiri zomwe zimapangidwa ndikugulitsidwa ndi 5a-hydroxy laxogenin ufa wopanga, kwenikweni amachokera ku chomera china cha steroid diosgenin. Chomera ichi cha steorid chimagwiritsidwanso ntchito popanga mahomoni ena ambiri opangidwa monga progesterone, omwe amagwiritsidwa ntchito kwambiri m'mapiritsi oletsa kubereka.

Mitundu yambiri yomwe ili ndi 5a hydroxy laxogenin ufa wogulitsidwa, monga chowonjezera, ili ndi chotengera ichi cha laxogenin, chomwe chimachokera ku diosgenin, m'malo mokhala ndi laxogenin yachilengedwe. Komabe, izi sizodetsa nkhawa kwambiri chifukwa phindu la 5-alpha-hydroxy-laxogenin ndilofanana ndi laxogenin.

 

Kodi 5-alpha-hydroxy laxogenin ndi prohormone?

Ambiri a 5a hydroxy laxogenin opanga ndi 5a hydroxy laxogenin operekera ufa amalemba chigawocho ngati prohormone. Prohormone ndi chinthu chomwe chikalowa m'thupi, chidzasintha kuti chikhale hormone yeniyeni.

Chitsanzo choyenera chingakhale ma androgens, omwe amakhala ngati prohormones ndipo kamodzi atalowetsedwa ndi kusungunuka, amatembenuzidwa ku hormone, testosterone. 5a hydroxy laxogenin powder si pre-hormone chifukwa sichimasintha kukhala hormone, koma imakhala ndi phindu lofanana ndi hormone ya steroid.

 

Kodi 5-alpha-hydroxy laxogenin ndi steroid?

5a hydroxy laxogenin ndi chomera cha steroid chomwe chimagawana zofananira zingapo ndi mahomoni amtundu wa nyama. Ndiwofanana kwambiri ndi mahomoni ogonana m'thupi la munthu omwe amachokera ku cholesterol. Ndikofunika kunena kuti 5a hydroxy laxogenin ufa uli ndi ntchito yowonjezera kukula kwa zomera koma zotsatira zake pa thupi la munthu zimakhala zovuta kwambiri kuposa izo.

M'malo modutsa nembanemba ndikupangitsa kusintha kokha, kaphatikizidwe kameneka kamamangiriza ku cholandirira ndikuyambitsa chizindikiro, chomwe chimatha ndi kuwonjezeka kwakukulu kwa mphamvu zomanga minofu ya thupi.

Puloteni yeniyeni yomwe imayendetsedwa ndi 5a hydroxy laxogenin powder ndi protein kinase B kapena AKT 1. Puloteniyi imadziwika bwino chifukwa cha mphamvu zake osati kuwonjezera kupanga minofu m'thupi la munthu komanso kupewa kusokonezeka kwa minofu.

Mapuloteni aminofu amawonongeka panthawi yolimbitsa thupi kwambiri koma amaganiziridwa kuti mapindu osiyanasiyana a 5-alpha-hydroxy laxogenin amaphatikizapo kupewa kuwonongeka kwa mapuloteni ndi kuwonongeka panthawi yolimbitsa thupi.

Njira ina yomwe 5a hydroxy laxogenin ufa imapanga phindu lomwe limakondweretsa omanga thupi ndi othamanga ndikuletsa kuwonongeka kwa enzyme yofunikira, yomwe ndi, cAMP.

Kuchulukitsa kuchuluka kwa enzyme iyi m'thupi mwa kulepheretsa kuwonongeka kwake kumabweretsa kuwonongeka kwakukulu kwamafuta m'thupi. Panthawi imodzimodziyo, kuwonjezereka kwa enzymeyi kumapangitsanso kuti pakhale kuwonjezereka kwa kumenyana-kapena-kuthawa.

Zonsezi, 5a hydroxy laxogenin ufa ogulitsa akugulitsa mankhwala omwe amachulukitsa minofu, amachepetsa kuwonongeka kwa mapuloteni, komanso amawonjezera kuwonongeka kwa mafuta, nthawi imodzi. Zotsatirazi zimakhulupirira kuti zimachitika chifukwa izi ndi zotsatira zomwe nthawi zambiri zimawonedwa mumitundu yosiyanasiyana ya maphunziro a 5a hydroxy powder omwe amachitidwa pazitsanzo za nyama kapena mu vitro, mu labu. Komabe, zotsatirazi sizingawonekere m'thupi la munthu pamene zowonjezera zomwe zimagulitsidwa ndi osiyana 5a hydroxy laxogenin opanga ufa amatengedwa.

