Mafuta akuluakulu a Tadalafil (171596-29-5)

October 20, 2018

Tadalafil yaiwisi yaiwisi yotchedwa Cialis imagwiritsidwa ntchito pochiza kukanika (kusowa mphamvu) ndi zizindikiritso za Prostatic Prostatic ………


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum
mphamvu: 1190kg / mwezi

Tadalafil ufa video

 

Mfundo Zachidule

Name mankhwala Tadalafil powder
Mankhwala Name (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand NAme Cialis, Adcirca
Kalasi ya Mankhwala PAH, PDE-5 Inhibitors; Phosphodiesterase-5 Enzyme Inhibitors
Nambala ya CAS 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
Maselo Fmphutsi C22H19N3O4
Maselo Wasanu ndi atatu 389.4
Misa ya Monoisotopic 389.138 g / mol
Kusungunula Pmafuta  298-300 ° C
Fkubwezeretsanso Pmafuta 2 ℃
Halimo Half-Life hours 17.5
mtundu Yoyera mpaka Yoyera Yogwedeza Mpweya Wolimba
Szovuta  Zosungunuka mu DMSO (78 mg / ml pa 25 ° C), methanol, madzi (<1 mg / ml pa 25 ° C), dichloromethane, ndi ethanol (<1 mg / ml pa 25 ° C)
Smazunzo Tkutentha  Sungani kutentha kwapakati pakati pa 59 ° F ndi 86 ° F (15 ° C ndi 30 ° C). Musasunge mankhwalawa m'malo onyowa kapena onyowa.
Tadalafil Amalingaliro Mafuta akuluakulu a Tadalafil, mapepala ogonana, ma khofi akugonana, ndi zina zotero.

 

Tadalafil Powder

Kulephera kwa Erectile ndi vuto lodziwika bwino logonana mwa amuna lomwe limakhudza pafupifupi 52% ya amuna azaka zopitilira 18, padziko lonse lapansi. Kusinthasintha mwamphamvu, kuwonongeka kwa erectile nthawi zambiri kumachitika chifukwa chotsika kwa magazi kupita m'mitsempha yama penile, yomwe ndi gawo lalikulu pakupanga erection. 

Kulephera kwa erectile ndi vuto lomwe lingathe kuchiritsidwa komanso kuchiritsidwa ndi mankhwala osiyanasiyana omwe amayang'ana michere yapadera pakhoma la mitsempha ya penile. Imodzi mwa mankhwala amphamvu kwambiri ku ED ndi Tadalafil powder wokhala ndi theka la maola 17.5. 

 

Kodi Tadalafil Powder ndi chiyani?

Tadalafil Powder ndi ya mankhwala osokoneza bongo monga mankhwala omwe amapangidwira amuna azaka zopitilira 18, omwe ali ndi vuto la erectile. Tadalafil, kapena (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6 , 3,4] pyrido [1,4-b] indole-XNUMX-dione ndi mankhwala ofanana ndi Sildenafil kapena Viagra, akugwira, koma osiyana ndi kapangidwe kake. Tadalafil imasiyananso ndi mankhwala wamba a erectile dysfunction, Viagra, potency chifukwa ndiyamphamvu kwambiri komanso yothandiza kuposa yotsirizira. 

Tadalafil Powder ndi PDE5 inhibitor mankhwala, zomwe zikutanthauza kuti imayang'ana michere ya PDE5 yomwe imapezeka m'maselo osalala amitsempha yama penile. Ntchito yoletsa mankhwalawa ndiyopindulitsa chifukwa cholinga chachikulu cha enzyme ndikupangitsa vasoconstriction, yomwe mumitsempha yama penile, imapangitsa kutsika kwa magazi ndikumapangitsa kuti erectile iwonongeke. 

