NMN ufa (1094-61-7)

October 30, 2018

Fakitole yathu imatha kutulutsa ufa wopitilira 1370kg Nicotinamide Mononucleotide (nmn) pamwezi pamikhalidwe ya GMP.


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1370kg / mwezi

Video

 

zofunika

Name mankhwala Mphungu yaikulu ya Nicotinamide Mononucleotide (NMN)
Dzina Lofanana NAMN, β-NMN, β-Nicotinamide Mononucleotide kapena Beta Nicotinamide Mononucleotide; NMN;

beta-NMN

Kalasi ya Mankhwala Zakudya zowonjezera
Nambala ya CAS 1094-61-7
InChIKey DAYLJWODMCOQEW-TURQNECASA-N
Makhalidwe a Maselo C11H15N2O8P
Kulemera kwa Maselo 334.22 g / mol
Misa ya Monoisotopic 334.056602 g / mol
Kusungunuka  166 ° C (Dis.)
Malo Ozizira N / A
Halimo Half-Life N / A
mtundu Kuyera mpaka ufa woyera
Kutupa  Beta-NMN imaperekedwa ngati cholimba cha crystalline. Beta-NMN imasungunuka pang'ono pang'ono m'madzi osungunulira zinthu monga ethanol, DMSO, ndi dimethyl formamide. Pazoyesera zachilengedwe, tikupangira kuti mayankho amadzimadzi osagwiritsa ntchito zosungunulira a Beta-NMN akhale okonzeka pothetsa molimba kwambiri ma crystalline olimba m'malo opumira madzi. Kusungunuka kwa Beta-NMN mu PBS, pH 7.2, pafupifupi 10 mg / ml. Sitikulangiza kuti tisunge yankho lamadzimadzi kwanthawi yopitilira tsiku limodzi.
Yosungirako Kutentha  Chipinda chotentha;

Sungani pa -20 ° C kwa zaka ziwiri.

ntchito Zakudya zotsutsana ndi ukalamba

 

Mbiri ya NMN

Nicotinamide mononucleotide (molekyulu: C11H15N2O8P, CAS nambala: 1094-61-7, yotchedwanso NMN, beta-Nicotinamide mononucleotide kapena β-NMN) ndi vitamini B3 metabolite [1], yomwe imapezeka mwathupi, zakudya monga broccoli ndi kabichi pang'ono pang'ono [2].

NMN idayamba kupeza chidwi ngati chowonjezera cha zakudya mu 2013, atachita kafukufuku wopangidwa ndi asayansi a Harvard pa mbewa [3,4].

NMN idapangidwa koyamba ngati chowonjezera cha anthu mu 2015 [5], koma inali yokwera mtengo kwambiri popanga, mpaka njira zidapangidwa kuti muchepetse ndalama zopangira ndikuwonjezera kuyera mu 2018 [6], pomwe ma laboratories omwe amapangira kupanga misa adayamba bwerani pa intaneti.

 

Kodi ufa wa NMN ndi chiyani?

Nicotinamide mononucleotide (molekyulu: C11H15N2O8P, CAS nambala: 1094-61-7, yotchedwanso NMN, beta-Nicotinamide mononucleotide kapena β-NMN) ndi vitamini B3 metabolite [1], yomwe imapezeka mwathupi, zakudya monga broccoli ndi kabichi pang'ono pang'ono [2].

Nicotinamide Mononucleotide (NMN) ndi chinthu chachilengedwe chomwe chimakhala chochepa mthupi la munthu komanso zakudya zina. NMN imapezeka pakamwa, ndipo ikamamveka pakamwa imatha kuthandizira milingo ya NAD + mkati mwa ziwindi ndi minofu.

Kafukufuku waposachedwa akuti NMN itha kuthandizira thanzi lamtima, kupanga mphamvu, thanzi lanzeru, komanso thanzi la m'maso ndi mafupa. Chimodzi mwazosangalatsa zomwe kafukufuku wa NMN adachita ndikuti zitha kulimbikitsa kukonza kwa DNA ndikuthandizira kuyambitsa kwa majini a SIRTUIN omwe akuganiza kuti amathandizira kukalamba bwino.

 

Zimagwira bwanji?

NMN ndiyotsogola kwa NAD + molekyulu; thupi la munthu limafuna NMN kuti ipange NAD + yake.

NAD + ndi mawonekedwe a NAD (Nicotinamide adenine dinucleotide), molekyulu yomwe idapezeka koyamba mu 1906, ndipo imapezeka m'maselo amoyo onse [7].

Kuphatikiza ndi NAD + palokha sindiyo njira yolimbikitsira milingo ya NAD, chifukwa ndi yayikulu kwambiri kuti ingadutse mosavuta khungu kuti ilowe m'maselo, chifukwa chake silingakhudze metabolism [8].

