Meclofenoxate (Centrophenoxine) (51-68-3)

March 11, 2020
SKU: 541-15-1
5.00 kuchokera 5 kutengera 1 kasitomala mlingo

Meclofenoxate (Centrophenoxine), wogulitsidwa pansi pa dzina la brand Lucidril, ndi m'modzi wakale kwambiri ndipo amaphunziridwa bwino kwambiri ………


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

Meclofenoxate (Centrophenoxine) (51-68-3) kanema

Meclofenoxate (Centrophenoxine) ufa Szizindikiro

Name mankhwala Meclofenoxate (Centrophenoxine) (51-68-3)
Mankhwala Name Clophenoxate;
Meclophenoxate;
Clofenoxin;
Proseryl;
2- (dimethylamino) ethyl 2- (4-chlorophenoxy) acetate
Brand NAme N / A
Kalasi ya Mankhwala Ma Anti-Allergic Agents, Ma Antineoplastic Agents, Ageparasitic Age
Nambala ya CAS 51-68-3
InChIKey XZTYGFHCIAKPGJ-UHFFFAOYSA-N
Maselo Fmphutsi C12H16ClNO3
Maselo Wasanu ndi atatu 257.71 g / mol
Misa ya Monoisotopic 257.081871 g / mol
Malo otentha 345.941 ° C pa 760 mmHg
Fkubwezeretsanso Pmafuta N / A
Halimo Half-Life hours 2-4
mtundu woyera
Szovuta Mumadzi Amadzi: 2.9 mg / mL
Smazunzo Tkutentha -20 ° C
Amalingaliro Centrophenoxine ufa wagwiritsa ntchito mankhwala a nootropics komanso zakudya zina.

Zowona mwachidule za Meclofenoxate (Centrophenoxine)

Meclofenoxate (Centrophenoxine), wogulitsidwa ndi dzina lodziwika bwino la Lucidril, ndi imodzi mwakale kwambiri komanso yapamwamba kwambiri yophunzirira za nootropics kapena mankhwala otchedwa "anzeru". Ndi nootropic yodziwika bwino komanso yolemekezeka yomwe yadzitsimikizira kwazaka zoposa makumi asanu yogwiritsa ntchito komanso kuyesa mwamphamvu kachipatala.

Loyambitsidwa mu 1959 ndi asayansi ku French National Science Scient Center ngati chithandizo cha matenda a Alzheimer's, magazi osakwanira mpaka muubongo, ‍ komanso kuchepa kwokhudzana ndi zaka, mankhwalawa agwiritsidwa ntchito kwambiri pochiza matenda obwera chifukwa cha ukalamba, komanso matenda a Alzheimer's and dementia. Amagwiritsidwanso ntchito ndi anthu athanzi kuti apititse patsogolo kukumbukira ndi kuzindikira komanso kukonza thanzi lathunthu.

Kafukufuku wasonyeza kuti Centrophenoxine ufa ndiwothandiza kukumbukira zakale komanso wothandizirana ndi ukalamba.

Ku Europe, amalembera chithandizo chamankhwala okhudzana ndi zaka, koma amapezeka pakapaka monga chakudya chamagulu aku US ndi Canada, komwe amagwiritsidwa ntchito kwambiri pazinthu zawo zowonjezera kuzindikira.

Kodi Meclofenoxate (Centrophenoxine) ndi chiyani?

Centrophenoxine wagwiritsidwa ntchito ngati chakudya chowonjezera chifukwa chokhoza kukumbukira mphamvu zake.

Centrophenoxine ndi mitundu iwiri ya mankhwala:

Dimethyl-aminoethanol (DMAE), chomwe ndi chinthu chachilengedwe chomwe chimapezeka m'zakudya zina (nsomba, nsomba zam'madzi) komanso zochepa. Imakhala gwero la choline ndipo imakhala ndi zotsitsimutsa bongo.