Tadalafil Powder amapangidwa ndi Pharmax Lifesciences ndipo atha kugwiritsidwa ntchito pochizira zochulukirapo kuposa kusokonekera kwa erectile. Tadalafil Powder amaperekedwanso kwa amuna omwe ali ndi vuto la benign prostatic hyperplasia komanso ngakhale m'mapapo mwanga kuthamanga kwa magazi. Komabe, Tadalafil Powder siyothandiza pochiza matenda ena okhudzana ndi kugonana mwa amuna ndi akazi. 

 

Mitundu ya Tadalafil

Tadalafil ndi PDE5 inhibitor yamphamvu, yomwe imapezeka m'njira zosiyanasiyana komanso imathandizanso kwa odwala. Mankhwalawa amapezeka ngati mapiritsi kapena makapisozi, pomwe mlingo wake ndi 5 mg, 10 mg, ndi 25 mg. Ndikofunikira kudziwa kuti kuchuluka kwa Tadalafil kumasiyana malinga ndi kampani yopanga. 

Tadalafil imapezekanso ngati ufa, ngakhale imagulitsidwa kwambiri kuti igwiritsidwe ntchito m'mafakitale. Ichi ndiye chifukwa chachikulu chogulitsira malonda a Tadalafil Powder kukhala otchuka kwambiri ndi mtundu uwu wa mankhwala. Fomuyi imagulitsidwa m'makontena a 25 kg mpaka 50 kg, kutengera zofunikira zonse. 

Mlingo waukulu wa Tadalafil powder, kuyamba ndi, ndi 10 mg. Kuchuluka kwake, pasanathe maola 24, ndi 20 mg, ndipo kupitirira muyesowu sikuvomerezeka.

Mankhwalawa ndi otetezedwa ndi anthu chifukwa adalandira kuvomerezedwa ndi FDA kuchokera kwa oyang'anira aku India, Canada, Australia, ndi Britain. A FDA adavomereza kugwiritsa ntchito mapiritsi a Tadalafil mchaka cha 2002, ndipo posakhalitsa, kugwiritsa ntchito tadalafil powder kudavomerezedwa ndi FDA. 

Fakitale yopanga ufa wa Tadalafil imati imapanga mankhwala okhawo mwatsatanetsatane mwatsatanetsatane. Opangawa ali ndi chidwi chachikulu ndi chitetezo cha anthu, chomwe chimawonekera bwino kwambiri potency, chitetezo, ndi mphamvu ya zinthu zomalizira. 

 

Kodi Tadalafil Powder Amagwira Ntchito Bwanji?

Tadalafil Powder ili ndi Tadalafil, PDE5 inhibitor yomwe idasanthulidwa koyambirira ndikupangidwa ndi GlaxoSmithKline atapeza Sildenafil, gulu lofananalo. Sildenafil, kumbali inayo, anali kufufuzidwa koyamba ngati chithandizo cha angina ndi matenda oopsa koma kafukufukuyu adachotsedwa pambuyo poti zotsatira zalephera koyambirira kwa kafukufukuyu. Komabe, powunikiridwa, zidapezeka kuti Sildenafil atha kutulutsa zovuta ngati odwala atalimbikitsidwa.

Monga sildenafil ndi PDE5 inhibitor, GlaxoSmithKline adaganiza zofufuza mosiyanasiyana pazinthu zomwe Sildenafil amachita. Kafukufukuyu adatsogolera pakupezeka ndikupanga kwa Tadalafil. 

Tadalafil ndi PDE5 inhibitor yamphamvu yokhala ndi theka la moyo wa maola 17.5 omwe amatenga pafupifupi maola 96 kuti atuluke m'thupi la munthu. Poyerekeza ndi piritsi wamba wabuluu, Viagra, yomwe imangogwira ntchito kwa maola 3 mpaka 4 maola mutadya, Tadalafil imatuluka pamwamba. 

Njira yayikulu yogwiritsira ntchito mankhwala ndikuletsa michere ya PDE5 yomwe imapezeka m'maselo osalala amitsempha yama penile. Kuletsa mavitaminiwa kumayambitsa kupuma kwa magazi ndipo pamapeto pake, kumawonjezera magazi kudzera mumitsempha yamagazi, yomwe yazunguliridwa ndi corpus cavernosa. Minofu iyi ya mbolo, ikapanikizika chifukwa cha kuchuluka kwa magazi, imapanikizidwa kuti ikhale yolimba, yomwe imadziwika kuti erection.