 

Phindu la NMN.

Njira imodzi yomwe tingakhalire ndi thanzi labwino la NAD + ndikuthandizira matupi athu ndi zomwe zidalipo kale, nicotinamide mononucleotide (NMN).

Kafukufuku wapano akuwonetsa kuti kusinthaku pakati pa NR ndi NMN kuyenera kuchitika kuti alowe mumitundu ingapo yama cell. Izi zimapangitsa ofufuza kuti akhulupirire kuti NMN ndiye njira yachangu kwambiri yolimbikitsira kupanga NAD. Komabe, Nicotinamide mononucleotide powder akuwonetsanso kuti ali ndi zabwino zawo zotsutsana ndi ukalamba kupitilira zomwe zimapangidwa ndi NAD zokha.

Kuphatikiza pa njira yamagetsi ya NAD, ufa wa NMN ukhoza kuwonjezeredwa mwachindunji kumaselo osatembenukira ku NAD. Izi zimatheka chifukwa cha mapuloteni onyamula kumene omwe angotuluka kumene omwe amachulukitsa pambuyo poti milingo ya NAD yatsika. Mwa mawonekedwe awa, NMN imathandizira pama cell cell ndikulola chilichonse mwazinthu zotsutsana ndi ukalamba zomwe zimalimbikitsidwa ndi ma cell omwe ali ndi kuthekera kokwanira kukula ndikusintha.

Kusankha kuwonjezera ndi ufa wa NMN limodzi ndi NAD kumapereka njira yowongoka kwambiri yolimbikitsira kagayidwe kake ka cell ndipo motero ndi njira yofulumira kwambiri kuchitira zomwezo. Kuphatikiza apo, Nicotinamide mononucleotide powder yapezeka kuti ikuthandizira magwiridwe antchito a insulin komanso kupanga, zomwe zimapangitsa phindu lina la kagayidwe komanso kulekerera kwa glucose. Makamaka, zowonjezera za NMN zitha kuthandiza kuti muchepetse kagayidwe kachakudya monga matenda ashuga, matenda a chiwindi, ndi kunenepa kwambiri. [11]

 

Zopindulitsa Zina za NMN

  • Imalimbikitsa Zaumoyo Wa Mitsempha ndi Magazi Kuyenda. [11]
  • Bwino Kupirira Minofu ndi Mphamvu
  • Zimateteza ku Matenda a Mtima
  • Amachepetsa Kuopsa Konenepa Kwambiri. [10]
  • Zimathandizira Kukonzanso kwa DNA
  • Kuchulukitsa Ntchito ya Mitochondrial. [9]

 

Momwe mungakhalire okhazikika, oyera, otetezeka a NMN?

Pofuna kudziwa momwe chinthu chokhazikika, chowonadi, choyera komanso chotetezeka chingapezedwere, mayeso ndi kuwunika kambiri kunachitika. Malipoti a COA, HPLC ndi HNMR atha kuperekedwa.

 

Kukhazikika bwino

Pofufuza momwe Nicotinamide mononucleotide imagwirira ntchito ndikugwiritsa ntchito njira zowunikira ma FTIR, zimapezeka kuti NMN ili ndi mchere wamkati wamkati komanso mchere wamkati wamkati ndichofunikira kwambiri pakusakhazikika kwa NMN. Madzi, ngati molekyulu imodzi yakumtunda, imathandizira kusamutsa kwamagetsi mkati mwa NMN komwe kumatha kuwononga mafupa okhazikika amchere amkati a NMN. Ngati ndi choncho, NMN iwonetsa kusintha kosinthika komwe kumawononga mosavuta, zomwe zili mumadzi opangidwa ndi mamolekyu amadzi aulere mlengalenga zidzawononga mwachindunji gawo lamchere lamkati ndikuchepetsa kuyera kwa NMN. Uku ndikuchitika kwakukulu pakufufuza kwa kukhazikika kwa ufa wa NMN, komwe kudzakhala kuyamba koyambira.

Pofuna kukonza bata la NMN mkati, ofufuza adapanga ufa watsopano wa NMN mwadongosolo komanso mwadongosolo.

 

Kukhazikika kolimba, moyo wautali wautali.

Phcoker NMN ufa ndi wadongosolo komanso wophatikizika, kutsekereza kuyanjana ndi madzi aulere mlengalenga, kukulitsa kukhazikika kwa NMN ndikuwonjezera moyo wa alumali wa malonda. Mosiyana ndi buku laling'ono la NMN laling'ono, kapangidwe koyamba ka sawtooth kamawonetsa chisokonezo komanso chosakwanira, chifukwa chake mamolekyulu onse amakhala ndi mpweya wambiri komanso amamwa madzi ambiri.