Parachlorphenoxyacetic acid (pCPA), mtundu wopanga wa mahomoni okula msika otchedwa "auxins".

DMAE ndiye gawo lalikulu la mankhwala. DMAE simadutsa chotchinga-magazi chotchinga bwino. Komabe, mkati mwa centrophenoxine, imatha kudutsa chotchinga cha magazi ndi kulowa mu ubongo moyenera

Ikakamizidwa m'thupi, gawo la centrophenoxine limagwera DMAE ndi pCPA m'chiwindi. DMAE imasinthidwa kukhala choline, pomwe centrophenoxine yomwe imazungulira thupi lonse.

Mapindu a Meclofenoxate (Centrophenoxine)

Centrophenoxine angathandize kulimbana ndi khansa.

Centrophenoxine imatha kuthandizira kuuma kwa dyskinesia.

Centrophenoxine imathandizira kukumbukira komanso kuphunzira, ikhoza kusintha kukumbukira kwa odwala omwe ali ndi dementia.

Centrophenoxine yawonetsedwa kuti ikulimbikitsa mapangidwe, kusungirako, ndikubwezeretsanso kukumbukira. Mapangidwe a kukumbukira amakwaniritsidwa tikakhala ndi milingo yayikulu ya acetylcholine. Popeza kuti Centrophenoxine imathandizira zochitika zosiyanasiyana za cholinergic, chimodzi mwazinthu zomwe zimapangidwa ndi choline, pakati pa phospholipids osiyanasiyana

Ntchito Zothandiza Kuzindikira

Centrophenoxine itha kugwiritsidwa ntchito ngati DMAE prodrug ndipo izi ndizofunikira kwambiri, chifukwa molekyuyi imakhala yothandiza kwambiri pakuwongolera molekyulu ina yowononga mkati mwa ubongo yomwe ingapangitse kuchepa kwakukulu pantchito zakuzindikira. Ndi mamolekyulu amachotsedwa, anthu okalamba amatha kuchepetsa kukalamba kwawo ndikusintha zina zoyipa zaukalamba.

Centrophenoxine ili ndi anti-Ukalamba ndi Ziphuphu za Neuroprotective

Centrophenoxine yawonetsedwa kuti ikukweza moyo wama makoswe mpaka 50%.

Centrophenoxine imasintha Mood ndi Motivation, zingathandize kuchepetsa nkhawa.

Kafukufuku wazinyama akusonyeza kuti centrophenoxine imakhala ndi mphamvu yolimbana ndi nkhawa.‍

Meclofenoxate (Centrophenoxine) kagayidwe

Centrophenoxine imagwira ntchito populumutsa ndikuwonjezera zochita za choline. Choline ndiye wotsogola wa acetylcholine, neurotransmitter yofunikira komanso yopanda malire yomwe imalumikizidwa mwamphamvu ndi cuquity acuity, plasticity, ndi kukumbukira. Sizikudziwika bwino momwe kuchuluka kwa Centrophenoxine kumachulukitsira milingo ya choline ndi acetylcholine, koma akuganiza kuti mwina imasinthika mwanjira ina kukhala choline kapena imatembenukira ku phospholipid yapakatikati yomwe imagwiritsidwa ntchito kupanga acetylcholine. Mosasamala kanthu za njira, ndi mphamvu ya cholinergic yomwe imapangitsa kuti Centrophenoxine akhale wamphamvu pototatorator mu ufulu wake.

Kuphatikiza pa kukonzanso kwa kupanga kwa acetylcholine, centrophenoxine imadziwikanso kuti ndi mphamvu ya neuro yomwe imalimbikitsa ntchito zonse za ubongo mwa kukonza kuyamwa kwa glucose ndikuwonjezera kukwezedwa kwa oxygen. Mwakutero, centrophenoxine imapangitsa ubongo kugwira ntchito bwino, motero imapangitsa chidwi, kuyika chidwi, komanso kumveka bwino kwa malingaliro, kuchotsa zomwe zimadziwika kuti ndi chifunga cha ubongo. Monga antioxidant wamphamvu, imasunthika ma radicals aulere, imayamwa poizoni ndikuthandizira kukonza maselo owonongeka. Pomaliza, imabwezeretsa kukalamba kwachidziwitso pochepetsa kapena kuchotsanso zopangidwira zotayidwa zomwe zimawonedwa kuti ndi "zotopetsa ndi zowala."

