Omwe adamvapo kale Nicotinamide Adenine Dinucleotide (NAD +) kapena “Kasupe wa unyamata”? ” Ndikudya mokwanira komanso kuchita masewera olimbitsa thupi, thupi lanu nthawi zambiri limapangidwa kuti lizikhala ndi metabolism yoyenera.

Mwatsoka, ndi matenda, ukalamba ndi / kapena moyo zilakolako zoipa, thupi wanu wayamba kukumana deficiencies zosiyanasiyana kuti kuona dzuwa kuchepa ake ochuluka. Mitengo yochepa ya nicotinamide adenine dinucleotide (NAD +) ili m'gulu la zofooka, ndipo ndi pomwe pali. Nad + zowonjezerazo akubwera imathandiza kutseka mu kusiyana akusowa, makamaka popititsa patsogolo thanzi ukalamba ndondomeko.

Nicotinamide adenine dinucleotide (NAD) amatanthauza coenzyme wopanga ma adenine onse ndi nicotinamide. Aliyense selo moyo uli pawiri izi mankhwala, zomwe ndilochokera ku Nicotinamide Riboside. Miyezo ya NAD m'thupi la munthu imathandizira kuchuluka kwake kukalamba.

Pali mitundu iwiri ya NAD, yomwe ndi, nicotinamide adenine dinucleotide (NAD +) ndi nicotinamide adenine dinucleotide (NAD) + hydrogen (H) (NADH). Akale ali ma elekitironi ziwiri zowonjezera, ndi kuti ndi chiyani zimasiyanitsa otsiriza.

NAD + 01

Kodi NAD + ndi chiyani?

Nicotinamide adenine dinucleotide (nad +) ndi pyridine nyukiliotayidi kuti 'm pano ndi zofunika kwambiri iliyonse selo lamoyo. Izi pyridine nucleotide imathandizira njira zambiri mwachilengedwe momwe imagwirira ntchito ngati chinsinsi cha cofactor komanso gawo lapansi. Njirazi zimaphatikizapo kupanga mphamvu, kukonza bwino za DNA ndikukonza, kugwiritsira ntchito katemera komanso kutulutsa majini. Amene akufotokoza nad + okalamba chizindikiro kusintha mphamvu.

NAD + imakhalanso ndi gawo lofunikira kwambiri pamthenga wachiwiri wa siginecha komanso ntchito za immunoregulatory.

Monga molekyulu wachinyamata, NAD + yadziwika kuti ndi yofunika kwambiri kukalamba. maphunziro osiyanasiyana anathandiza malo kuti madzi nad + mu thupi la munthu lili ndi malumikizanidwe mwachindunji ndi kuchepa kwa msinkhu wa munthu. Akuluakulu a NAD + amakhala ocheperako, maselo amthupi, minofu ndi mawonekedwe athupi lonse. Izi ndizo maziko a kutchuka kwa kukalamba kwa NAD +.

Kumbali ina, kuchepa kwa NAD + kumatha kubweretsa kutopa ndi matenda osiyanasiyana. Monga, okwanira nad + misinkhu ndi mosakayikira zofunika kuti thanzi la munthu.

Kodi NAD + Imagwira Bwanji?

Pamene thupi lanu sangathe kukwaniritsa wathanzi enzyme ndi timadzi milingo kupanga izo zikuyamba nkhani kuwonetseredwa zosiyanasiyana umoyo monga wotsikirapo see, nkhani kukumbukira ndi mlingo wotsikirapo maganizo. Izi ndichifukwa choti mulibe magawo okwanira a NAD + ndi NADH kuti athandizire kubadwanso kwina ndi magwiridwe antchito a maselo amthupi.

Makamaka, fungulo NAD + ntchito ndi kuthandiza thupi Poyankha kagayidwe kachakudya, ndi kuwapangitsa kulanda ma elekitironi ku molekyulu ndi mzake, mwa ndondomeko yodziwika monga redox anachita. Kudzera kwa redox, michere imatha kumasula mphamvu zomwe zimasungidwa mu oxygen yochepa kwambiri ya oxygen.

