Nicotinamide adenine dinucleotide (53-84-9)

March 15, 2020

Nicotinamide adenine dinucleotide (NAD) ndi cofactor yomwe imathandizira kagayidwe kamene kamapezeka m'maselo amoyo onse. Ilipo m'njira ziwiri …….

 


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

 

Kanotinamide adenine dinucleotide (53-84-9) kanema

Nicotinamide adenine dinucleotide (53-84-9) Szizindikiro

Name mankhwala Nicotinamide adenine dinucleotide (NAD +)
Mankhwala Name Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
Nambala ya CAS 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
MUZIKONDWERETSA C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Molecular Formula C21H27N7O14P2
Kulemera kwa maselo 663.4 g / mol
Misa ya Monoisotopic 663.109123 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
mtundu White
Stempage temp 2-8 ° C
Kutupa H2O: 50 mg / mL
ntchito Chakudya chathanzi, zodzola, zowonjezera chakudya

 

Kodi Nikotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) ndi cofactor yomwe imathandizira metabolism yomwe imapezeka m'maselo onse amoyo. Amapezeka m'mitundu iwiri, oxidized (NAD +) ndikuchepetsedwa (NADH).

Coenzyme NAD +, mtundu wa oxidized wa NAD, adapezeka koyamba mu 1906 ndi a Arthur Harden ndi a William John Young a biochemists. NAD + imapangidwa ndi njira ziwiri za metabolic, zomwe zimatha kupangidwa kuchokera ku devo novo amino acid way, kapena kupangidwa ndi kubwezeretsanso zinthu zomwe zimapangidwa kale (monga nicotinamide) kubwerera ku njira yopulumutsira ya NAD +. Ndi pyridine nucleotide yofunikira ndipo imagwira ntchito monga cofactor yofunikira ndi gawo lapansi pazinthu zambiri zama cell zomwe zikuphatikiza ndi oxidative phosphorylation ndi kupanga kwa ATP, kukonza kwa DNA, epigenetic regree of gene expression, intracellular calcium signaling and Immunological function.

NAD + ndiye molekyulu wamkulu wovomereza ma elexandridi mu oxidation wachilengedwe. Imalandila ma elekitironi kuchokera ku mamolekyulu ena ndipo amachepetsedwa. Imakhalanso ngati coenzyme ya hydride transferase ndi gawo lapansi lomwe limadya NAD (+) polymerase, ndikupanga coenzyme redox jozi ndi β-nicotinamide adenine dinucleotide (NADH). NAD (R) ndi nthiti yopanga ma riboni ya ADP-ribose ku ADP-A. Ndizotithandiziranso ku cyclic ADP-ribose (ADP-ribosyl cyclase).

Monga okosijeni m'maselo am'magazi, NAD (R) imathandizanso pa adenosine diphosphate (ADP) -kumasulira zomwe zimachitika ndi diadenylate (ADP-ribose) polymerase ndi njira zina zingapo za enzymatic. Itha kupatsa NAD kupewa kapena kuchepetsa matenda ashuga, khansa ndi matenda ena okhudzana ndi zaka. Komanso, othandizira NAD + atha kugwira ntchito mogwirizana ndi zowonjezera zowonjezera monga resveratrol kuti athandizirenso mitochondria ndikuthana ndi matenda okalamba.

 

Nikotinamide adenine dinucleotide(NAD +) maubwino

Monga oxidant yothandiza, Nicotinamide adenine dinucleotide imawonetsa kuti zabwino zina pamachitidwe a anthu.

♦ Konzani zochitika zanu zamagetsi,

♦ Lonjezerani mphamvu zanu mwachilengedwe;

♦ Kupititsa patsogolo ntchito kwa ubongo, chidwi ndi kukumbukira;

♦ Kulimbitsa thupi lanu;

♦ Kusintha kugona;

♦ Kulimbikitsa ntchito yapadziko lonse ya sirtuin;

♦ Kupititsa patsogolo mphamvu ya antioxidant;

♦ Kuchepetsa kutupa;

Balance Kulimbitsa bwino, kusinthasintha, kuwona ndi kumva;

Nicotinamide adenine dinucleotid imakhudzidwanso ndi mankhwalawa isoniazid, omwe amagwiritsidwa ntchito pochiza TB, matenda omwe amayambitsidwa ndi chifuwa chachikulu cha Mycobacterium. Poyeserera kamodzi, mbewa zopatsidwa NAD sabata limodzi zidasintha kulumikizana kwa mitochrondrial.

Kuphatikiza apo, Nicotinamide adenine dinucleotide (NAD +) imakhalanso ndi kupewa komanso kuchiza mtima, chipika cha sinus ndi ntchito yotsutsa-kuyesera arrhythmias, nicotinamide imatha kusintha kwambiri kugunda kwa mtima komanso mtima wa atriove ntricular block chifukwa cha verapamil.

 

Nikotinamide adenine dinucleotide(NAD +) ntchito:

  1. Diagnostic reagents yaiwisi, kuyesa kwa sayansi.
  2. Chakudya chathanzi, zodzola, zowonjezera chakudya
  3. Kupanga kwa API

 

Zambiri Nikotinamide adenine dinucleotide(NAD +) kafukufuku

Mavitamini omwe amapanga ndi kugwiritsa ntchito NAD + ndi NADH ndi ofunikira pa zamankhwala ndi kafukufuku wazithandizo zamtsogolo zamatenda. Coenzyme NAD + siyomwe imagwiritsidwa ntchito ngati chithandizo cha matenda aliwonse. Komabe, ikuwerengedwa kuti ingagwiritsidwe ntchito pochiza matenda opatsirana pogonana mongaAlzheimer's andParkinson matenda.

 

Tsamba:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism mu thanzi ndi matenda" (PDF). Zochitika Zachilengedwe. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Zidasungidwa koyambirira (PDF) pa 4 Julayi 2009. Zidapezedwa 23 Disembala 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Kuzindikiritsa wonyamula wa mitochondrial NAD + ku Saccharomyces cerevisiae". J. Zachilengedwe. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. MAFUNSO OTHANDIZA:
  • Lin SJ, Guarente L (Epulo 2003). "Nicotinamide adenine dinucleotide, kagayidwe kabwino ka kagwiritsidwe ka mawu, moyo wautali ndi matenda". Wotchinga. Tsegulani. Cell Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. MAFUNSO: PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Dziko la redox la nicotinamide-adenine dinucleotide yaulere mu cytoplasm ndi mitochondria ya chiwindi cha khoswe". Zamoyo. J. 103 (2): 514– doi: 10.1042 / bj1030514. Mphatso ya PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Marichi 1980). "Nicotinamide adenine dinucleotide biosynthesis ndi pyridine nucleotide cycle metabolism mu ma microbial system". Microbiol. Chibvumbulutso 44 (1): 83– PMC 373235. PMID 6997723.
  • French SW. Kumwa mowa mopitirira muyeso kumavulaza chiwindi ndi ziwalo zina pochepetsa milingo ya NAD⁺ yofunikira kuchitira sirtuin's deacetylase. Kutulutsa Mol Molol. 2016 Apr; 100 (2): 303-6. onetsani: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins ndi NAD + mu Kukula ndi Chithandizo cha Matenda a Metabolic ndi Cardiovascular. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.