Komabe, minofu ya penile, corpus cavernosa kuti ikhale yolondola, imayenera kumasuka kaye kuti mitsempha yamagazi izitambasula ndikulandila magazi ambiri. Kupumula kumeneku kwa minofu yosalala ndiyonso gawo la chopinga cha enzyme ya PDE5, ngakhale yosakhala mwachindunji. Kuletsa kwa PDE5 kumabweretsa kuchuluka kwa Guanosine MonoPhosphate kapena GMP, komwe ndikofunikira pakutsitsimula kwa minofu yosalala, monga corpus cavernosa. 

Komabe, sikuti ndi njira yokhayo yogwiritsira ntchito Tadalafil Powder. Mankhwala okhawo omwe amagwiritsidwa ntchito amagwiritsidwanso ntchito pa benign prostatic hyperplasia, matenda amikodzo omwe amayamba chifukwa chokulitsa prostate gland ndikuwonetsa ngati kukodza kowawa. Njira yogwiritsira ntchito chithandizo cha kukula kwa prostate gland imadutsanso kuchuluka kwa GMP m'maselo osalala a minofu. Kupumula kwa maselowa kumathandiza kuti mkodzo usadutse mosavuta komanso kupewa kusunga mkodzo komanso kupweteka. 

Tadalafil Powder imapangidwanso kuti ipatsidwe kuthamanga kwa magazi m'mapapo mwanga, chifukwa PDE5 yoletsa kutulutsa sikuti imangowonjezera kuthamanga kwa magazi komanso imachepetsa kuthamanga kwa magazi, komwe kumathandiza kwambiri pochiza PAH. 

 

Kodi Tadalafil Powder Angagwiritsidwe Ntchito Motani?

Tadalafil Powder imagwiritsidwa ntchito pochiza zinthu izi:

  • Kusokonekera kwa Erectile
  • Benign Prostatic Hyperplasia 
  • Matenda a m'mapapo mwanga

Ngakhale kafukufuku akuchitidwa pazomwe angagwiritse ntchito mankhwalawa, pakadali pano amangofunikira kupatsidwa kwa amuna azaka zopitilira 18, omwe ali ndi vuto limodzi mwazomwe zatchulidwa pamwambapa. Nthawi zambiri, mankhwalawa amagwiritsidwa ntchito pochiza matenda osokoneza bongo. 

 

Ubwino wa Tadalafil Powder

Tadalafil ili ndi maubwino angapo payokha komanso poyerekeza ndi ma PDE5 inhibitors ena omwe ali mgulu la mankhwala osokoneza bongo. Mankhwalawa ndi amphamvu komanso okhalitsa chifukwa zimatenga maola 36 kuti achotsedwe m'dongosolo, osangowonekeranso pambuyo pa maola 96. Zotsatira za mankhwalawa zimawonekera ndikuwonekera mozungulira mphindi 20 mpaka 60 mphindi zitatha, ndipo ufa wa Tadalafil umakhalabe wogwira ntchito pafupifupi maola 3 mpaka maola 4 mutatha. Ndikofunika kunena kuti ntchito ya mankhwala siyofanana ndi nthawi yakumangirira. 

Tadalafil Powder sichitha kupanga zodzitchinjiriza zokha ndipo imafunikira kukondweretsedwa koyenera ndikukakamiza kuti ikhale yothandiza popanga erection. Ngati kukakamizidwa kugonana kumaperekedwa m'maola anayi kutsatira mankhwalawo, mankhwalawo amatha kupanga erection ndikuchepetsa zizindikiritso za kuwonongeka kwa erectile. 