 

Ndi 5a-hydroxy laxogenin mofanana ndi Laxogenin: 5a hydroxy laxogenin vs laxogenin

5a-hydroxy laxogenin imachokera ku hormone ya zomera, laxogenin. Ali ndi maubwino omwewo, malinga ndi kafukufuku wosiyanasiyana wopangidwa pazitsanzo za nyama. Komabe, iwo sali chinthu chomwecho.

 

Kodi 5-alpha-hydroxy laxogenin imachita chiyani?

5-alpha hydroxy laxogenin ndi ofanana kwambiri ndi mahomoni ogonana omwe amapangidwa kuchokera ku cholesterol m'thupi la munthu. Mahomoni ogonana awa omwe amapezeka mwachilengedwe m'thupi la munthu amachitapo kanthu pa zolandilira za nyukiliya, pomwe 5a hydroxy laxogenin imamangiriza ku cholandilira cha cell, pamwamba pa selo.

Makampani ambiri omwe ali ndi 5a hydroxy laxogenin ufa wogulitsidwa nthawi zambiri amagulitsa chowonjezera ichi ndi malonda omwe ali ndi 200 peresenti ya potency ndipo amatha kusintha minofu pakati pa othamanga kwambiri. Zonena izi zopangidwa ndi opanga osiyanasiyana ndi zotsatira za maphunziro angapo omwe apangidwa ndi cholinga chowunika kuchuluka kwa minofu ya laxogenins.

Kafukufuku waposachedwa waku Russia wokhudza zitsanzo za nyama adapeza kuti mankhwala a thermogenic amachokera ku gulu lomwelo la mahomoni omera monga laxogenin, omwe ali ndi zotsatira zofanana ndi laxogenin. Malinga ndi kafukufukuyu, zotumphukira za brassinosteroidzi zimatha kukulitsa mapuloteni a chiwindi, mtima, impso, ndi miyendo. Komanso, ofufuza adapeza kuti zotumphukira izi sizinapange zopindulitsa izi pobwereza kapena kutsanzira momwe mahomoni ogonana amagwirira ntchito m'thupi la munthu.

Kafukufuku wina wofufuza yemwe adapangidwanso pazitsanzo za nyama ndikugwiritsa ntchito mahomoni omwe ali m'gulu lomwelo la mahomoni omera monga laxogenin adatha kubwereza zomwezo monga kafukufuku waku Russia. Zofukufuku zina zambiri zidachitidwa kuti zitsimikizire kuti zotsatira zake ndi zovomerezeka ndipo zotsatira zake zidapezeka kuti zimabwerezedwa mosavuta, chifukwa chake, zimatsimikizira mphamvu zawo komanso mphamvu zawo.

Ndikofunika kunena kuti ngakhale ambiri ogwiritsa ntchito 5a hydroxy laxogenin powder amanena kuti akuwona zotsatira zomwe ogulitsa adalengeza, kupeza umboni weniweni wa sayansi wothandizira ntchito yawo wakhala wovuta. Maphunziro ambiri amachitidwa pazitsanzo za nyama ndikugwiritsa ntchito mankhwala omwe mwina ali m'gulu la mahomoni a brassinosteroid kapena mahomoni ofananira a chomera, phytoecdysteroids. Laxogenins ndi ofanana ndi mahomoniwa ndipo 5a hydroxy laxogenin ndi yochokera ku laxogenins, koma izi sizikutanthauza phindu lomwe limawonedwa ndi mahomoni ena.

Kafukufuku wina yemwe anachitidwa pogwiritsa ntchito laxogenin yachilengedwe komanso yopangidwa mu labotale inapeza kuti ufa umenewu ukhoza kuchepetsa kupsinjika kwa okosijeni m'thupi kwambiri. Kuchepetsa kupsinjika kwa okosijeni ndi laxogenins kunachitika pochepetsa ma free radicals, mtundu wa zinthu zovulaza m'thupi zomwe zimatha kuchita nawo machitidwe osiyanasiyana amankhwala ndikuvulaza thupi kwambiri. Kuchepetsa uku kwa ma radicals aulere komanso kupsinjika kwa okosijeni kumatha kufotokozera momwe 5a hydroxy laxogenin ufa amatha kupititsa patsogolo kuchira kwa minofu, pambuyo pochita masewera olimbitsa thupi. Komabe, phunziroli liyenera kuchitidwa pa zinyama zonse ndi nkhani za anthu zotsatira za phunziroli zisanakhulupirire.

Maphunziro onse omwe tawatchulawa anachitidwa ndi cholinga chofuna kudziwa ngati laxogenins adzatha kuwonjezera minofu ndi mamvekedwe. Komabe, ntchito yokhayo ya 5 alpha-hydroxy laxogenin si yomanga thupi ndipo ndi zomwe ena mwa zidutswa zina za kafukufuku anali kuyembekezera kutsimikizira.

