Mafuta a orlistat (96829-58-2)

October 30, 2018

Mafuta akulu a Orlistat ndi mankhwala omwe amagwiritsidwa ntchito pochiza kunenepa kwambiri. Ntchito yake yayikulu ndikuteteza kuyamwa kwa mafuta kuchokera kuzakudya za anthu….


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1470kg / mwezi

Mawindo obiridwa a Orlistat (96829-58-2) kanema

Mafuta a orlistat (96829-58-2)

Mafuta akulu a Orlistat ali mgulu la mankhwala otchedwa lipase inhibitors omwe amagwira ntchito poletsa kuyamwa kwa 25% ya mafuta pachakudya ndipo amagwiritsidwa ntchito pochepetsa anthu olemera kwambiri, azaka 18 kapena kupitilira apo, akagwiritsidwa ntchito limodzi ndi kalori wochepa zakudya zamafuta ochepa. Mafuta akulu a Orlistat ndi mankhwala omwe amapangidwa kuti athetse kunenepa kwambiri. Ntchito yake yayikulu ndikuletsa kuyamwa kwa mafuta kuchokera pazakudya za anthu, potero kumachepetsa kudya kwama caloriki. Mafuta akulu a Orlistat amagwira ntchito poletsa pancreatic lipase, enzyme yomwe imaphwanya triglycerides m'matumbo. Popanda enzyme iyi, triglycerides kuchokera pachakudya sichimalepheretsedwanso kukhala hydrolyzed kukhala mafuta osavuta omwenso amachotsedwa. Mankhwala a Raw Orlistat amagwiritsidwa ntchito kwa anthu onenepa kwambiri omwe amathanso kukhala ndi kuthamanga kwa magazi, matenda ashuga, cholesterol, kapena matenda amtima. Mphamvu ya ufa wa Raw Orlistat polimbikitsa kutaya thupi ndiyotsimikizika koma modzichepetsa. Zambiri zophatikizidwa kuchokera kumayesero azachipatala zikuwonetsa kuti anthu amapatsidwa ufa wa Raw Orlistat kuphatikiza pa kusintha kwa moyo, monga zakudya ndi masewera olimbitsa thupi, amataya pafupifupi 2-3 kilogalamu (4.4-6.6 lb) kuposa omwe samamwa mankhwalawo kwa chaka chimodzi. Mafuta a Orlistat amadzichepetsanso amachepetsa kuthamanga kwa magazi ndipo amawoneka kuti amaletsa kuyambika kwa matenda amtundu wa 2, mwina kuchokera kuwonda wokha kapena zovuta zina. Amachepetsa matenda ashuga amtundu wachiwiri mwa anthu omwe ali onenepa kwambiri mofanana ndi momwe amasinthira moyo wawo.

 

Mafuta a orlistat (96829-58-2) Mafotokozedwe

Name mankhwala Mafuta aakulu a Orlistat
Mankhwala Name Tetrahydrolipstatin, 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate
Brand NAme Alli, Xenical
Kalasi ya Mankhwala lipase inhibitors
Nambala ya CAS 96829-58-2
InChIKey AHLBNYSZXLDEJQ-FWEHEUNISA-N
Maselo Fmphutsi C29H53NO5
Maselo Wasanu ndi atatu 495.745 g / mol
Misa ya Monoisotopic 495.392 g / mol
Kusungunula Pmafuta  <50 ° C
Fkubwezeretsanso Pmafuta Palibe tsiku likupezeka
Halimo Half-Life Malingana ndi deta yochepa, theka la moyo wa ufa wofiira wa Raw Orlistat uli m'kati mwa ma 1 mpaka maola 2.
mtundu White powder
Kutupa  DMSO: 19 mg / mL
yosungirako Tkutentha  nyengo yosungirako. 2-8 ° C
Amalingaliro Gwiritsani ntchito kuchiza kunenepa kwambiri.

