Mphungu ya Lorcaserin HCL (846589-98-8)

October 30, 2018

Yaikulu Lorcaserin hydrochloride powder ndi serotonin 2C (5-HT2C) receptor agonist ndi mankhwala operekedwa pakamwa omwe amalimbikitsa….


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1380kg / mwezi

Mawotchi a Lorcaserin HCL powder (846589-98-8)

 

Mafinya a Lorcaserin HCL (846589-98-8) Zomwe zimayambitsa

Name mankhwala Mafuta a Lorcaserin Hydrochloride powder
Mankhwala Name Mbalame yotchedwa Lorcaserin HCL powder, Lorcaserin
Brand NAme BELVIQ
Kalasi ya Mankhwala 5-HT2C receptor inhibitor
Nambala ya CAS 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
Maselo Fmphutsi C11H15Cl2N
Maselo Wasanu ndi atatu 232.15
Misa ya Monoisotopic 231.058154899
Kusungunula Pmafuta  Palibe deta yomwe ilipo
Fkubwezeretsanso Pmafuta Palibe deta yomwe ilipo
Halimo Half-Life Hafu ya moyo ya lorcaserin ili pafupi maola a 11.Chulukidwe cha ufa chimachotsedwa makamaka mu mkodzo (92%) ndi m'zinyama (2.2%)
mtundu White powder
Kutupa  Kutha kwa madzi: 0.0709 mg / mL
yosungirako Tkutentha  -20 ° C.
Amalingaliro Serotonin 2C (HT2C) receptor agonist kulemera kwake.Kuonjezera zakudya komanso kumalimbikitsa kwambiri

 

Mafinya a Lorcaserin Hcl ufa (846589-98-8) Ndemanga

Mafuta a Lorcaserin hydrochloride powder ndi hydrochloride omwe amapezeka ndi lorcaserin powder ndi ofanana ndi hydrochloric acid. Amagwiritsidwa ntchito ngati mankhwala odana ndi kunenepa kwambiri. Lorcaserin hydrochloride ndi 5HT2c receptor agonist yomwe imagwiritsidwa ntchito kwa achikulire omwe ali ndi BMI -30, kapena omwe ali ndi BMI -27 komanso osachepera chimodzi chokhudzana ndi kulemera ngati matenda oopsa, mtundu wa 2 shuga kapena dyslipidemia. amachititsa kuti munthu akhale wosangalala, ndipo amaganiza kuti amapewa mvula yamatenda a mtima yokhudzana ndi kuyambitsa kwa ma 5-HT2B receptors, dera laubongo lomwe limadziwika kuti limagwira ntchito yayikulu pakukhazikitsa njala ndi kudya. Pogwiritsira ntchito mapulogalamuwa, Lorcaserin hydrochloride powder ikhoza kuchepetsa kudya mwa kuchepa kwa njala ndikupangitsa munthu kumverera wokhutira ngakhale atadya chakudya chochepa kuposa nthawi zonse. idavomerezedwa lero ndi a FDA pamalingaliro apadera pambuyo pofufuza zaka 2.

Lorcaserin hydrochloride powder amawonetseratu kuti ali ndi zakudya zochepa zowonjezera ma calorie komanso kuwonjezereka kwa thupi la anthu okalamba kwambiri (BMI ya 30 kg / m2 kapena akuluakulu) komanso anthu olemera kwambiri (BMI ya 27 kg / m2 kapena yaikulu) ndi chiwerengero cha comorbid chimodzi cholemera.

Lorcaserin hydrochloride powder amagwiritsidwa ntchito limodzi ndi zakudya ndi masewera olimbitsa thupi kuti athetse kunenepa kwambiri. Nthaŵi zina amagwiritsidwa ntchito pofuna kuchiza kunenepa kumene kumakhudzana ndi shuga, cholesterol yapamwamba, kapena kuthamanga kwa magazi.

Lorcaserin hydrochloride sichidzachiza matenda alionse (monga matenda a mtima, shuga, kuthamanga kwa magazi). Pitirizani kutenga mankhwala ena omwe dokotala wanu wakuuzani kuti muwathandize.

Lorcaserin Hcl ufa (846589-98-8) Njira yogwira ntchito

Ngakhale kuti njira yeniyeniyo sidziwika, zimakhulupirira kuti zimapangitsa kuti 5-HT2C receptors ikhale yovomerezeka m'zinthu zosawerengeka za pro-opiomelanocortin neurons mumtundu wa hypothalamus. Izi zimapangitsa kuchepa kwa zakudya komanso kuchepetsa chakudya mwa kulimbikitsa kutulutsa kwa alpha-melanocortin yotulutsa hormone, yomwe imagwira pa mapulogalamu a melanocortin-4.

