Cycloastragenol ufa

April 17, 2020

Cycloastragenol ndi mankhwala ena othandizira kukalamba omwe amapezeka pamsika.

Cycloastragenol ufa (78574-94-4) kanema

Kupititsa patsogolo ufa Szizindikiro

Name mankhwala Cycloastragenol ufa
Mankhwala Name N / A
Mafananidwe anthonymakonin

cyclogwogigenin

GRN510

CAG

Kalasi ya Mankhwala N / A
Nambala ya CAS 78574-94-4
InChIKey WENNXORDXYGDTP-UOUCMYEWSA-N
Maselo Fmphutsi C30H50O5
Maselo Wasanu ndi atatu 490.7 g / mol
Misa ya Monoisotopic 490.365825 g / mol
Malo otentha  N / A
Fkubwezeretsanso Pmafuta N / A
Halimo Half-Life N / A
mtundu zoyera kuti zikhale
Szovuta  DMSO: 10 mg / mL, momveka bwino
Smazunzo Tkutentha  2-8 ° C
Amalingaliro Cycloastragenol ndi wogwiritsa ntchito telomerase woyambitsa. Komanso, zimatha kulumikizidwa ndi anti-ukalamba mu mankhwala achikhalidwe achino.

mwachidule

Cycloastragenol ndi mankhwala ena othandizira kukalamba omwe amapezeka pamsika. Amagwiritsidwanso ntchito pamapangidwe apamwamba a skincare komanso zodzoladzola. Cycloastragenol idayamba kugulitsidwa m'zakudya ku USA mu 2007 pansi pa dzina la TA-65, ndichifukwa chake TA 65 kapena TA65 lidakali dzina lodziwika bwino la cycloastragenol.

Kodi Cycloastragenol ndi chiyani?

Cycloastragenol ndi molekyu yochokera ku zitsamba za Astragalus membranaceus. Zomera za Astragalus zakhala zikugwiritsidwa ntchito ngati mankhwala ku China kwazaka zambiri. Wachichaina adati Astragalus imatha kutalikitsa moyo ndipo idagwiritsidwa ntchito pochiza kutopa, chifuwa, chimfine, matenda amtima komanso matenda ashuga.

Cycloastragenol ndi imodzi mwazinthu zosakaniza ku Astragalus. Cycloastragenol ilinso ndi mawonekedwe ofanana ndi molekyulu ya Astragaloside IV, koma ndiyocheperako komanso mochuluka kwambiri, zomwe zimapangitsa kuti mitundu yotsika iyambe. Imagwiritsidwa ntchito ngati immunostimulant chifukwa amatha kuwonjezera T lymphocyte kuchuluka. Komabe, ndizochulukitsa zomwe zimapangitsa chidwi cha asayansi.

Cycloastragenol imathandizira kukonzanso kuwonongeka kwa DNA poyambitsa telomerase, michere ya nucleoprotein yomwe imathandizira kaphatikizidwe ndi kukula kwa DNA ya telomeric. Ma telomere amapangidwa ndi ulusi wopyapyala ndipo amapezeka pamalangizo a ma chromosomes. Kusunga kukhazikika kwawo kumathandizira kuti maselo azitha kupewa kuwonekera mobwerezabwereza komanso kufalikira kosatha kupitirira 'malire a Hayflick'. Ma telomere amafupikitsa nthawi iliyonse yamagawa, kapena akamapanikizika ndi oxidative. Mpaka pano, iyi yakhala njira yosapeweka yakukalamba.

Njira za zochita za cycloastragenol

Maphunziro ambiri awonetsa kuti kufupikitsa telomeres pang'onopang'ono kumalumikizana ndimatenda ambiri okhudzana ndi zaka (matenda a mtima, matenda, ndi zina) ndipo zimaneneratu za kufa msanga m'maphunziro okalamba. Telomeres imafupikitsidwa ndi kuzungulira kulikonse kwa magawano am'magazi, kapena mukapanikizika ndi oxidative. Mpaka pano, iyi ndi njira yolepheretsa kukalamba.