 

Zam'mwamba Orlistat ufa (96829-58-2) Kufotokozera

Mafuta owopsa a Orlistat ali m'kalasi la mankhwala omwe amatchedwa lipase inhibitors omwe amagwira ntchito poletsa kutaya kwa 25% mwa mafuta omwe amadya ndipo amagwiritsidwa ntchito kulemera kwa anthu olemera kwambiri, zaka 18 ndi zakale, pamene amagwiritsidwa ntchito pamodzi ndi kuchepetsa-kalori ndi zakudya zonenepa.

Mafuta aakulu a Orlistat ndi mankhwala omwe amachititsa kuti munthu azidya kwambiri. Ntchito yake yaikulu ndikuteteza kutentha kwa mafuta kuchokera ku zakudya zaumunthu, motero kuchepetsa kudya kwa caloric. Mafuta akuluakulu a Orlistat amagwira ntchito poletsa kutentha kwa pancreatic lipase, yomwe imayambitsa triglycerides m'matumbo. Popanda mavitaminiwa, triglycerides kuchokera ku zakudya amaletsedwa kuti asadetsedwe m'malo mwa mafuta omwe amawathandiza kuti azikhala opanda mafuta. Mafuta Odzola Odzola Amagwiritsidwa ntchito pa anthu olemera kwambiri omwe angakhalenso ndi kuthamanga kwa magazi, shuga, cholesterol, kapena matenda a mtima. Mphamvu ya ufa wokhala ndi Raw Orlistat popititsa patsogolo kulemera kwake ndi yeniyeni koma yodzichepetsa. Zosungidwa zomwe zimachokera ku mayesero a zachipatala zimasonyeza kuti anthu amapatsidwa ufa Wowonjezera Wowonjezera, kuphatikizapo zakudya zakusintha, monga zakudya ndi masewero olimbitsa thupi, kutaya 2-3 kilogalamu (4.4-6.6 lb) kuposa omwe samamwa mankhwala pa chaka chimodzi. Mafuta oopsa a orlistat amadzichepetsa komanso amachepetsa kuthamanga kwa magazi ndipo amawoneka kuti amaletsa mtundu wa shuga wa 2, kaya ukhale wolemera kwambiri kapena zotsatira zina. Amachepetsa chiwerengero cha matenda a shuga a mtundu wachiwiri mwa anthu omwe ali ochepa kwambiri kuposa momwe moyo umasinthira.

Orlistat ufa (96829-58-2) Njira yogwira ntchito

Mafuta a orlistat ndi mtundu wa lipase womwe umaletsa kutaya mankhwala osokoneza bongo ndipo ndimomwe amachokera ku lipostatin. Orlistat imathandizira komanso imalepheretsa m'mimba lipase ndi pancreatic lipase, pomwe sizimakhudza ma enzyme ena am'mimba (monga amylase, trypsin ndi chymotrypsin) komanso phospholipase, komanso sizimakhudza kuyamwa kwa chakudya, mapuloteni ndi phospholipids. Mankhwalawa samayamwa ngakhale m'mimba mwa m'mimba ndipo amatha kusintha lipase. Orlistat imachepetsa ma enzyme ndikumangirira kophatikizana ndi zotsalira za serine m'malo omwe ali m'mimba ndi kapamba wa lipase. Izi zimalepheretsa mafuta omwe ali mchakudya kuti asagwidwe mafuta aulere ndi diacylglycerol, chifukwa chake sichingathe kuyamwa, kutsitsa kudya kwama caloriki motero kuwongolera kulemera kwa thupi. Mankhwalawa safunika kulowetsedwa ndi thupi lonse kuti agwire ntchito. Zochita za Orlistat zimadalira kuchuluka kwa mankhwala: kuchuluka kwa mankhwala a Orlistat (120mg / d, tid, otengedwa ndi chakudya), kuphatikiza zakudya zamafuta ochepa, kumatha kuchepetsa mpaka 30% ya kuyamwa kwamafuta. Pakafukufuku ofananira odzipereka abwinobwino komanso onenepa kwambiri, Orlistat sanatengeke ndi thupi konse ndipo anali ndi magazi ochepa kwambiri. Pambuyo pa mlingo umodzi wamlomo (waukulu kwambiri kukhala 800mg), kuchuluka kwa magazi kwa Orlistat m'maola otsatirawa a 8 anali <5 ng / ml. Nthawi zambiri, kuchuluka kwa mankhwala a Orlistat kumangotengera thupi pang'ono ndipo sikudzapezekanso munthawi yochepa. Poyesa mu vitro, kuchuluka kwa Orlistat ndi mapuloteni ena a seramu kunaposa 99% (mapuloteni omangidwa anali makamaka lipoproteins ndi albumin), ndipo kuchuluka kwake kwama cell ofiira ofiira kunali kotsika kwambiri.

