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Nicotinamide adenine dinucleotide (53-84-9)

Nicotinamide adenine dinucleotide (NAD) ndi cofactor yomwe imathandizira metabolism yomwe imapezeka m'maselo onse amoyo. Ilipo m'mitundu iwiri …….


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Nicotinamide adenine dinucleotide (53-84-9) Szizindikiro

Name mankhwala Nicotinamide adenine dinucleotide (NAD +)
Mankhwala Name Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
Nambala ya CAS 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
MUZIKONDWERETSA C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Molecular Formula C21H27N7O14P2
Kulemera kwa maselo 663.4 g / mol
Misa ya Monoisotopic 663.109123 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
mtundu White
Stempage temp 2-8 ° C
Kutupa H2O: 50 mg / mL
ntchito Chakudya chathanzi, zodzola, zowonjezera chakudya

Kodi Nikotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) ndi cofactor yomwe imathandizira metabolism yomwe imapezeka m'maselo onse amoyo. Amapezeka m'mitundu iwiri, oxidized (NAD +) ndikuchepetsedwa (NADH).

Coenzyme NAD +, mtundu wa oxidized wa NAD, adapezeka koyamba mu 1906 ndi a Arthur Harden ndi a William John Young a biochemists. NAD + imapangidwa ndi njira ziwiri za metabolic, zomwe zimatha kupangidwa kuchokera ku devo novo amino acid way, kapena kupangidwa ndi kubwezeretsanso zinthu zomwe zimapangidwa kale (monga nicotinamide) kubwerera ku njira yopulumutsira ya NAD +. Ndi pyridine nucleotide yofunikira ndipo imagwira ntchito monga cofactor yofunikira ndi gawo lapansi pazinthu zambiri zama cell zomwe zikuphatikiza ndi oxidative phosphorylation ndi kupanga kwa ATP, kukonza kwa DNA, epigenetic regree of gene expression, intracellular calcium signaling and Immunological function.

NAD + ndiye molekyulu wamkulu wovomereza ma elexandridi mu oxidation wachilengedwe. Imalandila ma elekitironi kuchokera ku mamolekyulu ena ndipo amachepetsedwa. Imakhalanso ngati coenzyme ya hydride transferase ndi gawo lapansi lomwe limadya NAD (+) polymerase, ndikupanga coenzyme redox jozi ndi β-nicotinamide adenine dinucleotide (NADH). NAD (R) ndi nthiti yopanga ma riboni ya ADP-ribose ku ADP-A. Ndizotithandiziranso ku cyclic ADP-ribose (ADP-ribosyl cyclase).

Monga oxidant mu cell metabolism, NAD (R) imathandizanso mu adenosine diphosphate (ADP) -apatsa kusintha kosiyanasiyana kokhudza diadenylate (ADP-ribose) polymerase ndi njira zina zingapo za enzymatic. Itha kuperekanso NAD kupewa kapena kuchepetsa matenda ashuga, khansa ndi matenda ena okalamba. Komanso, othandizira a NAD + amatha kugwira ntchito mogwirizana ndi zowonjezera monga resveratrol kuti atithandizenso kukonzanso mitochondria komanso kuthana ndi matenda okalamba.

Nikotinamide adenine dinucleotide(NAD +) maubwino

Monga oxidant yothandiza, Nicotinamide adenine dinucleotide imawonetsa kuti zabwino zina pamachitidwe a anthu.

Sinthani ntchito yanu yam'manja,

Kuchulukitsa mphamvu zanu mwachilengedwe;

♦ Kupititsa patsogolo ntchito za ubongo, malingaliro ndi kukumbukira;

- Kwezani kagayidwe kanu;

Kupititsa patsogolo kugona;

- Kukulitsa ntchito ya Sirtuin yapadziko lonse;

♦ Kukweza mphamvu ya antioxidant;

Kuchepetsa kutupa;

Balance Kusintha moyenera, momwe mukumvera, kuwona ndi kumva;

Nicotinamide adenine dinucleotid imadziwikanso mwachindunji mankhwala isoniazid, omwe amagwiritsidwa ntchito pochiza matenda a chifuwa chachikulu cha chifuwa chachikulu cha chifuwa chachikulu cha Mycobacterium. Poyesa kamodzi, mbewa zopatsidwa NAD kwa sabata limodzi zidasintha kulumikizana kwa nyukiliya.

Kuphatikiza apo, Nicotinamide adenine dinucleotide (NAD +) imakhalanso ndi kupewa komanso kuchiza mtima, chipika cha sinus ndi ntchito yotsutsa-kuyesera arrhythmias, nicotinamide imatha kusintha kwambiri kugunda kwa mtima komanso mtima wa atriove ntricular block chifukwa cha verapamil.

Nikotinamide adenine dinucleotide(NAD +) ntchito:

  1. Diagnostic reagents yaiwisi, kuyesa kwa sayansi.
  2. Chakudya chathanzi, zodzola, zowonjezera chakudya
  3. Kupanga kwa API

Zambiri Nikotinamide adenine dinucleotide(NAD +) kafukufuku

Ma enzyme omwe amapanga ndikugwiritsa ntchito NAD + ndi NADH ndiwofunikira mu pharmacology komanso kafukufuku wamankhwala amtsogolo a matenda. Coenzyme NAD + siigwiritsa ntchito pakali pano ngati chithandizo cha matenda aliwonse. Komabe, amawerengedwa kuti azigwiritsa ntchito moyenera pakuthandizira matenda a neurodegenerative matenda mongaAlzheimer's andParkinson matenda.

Tsamba:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + kagayidwe kachakudya ndi matenda" (PDF). Amakonda Biochem. Sayansi. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Zolembedwa kuchokera koyambirira (PDF) pa 4 Julayi 2009. Zabwezedwa 23 Disembala 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). Kuzindikiritsa transporter ya mitochondrial NAD + mu Saccharomyces cerevisiae ”. J. Biol. Chem. 281 (3): 1524- doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Epulo 2003). "Nicotinamide adenine dinucleotide, kagayidwe kazinthu kolemba, kutalika kwa moyo komanso matenda". Curr. Opin. Cell Biol. 15 (2): 241- doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Redox state of nicotinamide-adenine dinucleotide mu cytoplasm ndi mitochondria ya rat chiwindi". Biochem. J. 103 (2): 514- doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Limbikitsani JW, Moat AG (1 Marichi 1980). "Nicotinamide adenine dinucleotide biosynthesis ndi pyridine nucleotidejikelezo kagayidwe kazinthu m'magulu a micros". Microbiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
  • French SW. Kuluma kwambiri kwamankhwala kumavulaza chiwindi ndi ziwalo zina pochepetsa milingo ya NAD⁺ yofunikira pa ntchito ya deacetylase ya sirtuin. Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins ndi NAD + mu Kukula ndi Chithandizo cha Matenda a Metabolic ndi Cardiovascular. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.

KULAMBIRA NDI KUSINTHA:

Nkhaniyi Ikagulitsidwa Kugwiritsa Ntchito Kafukufuku kokha. Migwirizano Yogulitsa. Osati Zongogwiritsa Ntchito Anthu, kapena Zamankhwala, Zoweta Zanyama, kapena Zogwiritsa Ntchito Panyumba.


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