Lorcaserin hydrochloride powder imagwira ntchito poletsa chilakolako - makamaka poyambitsa mapulogalamu a ubongo a serotonin, neurotransmitter yomwe imayambitsa kukhuta komanso kukhutira. Kudya chakudya kumayang'aniridwa ndi malo okhutira, omwe amapezeka pakatikati pa hypothalamus ndi njala yomwe imapezeka mu lateral hypothalamus. Zowonjezera zosiyanasiyana zochokera kumalo apamwamba komanso mathirakiti am'mimba zimasunthika pakatikati, pomwe pali mitundu iwiri ya ma neuron omwe amayang'anira kudya. Choyamba, gulu lolimbikitsa kudya lomwe limapanga mapuloteni okhudzana ndi agouti ndi neuropeptide Y; ndipo chachiwiri, gulu loletsa kudya lomwe lili ndi cocaine ndi amphetamine yolembedwa (CART) ndi pro-opiomelanocortin (POMC) neurons. POMC imakhala ndi 5-HT 2C receptors, yomwe ikatsegulidwa imatulutsa alpha-melanocyte-stimulating hormone (alfa-MSH). Paraventricular nucleus imakhala ndi melanocyte 4 receptors (MC4R) yomwe imalepheretsa kudya m'mankhwala a lorcaserin hydrochloride powder amakhala ngati 5-HT 2C agonist pa POMC neurons, yomwe imatulutsanso alfa MSH. Alfa MSH imagwiranso ntchito pa MC4R pamutu wozungulira mu hypothalamus, zomwe zimapangitsa kuchepa kwa njala. Mlingo wa supratherapeutic, lorcaserin hydrochlorider imagwiranso ntchito 5-HT 2B ndi 5-HT 2A receptors.

ubwino ya Lorcaserin Hcl powder (846589-98-8)

  • Lorcaserin HCL ufa ndiwosankha 5-HT2C receptor agonist yomwe imalingalira kuchepetsa kudya kwa chakudya kudzera pakati pa POMC dongosolo. Mankhwala a Lorcaserin HCL powder:
  • Mankhwala a Lorcaserin HCL amagwiritsidwa ntchito pamodzi ndi zakudya komanso masewera olimbitsa thupi kuti athetse kunenepa kwambiri.
  • Nthaŵi zina ufa wa Lorcaserin HCL umagwiritsidwa ntchito pofuna kuchiza kunenepa kumene kumakhudzana ndi matenda a shuga, mafuta otsekemera kwambiri, kapena kuthamanga kwa magazi.
  • Mankhwala a Lorcaserin HCL sangasamalire matenda aliwonse (monga matenda a mtima, shuga, kuthamanga kwa magazi).

Analimbikitsa Lorcaserin Hcl ufa (846589-98-8) Mlingo

Mafuta a Lorcaserin HCL amabwera m'mapiritsi ndipo amatengedwa nthawi 1-2 pa tsiku, popanda chakudya. Lorcaserin iyenera kugwiritsidwa ntchito limodzi ndi zakudya zopatsa mphamvu zopatsa mphamvu komanso zolimbitsa thupi.

Mlingo woyenera wa lorcaserin hcl ufa ndi 10 mg womwe umaperekedwa ndi pakamwa kawiri patsiku. Lorcaserin imatha kumwedwa osadya chilichonse. Lorcaserin hcl iyenera kuthetsedwa kwa odwala omwe amalephera kupeza 5% yochepera thupi sabata ya 12 popeza odwalawa sangakhale ndi vuto locheperako ndi chithandizo chamankhwala.

Zotsatira zoyipa ya Lorcaserin Hcl powder (846589-98-8)

Mafuta a Lorcaserin Hcl amagwiritsidwa ntchito pochiza matenda osachiritsika kwa achikulire omwe ali ndi index ya mass mass (BMI) ya 30 kapena kupitilira apo (onenepa kwambiri) monga kuwonjezera pakudya kwakanthawi kochepa komanso masewera olimbitsa thupi. Amavomerezedwanso kuti agwiritsidwe ntchito ndi achikulire omwe ali ndi BMI ya 27 kapena kupitilira apo (onenepa kwambiri) ndipo omwe ali ndi vuto limodzi lolemera monga kuthamanga kwa magazi (kuthamanga kwa magazi), kapena cholesterol (dyslipidemia). Komabe, itha kukhala ndi zovuta zina. Monga pansipa:

 Tzotsatira zake zofala:

  • -Mafupi,
  • -Dzinessess,
  • -Wotopa,
  • -Nkhani,
  • -Khala mkamwa,
  • -Constipation, ndi
  • -Hayglycemia (shuga wotsika magazi).

 Zotsatira zina zochepa koma zovuta zomwe zimakhudzana ndi lorcaserin zikuphatikizapo:

  • -Sinthani mavuto a valve,
  • -Makondwerero akumbukira kapena kukumbukira,
  • -Mabvuto a m'mtima,
  • -Kusokonezeka kapena maganizo a kudzipha,
  • -Kusintha kwabwino,
  • -Kukonda mtima pang'ono,
  • -Kuthyoka muwerengero wa magazi, ndi
  • -Zowonjezera mahomoni, prolactin.