Cannabidiol (CBD)

June 21, 2021

Cannabidiol (Cannabidiol, CBD) ndichimodzi mwazinthu zopitilira zana zogwiritsa ntchito mankhwala osokoneza bongo. Imatsitsimutsa thupi ndi malingaliro, imateteza mitsempha, imathandizira kutupa kwa khungu, ma antioxidants, imathandizira kufiira kwa khungu, ndikumanga chotchinga pakhungu. Kupititsa patsogolo luso lakudziwongolera pakhungu; Kubwezeretsa thanzi pakhungu ndikuthana ndi mavuto akhungu, kumatha kuchiza chikanga ndi matenda ena.

Cannabidiol (CBD) ndiye chinthu chachikulu chopanda matenda amisala ndipo chimakhala ndi zovuta zosiyanasiyana zamankhwala, kuphatikizapo anti-nkhawa, anti-psychotic, antiemetic ndi anti-inflammatory properties.

Zambiri zamankhwala a Cannabidiol (CBD)

Name mankhwala Cannabidiol ufa
Mafananidwe (-) - Cannabidiol

(-) - trans-Cannabidiol

Epidiolex

CBD

Chiyeretso 99% PEZANI / Extrapure PEZANI (CBD≥99.5%)
Nambala ya CAS 13956-29-1
Kalasi ya Mankhwala Mankhwala osokoneza bongo
InChI Mfungulo Gawo #: QHMBSVQNZZTUGM-ZWKOTPCHSA-N
MUZIKONDWERETSA CCCCCC1 = CC (= C (C (= C1) O) C2C = C (CCC2C (= C) C) C) O
Molecular Formula C21H30O2
Kulemera kwa maselo 314.5 g / mol
Misa ya Monoisotopic 314.224580195
Melting Point 66 ° C
Malo otentha 160 ° C - 180 ° C
Ekusiya theka la moyo Maola 18-32
mtundu Woyera mpaka kuwala ufa wachikasu wa crystalline
Kutupa Kusungunuka kwamafuta, kusungunuka kwambiri mu ethanol ndi methanol, osasungunuka m'madzi
Stempage temp Kutentha kwapakati, khalani owuma komanso opanda kuwala
ntchito Pazofufuza zasayansi zokha, kapena ngati zopangira zopangira zotsika, kapena zogulitsa m'maiko ovomerezeka ndi zigawo zakunja. Chonde dziwani kuti mankhwalawa sayenera kugwiritsidwa ntchito mwachindunji kapena kugwiritsidwa ntchito kuchipatala ku China
Ubwino wathu Kore L 100% m'zigawo zachilengedwe, mafakitale-ang'ono-kupanga

L Chitsimikizo chadongosolo (GMPC, ISO22716, KOSHER, HALAL)

L Laboratory lachitatu chipani anayesedwa, khola ndi mkulu zili CBD, THC mfulu

L Njira HPLC. Zitsulo zolemera, zotsalira ndi tizilombo tating'onoting'ono timakwaniritsa miyezo ya CHP, JP ndi USP

 

Kodi Cannabidiol (CBD) ndi chiyani? Tanthauzo la Cannabidiol

Cannabidiol ndi mankhwala mu chamba cha Cannabis sativa, chotchedwanso chamba kapena hemp. Mankhwala opitilira 80, omwe amadziwika kuti cannabinoids, apezeka mu chomera cha Cannabis sativa. Ngakhale delta-9-tetrahydrocannabinol (THC) ndiye chinthu chofunikira kwambiri chamba, cannabidiol imapezekanso ku hemp, yomwe imangokhala ndi THC yochepa kwambiri. Onse hemp ndi chamba ndi mtundu wa Cannabis sativa, koma mosiyanasiyana.

  • Chamba chimakula ndi magawo ochulukirapo a THC (psychoactive; amachititsa kumverera kwa "okwera"), komanso magawo ochepa a CBD (osakhala oledzeretsa).
  • Hemp imakula ndi magawo apamwamba a Cannabidiol (CBD), ndi magawo ochepa a THC.

Ngakhale kuti THC ndiyotchuka kwambiri cannabinoid chifukwa chazovuta zake, Cannabidiol (CBD) yapeza zokopa chifukwa chosamwa [2], phindu la mankhwala. Malinga ndi World Health Association, CBD siyosokoneza bongo, ilibe zisonyezo zakudzitchinjiriza, ndipo ili ndi mbiri yotetezeka, motero sizosadabwitsa kuti ambiri akutembenukira ku ufa wa Cannabidiol (CBD) pazithandizo zake zambiri. Makamaka, ufa wa CBD ungathandize kuthana ndi nkhawa [1], zotupa, komanso ululu wosaneneka.

Phcoker cannabidiol ufa, 100% mwachilengedwe amachokera ku mafakitale a hemp, THC yaulere.

