Cycloastragenol ufa (78574-94-4)

April 17, 2020

Cycloastragenol ndi mankhwala ena othandizira kukalamba omwe amapezeka pamsika.

Cycloastragenol ufa (78574-94-4) kanema

Cycloastragenol ufa Szizindikiro

Name mankhwala Cycloastragenol ufa
Mankhwala Name N / A
Mafananidwe anthonymakonin

cyclogwogigenin

GRN510

CAG

Kalasi ya Mankhwala N / A
Nambala ya CAS 78574-94-4
InChIKey WENNXORDXYGDTP-UOUCMYEWSA-N
Maselo Fmphutsi C30H50O5
Maselo Wasanu ndi atatu 490.7 g / mol
Misa ya Monoisotopic 490.365825 g / mol
Malo otentha N / A
Fkubwezeretsanso Pmafuta N / A
Halimo Half-Life N / A
mtundu zoyera kuti zikhale
Szovuta DMSO: 10 mg / mL, momveka bwino
Smazunzo Tkutentha 2-8 ° C
Amalingaliro Cycloastragenol ndi wogwiritsa ntchito telomerase woyambitsa. Komanso, zimatha kulumikizidwa ndi anti-ukalamba mu mankhwala achikhalidwe achino.

mwachidule

Cycloastragenol ndi mankhwala ena othandizira kukalamba omwe amapezeka pamsika. Amagwiritsidwanso ntchito pamapangidwe apamwamba a skincare komanso zodzoladzola. Cycloastragenol idayamba kugulitsidwa m'zakudya ku USA mu 2007 pansi pa dzina la TA-65, ndichifukwa chake TA 65 kapena TA65 lidakali dzina lodziwika bwino la cycloastragenol.

Kodi Cycloastragenol ndi chiyani?

Cycloastragenol ndi molekyu yochokera ku zitsamba za Astragalus membranaceus. Zomera za Astragalus zakhala zikugwiritsidwa ntchito ngati mankhwala ku China kwazaka zambiri. Wachichaina adati Astragalus imatha kutalikitsa moyo ndipo idagwiritsidwa ntchito pochiza kutopa, chifuwa, chimfine, matenda amtima komanso matenda ashuga.

Cycloastragenol ndi imodzi mwazinthu zosakaniza ku Astragalus. Cycloastragenol ilinso ndi mawonekedwe ofanana ndi molekyulu ya Astragaloside IV, koma ndiyocheperako komanso mochuluka kwambiri, zomwe zimapangitsa kuti mitundu yotsika iyambe. Imagwiritsidwa ntchito ngati immunostimulant chifukwa amatha kuwonjezera T lymphocyte kuchuluka. Komabe, ndizochulukitsa zomwe zimapangitsa chidwi cha asayansi.

Cycloastragenol imathandizira kukonza kwa kuwonongeka kwa DNA poyambitsa telomerase, michere ya nucleoprotein yomwe imapangitsa kaphatikizidwe ndi kukula kwa telomeric DNA. Ma Telomeres amapangidwa ndi mafayilo ocheperako ndipo amapezeka pamalangizo a chromosomes. Kusunga kukhazikika kwawo kumathandizira kuti maselo azipewa kukhala ndi nthawi yayitali komanso kuchuluka kwa nthawi yayitali kupitirira malire a 'Hayflick'. Telomeres imafupikitsidwa ndi kuzungulira kulikonse kwa magawano am'magazi, kapena mukapanikizika ndi oxidative. Mpaka pano, iyi ndi njira yolepheretsa kukalamba.

Njira za zochita za cycloastragenol

Maphunziro ambiri awonetsa kuti kufupikitsa telomeres pang'onopang'ono kumalumikizana ndimatenda ambiri okhudzana ndi zaka (matenda a mtima, matenda, ndi zina) ndipo zimaneneratu za kufa msanga m'maphunziro okalamba. Telomeres imafupikitsidwa ndi kuzungulira kulikonse kwa magawano am'magazi, kapena mukapanikizika ndi oxidative. Mpaka pano, iyi ndi njira yolepheretsa kukalamba.