Mankhwala osokoneza bongowa ndi othandiza kwambiri pochiza kukanika kwa erectile chifukwa chazomwe amachita nthawi yayitali, zomwe zimapangitsa kuti zikhale mankhwala osankhika kwa ambiri omwe ali ndi vuto la erectile komanso benign prostatic hyperplasia. Tadalafil Powder atha kuphatikizidwa ndi Tamulsin, mankhwala ena amphamvu ochiritsira benign prostatic hyperplasia ngakhale mphamvu ya kusakaniza kwa mankhwalawa ikuphunziridwa ndikuwunikiridwa. 

 

Mlingo woyenera wa Tadalafil Powder

Tadalafil Powder, monga tafotokozera pamwambapa, nthawi zambiri imayamba pa 10 mg ngati mankhwala otsika kwambiri. Pambuyo pa mlungu umodzi wogwiritsa ntchito mankhwalawa, mlingowo umatha kuchepetsedwa, kukulitsidwa, kapena kusungidwa pamlingo wofanana kutengera zotsatira. Komabe, ndikofunikira kukumbukira kuti mankhwalawa ndi mankhwala okhawo omwe muyenera kugwiritsa ntchito mukafunika. Iyeneranso kugwiritsidwa ntchito kamodzi m'maola 24 kuti musakulitse zovuta zamankhwala.

Kuopsa kwa kusowa kwa mankhwala omwe ayenera kumwa pokhapokha ngati kuli kofunikira kulibe, komabe, ndikofunikira kufotokoza malangizidwe a mlingo womwe wasowa. Izi ndichifukwa choti mankhwalawa amaperekedwa kuti azigwiritsidwa ntchito tsiku lililonse, katatu patsiku mukamagwiritsa ntchito matenda amitsempha yamagazi ndi benign prostatic hyperplasia. Ngati mulibe mlingo, ndibwino kuti musapewe mlingowo, ndipo sizingachitike kuti mulingo womwe mudzaphonye udzabwezeredwa kawiri nthawi ina. Izi zitha kubweretsa zovuta zazitali komanso zosafunikira zomwe zitha kubweretsa zovuta zakufa. 

 

Ndani Sayenera Kugwiritsa Ntchito Tadalafil Powder

Tadalafil Powder ili ndi maubwino osiyanasiyana komanso imagwiritsidwa ntchito koma imapangidwira makamaka amuna kapena akazi, makamaka azaka zopitilira 18. Mankhwalawa sayenera kumwa amayi ndi ana chifukwa atha kukhala pachiwopsezo chachikulu chotenga zovuta zingapo zomwe zimafala chifukwa chogwiritsa ntchito Tadalafil Power. 

Anthu otsatirawa sayenera kumwa Tadalafil Powder, kapena kukaonana ndi dokotala asanayambe mankhwala aliwonse a PDE5 inhibitors class class:

  • Anthu omwe ali ndi mbiri yakuchita opaleshoni m'miyezi itatu yapitayi
  • Anthu omwe ali ndi mbiri ya zochitika zamtima m'miyezi itatu yapitayi mpaka miyezi isanu ndi umodzi
  • Anthu omwe ali ndi matenda oopsa komanso hyperlipidemia
  • Anthu omwe ali ndi matenda aimpso
  • Anthu omwe ali ndi retinitis pigmentosa
  • Anthu omwe ali ndi hemophilia kapena zovuta zofananira zamagazi
  • Anthu omwe ali ndi myeloma angapo, kapena leukemia
  • Anthu omwe ali ndi zilonda zam'mimba
  • Anthu omwe ali ndi mbiri yokhudza kupwetekedwa kapena omwe ali pachiwopsezo chambiri chodwala matenda opha ziwalo

Anthuwa saloledwa kutenga Tadalafil chifukwa mankhwala omwe ali nawo pakadali pano amatha kulumikizana ndi mankhwalawa, zomwe zimawopsa. Nthawi zina, matupi a odwalawa amatha kukhala pachiwopsezo cha zovuta zomwe zimafalikira komanso zosakhala zoyipa za mankhwalawa koma kukula kwa zovuta kumatha kukhala kwakukulu kuposa masiku onse. 

