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Mphungu ya Lorcaserin HCL (846589-98-8)

(1 kasitomala review)

Mphalapala wa Lorcaserin hydrochloride powder ndi serotonin 2C (5-HT2C) yomwe imalandira mankhwala ovomerezeka ndi mankhwala omwe amalimbikitsa ....


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1380kg / mwezi

Kufotokozera

Mawotchi a Lorcaserin HCL powder (846589-98-8)

Mafinya a Lorcaserin HCL (846589-98-8) Zomwe zimayambitsa

Name mankhwala Mafuta a Lorcaserin Hydrochloride powder
Mankhwala Name Mbalame yotchedwa Lorcaserin HCL powder, Lorcaserin
Brand NAme BELVIQ
Kalasi ya Mankhwala 5-HT2C receptor inhibitor
Nambala ya CAS 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
Maselo Fmphutsi C11H15Cl2N
Maselo Wasanu ndi atatu 232.15
Misa ya Monoisotopic 231.058154899
Kusungunula Pmafuta Palibe deta yomwe ilipo
Fkubwezeretsanso Pmafuta Palibe deta yomwe ilipo
Halimo Half-Life Hafu ya moyo ya lorcaserin ili pafupi maola a 11.Chulukidwe cha ufa chimachotsedwa makamaka mu mkodzo (92%) ndi m'zinyama (2.2%)
mtundu White powder
Kutupa Kutha kwa madzi: 0.0709 mg / mL
yosungirako Tkutentha -20 ° C.
Amalingaliro Serotonin 2C (HT2C) receptor agonist kulemera kwake.Kuonjezera zakudya komanso kumalimbikitsa kwambiri

Mafinya a Lorcaserin Hcl ufa (846589-98-8) Ndemanga

Mafuta a Lorcaserin hydrochloride powder ndi hydrochloride omwe amapeza mwala wa lorcaserin ndi ofanana ndi hydrochloric acid. Amagwiritsidwa ntchito monga mankhwala odana ndi kunenepa kwambiri. Lorcaserin hydrochloride ndi 5HT2c receptor agonist yomwe ikugwiritsidwa ntchito kwa anthu akuluakulu omwe ali ndi BMI ≥30, kapena omwe ali ndi BMI ≥27 ndi vuto limodzi lolemera ngati matenda a hypertension, mtundu wa shuga wa 2 kapena dyslipidemia.Lorcaserin Hydrochloride powder amagwira ntchito pochotsa njala ndi amachititsa kuti munthu asamamve bwino, ndipo amalingalira kuti asagwidwe ndi matenda a mtima wa valvular wokhudzana ndi kuchitidwa kwa ziwalo za 5-HT2B, malo a ubongo wodziwika kuti amathandiza kwambiri pakulamulira njala ndi kudya. Pogwiritsa ntchito mapulogalamuwa, Lorcaserin hydrochloride powder angachepetse kudya kwa kuchepetsa kudya kwa chakudya komanso kupanga munthu kukhala wokhutira ngakhale atadya chakudya chocheperapo kusiyana ndi nthawi zonse. idavomerezedwa lero ndi FDA mu chisankho chodabwitsa pambuyo pa zaka 2 za kufufuza.

Lorcaserin hydrochloride powder amawonetseratu kuti ali ndi zakudya zochepa zowonjezera ma calorie komanso kuwonjezereka kwa thupi la anthu okalamba kwambiri (BMI ya 30 kg / m2 kapena akuluakulu) komanso anthu olemera kwambiri (BMI ya 27 kg / m2 kapena yaikulu) ndi chiwerengero cha comorbid chimodzi cholemera.

Lorcaserin hydrochloride powder amagwiritsidwa ntchito limodzi ndi zakudya ndi masewera olimbitsa thupi kuti athetse kunenepa kwambiri. Nthaŵi zina amagwiritsidwa ntchito pofuna kuchiza kunenepa kumene kumakhudzana ndi shuga, cholesterol yapamwamba, kapena kuthamanga kwa magazi.

Lorcaserin hydrochloride sichidzachiza matenda alionse (monga matenda a mtima, shuga, kuthamanga kwa magazi). Pitirizani kutenga mankhwala ena omwe dokotala wanu wakuuzani kuti muwathandize.

Lorcaserin Hcl ufa (846589-98-8) Njira yogwira ntchito

Ngakhale kuti njira yeniyeniyo sidziwika, zimakhulupirira kuti zimapangitsa kuti 5-HT2C receptors ikhale yovomerezeka m'zinthu zosawerengeka za pro-opiomelanocortin neurons mumtundu wa hypothalamus. Izi zimapangitsa kuchepa kwa zakudya komanso kuchepetsa chakudya mwa kulimbikitsa kutulutsa kwa alpha-melanocortin yotulutsa hormone, yomwe imagwira pa mapulogalamu a melanocortin-4.