Telomerase ndi michere ya nucleoprotein yomwe imafotokozera kapangidwe ndi kukula kwa telomeric DNA ndikuthandizira kukonza kuwonongeka kwa DNA.

Cycloastragenol imayendetsa ndikuwonjezera mphamvuyi, motero imachepetsa kufupikitsa kwa ma telomeres komanso kukulitsa kuchuluka kwawo. Mwanjira imeneyi, imalola kutalika kwa ma telomeres ndipo chifukwa chake, imakulitsa nthawi yamoyo.

Chifukwa cha kulemera kwake pang'ono, Cycloastragenol imadutsa mosavuta kudzera khoma lamatumbo. Mulingo woyenera wabwino kwambiri umalola kugwira bwino ntchito, ngakhale pa mlingo wochepa. Kuphatikiza tsiku ndi tsiku mwina pakokha, kapena kuphatikiza kapena kusakanikirana ndi, astragaloside IV, motero kuthandizira kuletsa ukalamba ndikupatsa mwayi wokhala ndi moyo.

Kupititsa patsogolo ubwino

Astragalus membranaceus ndi imodzi mwazitsamba zofunika kwambiri m'mbiri ya Chinese Chinese Medicine monga zithandizo zachilengedwe zothana ndi kutopa, matenda, zilonda zam'mimba, khansa, hay fever, post stroke, moyo wautali etc. Komabe, maubwino ofunikira a cycloastragenol ufa ali ngati zotsutsana ndi ukalamba komanso kuthandizira chitetezo chamthupi.

Kupititsa patsogolo ndi thandizo lachitetezo cha mthupi

Cycloastragenol ikhoza kugwiritsidwa ntchito kuteteza chitetezo cha mthupi, antibacterial, ndi antiinfrance, popewa chimfine ndi matenda apamwamba kwambiri oyambitsa matenda. Yagwiritsidwa ntchito ngati othandizira chitetezo mthupi chifukwa chokhoza kuwonjezera kuchuluka kwa T lymphocyte. Komabe, chomwe asayansi ali nacho chidwi kwambiri ndi kukana kwake kwabwino. Cycloastragenol imalimbikitsa DNA kukonza zowonongeka poyambitsa telomerase ndikulola proteinase ya nyukiliya yomwe yathandizira kapangidwe ndi kukula kwa telomere DNA.

Kupititsa patsogolo komanso odana ndi ukalamba

Anti-ukalamba ndi phindu lochuluka kwambiri la cycloastragenol. Cycloastragenol sikuti imachedwetsa kukalamba kwa anthu, komanso kuwonjezera mphamvu ya chitetezo cha m'thupi, kupewera poizoni, kuteteza khungu lamtima, makamaka lochokera ku hydragaloside (Astragaloside Ⅳ) hydrolysis.

Mapindu ena a Cycloastragenol

  1. cycloastragenol ufa umatha kuchepetsa nkhawa komanso kuteteza thupi ku mavuto osiyanasiyana, kuphatikizapo kupsinjika kwamthupi, m'maganizo, kapena m'malingaliro;
  2. cycloastragenol ufa umakhala ndi ma antioxidants, omwe amateteza maselo ku zowonongeka zomwe zimayambitsidwa ndi ma free radicals;
  3. cycloastragenol ufa umatha kutsitsa kuthamanga kwa magazi, kuchiza matenda ashuga komanso kuteteza chiwindi.

Kupititsa patsogolo zovuta zoyipa

Mpaka pano, palibe lipoti lililonse kapena kuwunikiridwa kwa zoyipa kapena zotsutsana ndi kutenga cycloastragenol supplement.

