Sulforaphane (4478-93-7)

March 8, 2020

Sulforaphane, yemwenso amadziwika kuti "dl-sulforaphane", ndi chomera chachilengedwe chomwe chimapezeka m'mitengo yambiri yofanana ndi …… ..

 


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

 

Sulforaphane (4478-93-7) kanema

Sulforaphane Szizindikiro

Name mankhwala Sulforaphane
Mankhwala Name Sulforafan
DL-Sulforaphane
1-Isothiocyanato-4- (methylsulfinyl) butane
D, L-Sulforaphane
Brand NAme N / A
Kalasi ya Mankhwala Miyezo; Othandizira Enzyme ndi Oletsa;
Nambala ya CAS 4478-93-7
InChIKey Kufotokozera: SUVMJBTUFCVSAD-UHFFFAOYSA-N
Maselo Fmphutsi Yogulitsa
Maselo Wasanu ndi atatu 177.3 g / mol
Misa ya Monoisotopic 177.028206 g / mol
Malo otentha  125-135 ° C
Fkubwezeretsanso Pmafuta N / A
Halimo Half-Life N / A
mtundu yellow
Szovuta  DMSO: sungunuka 40 mg / mL
Smazunzo Tkutentha  -20 ° C
Amalingaliro Sulforaphane ufa makamaka amagwiritsa ntchito zowonjezera.

 

Kodi Sulforaphane ndi chiyani?

Sulforaphane, yomwe imadziwikanso kuti "dl-sulforaphane", ndi chomera chachilengedwe chomwe chimapezeka m'mitengo yambiri yotere monga broccoli, kabichi, kolifulawa, ndi kale.

Ndi antioxidant wamba komanso mbewu yabwino kwambiri yopezeka muz masamba. Sulforaphane samangokhala ndi zochitika zamphamvu zotsutsana ndi khansa, komanso ali ndi kuthekera kolimba kwa anti-oxidation. Imadziwika kuti ndi imodzi mwazinthu zachilengedwe zomwe zimakhala ndi anti-khansa komanso kukongola.

Sulforaphane amapangidwa pomwe enzyme myrosinase isintha glucoraphanin, glucosinolate, imakhala sulforaphane pakuwonongeka kwa chomera (monga kutafuna), komwe kumapangitsa kuti zinthu ziwirizi zisakanikirane. Nthata zazing'ono za broccoli ndi kolifulawa ndizambiri mu glucoraphanin ndi sulforaphane.

Sulforaphane (SFN) ndi isothiocyanate, mankhwala okhala ndi sulufuti.Sulforaphane Tingafinye amakhala ndi antioxidant, antimicrobial, anticancer, anti-inflammatory, anti-okalamba, neuroprotective, ndi anti-diabetes.

 

Sulforaphane ubwino

Zopindulitsa Zaumoyo wa Sulforaphane

Zowonjezera za Sulforaphane sizinavomerezedwe ndi FDA kuti azigwiritsa ntchito pazachipatala ndipo nthawi zambiri zimasowa kafukufuku wolimba wazachipatala. Malamulo amakhazikitsa miyezo ya iwo opangira koma samatsimikizira kuti ndi otetezeka kapena ogwira ntchito.

  • kulimbikitsa kuletsa
  • kuwonjezera ubongo
  • kuthandiza thupi kupanga mankhwala olimbana ndi khansa
  • Kuthandiza mtima wathanzi ntchito
  • akuwonjezera glutathione ngati woyambitsa Nrf2
  • kulimbikitsa kunenepa
  • kuchedwetsa ukalamba pogwiritsa ntchito mapuloteni otentha
  • kulimbikitsa chiwindi ntchito
  • kuchepetsa kutupa ndi ululu
  • Kuyimitsa ndikusintha tsitsi.
  • Sulforaphane akhoza kuchepetsa LDL cholesterol
  • shuga

Amamera a Broccoli amasintha magawo ambiri a shuga. Mtundu wachiwiri wa odwala matenda ashuga, kudya ma broccoli kumatulutsa mphamvu ya antioxidant ndi HDL cholesterol, ndikuchepetsa kupsinjika kwa oxidative, triglycerides, insulin, insulin, ndi CRP.

  • Zowonongeka za Khungu

Sulforaphane akhoza kupereka chitetezo ku UVA ndi UVB kutupa, kutentha kwa dzuwa, ndi khungu.

  • Sulforaphane Amachepetsa Zizindikiro za Autism

Sulforaphane amatha kuyambitsa majini ena omwe amateteza maselo ku oxidative nkhawa, kutupa, ndi kuwonongeka kwa DNA, zonsezi zomwe zimagwirizanitsidwa ndi vuto la Autism spectrum.

  • Ntchito Yothandizira

Sulforaphane awonetsa ntchito yotsutsana ndi ma cell omwe ali ndi kachilombo atawululidwa mwachindunji

Zotsatira zoyipa za Sulforaphane ndi chitetezo.

Sulforaphane ndiotetezeka mukamagwiritsa ntchito kuchuluka komwe kumapezeka muzakudya. Koma palibe zambiri zokwanira kudziwa ngati ndi bwino kumwa pakamwa ngati mankhwala.