Lorcaserin hydrochloride powder amagwira ntchito poletsa chilakolako - makamaka poyambitsa ubongo wa seroton, serotonin, neurotransmitter yomwe imayambitsa chisangalalo cha kukhutira ndi kukhutira. Kudya kwa chakudya kumayendetsedwa ndi malo osungirako zinthu, omwe ali mu nucleus of hypothalamus ndi njala yomwe ilipo panthawi yowonjezera hypothalamus. Zipangizo zosiyanasiyana zochokera m'mapiritsi apamwamba ndi m'mimba zimatuluka pamtunda, pomwe pali mitundu iŵiri ya neuroni yomwe imalamulira chakudya. Choyamba, gulu lothandizira zakudya zomwe zimapanga mapuloteni okhudzana ndi agouti ndi neuropeptide Y; ndipo kachiwiri, gulu lokhala ndi chakudya chokhala ndi cocaine ndi amphetamine (MAP) ndi pro-opiomelanocortin (POMC) neurons. POMC ili ndi zizindikiro za 5-HT 2C, zomwe zimatulutsidwa kutulutsa mahomoni a al-Mano-melanocyte (stimulating hormone). Paraventricular nucleus ili ndi melanocyte 4 receptors (MC4R) yomwe imaletsa chilakolako cha mankhwala ochizira lorcaserin hydrochloride powder monga chotsalira cha 5-HT 2C agonist pa POMC neurons, zomwe zimayambitsa kutulutsa alfa MSH. Palinso alfa MSH amagwira MC4R mu nthenda yapamwamba mu hypothalamus, zomwe zimapangitsa kuchepa kwa njala. Mu mankhwala a supratherapeutic, lorcaserin hydrochlorider imathandizanso pa 5-HT 2B ndi 5-HT 2A receptors.

ubwino ya Lorcaserin Hcl powder (846589-98-8)

  • Lorcaserin HCL ufa ndiwosankha 5-HT2C receptor agonist yomwe imalingalira kuchepetsa kudya kwa chakudya kudzera pakati pa POMC dongosolo. Mankhwala a Lorcaserin HCL powder:
  • Mankhwala a Lorcaserin HCL amagwiritsidwa ntchito pamodzi ndi zakudya komanso masewera olimbitsa thupi kuti athetse kunenepa kwambiri.
  • Nthaŵi zina ufa wa Lorcaserin HCL umagwiritsidwa ntchito pofuna kuchiza kunenepa kumene kumakhudzana ndi matenda a shuga, mafuta otsekemera kwambiri, kapena kuthamanga kwa magazi.
  • Mankhwala a Lorcaserin HCL sangasamalire matenda aliwonse (monga matenda a mtima, shuga, kuthamanga kwa magazi).

Analimbikitsa Lorcaserin Hcl ufa (846589-98-8) Mlingo

Lorcaserin HCL ufa imabwera mu ma tebulo ndipo imatengedwa nthawi zambiri 1-2 pa tsiku, popanda chakudya. Lorcaserin iyenera kugwiritsidwa ntchito limodzi ndi zakudya zoperewera za calorie ndi ndondomeko yochita masewera olimbitsa thupi.

Mlingo woyenera wa lorcaserin hcl ufa ndi 10 mg yomwe imayendetsedwa kamodzi pa tsiku. Lorcaserin ikhoza kutengedwa popanda kudya chakudya. Lorcaserin hcl iyenera kuthetsedwa kwa odwala omwe amalephera kukwaniritsa osachepera 5% kulemera kwa sabata pa sabata 12 chifukwa odwalawa sangakhale ndi zolemetsa zofunikira ndi mankhwala opitilira.

Zotsatira zoyipa ya Lorcaserin Hcl powder (846589-98-8)

Mankhwala a Lorcaserin Hcl amagwiritsidwa ntchito pochiza kasamalidwe kalemera kwa akuluakulu omwe ali ndi chiwerengero cha mthupi (XIUMX) cha 30 kapena chachikulu (owonjezera) monga kuwonjezera pa zakudya zochepa zowonjezera mafuta. Amavomerezedwa kuti agwiritsidwe ntchito ndi anthu akuluakulu omwe ali ndi BMI ya 27 kapena oposa (olemera kwambiri) ndipo omwe ali ndi vuto limodzi lolemera, monga kuthamanga kwa magazi (hypertension), kapena cholesterol (dyslipidemia). Komabe, zingakhalenso ndi zotsatira zina. Monga pansipa:

Tzotsatira zake zofala:

  • -Mafupi,
  • -Dzinessess,
  • -Wotopa,
  • -Nkhani,
  • -Khala mkamwa,
  • -Constipation, ndi
  • -Hayglycemia (shuga wotsika magazi).

Zotsatira zina zochepa koma zovuta zomwe zimakhudzana ndi lorcaserin zikuphatikizapo:

  • -Sinthani mavuto a valve,
  • -Makondwerero akumbukira kapena kukumbukira,
  • -Mabvuto a m'mtima,
  • -Kusokonezeka kapena maganizo a kudzipha,
  • -Kusintha kwabwino,
  • -Kukonda mtima pang'ono,
  • -Kuthyoka muwerengero wa magazi, ndi
  • -Zowonjezera mahomoni, prolactin.


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Mafotokozedwe ndi zolemba zamagulu

FDA Yavomerezedwa ndi Lorcaserin HCL Kwa Chithandizo Cha Kunenepa

Zothandizira

  1. Bohula, Erin A., Wiviott, Stephen D., McGuire, Darren K., Inzucchi, Silvio E., ndi al: Moyo wa Carcascular Safety wa Lorcaserin pa Odwala Overweight Kapena Odwala Onse, The New England Journal of Medicine, 2018
  2. Ulamuliro wa Zakudya ndi Zamankhwala, Mankhwala Othandizira Kugwiritsa Ntchito Mankhwala Otalikitsa Kwambiri, Online, Published 17 July 2012
  3. Ashley Gustafson, Cammile King, Jose AR, National Center For Biotechnology Information, PMC Nkhani, MediMedia, USA Lorcaserin (Belviq), Online, September 2013

1 review kwa Mphungu ya Lorcaserin HCL (846589-98-8)

  1. phcoker -

    Wakuda kwambiri wa Lorcaserin HCL powayesa, zotsatira zowonetsera ziwonetsero zapamwamba komanso zoyera!

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