 

Zotsatira zoyipa za Tadalafil Powder

Tadalafil Powder, monga mankhwala ambiri, ali ndi zovuta zingapo zomwe zimafunikira chifukwa chogwiritsa ntchito. Komabe, palibe ngakhale imodzi mwazochita zazikulu, zochitika zatsiku ndi tsiku zosintha, kapena zowopseza moyo. M'malo mwake, ambiri a iwo adzisankhira pawokha ndipo safuna kuchitapo kanthu kuchipatala. 

Zotsatira zoyipa za Tadalafil zimaphatikizapo, koma sizingokhala pa:

  • Mphuno ya Stuffy
  • litsipa
  • Dyspepsia
  • Kuwawa kwam'mimba
  • Kuthamanga; kutentha ndi kufiira kwa khungu
  • Tinnitus; kulira kosalekeza khutu
  • Mavuto akumva
  • Masomphenya a Blurry
  • Kutaya masomphenya
  • Kupembedza

Zotsatira zomaliza zimakhala zoyipa kwambiri ndipo zimatanthawuza erection yayitali komanso yopweteka yomwe yakhalapo, nthawi zambiri kuposa maola anayi. Zikatero, tikulimbikitsidwa kuti mupite kuchipatala mwachangu chifukwa ndizovuta, ngakhale zosowa, zoyipa za Tadalafil. 

Kuyambira Okutobala 2007, FDA ikufuna kuti zonse zomwe zili ndi PDE5 zoletsa mankhwala kuti zizikhala ndi chizindikiritso chomwe chimapangitsa ogwiritsa ntchito kudziwa kuti mankhwalawa amatha kupangitsa kumva kwakanthawi kwakanthawi. Lingaliro la FDA lidachitika chifukwa chodandaula zingapo zakumva kwa odwala omwe amagwiritsa ntchito Tadalafil kapena mankhwala omwewo omwe adalembetsedwa ndi FDA, kuwapangitsa kuti awunikenso bwino nkhaniyi. Kafukufuku wa FDA adapeza kuti kumva kwakumva kukhala zotsatira zoyipa za TAdalafil zomwe amakhulupirira kuti odwala onse ayenera kudziwitsidwa, momveka bwino, kuti athe kupanga chisankho chodziwitsa. 

Kuwonongeka kwa masomphenya kunalinso kudandaula pafupipafupi komwe kumalumikizidwa ndi kugwiritsidwa ntchito kwa Tadalafil ndipo FDA itayang'ana madandaulowa, zidapezeka kuti zotsatirazi zimachitika makamaka kwa odwala omwe ali ndi vuto la maso, omwe siopanga arteritic anterior ischemic optic neuropathy kapena NAION. Popeza panalibe chifukwa chenicheni ndi zotsatira zomwe a FDA adapeza, palibe chizindikiro chochenjeza chokhudzana ndi kutayika kwa masomphenya pa Tadalafil powder kapena zoletsa zina za PDE5 zolembera. 

 

Kugwiritsa Ntchito Mankhwala Osokoneza bongo ndi Tadalafil Powder

Mankhwala ena sayenera kumwedwa limodzi chifukwa amatha kuyanjana ndi aliyense chifukwa cha kuchepa kwa zonse ziwiri, kuwonjezeka kwa zonsezo, kapena kukulitsa zovuta za mankhwala onsewa. 

Tadalafil Powder ndi imodzi mwa mankhwala omwe sayenera kumwa pamodzi ndi mankhwala otsatirawa.