Nthawi zambiri, maselo a thupi lanu amafunika mphamvu kuchokera m'magazi kuti awalimbikitse kuchita ma metabolic angapo. Makamaka, mphamvu imafunika awasungira monga zidulo mafuta ndi shuga. Chifukwa chake, gawo loyambirira la NAD + enzyme pano ndikuthandizira kayendedwe kazinthu zamagetsi kuchokera kumagazi kupita ku maselo oyenerera.

Pamene mafuta acids ndi glucose amasulidwa mphamvu, NAD + enzyme imathandizira kayendedwe kazinthu zamagetsi kupita ku mitochondria kuti ikasanduke mphamvu yama cell. Kupanda kutero, ngati vuto la NAD + likusowa, kusintha kwa mphamvu mu cell kumasokonekera, ndipo izi zimayambitsa kusokonekera kwa mitochondrial, komwe kumathandizira kukalamba.

NAD + 02

Pakuti yense NADH, nad + amatha kupanga mamolekyulu ATP atatu. Chifukwa cha mphamvu ya maselo, mumakhala olimba, onse m'maganizo komanso m'thupi, chifukwa NAD + yapereka njira zanu zokhudzana ndi ukalamba kuti zizikulitsa.

Mwachindunji, waukulu nad + ntchito kumaphatikizapo mphamvu michere udindo zochita redox mu thupi. Ma enzyme amenewa amadziwika pamodzi kuti ndi oxidoreductases. Zikuphatikizapo Sirtuin michere (SIRT), pole-ADP-ribose polymerases ndi ozungulira ADP ribose hydrolase (CD38).

Poganizira za kutsegula kwa Sirtuin, ndikofunikira kudziwa kuti ntchito yoyamba ya michere ya Sirtuin ndikuzimitsa majini omwe amathandizira kukalamba. Mitunduyi imaphatikizanso omwe amatenga nawo gawo pazomwe zimapangidwira mafuta ndikusunga, zotupa komanso malamulo a shuga wamagazi. Pakuti sirtuin michere kukwaniritsa kuti, imafunika nad + michere monga awa mamolekyulu nad kuwathandiza kubudula magulu Tingafinye acetyl kwa mapuloteni kwa kusinthidwa.

Chifukwa chake, kuwonjezeka kwa milingo ya NAD + kumasulira kukhala kuchuluka kwa Sirtuins. Izi zimapangitsa kuwonjezera kupumira kwa mitochondrial komanso kumva mphamvu ya insulin.

Zotsatira za kusinthika kwa kagayidwe kameneka kumabweretsa kusinthika kwa mphamvu ya kukalamba kwa ubongo, chifukwa cha mphamvu ya kukalamba ya NAD +. Komanso, bwino insulin tilinazo amathandiza thupi lanu kukhalabe shuga athanzi. Choncho, maselo thupi kuoneka ang'ono ndi Makhalidwe anu zambiri za unyamata, akukupatsa ndi ambiri kwambiri unyamata tione komanso.

Kuphatikiza apo, NAD + yazindikiridwa ngati molekyulu yomwe imayambitsa kwambiri ma signation akunja, omwe amapanga maziko a kulumikizana kwa ma cell. Komanso, imagwira ntchito ngati ma neurotransmitter, yotumiza chidziwitso kuchokera ku mitsempha kupita ku maselo othandizira a minofu.

Ubwino / Ntchito ya NAD +

Pali zambiri Mapindu a NAD ndi ntchito zomwe zikuphatikiza:

1.Protection kwa zaka okhudza zinthu osachiritsika

The nad + odana okalamba ubwino ndi zina mwa zifukwa zazikulu zimene anthu thanzi-savvy akufuna aone nad + milingo wathanzi nthawi zonse. Pamene anthu akukalamba, kuwonongeka kwawo kwa DNA kumawonjezeka, ndipo izi zimayambitsa kuchepa kwa ma NAD +, ntchito ya SIRT1 ikuchepa ndikuchepetsa ntchito ya mitochondrial. Izi zimachitika chifukwa cha kuphatikiza kwa ma cellular oxidative, komwe, mu chilankhulo cha layman, kumatanthawuza kuti ma antioxidants a thupi ndi mafayilo aulere samagwirana.

Zotsatira zake, munthu wokalamba amatha kutenga zovuta zosiyanasiyana zamatenda monga atherosulinosis, matenda amtima, nyamakazi, matenda am'mimba, matenda ashuga komanso matenda oopsa.