 

Kutalika kochulukirapo, mlingo wodekha komanso kapangidwe kake kosasintha.

Ufa wa NMN wokhala ndi dongosolo laling'ono komanso laling'ono kwambiri amakhala ndi kachulukidwe kakang'ono komanso madzi, omwe amapewa kuchuluka kosakhazikika chifukwa chofukula fumbi pokonzekera. Kuonjezera apo, zidzakhudza yunifolomu Mlingo wa makapisozi. Pakadali pano, popeza ili ndi madzi abwino, ufa wathu wa NMN ungathandize kuchepetsa nthawi yopanga komanso mtengo wopangira panthawi yopanga.

 

Zotsimikizika zapamwamba kwambiri komanso zoyera

Malipoti oyeserera labu lachitatu ayenera kukhala ofunikira kutsimikizira kuti NNM ndi yotani. Gulu lirilonse la zopangira liyenera kuyesa kudziyesa mosamalitsa ndikuyesedwa kwachitatu. Malipoti oyesa a HNMR ndi HPLC atha kutsimikiziranso kuti NMN ndiyowona, ndiyabwino kwambiri.

 

Phcoker ndi Nicotinamide mononucleotide (NMN) wopanga ufa

Ndi fakitale yathuyathu, ufa wathu wa NMN pamwezi umafikira matani 2.

 

ntchito

Zodzikongoletsera zopangira:

NMN ndi chinthu m'thupi la maselo, ndipo NMN ndi molekyulu ya monomer, ndizotsutsana ndi kukalamba ndizodziwikiratu, chifukwa chitha kugwiritsidwa ntchito popangira zodzikongoletsera.

 

Mankhwala:

NMN ufa ukhoza kukonzekera ndi yisiti nayonso mphamvu, kaphatikizidwe wa mankhwala kapena mu vitro enzymatic catalysis.

Ufa wa NMN wogwiritsidwa ntchito kwambiri m'makampani azachipatala.

 

Tsamba:

[1] Nicotinamide mononucleotide. Kuchokera ku Wikipedia, encyclopedia yaulere. 2019.

[2] Kulamulira Kwa Nthawi Yaitali Kwa Nicotinamide Mononucleotide Kumachepetsa Kuthupi Kogwirizana Ndi Zamoyo Pamagulu. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Cell Metab. 2016 Dec 13.

[3] Kuchepetsa NAD + Kumapangitsa Pseudohypoxic State Kusokoneza Kuyankhulana kwa Nyukiliya-Mitochondrial Pakukalamba. Gomes AP, Mtengo NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dis 19; 155 (7): 1624-38. onetsani: 10.1016 / j.cell.2013.11.037.

[4] Chatsopano — Chosinthika — Choyambitsa Ukalamba. David Cameron. Harvard Medical School, News & Research, Disembala 19, 2013

[5] Thumba lotetezedwa la NAD + lomwe limayang'anira zochitika zamapuloteni-protein pakakalamba. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. Sayansi. 2017 Mar 24; 355 (6331): 1312-1317. (Adasankhidwa) onetsani: 10.1126 / science.aad8242.

[6] Njira Yopatula Kukula kwa Chromatography Yotsuka Nicotinamide Mononucleotide (NMN) kuchokera ku Maselo a Bakiteriya. George Cătălin Marinescu, Roua-Gabriela Popescu & Anca Dinischiotu. Malipoti a Sayansivolume 8, Nambala nambala: 4433 (2018).

[7] Nicotinamide adenine dinucleotide. Kuchokera ku Wikipedia, encyclopedia yaulere. 2019.

[8] Kuzindikiritsa wa mitochondrial NAD + wonyamula ku Saccharomyces cerevisiae., Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. 2006 Jan 20; 281 (3): 1524-31. Epub 2005 Novembala 16.

[9] Katalin Sas, Elza Szabó, László Vécsei. Mitochondria, Kupsinjika kwa okosijeni ndi dongosolo la Kynurenine, lomwe limayang'ana ukalamba ndi Neuroprotection. Mamolekyulu, 2018; DOI: 10.3390 / mamolekyulu23010191.

[10] Kuonjezera kwa Nicotinamide mononucleotide (NMN) kumalimbikitsa mphamvu ya kunenepa kwambiri kwa amayi mu mbewa: kuyerekezera ndi masewera olimbitsa thupi. Oddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.

[11] Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai. Nicotinamide Mononucleotide, NAD + Wapakati, Amathandizira Pathophysiology ya Zakudya- ndi Matenda A Shuga Omwe Amayambitsa Matenda a Mbewa. Cell Metab, 2011; CHINTHU: 10.1016 / j.cmet.2011.08.014.

[12] Mankhwala Atsopano Oletsa Ukalamba: Nicotinamide Mononucleotide (NMN)