Telomerase ndi michere ya nucleoprotein yomwe imafotokozera kapangidwe ndi kukula kwa telomeric DNA ndikuthandizira kukonza kuwonongeka kwa DNA.

Cycloastragenol imayendetsa ndikuwonjezera mphamvuyi, motero imachepetsa kufupikitsa kwa ma telomeres komanso kukulitsa kuchuluka kwawo. Mwanjira imeneyi, imalola kutalika kwa ma telomeres ndipo chifukwa chake, imakulitsa nthawi yamoyo.

Chifukwa cha kulemera kwake pang'ono, Cycloastragenol imadutsa mosavuta kudzera khoma lamatumbo. Mulingo woyenera wabwino kwambiri umalola kugwira bwino ntchito, ngakhale pa mlingo wochepa. Kuphatikiza tsiku ndi tsiku mwina pakokha, kapena kuphatikiza kapena kusakanikirana ndi, astragaloside IV, motero kuthandizira kuletsa ukalamba ndikupatsa mwayi wokhala ndi moyo.

Cycloastragenol ubwino

Astragalus membranaceus ndi zina mwazitsamba zofunika kwambiri m'mbiri ya Chinese Chinese Medicine monga mankhwala achilengedwe ochizira kutopa, matenda, zilonda zam'mimba, khansa, hay fever, post stroke, moyo wautali ndi zina zambiri. Komabe, maubwino ofunikira a cycloastragenol ufa ali ngati zotsutsana ndi ukalamba komanso zothandizira pakulimbana ndi chitetezo.

Cycloastragenol ndi thandizo lachitetezo cha mthupi

Cycloastragenol ikhoza kugwiritsidwa ntchito kuteteza chitetezo cha mthupi, antibacterial, ndi antiinfrance, popewa chimfine ndi matenda apamwamba kwambiri oyambitsa matenda. Yagwiritsidwa ntchito ngati othandizira chitetezo mthupi chifukwa chokhoza kuwonjezera kuchuluka kwa T lymphocyte. Komabe, chomwe asayansi ali nacho chidwi kwambiri ndi kukana kwake kwabwino. Cycloastragenol imalimbikitsa DNA kukonza zowonongeka poyambitsa telomerase ndikulola proteinase ya nyukiliya yomwe yathandizira kapangidwe ndi kukula kwa telomere DNA.

Cycloastragenol komanso odana ndi ukalamba

Anti-ukalamba ndi phindu lochuluka kwambiri la cycloastragenol. Cycloastragenol sikuti imachedwetsa kukalamba kwa anthu, komanso kuwonjezera mphamvu ya chitetezo cha m'thupi, kupewera poizoni, kuteteza khungu lamtima, makamaka lochokera ku hydragaloside (Astragaloside Ⅳ) hydrolysis.

Mapindu ena a Cycloastragenol

  1. cycloastragenol ufa umatha kuchepetsa nkhawa komanso kuteteza thupi ku mavuto osiyanasiyana, kuphatikizapo kupsinjika kwamthupi, m'maganizo, kapena m'malingaliro;
  2. cycloastragenol ufa umakhala ndi ma antioxidants, omwe amateteza maselo ku zowonongeka zomwe zimayambitsidwa ndi ma free radicals;
  3. cycloastragenol ufa umatha kutsitsa kuthamanga kwa magazi, kuchiza matenda ashuga komanso kuteteza chiwindi.

Cycloastragenol zovuta zoyipa

Mpaka pano, palibe lipoti lililonse kapena kuwunika kwa zinthu zoyipa kapena kuponderezedwa pakutenga mankhwala a cycloastragenol.