Mwamwayi, kafukufuku wambiri akuwonetsa kuti NAD + imapereka chitetezo cha oxidative pama cell a thupi. Choncho, kutenga nad + zakudya zowonjezera kapena mukutengera zikunena ena kusintha nad + mlingo akhoza kuthandiza anthu okalamba, makamaka amene ali kutsidya lina zaka 50, kukhala ndi thanzi labwino ngakhale pamene anakhala awo pa ukuwonjezeka lapansi.

NAD yowonjezera + imathandizira magwiridwe antchito ndikuthandizira kukula kwa mitochondria. Zimagwira ntchito yofunika kwambiri pakukonza milingo ya ATP yokwanira m'maselo, zomwe zikanapanda kusokonezedwa ndi ukalamba wambiri.

mpumulo 2.Fatigue

Monga tanena kale, NAD + imathandizira kupangira mphamvu kwa mitochondria ya thupi lanu. Ma mitochondria anu akapanda kupanga mphamvu zokwanira, ziwalo zofunika monga mtima, ubongo, minofu ndi mapapu sizitha kuchita bwino ndipo zimapangitsa kutopa komanso kuchepa mphamvu.

Komano, pamene thupi lanu lili okwanira nad + msinkhu, ziwalo zimenezi ndi wokhoza kuchita misinkhu thanzi ndi chifukwa mumaona amayesetsa, kuwalimbikitsa tikuyamba ndi malingaliro bwino. Iri yonse yochepetsetsa wamoyo ayenera coenzyme monga kulimbikitsa ulimi wa adenosine triphosphate.

Maselo amagwiritsa ntchito adenosine triphosphate kuti apange mphamvu zomwe ziwalo zanu zosiyanasiyana zimafunikira pakuchita komwe mukufuna. Thupi lanu likapatsidwa mphamvu, maselo anu amatha kulimbana ndi kutopa konse.

NAD + 03

3.Kuchita bwino kwa ubongo

Kutopa kumachepetsa ntchito yanu yazidziwitso. Mumamva ngati maganizo anu ndi chimbuuzi kapena mitambo. Komabe, tawona kale kuti NAD + imapereka mpumulo wotopa. Chifukwa chake, coenzyme imathandizira kuti ubongo wanu ugwire ntchito poyambitsa mphamvu zochuluka za maselo muubongo wanu, ndikuwathandiza kuthana ndi kutopa. Chifukwa, malingaliro anu tcheru ndi amayesetsa zokwanira bwino ntchito zosiyanasiyana zimene amafuna inu kuganiza.

4.Improved khungu maganizo kukaniza

Pakufufuza kwina komwe kunayambitsa kukhazikitsa zovuta za NAD + pazovuta zama cellular oxidative, ofufuza adazindikira kuti Chithandizo cha NAD + zinapangitsa kuti ma cell labu azikhala osapanikizika kwambiri. Kumbali inayo, maselo omwe sanaperekedwe ndi NAD + adagwiritsa ntchito kupsinjika kwa oxidative. Chifukwa chake, zikutanthauza kuti coenzyme iyi imakulitsa nthawi yamoyo ya maselo a mthupi, kuthandiza thupi lanu kuthana ndi zinthu zosiyanasiyana zoyambitsa matenda mokwanira.

Kukonza kwa 5.DNA kwa nthawi yayitali

M'moyo wanu watsiku ndi tsiku, mumadziwika zinthu zosiyanasiyana zomwe mwina zitha kuwononga DNA yanu. DNA yowonongeka imafupikitsa moyo wanu. Komabe, ndikupereka zokwanira za NAD + mthupi lanu, ma coenzymes amenewa amathandizira kukonza kwa zowonongeka poyendetsa ma elekitron kumadera omwe ali ndi DNA yowonongeka. Izi zikutengera maphunziro ambiri omwe abwera ndi lingaliro loti kubwezeretsanso kwa NAD + kumawonjezera moyo wa nyama kapena munthu.

6.Kudya kugona komanso kudya

Ofufuza osiyanasiyana adazindikira kuti NAD + imakhudzanso modabwitsa momwe munthu amagonera komanso njira yanjala. Nthawi yomwe mumagona kapena kudzuka komanso kutuluka kwa tsiku lanu labwinobwino zimadalira mtima wanu. Komanso, kupanga kwa mahomoni am'madzi m'thupi lanu kumachitika chifukwa cha mankhwala.