Mu maphunziro awiri osiyana, kugwiritsa ntchito 5-alpha-hydroxy laxogenin ufa mu odwala khansa ya m'matumbo kunachepetsa kukula kwa khansara kwambiri. Mofananamo, chitukuko cha khansa ya m'mapapo chinapezeka kuti chachepetsedwa pogwiritsa ntchito 5a hydroxy laxogenin ufa mu zitsanzo za nyama. Ngakhale kuti maphunzirowa sangathe kupereka umboni wotsimikizirika umene umafunika kuti chowonjezera chilichonse kapena mankhwala aphatikizidwe mu ndondomeko ya chithandizo, ndi sitepe yolondola.

 

Ndi liti pamene mungatenge 5-alpha-hydroxy laxogenin?

Mlingo wa 5-alpha-hydroxy laxogenin ufa umayamba kuchokera ku 25 mg, ndipo ndizomwe munthu ayenera kutenga nthawi iliyonse. Komabe, mpaka 6, ndi osachepera 3, Mlingo ukhoza kutengedwa tsiku lonse, kupanga mlingo wa zowonjezera, 150 mg pa tsiku. Zimalimbikitsidwanso kuti mutenge ufa wowonjezera ndi chakudya kuti muwonjezere kuyamwa m'mimba.

5a hydroxy laxogenin ufa ukhoza kutengedwa kwa miyezi 3 mpaka miyezi 4 panthawi imodzi chifukwa ndi pamene zotsatira zake zidzawonekera. Itha kutengedwa mosalekeza kwa nthawi yayitali kuposa pamenepo ngati ikufunika kapena mukufuna. Monga chigawo chachilengedwe chilibe mphamvu pamagulu a mahomoni a thupi, sichiyenera kukhala ndi nthawi yochepa.

Zotsatira za 5-alpha-hydroxy laxogenin sizidziwika bwino chifukwa maphunziro ambiri omwe amachitidwa kuti awone momwe zowonjezerazo zimagwirira ntchito sizimachitidwa pa maphunziro a anthu. Amachitidwa pazitsanzo za zinyama ndipo sizingatheke kudziwa ubwino ndi zotsatira za maphunzirowa. Komabe, ogwiritsa ntchito zowonjezerazo sananenepo za poizoni kapena zotsatirapo zoipa, zomwe zachititsa kuti akhulupirire kuti zowonjezerazo zilibe zotsatirapo.

 

Ndani ayenera kuganizira kugwiritsa ntchito?

Omanga thupi, othamanga, ndi wina aliyense amene angafune kuwonjezera minofu ndi misala pamene amachepetsa mafuta m'thupi ayenera kuganizira kugwiritsa ntchito 5a hydroxy laxogenin powder.

 

Kodi 5-alpha-hydroxy laxogenin ndi yovomerezeka?

5a hydroxy laxogenin imatengedwa kuti ndi chinthu choletsedwa chomwe bungwe la Food and Drug Association kapena FDA ku United States lapereka machenjezo angapo. Chosakanizacho chakhala chikuyang'aniridwa ndi USADA kwa nthawi yayitali chifukwa apeza kuti ali muzinthu kapena zowonjezera zomwe zilinso ndi zinthu zina zowonjezera. Chifukwa china chodetsa nkhaŵa ndi 5a hydroxy laxogenin ufa ndi chakuti amalengezedwa ngati chilengedwe, chochokera ku zomera anabolic steroid. Onse a FDA ndi USADA afunsa mafunso okhudza gwero lenileni la 5a hydroxy laxogenin monga gwero lachilengedwe la zomera limapereka laxogenin hormone yokha. Sizinafotokozedwe momwe hydroxy laxogenin imachokera ku laxogenin.

USADA yasanthula mwatsatanetsatane mitundu yosiyanasiyana ya ufa wa 5a hydroxy laxogenin omwe amagulitsidwa ndipo yapeza theka lazowonjezerazo kuti zili ndi mankhwala osokoneza bongo. Poyesa kupulumutsa othamanga ndi omanga thupi ku doping mwangozi pogwiritsa ntchito 'natural plant steroid', USADA yawapempha kuti ayang'ane zowonjezera zowonjezera zomwe zili ndi laxogenin zomwe zingatchulidwe pamndandanda wazinthu monga:

  • Chithunzi cha UNII-HT7W184YG4
  • Chithunzi cha HT7W184YG4
  • SCHEMBL4027062
  • ZINC70691911
  • (25r) -3beta-hydroxy-5alpha-spirostan-6-imodzi
  • Q272800835
  • alpha-hydroxy-laxogenin
  • 5a-hydroxy-laxogenin
  • 5-laxogenin
  • (25R) -3beta,5alpha-dihydroxyspirostan-6-imodzi
  • 25-R-spirostan-5a-diol-6-imodzi-3-imodzi
  • 25R spirostan-5a-diol-6-one-3-one decanoate
  • 25R spirostan-5a-diol-6-one-3-one undecanoate

USADA imakayikiranso kuti mawu akuti laxogenin pamndandanda wazinthu zitha kukhala chidziwitso chobisika kwa omwe akufunafuna zowonjezera zowonjezera, kutanthauza kuti palibe laxogenin yeniyeni kapena 5a hydroxy laxogenin pazowonjezera.