Cycloastragenol kuwonjezera mlingo

Cycloastragenol ndi yatsopano kwambiri osati mitundu yambiri yazowonjezera pamsika, ndipo palibe mlingo wolimbikitsidwa. Malinga ndi zomwe takumana nazo, mlingo umasiyana ndi zolinga zosiyanasiyana, zaka. Inde, cycloastragenol imakhala yamphamvu kwambiri kuposa Astragaloside IV yemwe mlingo wake ndi 50mg patsiku. Ngakhale cycloastragenol, kutulutsa 10mg mpaka 50mg zonse zili bwino. Wakale amafunika kutenga zoposa akulu azaka zapakati. Ena amati kuyambira ndi 5mg patsiku, kenako onjezani pang'onopang'ono. Popeza cycloastragenol ndiyotulutsa zachilengedwe, zimatenga nthawi kuti muwone zotsatira zake, pafupifupi miyezi isanu ndi umodzi.

Cycloastragenol chitetezo

Cycloastragenol adalengezedwa ndi ena ngati othandizira odana ndi ukalamba. Kafukufuku wakale akuwoneka kukhala wopatsa chidwi, akuwonetsa kuti ali ndi kuthekera kochulukitsa kutalika kwa telomere, komabe pali kuchepa kwa kafukufuku wowunika wowonedwa ndi anzawo. Kuphatikiza apo, pali nkhawa ina yoti kutenga Cycloastragenol kuonjezera ngozi ya khansa zina. Komabe, kafukufuku wofufuza sanathe kukhazikitsa chiwopsezo chilichonse cha khansa chokhudzana ndi kugwiritsa ntchito cycloastragenol.

Cycloastragenol imawoneka ngati yolimbikitsa anti-kukalamba. Ngakhale sizinatsimikizidwe kuti zikuwonjezera moyo komabe zikuwonetsedwa kuti zikuchepetsa mitundu yosiyanasiyana yokhudzana ndi zotsalira. Kuphatikiza apo adawonetsedwa kuti akuchepetsa zizindikiritso zaukalamba monga mizere yabwino ndi makwinya. Zimathandizanso kuchepetsa chiwopsezo cha matenda osachiritsika monga Alzheimer's, Parkinson's, retinopathies, and cataracts.

Cycloastragenol ufa umagwiritsidwa ntchito

Cycloastragenol imagwiritsidwa ntchito pochiza, kupewa, kupewa, ndi kukonza matenda otsatirawa, mikhalidwe ndi zizindikilo:

  • Kutupa
  • Apoptosis
  • Zosokoneza za Homeostasis
  • Cycloastragenol itha kugwiritsidwanso ntchito pazolinga sizomwe zalembedwa pano.

Bulc cycloastragenol ufa wagwiritsidwa ntchito pansipa:

  1. Yogwiritsidwa ntchito m'munda wazakudya, nthawi zambiri imagwiritsidwa ntchito ngati chakudya chowonjezera;
  2. Yogwiritsidwa ntchito m'munda wazogulitsa zamtundu waumoyo, izi zowonjezera ndizothandiza thupi la munthu;
  3. Kuyika zodzikongoletsera, ngati mtundu wa zopangira, zimatha kusakaniza zodzikongoletsera zachilengedwe.

Reference:

  • Zotsatira zotsutsa okalamba za cycloastragenol zopangidwa ndi biotransfform.Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G.Nat Prod Res. 2019 Sep 9: 1-6. doi: 1080 / 14786419.2019.1662011.
  • Cycloastragenol: Wopatsa chidwi waanenapo za matenda okhudzana ndi zaka.Yu Y et al. Exp Ther Med. (2018) Zochokera ku kukalamba zomwe zimachokera ku cycloastragenol zopangidwa ndi biotransfform. Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. doi: 10.1080 / 14786419.2019.1662011
  • Cycloastragenol ikhoza kulepheretsa kuchitika kwa STAT3 ndikuthandizira kupanikizika kwa chiplitaxel-m'magazi a khansa ya m'mimba ya anthu.Hwang ST, Kim C, Lee JH, Chinnathambi A, Alharbi SA, Shair OHM, Sethi G, Ahn KS. 2019 Juni
  • Astragaloside VI ndi cycloastragenol-6-O-beta-D-glucoside amalimbikitsa machiritso a bala mu vitro komanso mu vivo.Lee SY et al. Phytomedicine. (2018)