Kulumikizana koyenera pakati pa sirtuins ndi Zotsatira za NAD + pamtima wachikondi wamanjenje. Kupanda kutero, kusokonezeka kwa NAD + kapena sirtuins kumayambitsa phokoso losavomerezeka la circadian, mwakutero kudya kosavomerezeka ndi mawonekedwe ogona. Chifukwa chake, NAD + imakhala yothandiza kuti mugone mokwanira komanso muzolowera kudya. Ndi awa pawiri, zidzakhala zosavuta kuti mukhale ndi thanzi labwino.

Mwa kupereka ntchito zabwino zonse pamwambapa, palibe kukayika kuti NAD + ili ndi gawo lofunikira kwambiri lothandizira anthu kukhala ndi moyo wathanzi ngakhale atakalamba.

Kugwiritsa / Ntchito kwa NAD +

1.Ndalimbitsa kuphunzira ndi kukumbukira

Anthu ambiri amadziwa kuti mankhwala awa amapatsa zachilengedweNAD + 04

Kubwezeretsa ndi kukonza njira za neural mu ubongo.

Kupatula apo, amachotsa kutopa kwamaganizidwe komanso, potero kumapangitsa kuti kumveketsa malingaliro.

Zotsatira zake, munthu amatha kuphunzira ndikukumbukira bwino kwambiri.

Misomali 2.Thicker ndi tsitsi

Misomali ndi tsitsi zimawonedwa kwambiri pofotokoza kukongola kwa munthu, makamaka akazi. Chifukwa cha kuthekera kwake kulimbikitsa kukonza kwa DNA yowonongeka, NAD + ndiyofunikira kwambiri misomali ndi tsitsi lakuda. Mwakutero, ndi mankhwala omwe amafunidwa kwambiri kwa anthu omwe amakhudzidwa ndi tsitsi lawo loonda / / kapena misomali.

3.Better khungu thanzi

Ukalamba pakati pa anthu umabwera ndi zolakwika pakhungu monga makwinya, mizere yabwino komanso mawonekedwe osasinthika. Komabe, iwo amene akufuna kupeputsa zizindikiro za ukalamba amatenga zowonjezera za NAD +, zomwe zimagwira bwino ntchito ndicholinga. The Kukalamba kwa NAD + kupindula kumatchuka kwambiri.

4.Muscle ntchito bwino

Pamene anthu akukalamba, amakhala ofupika ndi ofooka chifukwa cha kusokonezeka kwa minofu komwe kumadza ndi ukalamba. Komabe, iwo omwe apeza mphamvu yotsutsa kukalamba kwa NAD + yowonjezera pa izo kuti athe kukonza minofu yawo.

5. Kupanga matenda okalamba

Kuphatikiza apo, anthu omwe ali ndi NAD + yochepa m'matupi awo chifukwa cha ukalamba amayang'ana kunja kwa mankhwala opanga mphamvu kuti chitetezo chawo chikhale chokwanira. Kuphatikiza kowonjezereka kwa enzyme kumapangitsa kuti matupi awo azitha kukana mwamphamvu matenda osiyanasiyana ogwirizana ndi ukalamba.

Mlingo wa NAD +

Ngakhale NAD + ndi malo achilengedwe, iyenera kutengedwa mosamala. Malinga ndi bungwe la Food and Drug Administration (FDA), lotetezeka kwambiri Mlingo wa NAD + pafupifupi magalamu awiri patsiku. Nthawi yolimbikitsidwayo ndi masiku 7 mpaka 16, kutengera mbiri ya chipatala ya wogwiritsa ntchito.