  • Maantacid: Mankhwalawa amalumikizana ndi Tadalafil kotero kuti amachepetsa kuchepa kwa mankhwalawa, ngakhale njira yake siyikudziwika. Komabe, ndikofunikira kuchenjeza odwala za kulumikizana komwe kungachitike pakati pa mankhwala awiriwa, makamaka popeza mankhwala omwe kale anali mankhwala wamba apabanja. 
  • PDE5 Inhibitors: Kugwiritsa ntchito mankhwala omwe ali ndi njira yofananira ndi Tadalafil kumatha kubweretsa kuwonjezeka kwakukulu kwa magazi komanso kuchepa kwa magazi. Kusakaniza ma PDE5 inhibitors awiri kapena kumwa kawiri mankhwala omwewo kumatha kubweretsa zovuta m'malo mopindulitsa. 
  • Mowa: Kutenga ufa wa Tadalafil ndi mowa sikungayambitse zovuta zina koma kungapangitse kuwonjezeka kwakukulu pakukula kwa zotsatirapo zake. Zitha kukhala zodziwika bwino koma zikawonjezeka, zimatha kupiririka ndipo zimafunikira chithandizo chamankhwala. 
  • Nitrate: Mankhwalawa amagwiritsidwa ntchito pazolinga zamtima ndipo ntchito yawo yayikulu ndikuwonjezera magazi kudzera mumitsempha yamagazi pokhala ndi mphamvu ya vasodilatory pa iwo. Njira yochitirayi ndi yofanana ndi ya Tadalafil, chifukwa chake kuphatikiza kwa mankhwala awiriwa kumakokomeza zovuta zoyipa zamankhwala onsewa.
  • Anti Hypertensives: Chifukwa cha izi ndi chimodzimodzi ndi nitrate. Anti hypertensives ndi Taladafil onse amagwira ntchito yochepetsera kuthamanga kwa magazi ndi zotengera za vasodilating, zomwe zikaphatikizidwa, zitha kutsika magazi kwambiri zomwe zitha kubweretsa imfa, ngati sizingalandiridwe.
  • CYP3A4 Inducers: CYP3A4 ndi enzyme yomwe imayambitsa kutulutsa kwa gulu la Tadalafil mthupi itakwaniritsa cholinga chake. Komabe, mankhwala omwe amachulukitsa zotsatira za mavitaminiwa amadzetsa kuwonjezeka kwa Tadalafil, ngakhale isanathe kukwaniritsa cholinga chake. Izi zimapangitsa omaliza kukhala osagwira ntchito komanso opanda ntchito. 
  • CYP3A4 Inhibitors: Mankhwala aliwonse omwe amaletsa mphamvu ya michere ya CYP3A4 angapangitse kuchepa kwa Tadalafil komwe kumatha kusiya dongosolo laumunthu nthawi yayitali kuposa momwe amafunikira. Izi zomwe zidatenga nthawi yayitali ndizosafunikira ndipo zitha kukhala zowopsa ponseponse, ndichifukwa chake kuphatikiza kwa awiriwa kuyenera kupewedwa zivute zitani. 
  • Zolimbikitsa za Guanylate Cyclase: Mankhwalawa amalunjika m'mapapu, pofuna kuchepetsa kuthamanga kwa magazi akuyenda. Komabe, ichi ndichimodzi mwazothandiza komanso kugwiritsa ntchito kwa Tadalafil. Kuwatengera awiriwa palimodzi kungapangitse kuthamanga kwa magazi m'mapapo, komwe kumatha kupha ngati sichichiritsidwa moyenera komanso munthawi yake. 

 

Kodi Tadalafil Powder Wagulitsidwa Kuti?

Malonda a Tadalafil a Powder ndiofala kwambiri kuposa kugulitsa monga amagulitsidwa ambiri kuchokera ku fakitale yopanga Tadalafil Powder. Nthawi zambiri, mankhwala amtundu wachinsinsi omwewa amagulidwa pa intaneti chifukwa amapatsa odwala nzeru komanso chinsinsi chomwe amafunikira. Mankhwalawa amapezeka m'ma pharmacies am'deralo komanso paintaneti koma odwala amafunika kukhala ndi mankhwala oti athe kugula. 