Ubwino wa ufa wa Orlistat (96829-58-2)

▪ Orlistat imachepetsa kuchuluka kwa thupi kupitilira 20% chifukwa cha mafuta amthupi

▪ Orlista imakuthandizani kuphunzira kuwerengera zopatsa mphamvu

▪ Orlista imakupatsani chisangalalo

▪ Orlista ili ndi zotsatira zabwino zimapereka chidaliro komanso chisangalalo kwa ogwiritsa ntchito

▪ Orlista imapereka zotsatira zanthawi yayitali

▪ Orlista amachepetsa kuopsa kwa matenda monga hypotension, matenda ashuga, atherosclerosis komanso

cholesterol.

Analimbikitsa Orlistat ufa (96829-58-2) Mlingo

Mlingo woyenera wa ufa wa Orlistat ndi kapu imodzi ya 120-mg katatu patsiku ndi mafuta aliwonse omwe ali ndi mafuta (nthawi kapena pakutha pa ola la 1 pambuyo pa chakudya). Mankhwala pamwamba pa 120 mg katatu patsiku sanawonetsere kuti amapereka phindu lina.

Anthu ayenera kudya zakudya zopatsa thanzi, zochepa zomwe zimakhala ndi pafupifupi 30% ya mafuta kuchokera ku mafuta. Kudyetsa mafuta tsiku ndi tsiku, mafuta, mavitamini, ndi mapuloteni ayenera kugawidwa pazipangizo zitatu. Ngati chakudya nthawi zina chimasowa kapena mulibe mafuta, mlingo wa ufa wa Orlistat ukhoza kutayidwa.

Chifukwa ufa wa Orlistat wasonyeza kuti amachepetsa kuyamwa kwa mavitamini osungunuka ndi mafuta ndi betacarotene, anthu ayenera kulangizidwa kuti atenge multivitamin yokhala ndi mavitamini osungunuka mafuta kuti akhale ndi chakudya chokwanira. Kuphatikiza apo, mavitamini othandizira ayenera kumwedwa osachepera maola 2 asanafike kapena pambuyo pa kuyamwa kwa ufa wa Orlistat, monga nthawi yogona.

Zotsatira za ufa wa Orlistat (96829-58-2)

Ndi zachilendo kuona zotsatira za ufa wa Orlistat mutagwiritsa ntchito. Mukhoza kukhala ndi zotsatira zina kapena osati monga mutatha kumwa mankhwala ena onse. Zotsatira zambiri zomwe zimadza ndi kugwiritsa ntchito ufa wa Orlistat zimagwirizana ndi momwe zimagwirira ntchito m'thupi lanu. Nthawi zambiri zimakhala zofewa ndipo zimachitika nthawi zonse mutayamba mankhwala. Zimakhalanso zomwe mutatha mutatenga chakudya chambiri. Mwamwayi, ambiri amachoka pamene mankhwala akupitirira ndikutsatira chakudya choyenera.

Zotsatirazi ndizo zotsatira zofala:

 mutu

 Kumva ululu / kusokonezeka

 Kutaya kwa mafuta

 Mafuta odyera

 Khungu lachikopa

 Ululu wammbuyo

Kupatulapo, ngati mutadutsa zowawa zilizonsezi, muyenera kuchitapo kanthu mwamsanga ndikuitana dokotala mwamsanga. Ali;

 Kupweteka kwakukulu kwa m'mimba kumene sikuchoka.

 Njuchi kapena kuyabwa kwambiri

 Zovuta kumeza

 Kuvuta kupuma