Zotsatira zakugwa NAD + Levels

Ndizofunikira kwambiri kwa aliyense kuti awonetsetse kuti ali ndi magulu a NAD + okwanira. Kuchulukana

Zambiri za NAD + ndizofunikira kwa anthu omwe ali ndi vuto la NAD +. Izi ndichifukwa choti kuperewera kwa NAD + kuli ndi zotsatira zingapo zosavomerezeka kuphatikizapo:

1. Zizindikiro zaukalamba

Mwa munthu wachichepere, NAD + ndi NADH ndizochulukirapo poyerekeza ndi misinkhu yomwe imapezeka mwa anthu achikulire. Kuchepetsa magawo a NAD + ndi ukalamba kumabweretsa kuchepa kwa ntchito ya SIRT1, motero kufulumizitsa kuchitika kwa zizindikiro za ukalamba. Zikatero, njira yothandiza kwambiri yosinthira kapena kuletsa zizindikirazi ndi kukulitsa mulingo wa NAD + m'thupi. Ndi mphamvu ya coenzyme imayambitsa zochitika zambiri za SIRT1, motero kukhala ndi mawonekedwe omvekanso bwino mthupi ndi kumverera.

NAD + 05

2. Hypoxia

Hypoxia ndi mkhalidwe womwe umadziwika ndi kuperewera kwa okosijeni mthupi la munthu. Mkhalidwewo umatsogolera ku NADH yowonjezereka ndi NAD yotsika + ndipo amadziwika ndi zizindikiro monga kusungunuka pakhungu, chisokonezo, kuchepa kwa mtima, kupuma movutikira, thukuta komanso chifuwa chosalekeza.

Anthu omwe akuvutika ndi hypoxia amatha kupeza mpumulo pazizindikiro powonjezera kuchuluka kwawo kwa NAD +. Omwe ali pachiwopsezo chachikulu cha vutoli atha kuchepetsanso chiwopsezo chawo mwa kukulitsa misinkhu yawo ya NAD +.

3. Kutentha kwa dzuwa komanso kuwonongeka kwa khungu

Mantha kutentha kwa dzuwa kapena kuwonongeka kwa khungu chifukwa cha kuwala kwa dzuwa? NAD + ndi NADH ndakuphimbirani. Onsewa amapereka khungu lanu kutetezedwa ndi dzuwa komanso khansa yapakhungu pofinya mawonekedwe a UVB ndi UVA, motsatana.

4. kutopa

Ngati mukumva kutopa kodabwitsa komanso kufooka kwa thupi, mutha kukhala otsika kwambiri a NAD +, motero kuchepetsa ntchito za SIRT1. Zikakhala conco, NADH kapena NAD + yowonjezera ikhoza kutsitsimutsa zizindikiro za kutopa kudzera pakulimbikitsa ntchito ya mitochondria.

5. Matenda a zamadzimadzi

Pogwiritsa ntchito ma Sirtuins, NAD + imasintha ntchito za majini osokoneza bongo mwachindunji. Monga, anthu omwe ali ndi mavuto owongolera kulemera chifukwa cha kuchepa kwa metabolism amatha kukwaniritsa kuchuluka kwawo komwe akufuna kudzera NAD +. Izi zitha kukhalanso yankho labwino kwa inu ngati mukuopa kufooka kapena kulemera kwambiri kwa LDL cholesterol chifukwa chokhala mukusokonekera kwa metabolism.

6. Matenda a mtima

NAD + ntchito mthupi imayendetsa zochitika za mitochondria, zomwe ndizofunikira kuti mtima ugwire bwino ntchito. Kuperewera kwa mankhwala opangira mankhwala kumatha kufulumizitsa kulephera kwa mtima, chinthu chomwe palibe amene angafune kuti akumane nacho. Chifukwa chake, ngati muli ndi magawo otsika a Nicotinamide Adenine Dinucleotide (NAD +), mwina chifukwa cha kuvulala kwa ischemia-reperfusion kapena matenda ena aliwonse amtima, mudzamva bwino ndipo thanzi la mtima wanu lidzasintha pakakulitsa chakudya cha coenzyme mthupi lanu.

7. Multiple Sclerosis (MS)

Kuvutika ndi multiple sclerosis? Ngati inde, ndiye kuti muyenera kulingalira ndikupopera pazopindulitsa za NAD + ufa kudzera Nad + zowonjezerazo kudya matendawo chizindikiro.

Multiple Sclerosis imadziwika ndi gawo lotsika la NAD + mu chitetezo cha mthupi pomwe mphamvu yamanjenje imakumana ndi kuchepa komweku. Kuphatikiza kwa NAD + kumachepetsa kuchepa kwa mankhwala omwe amapezeka mu dongosolo lamanjenje, potero kusintha kusintha kwanu kwa MS.