 

Kafukufuku Wina Wazachipatala ndi Zambiri

Tadalafil imafufuzidwa pafupipafupi ndikuwunikiridwa kuti iwunikire momwe angagwiritsire ntchito mankhwalawa. Tadalafil ndiye chinthu chofunikira kwambiri pamankhwala osiyanasiyana osiyanasiyana, onse omwe amagulitsidwa pansi pamazina osiyanasiyana, makamaka pamavuto monga erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Komabe, pali maphunziro osiyanasiyana omwe mgawo lawo loyamba awonetsa kuti Tadalafil, mtsogolomo, atha kuperekedwanso zovuta zina. 

Limodzi mwa maphunziro ofunikira kwambiri omwe akuchitidwa pa Tadalafil limayang'ana momwe lingagwiritsire ntchito chitetezo chake ngati agwiritsidwa ntchito tsiku lililonse ndi odwala omwe ali ndi vuto la erectile. Kafukufukuyu adasindikizidwa mu Indonesian Health Journal, ndipo potengera momwe ofufuzawo anafufuzira m'mabuku azamagetsi, zidatsimikiza kuti kugwiritsa ntchito Tadalafil kamodzi patsiku kumathandiza kwambiri kuthana ndi vuto la erectile kuposa kugwiritsa ntchito mankhwala akafunika. 

Chifukwa chomwe phunziroli ndilofunika ndichakuti lingathe kusintha njira zochiritsira zovuta za erectile. Komabe, maphunziro owonjezera amafunika kuchitidwa kusintha kusanachitike. 

Kafukufuku wina ku Tadalafil cholinga chake ndikubwezeretsanso mankhwala osokoneza bongo, komanso mankhwala omwe ali mgulu lomwelo, vardenafil, omwe adzagwiritsidwe ntchito pochiza matenda am'mafupa. Zovuta zam'mafupa pano zimatanthawuza zovuta zomwe ma osteoclast kapena maselo owononga mafupa akugwira ntchito mwachangu kwambiri komanso osagwirizana ndi magwiridwe antchito a ma osteoblast kapena maselo opanga mafupa. Izi zimapangitsa kuchepa kwa mafupa komwe kumapangitsa kuti odwala azitha kuphulika. 

Gawo la vivo la kafukufukuyu lawonetsa kuti mankhwala onsewa sangangowonjezera zochitika za ma osteoblast komanso nthawi yomweyo amachepetsa zochitika za ma osteoclasts. Mankhwalawa amatha kuchita izi chifukwa njira ya PDE5A ndiyofunikira pakupanga mitundu yonse yamaselo. Njira yomweyo ndiyomwe mankhwalawo amalunjika pochizira vuto la erectile. Pambuyo pakugwiritsa ntchito malingaliro a vivo pamitundu yazinyama ndi ofufuza omwe akutsogolera kafukufukuyu, zidapezeka kuti mankhwala onsewa ndi njira zabwino zowongolera mafupa athanzi. Komabe, maphunziro owonjezera akuyenera kuchitidwa pazotsatira zamankhwala onsewa pamafupa a anthu.  

Kusanthula kwa meta kofalitsidwa mu Endocrinology Journal kuyerekezera mphamvu ya mankhwala a tadalafil, mankhwala a tamsulosin, ndi tamsulosin kuphatikiza mankhwala a tadalafil pothandiza kuchotsedwa kwa miyala ya urethral. Cholinga cha phunziroli sichinali kungopeza njira zatsopano zothandizira odwala okhala ndi miyala yoberekera komanso kuwunika chitetezo cha mapulani awa. 

Kugwiritsa ntchito tadalafil yokha kapena tadalafil yokhala ndi tamsulosin ndi njira ziwiri zomwe zidapezeka kuti ndizothandiza kwambiri ndipo mwina sizingabweretse mavuto. Kuphatikiza apo, zotsatira za analgesic za Tadalafil zitha kuchepetsa ululu womwe odwala ambiri omwe amakhala ndi miyala ya ureteral pomwe mankhwalawa amathandizanso kutulutsa mwalawo m'dongosolo.