Meclofenoxate (Centrophenoxine) mavuto ndi chitetezo.

Centrophenoxine nthawi zambiri imawonedwa ngati yotetezeka komanso yopanda poizoni. Yakhala ikugwiritsidwa ntchito kwa zaka pafupifupi 50 popanda zoopsa zilizonse.

Amanenedwa kukhala mankhwala olekerera kwa anthu ambiri wathanzi komanso osachiritsika omwe akuvutika ndi kukumbukira.

Komabe, ogwiritsa ntchito ena adakumana ndi zovuta zochepa komanso zazing'ono, kuphatikiza mseru, mutu, zovuta m'mimba, komanso kusowa tulo.‍

Centrophenoxine samalangizidwa amayi apakati chifukwa cha DMAE.

Meclofenoxate (Centrophenoxine) Mlingo wa ufa

Centrophenoxine imapezeka pamwamba pa othandizira mu makapisozi omwe ali ndi 200- 300 mg iliyonse. Zoyesa zamankhwala zomwe zimayesa zotsatira za centrophenoxine pazinthu zanzeru zazigwiritsa ntchito tsiku lililonse

1,200 mg okalamba wathanzi komanso Mlingo wofikira 2,000 mg wa odwala dementia.

Kusungunula

Centrophenoxine ndi gwero labwino kwambiri la choline, mutha kuipeza m'matumba ambiri a nootropic - ena mwa omwe ndi Noopept ndi Racetams.

Centrophenoxine ndi Aniracetam Stack

Nachi zitsanzo cha chisonyezo cha centrophenoxine chomwe chimaphatikizapo mtundu wodziwika wa racetam aniracetam kuti uthandize kukumbukira kukumbukira, momwe mukumvera, kuchita zinthu, uku mukuchepetsa nkhawa.

1-2x patsiku

250 mg Centrophenoxine

750 mg Aniracetam

Centrophenoxine ndi Noopept Stack

Nachi zitsanzo cha stack ya centrophenoxine ndi Noopept, stack iyi ikhoza kupititsa patsogolo kukumbukira komanso kuphunzira, ndikupereka katundu wa neuroprotective.

1-2x patsiku

250 mg Centrophenoxine

20 mg Noopept

Reference:

  • Pa gawo la intracellular physicochemistry mu kuchuluka gene pakukalamba ndi mphamvu ya centrophenoxine. Ndemanga. Zs-Nagy I et al. Arch Gerontol Geriatr. (1989)
  • Cholinergic mankhwala a antipsychotic-anachititsa tysive dyskinesia. Tammenmaa-Aho I, Asher R, Soares-Weiser K, Bergman H. Cochrane Database Syst Rev. 2018 Mar 19
  • Cytotoxic ntchito ya alkylating othandizira pamaso pa centrophenoxine ndi mankhwala ake a hydrolysis. Sladek NE. J Pharmacol Exp Ther. 1977 Dec
  • Potentiation wa antitumor ntchito ya cyclophosphamide ndi centrophenoxine. Kanzawa F, Hoshi A, Tsuda S, Kuretani K. Gan. 1972 Aug
  • Centrophenoxine: zotsatira za ukalamba wa mabere a m'mayi. Nandy K et al. J Am Geriatr Soc. (1978)
  • Zotsatira zakusiyana kwa meclofenoxate pakuyiwala kukumbukira okalamba. Marcer D et al. Ukalamba. (1977)
  • Nootropics ufa centrophenoxine (meclofenoxate) maubwino ndi m'matumba