Cannabidiol imagwiritsidwa ntchito kwambiri pamavuto okomoka (khunyu). Amagwiritsidwanso ntchito pakakhala nkhawa [1], kupweteka, vuto la minofu lotchedwa dystonia, matenda a Parkinson, matenda a Crohn, ndi zina zambiri, koma palibe umboni wabwino wasayansi wotsimikizira izi.

 

Cannabidiol (CBD) ndi Ubale wa THC

CBD ili ndiubwenzi wovuta ndi anzawo cannabinoid delta-9-tetrahydrocannabinol (THC), chomwe ndichofunikira kwambiri pachakudya cha khansa, chomwe chimayambitsa chisangalalo cha chamba kapena hashish.

Mosiyana ndi THC, CBD siyogwira ntchito mwachindunji chifukwa siyimapatsa chisangalalo kapena 'kukwera'. Izi sizofanana ndi kunena kuti CBD siyabwino kwenikweni. Poyamba, pali umboni wochuluka wosonyeza kuti CBD imasintha zotsatira za THC. [8] [10]

Kachiwiri, ndi anthu ochepa (pafupifupi 5%) omwe amafotokoza zovuta zosintha za CBD, momwe odwala ena amatha kuyambukiridwa ndi Tylenol kapena Advil. Komabe, akukhulupirira kuti ambiri mwa malipotiwa amachokera pakuwononga CBD yomwe ili ndi zochitika za THC. Chifukwa chake kufunikira kopezera Cannabidiol kuchokera kuzinthu zapamwamba kwambiri.

 

Kodi Cannabidiol imagwira ntchito bwanji? Njira Yogwirira Ntchito ya CBD

CBD ndi THC zimagwirizana ndi matupi athu m'njira zosiyanasiyana. Njira imodzi yayikulu ndikutsanzira ndikuwonjezera zomwe zimachitika m'matupi athu zotchedwa "endogenous cannabinoids" - yotchulidwa chifukwa chofanana ndi mankhwala omwe amapezeka mchomera cha cannabis.

Cannabidiol ufa umakhudza ubongo. Zomwe zimayambitsa izi sizikudziwika. Komabe, cannabidiol ikuwoneka kuti imalepheretsa kuwonongeka kwa mankhwala muubongo omwe amakhudza kuwawa, malingaliro, ndi magwiridwe antchito. Kupewa kuwonongeka kwa mankhwalawa ndikuwonjezera kuchuluka kwake m'magazi kumawoneka kuti kumachepetsa zizindikiritso zama psychotic zokhudzana ndi mikhalidwe monga schizophrenia. Cannabidiol (CBD) itha kulepheretsanso zovuta zina za delta-9-tetrahydrocannabinol (THC). Komanso, cannabidiol ikuwoneka kuti imachepetsa kupweteka komanso nkhawa [1].

 

CBD ndi Endocannabinoid System (ECS)

ECS idapezeka mzaka za m'ma 1990 ndipo imalingaliridwa kuti ndi imodzi mwazinthu zofunikira kwambiri komanso zazikulu kwambiri zolandirira kuti munthu akhale ndi thanzi labwino ndipo amadziwika kuti ndi njira yofunika kwambiri yothandizira muubongo, endocrine ndi chitetezo chamthupi.

Sayansi yaposachedwa yapeza kuti ECS sikuti imangoyankha ma cannabinoids amkati omwe amapangidwa mthupi komanso imayankha ku Phytocannabinoids yakunja kapena CBD ngati njira yopititsira patsogolo matupi a ECS. [7]

Pakati pa ECS pali zolandilira CB1 ndi CB2, zomwe zimapezeka mthupi lonse. Ma neuron awa ndi mtundu wa loko, wokhala ndi ma cannabinoids omwe amakhala ngati kiyi. Ma receptors a CB1 amapezeka manambala muubongo, makamaka ku Hypothalamus, Hippocampus ndi Amygdala. Ma receptors a CB2 amapezeka makamaka mumphamba, matonil, thymus ndi ma immune immune. Dongosolo la endocannabinoid limagwira ntchito yoitanitsa ku homeostasis.

CBD siyigwirizana mwachindunji ndi ma cannabinoid receptors (CB1 ndi CB2) [9], koma m'malo mwake, imathandizira dongosolo la endocannabinoid kuti lipange ma cannabinoids ake. Kuphatikiza apo, imachedwetsa kuwonongeka kwawo poletsa michere ya FAAH, kotero ma endocannabinoids amatha kukhala mthupi lanu nthawi yayitali. CBD ndi cannabinoid yovuta kwambiri komanso momwe imagwirira ntchito ndi endocannabinoid system iyenera kufufuzidwa mozama kuti iwulule kuthekera konse.