8. Thanzi lam'maganizo ndi machitidwe a neurodegenerative

Ngati mukukumana ndi thanzi la m'maganizo kapena vuto la neurodegenerative monga matenda a Alzheimer's, matenda a Parkinson kapena stroke, ndiye kuti kuwonjezeredwa kwa NAD + kumakhala kothandiza pobwezeretsa thanzi lanu. Izi ndichifukwa choti izi zimayambitsa Kuperewera kwa NAD +, kutsogolera kuchepetsedwa kwa mphamvu ya ubongo wanu ndi dopamine. Popeza mphamvu zamagetsi ndi dopamine ndizofunikira kwambiri m'malingaliro anu amanjenje ndi amanjenje, zizindikiro zanu zimatha kuwonongeka ngati simupeza njira yowonjezera kuchuluka kwa NAD + yanu.

NAD + 06

Kodi Mungakulitse Bwanji Magulu a NAD + Mwachilengedwe?

1. Kuchita masewera olimbitsa thupi

Mukamakula, zolimbitsa thupi ndizofunikira kuti mukhale ndi thanzi. Ndi masewera olimbitsa thupi olimbitsa thupi nthawi zonse, mphamvu ya thupi lanu yopanga NAD + imapatsidwa mphamvu. Mumafunikira mphamvu kuti muchite masewera olimbitsa thupi. Chifukwa chake, mukakhala zolimbitsa thupi, thupi lanu limatulutsa mphamvu polimbikitsa mphamvu zapamwamba za mitochondria. Zotsatira zake, mulingo wanu wa NAD + umachuluka mwachilengedwe.

2. Kusala kudya pafupipafupi

Ngakhale kusala kumachitika makamaka ngati njira yodzipatulira kwachipembedzo, ilinso ndi mapindu osiyanasiyana azaumoyo omwe angapereke, kuphatikizapo kuwonjezera kuchuluka kwa NAD + ndi kuyambitsa kwa SIRT1.

3.Kukwera nthawi yayitali dzuwa

Ma radiation a ultraviolet ochokera ku dzuwa amawonjezera kukalamba kwa khungu lanu. Choyipa chachikulu, kuwonekera kwambiri ndi dzuwa kumawononga mashopu omwe amathandizira kukonza maselo owonongeka a khungu. Izi zimabweretsa kutsika kwa NAD +. Mwakutero, kuti izi zisachitike ndikuthandizira thupi lanu kukhalabe ndi thanzi la NAD + popewa kuwunika kambiri ndi dzuwa nthawi iliyonse yomwe mungathe. Komanso, dzitetezeni ku zowopsa za dzuwa pophimba khungu lanu ndi dzuwa labwino mukamatuluka panja dzuwa likuswa.

4. Kutenga NAD + chowonjezera

Ngakhale zakudya zopatsa thanzi moyenera ndi msana wa chakudya chokwanira cha NAD + m'matupi athu, nthawi zina china chochita. Makamaka, anthu azaka makumi asanu amafunikira NAD yochulukirapo kuposa zomwe zakudya wamba zomwe zimatha kupereka. Poterepa, zowonjezera-NAD-zomwe zimaphatikizidwa zimabwera. Izi zowonjezera zimabwera mu mawonekedwe a makapisozi ndipo ndizosavuta kupeza. Muli mavitamini B50 (nicotinamide riboside) omwe amasinthidwa pambuyo pake kukhala NAD + m'thupi.

5. Kugona mokwanira

Kugona mokwanira tsiku lililonse ndi njira ina yachilengedwe yolimbikitsira misempha ya mankhwala okana kukalamba. Kupumula kwabwino kumalimbikitsa kupanga injini zaku thupi m'thupi lanu.

6.Kudya zakudya za NAD +

Ofufuza adziwa kuti, nicotinamide riboside, mawonekedwe a vitamini B3, amasintha kukhala NAD + m'thupi. Ma coenzymes, monga NAD + yopangidwa ndi thupi, amagwiritsidwa ntchito m'njira zosiyanasiyana zomwe zimapangitsa kuti kuchepetsedwa kapena kubwezeretsanso ukalamba mthupi la munthu. Mwakutero, zakudya zomwe zimakhala ndi vitamini iyi (zakudya za NAD +) zimatha kupereka zowonjezera zabwino za NAD +.