Kupititsa patsogolo kuwonjezera mlingo

Cycloastragenol ndi yatsopano kwambiri osati mitundu yambiri yazowonjezera pamsika, ndipo palibe mlingo wolimbikitsidwa. Malinga ndi zomwe takumana nazo, mlingo umasiyana ndi zolinga zosiyanasiyana, zaka. Inde, cycloastragenol imakhala yamphamvu kwambiri kuposa Astragaloside IV yemwe mlingo wake ndi 50mg patsiku. Ngakhale cycloastragenol, kutulutsa 10mg mpaka 50mg zonse zili bwino. Wakale amafunika kutenga zoposa akulu azaka zapakati. Ena amati kuyambira ndi 5mg patsiku, kenako onjezani pang'onopang'ono. Popeza cycloastragenol ndiyotulutsa zachilengedwe, zimatenga nthawi kuti muwone zotsatira zake, pafupifupi miyezi isanu ndi umodzi.

Kupititsa patsogolo chitetezo

Cycloastragenol adalengezedwa ndi ena ngati othandizira odana ndi ukalamba. Kafukufuku wakale akuwoneka kukhala wopatsa chidwi, akuwonetsa kuti ali ndi kuthekera kochulukitsa kutalika kwa telomere, komabe pali kuchepa kwa kafukufuku wowunika wowonedwa ndi anzawo. Kuphatikiza apo, pali nkhawa ina yoti kutenga Cycloastragenol kuonjezera ngozi ya khansa zina. Komabe, kafukufuku wofufuza sanathe kukhazikitsa chiwopsezo chilichonse cha khansa chokhudzana ndi kugwiritsa ntchito cycloastragenol.

Cycloastragenol imawoneka ngati chida cholonjeza kukana kukalamba. Ngakhale sizinatsimikizidwe kuti zimawonjezera kutalika kwa moyo komabe zawonetsedwa kuti zimachepetsa zaka zosiyanasiyana zogwirizira zaka. Kuphatikiza apo awonetsedwa kuti amachepetsa zizindikilo za ukalamba monga mizere yabwino ndi makwinya. Zingathandizenso kuchepetsa matenda opatsirana monga Alzheimer's, Parkinson's, retinopathies, ndi cataract.

Kupititsa patsogolo ufa umagwiritsidwa ntchito

Cycloastragenol imagwiritsidwa ntchito pochiza, kuwongolera, kupewa, & kukonza matenda, mikhalidwe ndi zizindikilo izi:

  • Kutupa
  • Apoptosis
  • Zosokoneza za Homeostasis
  • Cycloastragenol itha kugwiritsidwanso ntchito pazolinga sizomwe zalembedwa pano.

Bulc cycloastragenol ufa wagwiritsidwa ntchito pansipa:

  1. Yogwiritsidwa ntchito m'munda wazakudya, nthawi zambiri imagwiritsidwa ntchito ngati chakudya chowonjezera;
  2. Yogwiritsidwa ntchito m'munda wazogulitsa zamtundu waumoyo, izi zowonjezera ndizothandiza thupi la munthu;
  3. Kuyika zodzikongoletsera, ngati mtundu wa zopangira, zimatha kusakaniza zodzikongoletsera zachilengedwe.

Reference:

  • Zotsutsana ndi kukalamba za cycloastragenol zopangidwa ndi biotransformation. Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. onetsani: 1080 / 14786419.2019.1662011.
  • Cycloastragenol: Wosangalatsa wolemba buku la matenda okhudzana ndi zaka. Yu Y et al. Kutulutsa Ther Med. (2018) Zotsutsa-kukalamba zotengera za cycloastragenol zopangidwa ndi biotransformation. Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. onetsani: 10.1080 / 14786419.2019.1662011
  • Cycloastragenol imatha kuthana ndi kuyambitsa kwa STAT3 ndikulimbikitsa kupititsa patsogolo kwa paclitaxel m'maselo a khansa ya m'mimba. Hwang ST, Kim C, Lee JH, Chinnathambi A, Alharbi SA, Shair OHM, Sethi G, Ahn KS. 2019 Jun
  • Astragaloside VI ndi cycloastragenol-6-O-beta-D-glucoside amalimbikitsa machiritso a bala mu vitro komanso mu vivo.Lee SY et al. Phytomedicine. (2018)