 

Kodi CBD ndi yovomerezeka? Mankhwala a Cannabidiol

CBD ndi gawo losakhala loledzeretsa la chomera cha cannabis chomwe chili ndi mphamvu yayikulu yochiritsa [2]. Cannabidiol (CBD) yatenga vuto chifukwa chakuledzera, mankhwala. Malinga ndi World Health Association, CBD siyosokoneza bongo, ilibe zizindikiritso, ndipo ili ndi chitetezo chambiri. Ngakhale kuti Food and Drug Administration (FDA) siziwongolera kuyera kapena chitetezo cha mankhwalawo, CBD imawonedwa ngati yotetezeka.

Ndime ya 2018 Farm Bill idavomereza kugulitsa mankhwala a hemp ndi hemp ku US Koma sizitanthauza kuti zinthu zonse zopangidwa ndi hemp za cannabidiol ndizovomerezeka. Popeza cannabidiol yawerengedwa ngati mankhwala atsopano, sizingaphatikizidwe mwalamulo muzakudya kapena zowonjezera zakudya. Komanso, cannabidiol sangaphatikizidwe pazogulitsidwa zomwe zanenedwa zakuchiritsa. Cannabidiol imangophatikizidwa ndi zinthu "zodzikongoletsera" pokhapokha ngati ili ndi zosakwana 0.3% THC. Koma palinso zinthu zomwe zimatchedwa kuti zowonjezera zakudya pamsika zomwe zimakhala ndi cannabidiol. Kuchuluka kwa cannabidiol komwe kumapezeka muzogulitsazi sikuti nthawi zonse kumafotokozedwa molondola pamalonda.

 

Ubwino wathanzi la CBD

Ovomerezeka Kuti Akwaniritse Khunyu

Zomwe sizili psychoactive za CBD zimapangitsa kukhala koyenera kugwiritsa ntchito mankhwala. Mu 2018, mankhwala oyamba ovomerezeka a FDA, cannabidiol (Epidiolex), okhala ndi CBD adatulutsidwa pamsika kuti athetse mitundu iwiri yosiyana ya khunyu [3] [4] - Dravet syndrome ndi Lennox-Gastaut syndrome.

A FDA adavomereza chithandizo cha odwala azaka ziwiri. Kafukufuku adawonetsa kuti inali yothandiza poyerekeza ndi placebo pochepetsa kugwa kwamphamvu pafupipafupi.

 

Kuthetsa nkhawa[1]

Ngakhale tikufunikira kafukufuku wowonjezera, nkhani yowunikira magazini ya zamankhwala ya 2015 idayang'ana CBD ndi momwe zimathandizira pamavuto angapo amanjenje, kuphatikiza matenda amisala wamba, kusokonezeka kwa nyengo, mantha, komanso kupsinjika kwakutsogolo.

Zotsatira zake zidawonetsa kuti panali "umboni wamphamvu" wothandizira kuchiza matenda amisala ndi CBD, ngakhale kuti kafukufuku wina amafunika pakulowetsa kwa nthawi yayitali.

 

Itha Kuthetsa Mavuto

Kafukufuku wasonyeza kuti CBD itha kuthandiza kuchepetsa kupweteka kwakanthawi pakukhudza zochitika za endocannabinoid receptor, kuchepetsa kutupa [6] komanso kuyanjana ndi ma neurotransmitters. CBD ikakopa TRPV1, imaletsa bwino zisonyezo zopweteka kufikira thupi lonse. Chomangacho chimapereka chilimbikitso kuchokera ku zowawa, kutupa, komanso kusapeza bwino.

 

Mutha Kuchepetsa Ziphuphu

Ziphuphu ndi khungu lofala lomwe limakhudza anthu opitilira 9%.

Amaganiziridwa kuti amayambitsidwa ndi zinthu zingapo, kuphatikiza ma genetics, mabakiteriya, kutupa komwe kumachulukitsa komanso kuchuluka kwa sebum, chinsinsi chamafuta chomwe chimapangidwa ndimatenda owoneka bwino pakhungu.

Kutengera kafukufuku waposachedwa wasayansi, mafuta a CBD atha kuthandiza kuthana ndi ziphuphu chifukwa chazitsulo zake [6] komanso kuthekera kochepetsa sebum.

Kafukufuku wina adapeza kuti mafuta a CBD amaletsa maselo am'magazi kuti asamatulutse sebum yambiri, amachita zinthu zotsutsana ndi zotupa ndikuletsa kuyambitsa kwa "pro-acne" othandizira ngati zotupa zotupa.

Kafukufuku wina adapeza zomwezi, pomaliza kunena kuti CBD ikhoza kukhala njira yothandiza komanso yotetezeka yochizira ziphuphu, makamaka chifukwa cha mawonekedwe ake odana ndi zotupa.