Zakudya zomwe zimakhala ndi nicotinamide riboside, komanso zomwe mungadalire kuti musinthe gawo lanu la NAD + mwachilengedwe zimaphatikizapo:

  • Mkaka wa mkaka: Kafukufuku akuwonetsa kuti mkaka uliwonse wa mkaka wa ng'ombe muli 9 μmol ya NAD +.

Nsomba: mitundu ina ya nsomba monga nsomba ndi nsomba ndi zambiri mu NAD +. Zomwe zili mu NAD + mu kapu imodzi ya nsomba ndi pafupifupi 20.5mg ndi 10.1mg kwa nsomba.

  • Bowa wa Crimini: Ngati mutatenga kapu yayikulu ya Crimini Mushroom, mupereka thupi lanu ndi 3.3mg ya NAD +.
  • Nyama yankhuku: kaya yapala, yokazinga kapena yokazinga, chikho chimodzi cha nyama yankhuku ikupatseni 9.1mg ya NAD +.
  • Zakudya za yisiti: Yisiti ndi gwero lolemera la NAD + poyerekeza ndi mkaka wa mkaka. Chifukwa chake, zakudya yisiti monga makeke ndi buledi zimatha kupangitsanso kuchuluka kwa NAD + mthupi lanu. Ngakhale ma mowa amathanso kukhala gwero la coenzyme, amayenera kumwedwa pang'ono.
  • Ma veggies obiriwira: Mitengo ina yobiriwira ilinso Zakudya za NAD + , makamaka nandolo ndi katsitsumzukwa, ali ndi chuma chochulukitsa mu mankhwala opangira achinyamata NAD +. Kapu ya nandolo imakhala ndi 3.2mg ya NAD + pomwe kapu ya katsitsumzukwa imakhala ndi 2mg ya gulu.
  • Kuzindikira zakudya za ketogenicKukhala mwa zakudya za keto kumatanthawuza kudziletsa pazakudya zomwe zili ndi mafuta koma otsika mafuta. Mukalandira chakudyachi, thupi lanu limalowa mkhalidwe lotchedwa ketosis pomwe limagwiritsa ntchito mafuta m'malo ndi glucose mphamvu. Izi zimapangitsa kuchuluka kwa NAD + mpaka NADH kuchuluka.

NAD + 07

Zina Zomwe Zikukula NAD +

Magulu a NAD + otsika amatha chifukwa cha zinthu zingapo kuphatikiza:

1. Kutupa kosalekeza

Kutupa kosafunikira kumalepheretsa enzyme ya NAMPT ndi majini omwe amayambitsa mtundu wa circadian. Zotsatira zake, milingo ya NAD + imatsika.

2. Kusokonezeka kwa miyambo ya Circadian

Kupanga kwa NAD + kumafuna enzyme ya NAMPT, makamaka mu gawo lomaliza la njirayi. Komabe, pamene phokoso la circadian likasokonekera, majini omwe amayambitsa kupanga enzymeyo amawonongeka ndipo chifukwa chake, kupanga kwa NAD + m'thupi kumachepa.

3. Kuchuluka kwa shuga ndi magazi

Miyezo ya shuga yamagazi ndi insulini ikachuluka kwambiri, kuchuluka kwa NADH / NAD + kumawonjezeka. Izi zikutanthauza kuti kuchuluka kwa NADH ndikokwera kwambiri poyerekeza ndi mulingo wa NAD +.

4. Mowa mopitirira muyeso

Kafukufuku wambiri akuwonetsa kuti kupanikizika kwa ethanol chifukwa cha Mowa wambiri zimayambitsa kuchepa pafupifupi 20% pama NAD +. Izi ndichifukwa chakuti mowa umayambitsa kuwonongeka kwakanthawi kwa oxidative komwe kumasokoneza kupanga coenzyme.

5. Kuwonongeka kwa DNA

DNA ikawonongeka kwambiri, ma molekyulu enanso a PARP adzafunika kuteroNAD + 08

kukonza ndi kubwezeretsa magwiridwe antchito a DNA yowonongeka. Popeza mamolekyulu ali

yoyendetsedwa ndi NAD +, chifukwa chake zikutanthauza kuti kutengapo gawo kowonjezereka kungathe

onani kuchepa kwa mankhwala m'thupi la wovulalayo.