Sulforaphane amagwiritsa ntchito ndi kugwiritsa ntchito

-Sulforaphane ungagwiritsidwe ntchito pochotsa mabakiteriya owononga m'mapapo.

-Sulforaphane ali ndi ntchito yothandizira anti-kutupa ndikuchotsa kupweteka kwa nyamakazi.

-Sulforaphane imatha kuyambitsa dongosolo la machiritso m'thupi, dongosolo la kuchotsa poizoni, kukonza ziwalo zisanu zamkati, kusamala, kukonza ziwalo zowonongeka, sulforaphane imatha kupewa ndi kuchiza gout.

-Sulforaphane itha kugwiritsidwa ntchito pochiza khansa. Sulforaphane imatha kuteteza zilonda zam'mimba, atrophic gastritis yosintha khansa ya m'mimba

-Sulforaphane umagwiritsidwa ntchito m'munda wazakudya, sulfforane ndi mtundu wazakudya zabwino zobiriwira kuti muchepetse kunenepa;

-Sulforaphane imagwiritsidwa ntchito m'munda wazopanga zathanzi, udzu winawake umatha kukhazikika ndikuchotsa mkwiyo;

-Sulforaphane umagwiritsidwa ntchito popanga mankhwala, kuchitira rheumatism ndi gout kumakhala ndi zotsatira zabwino.

Zambiri Research

 

Sulforaphane ufa mkati Kansa ya Prostate kafukufuku

Sulforaphane (mu mawonekedwe a broccoli yophukira) ali ndi umboni wamphamvu wakuchipatala wothandiza pantchito yoletsa khansa ya Prostate komanso njira zoyendetsera popewa kubwererenso khansa ya Prostate.

M'maphunziro angapo azachipatala, amuna omwe ali ndi khansa ya prostate yomwe imachitika pafupipafupi 60 mg tsiku la sforforaphane patsiku anali ndi antigen (PSA, chizindikiritso chogwiritsa ntchito poyesa kupitirira kwa khansa ya prostate) kuposa omwe sanatenge sulfforane.

Zomwe zanenedwa, a FDA sanavomereze sulforaphane popewa kubwezeretsanso khansa ya Prostate.

 

Reference:

  • Dietary Sulforaphane mu Cancer Chemoprevention: Udindo wa Epigenetic Regulation ndi HDAC Inhibition Stephanie M. Tortorella, Simon G. Royce, Paul V. Licciardi, Tom C. Karagiannis Antioxid Redox Signal. 2015 Jun 1; 22 (16): 1382-1424. doi: 10.1089 / ars.2014.6097 Sulforaphane amawongolera ma apoptosis- komanso kuchuluka kwa njira zokhudzana ndi kuchuluka kwa nthawi yayitali ndikugwirizana ndi chisplatin kupondereza khansa yamchiberekero cha Shi-Feng Kan, Jian Wang, Guan-Xing Sun Int J Mol Med. 2018 Nov; 42 (5): 2447–2458. Zofalitsidwa pa intaneti 2018 Sep 6. doi: 10.3892 / ijmm.2018.3860
  • Bioavailability wa Glucoraphanin ndi Sulforaphane ochokera ku High ‐ Glucoraphanin Broccoli Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W. Needs, Maria H. Traka, Henri Tapp, Jack R. Dainty, Richard F. Mithen Mol Nutr Food Res. 2018 Sep; 62 (18): 1700911. Wolemba pa intaneti 2018 Mar 8. Doi: 10.1002 / mnfr.201700911
  • Kupewa kwa Khansa ya M'magazi ya Carcinogen-Yolembedwa ndi Sulforaphane Julie E. Bauman, Yan Zang, Senab wa Malabika, Changyou Li, Lin Wang, Patricia A. Egner, Jed W. Fahey, Daniel P. Normolle, Jennifer R. Grandis, Thomas W. Kensler , Daniel E. Johnson Cancer Prev Res (Phila) Wolemba pamanja; likupezeka mu PMC 2017 Jul 1. Lofalitsidwa mu mawonekedwe osintha komaliza monga: Cancer Prev Res (Phila). 2016 Jul; 9 (7): 547-557. Zofalitsidwa pa intaneti 2016 Jun 23. doi: 10.1158 / 1940-6207.CAPR-15-0290
  • Kafukufuku wachiwiri wa broccoli wolemera kwambiri wa sulufaphane amapezeka mwa amuna omwe ali ndi khansa yokhazikika ya Prostate Joshi J. Alumkal, Rachel Slottke, Jacob Schwartzman, Ganesh Cherala, Myrna Munar, Julie N. Graff, Tomasz M. Beer, Christopher W. Ryan, Dennis R. Koop, Angela Gibbs, Lina Gao, Jason F. Flamiatos, Erin Tucker, Richard Kleinschmidt, Motomi Mori Ikani Mankhwala Atsopano. Zolemba pamanja; likupezeka mu PMC 2016 Apr 1. Yasindikizidwa mu mawonekedwe osintha komaliza ngati: Invest New Mankhwala Osokoneza bongo. 2015 Apr; 33 (2): 480-489. Yofalitsidwa pa intaneti 2014 Nov 29. doi: 10.1007 / s10637-014-0189-z