Urolithin A.

April 8, 2021

Urolithin A yawonetsedwa kuti imalimbikitsa mitophagy ndikusintha thanzi la nyama mu nyama zakale komanso zitsanzo za ukalamba. Pakadali pano, awonetsanso kuti adutsa chotchinga chaubongo wamagazi, ndipo atha kukhala ndi zoteteza ku matenda a Alzheimer's.

Urolithin A (1143-70-0) kanema

Urolithin A (1143-70-0)zofunika

Name mankhwala Urolithin A ufa
Mankhwala Name 3,8-dihydroxy-6H-benzo [c] chromen-6-m'modzi;

3,8-Dihydroxy-6H-dibenzo (b, d) pyran-6-m'modzi;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo [c] chromen-6-m'modzi;

6H-Dibenzo [b, d] pyran-6-one, 3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

Nambala ya CAS 1143-70-0
InChIKey Kufotokozera: RIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
Maselo Fmphutsi C13H8O4
Maselo Wasanu ndi atatu 228.2 g / mol
Misa ya Monoisotopic 228.042259 g / mol
Mfundo yosungunula 340-345 ° C
Malo otentha  527.9 ± 43.0 ° C (Wonenedweratu)
Pophulikira 214.2ºC
Halimo Half-Life Urolithin A amapezeka mumkodzo mpaka maola 48 mutatha kumwa makangaza.
mtundu Yoyera mpaka beige
Szovuta  DMSO: 20 mg / mL, momveka bwino
Smazunzo Tkutentha  2-8 ° C
Amalingaliro Kugwiritsidwa ntchito ngati chowonjezera chakudya komanso mankhwala odana ndi ukalamba, atha kugwiritsidwa ntchito kuchepetsa kutupa ndikulimbana ndi khansa;

 

Tsamba:

[1] Garcia-Munoz, Cristina; Vaillant, Fabrice (2014-12-02). "Thupi la Metabolic la Ellagitannins: Zokhudza Zaumoyo, ndi Kafukufuku Wokhudzana ndi Zakudya Zosintha Zatsopano". Ndemanga Zoyipa mu Science Science ndi Zakudya Zabwino. 54 (12): 1584–1598. onetsani: 10.1080 / 10408398.2011.644643. YAM'MBUYO MAFUNSO OTHANDIZA:

[2] Ryu, D. et al. Urolithin A imathandizira kusintha kwa mitophagy ndikuchulukitsa moyo wa C. elegans ndikuwonjezera kugwira ntchito kwa makoswe. Nat. Med. 22, 879-888 (2016).

[3] "Chidziwitso cha FDA GRAS GRN Na. 791: urolithin A". Ulamuliro wa Zakudya ndi Mankhwala ku US. 20 Disembala 2018. Chotsatira 25 August 2020.

[4] Singh, A .; Andreux, P .; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). "Urolithin A wothandizidwa pakamwa ndi otetezeka ndipo amasintha mitundu ya minofu ndi mitochondrial biomarkers okalamba". Kukalamba mu Ukalamba. 1 (suppl_1): 1223–

[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Chitetezo cha kuwunika kwa urolithin A, metabolite wopangidwa ndi m'matumbo a microbiota pakudya zakudya zamasamba zotengera ellagitannins ndi ellagic acid". Chakudya ndi Chemical Toxicology. 108 (Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.