6. Zochita za sirtuin zochepa

Poona kuti sirtuin imayang'anira gawo la circadian, kuchepetsedwa kwa ma Sirtuin kungapangitse zovuta kuzungulira kwa circadian. Zotsatira zake, mulingo wa NAD + umachepa.

Kodi Pali Zotsatira Zina Zokhudza NAD +?

Mwambiri, kuphatikiza kwa NAD + ndi kotetezeka konse. Kafukufuku waumunthu omwe adachitidwa kuti akhazikitse chitetezo kuti chiwonjezere coenzyme mthupi zimawonetsa kuti kuchuluka kwa 1,000mg mpaka 2,000 mg NAD + tsiku lililonse sikunawononge anthu.

Komabe, pali zochitika zingapo pomwe zovuta zoyipa zanenedwa kuti zimachitika chifukwa cha kudya kwa NAD +. Zotsatira zake zimaphatikizapo nseru, kudzimbidwa, kupweteka mutu, kutopa kwambiri (kutopa) komanso kutsegula m'mimba

Zambiri za NAD +

NAD + ufa, womwe umagwiritsidwa ntchito popanga NAD + zowonjezera, ndi yoyera, ya hygroscopic komanso yosungunuka kwambiri m'madzi. Mitundu ya mankhwala a NAD + ufa is C21H27N7O14P2.

Ngati ndinu opanga ovomerezeka komanso mukufuna NAD + ufa wa NAD + kuwonjezera zida, onetsetsani kuti mwachipeza kuchokera ku mbiri yabwino kuti mupewe kugula zachinyengo. Muyenera kutsimikizira kuti mukuchita ndi wogulitsa wodalirika mukamagula zowonjezera za NAD +. Dziwani kuti mutha kuyitanitsa mosavuta NAD + ufa kapena NAD + zowonjezera pa intaneti.

Kutsiliza

NAD + coenzyme ndi molekyu yomwe imagwira ntchito yofunika kwambiri pa thanzi la munthu. Zopindulitsa za NAD +, zomwe zimaphatikizapo thanzi labwino lamaganizidwe, kukana kupsinjika ndi kukonza kwa DNA, zimayang'ana zotsatira zoyipa zingapo zomwe zimagwirizanitsidwa ndi kuphatikizika kwa coenzyme. Kupatula apo, phindu la kukalamba kwa NAD + ndichinthu chomwe omwe akufuna kupeputsa zizindikiro za ukalamba ayenera kuyang'anitsitsa kudzera mu zowonjezera za NAD +. Komabe, ndikofunikira kuti muwonetsetse kuti mukupeza paketi yanu ya Nicotinamide Adenine Dinucleotide / NAD + kapena NAD + yowonjezera kuchokera ku gwero lodalirika.

Zothandizira
  1. Anderson RM, Bitterman KJ, Wood JG, et al. Kuwongolera kwa msewu waukadaulo waukadaulo wa NAD + kuchedwetsa ukalamba popanda kusintha magawo okhazikika a NAD +. J Biol Chem. 2002 Meyi 24; 277 (21): 18881-90.
  2. Gomes AP, Price NL, Ling AJ, et al. Kukhazikika kwa NAD (+) kumapangitsa dziko kukhala pseudohypoxic limasokoneza kulumikizana kwa mitochondrial paukalamba. 2013 Dec 19;155(7):1624-38.
  3. Imai SI, Guarente L. NAD ndi masisitini okalamba ndi matenda. Amakonda Cell Biol.2014 Aug;24(8):464-71.
  4. Mtengo NL, Gomes AP, Ling AJ, et al. SIRT1 imafunikira kutsegula kwa AMPK komanso zotsatira zabwino za resveratrol pa mitochondrial function. Ma Metab Cell. 2012 Meyi 2; 15 (5): 675-90.
  5. Satoh MS, Poirier GG, Lindahl T. NAD (+) - wodalira kukonza kwa DNA yowonongeka ndi ma cell amtundu wa anthu. J Biol Chem. 1993 Mar 15; 268 (8): 5480-7.
  6. Sauve AA. NAD + ndi vitamini B3: kuchokera ku metabolism kupita ku mankhwala othandizira. J Pharmacol Exp Ther. 2008 Mar;324(3):883-93.

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