 

Kugwiritsa ntchito ufa wa Cannabidiol (CBD) & kugwiritsa ntchito

Kafukufuku wapita patsogolo pomwe mabungwe azamalamulo, malamulo ndi malamulo okhudzana ndi kugwiritsa ntchito mankhwala osokoneza bongo akusintha m'malo ambiri padziko lapansi, ndikupanga chidziwitso chatsopano.

Kafukufuku wamankhwala wokhudzana ndi ufa wa CBD waphatikizira maphunziro okhudzana ndi nkhawa, kuzindikira, zovuta zamagulu ndi ululu.

Mafuta a CBD atha kulowetsedwa mthupi m'njira zingapo, kuphatikiza kupumira utsi kapena nthunzi, ngati chopopera cha aerosol patsaya, komanso pakamwa. Itha kugawidwa ngati mafuta a CBD kapena ngati mankhwala amadzimadzi.

Ponseponse ku US, anthu akupaka mafuta a CBD m'malo opweteka, akutaya mankhwala a CBD pansi pa malirime otopa, kutulutsa ma gummies a CBD, komanso kudzitukumula ndi ma vaporizers odzaza mafuta a CBD akuyembekeza kuti atha.

 

Zothandizira:

[1] Cannabidiol ngati Njira Yothetsera Mavuto A nkhawa. Madalitso EM, Steenkamp MM, Manzanares J, Marmar CR. Machiritso. 2015 Oct; 12 (4): 825-36. onetsani: 10.1007 / s13311-015-0387-1.

[2] Zotsatira zoyipa za Cannabidiol ndi Toxicity. Huestis MA, Solimini R, Pichini S, Pacifici R, Wogulitsa J, Busardò FP. Kutulutsa Neuropharmacol. 2019; 17 (10): 974-989 (Pamasamba) onetsani: 10.2174 / 1570159X17666190603171901.

[3] Khunyu ndi cannabidiol: chitsogozo chamankhwala. Arzimanoglou A, Brandl U, Cross JH, Gil-Nagel A, Lagae L, Landmark CJ, Specchio N, Nabbout R, Thiele EA, Gubbay O, Gulu la Akatswiri a Mayiko a Cannabinoids; Othandizira. Kusokonezeka Kwa Khunyu. 2020 Feb 1; 22 (1): 1-14. onetsani: 10.1684 / epd.2020.1141.

[4] Cannabidiol: Kuwunikanso kwa Kuchita Kwachipatala ndi Chitetezo mu Khunyu. Samanta D. Wodwala Neurol. 2019 Jul; 96: 24-29. onetsani: 10.1016 / j.pediatrneurol.2019.03.014. Epub 2019 Mar 22.

[5] Cannabidiol: Chikhalidwe cha zaluso ndi zovuta zatsopano pakugwiritsa ntchito mankhwala. Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M. Pharmacol Ther. 2017 Jul; 175: 133-150. (Adasankhidwa) onetsani: 10.1016 / j.pharmthera.2017.02.041. Epub 2017 Feb 22.

[6] Cannabidiol (CBD) ndi ma analogs ake: kuwunika kwawo pazotupa. Burstein S. Bioorg Med Chem. 2015 Apr 1; ​​23 (7): 1377-85. onetsani: 10.1016 / j.bmc.2015.01.059. Epub 2015 Feb 7.

[7] Endocannabinoid System ndi Kusinthasintha Kwake ndi Cannabidiol (CBD). Corroon J, Felice JF. Njira ina ya Ther Ther Med. 2019 Jun; 25 (S2): 6-14.

[8] Kuwunikiranso Kwambiri Udindo wa Cannabinoid Compound delta (9) -Tetrahydrocannabinol (delta (9) -THC) ndi Cannabidiol (CBD) ndi Mgwirizano Wawo mu Multiple Sclerosis Treatment. Jones É, Vlachou S. Mamolekyulu. 2020 Okutobala 25; 25 (21): 4930. doi: 10.3390 / mamolekyulu25214930.

[9] Mankhwala osiyanasiyana a CB1 ndi CB2 omwe amalandira mankhwala atatu a cannabinoids: delta9-tetrahydrocannabinol, cannabidiol ndi delta9-tetrahydrocannabivarin. Pertwee RG. Br J Pharmacol. 2008 Jan; 153 (2): 199-215. (Adasankhidwa) onetsani: 10.1038 / sj.bjp.0707442. Epub 2007 Sep 10.

[10] Umboni Wachipatala ndi Wotsogola Wogwira Ntchito Mgwirizano wa Cannabidiol ndi delta (9) -Tetrahydrocannabinol. Boggs DL, Nguyen JD, Morgenson D, Taffe MA, Ranganathan M. Neuropsychopharmacology. 2018 Jan; 43 (1): 142-154 (Pamasamba) onetsani: 10.1038 / npp.2017.209. Epub 2017 Sep 6.