FDA, mofanana ndi USADA, imasiyanasiyana ndi laxogenins mu zakudya zowonjezera zakudya chifukwa palibe chidziwitso chokwanira chokhudza kugwiritsidwa ntchito kwake, chitetezo, ndi potency. Ndi kafukufuku wochulukirapo, pali kuthekera kwakuti chophatikiziracho chivomerezedwe ngati chowonjezera champhamvu chowonjezera minofu.

Kuthekera kumeneku kulipo chifukwa, ngakhale USADA idalengeza kuti laxogenins ndi zotuluka zake ndi zinthu zosaloledwa, Bungwe Lolimbana ndi Kugwiritsa Ntchito Doping Authorities silinaletse kugwiritsidwa ntchito kwawo pakati pa othamanga. 5a hydroxy laxogenin simakwaniritsa zofunikira kuti iwonetsedwe ngati mankhwala osokoneza bongo.

Komanso, kuyezetsa kwa mankhwala a 5a hydroxy laxogenin sikungakhale kothandiza pofufuza zinthu za doping bola ufawo sunasokonezedwe kapena kuwonjezedwa ndi zinthu zina zoletsedwa.

 

Ndemanga za 5-alpha-hydroxy laxogenin

Ogwiritsa ntchito ambiri a 5-alpha-hydroxy laxogenin ufa amalumbirira ndipo amanena kuti akuwona zotsatira zonse zotsatsa paokha. Pafupifupi onse ogwiritsa ntchito amatamanda chowonjezeracho kuti chikuchita mwachangu pakuwonjezeka kwa minofu ndi kamvekedwe.

Pali ndemanga zambiri pa intaneti zomwe zimati zawona bwino minofu ndi kuwonjezeka kwa minofu, ndi kuchepa kwakukulu kwa mafuta ndi miyezi itatu kapena inayi yokha yogwiritsira ntchito 5a hydroxy laxogenin ufa.

 

Best 5a-hydroxy laxogenin ufa kugula?

Ufa wowonjezera ukhoza kugulidwa kudzera mu 5a hydroxy laxogenin ogulitsa katundu ngati pakufunika kapena akhoza kugulidwa pang'ono. Ufa wabwino kwambiri wogula ndi womwe wapangidwa, kuthandizidwa, ndi kupakidwa ndi malangizo okhwima otetezedwa chifukwa izi zimatsimikizira kuti 5a hydroxy laxogenin alibe zinthu zowononga komanso zoletsedwa.

 

Zothandizira:

  1. Zosakaniza Zosaloledwa, 5-Alpha-Hydroxy-Laxogenin, Zowonekera mu Zowonjezera Zambiri. Maphunziro, Mzimu Wamasewera / December 4, 2019
  2. Bioorg Med Chem. 2012 Apr 15;20(8):2690-700. doi: 10.1016/j.bmc.2012.02.026. Epub 2012 Feb 15.Zatsopano zokhudzana ndi ubale wa cytotoxicity wa spirostan saponins ndi ma glycosides ogwirizana. Karell Pérez-Labrada, Ignacio Brouard, Sara Estévez, María Teresa Marrero, Francisco Estévez, Jaime Bermejo, Daniel G Rivera. PMID: 22405922
  3. YW Zhang, I Morita, L Zhang, G Shao, XS Yao, S Murota. Kuwunika kwa anti-hypoxia/reoxygenation agents ndi njira ya in vitro. Gawo 2: Kuletsa kwa tyrosine kinase activation kunalepheretsa kuvulala kwa hypoxia / reoxygenation mu endothelial gap junctional intercellular communication. Planta Med. 2000 Marichi; 66(2):119-23. doi: 10.1055/s-2000-11126. PMID: 10763583
  4. Diana M. Cheng, Louis W. Kutzler, Dustin D. Boler, Jenny Drnevich, John Killefer, ndi Mary Ann Lilaa.Kulowetsedwa kosalekeza kwa 20-Hydroxyecdysone Kuwonjezeka kwa Misa ya Triceps Brachii mu C57BL / 6 Mice. Losindikizidwa pa intaneti 2012 Apr 12. doi: 10.1002/ptr.4679. PMC3410052
  5. Debora Esposito, Slavko Komarnytsky, Sue Shapses, and Ilya Raskin.Anabolic effect of plant brassinosteroid. FASEB J. 2011 Oct; 25 (10): 3708- doi: 10.1096/fj.11-181271. PMC3177571