Kodi pyrroloquinoline quinone (pqq) ndi chiyani?

Pyrroloquinoline quinone (PQQ) yemwe amadziwikanso kuti methoxatin ndi ufa wofanana ndi vitamini cofactor wopezeka muzakudya zambiri zam'mera. PQQ imapezekanso mwachilengedwe mkaka wa m'mawere amunthu komanso zimakhala zazikazi.

Komabe, zimapezeka pang'onopang'ono pazakudya zokha pqq ufa wambiri kupanga ndikofunikira kuti mupeze zokwanira mthupi.

PQQ koyambirira idapezeka ngati coenzyme m'mabakiteriya omwe ntchito yake inali yofanana ndi ya B-Vitamini mwa anthu, ndipo amathandizira pakukula kwa zolengedwa izi.

Mwa anthu, imagwira ntchito monga non-Vitamini kukula kwazinthu zambiri zopindulitsa m'thupi.

Njira yogwira ntchito

Pyrroloquinoline quinone (pqq) imawonetsa maubwino ambiri azaumoyo pogwiritsa ntchito njira zosiyanasiyana monga kutsata njira zamma cellular, kuthana ndi ma radicals aulere ndi ntchito ya redox.

Njira za pqq zopangira izi ndi monga:

• Imakhudza momwe majini amagwirira ntchito

Pyrroloquinoline quinone angakhudze momwe majini osiyanasiyana amafotokozedwera komanso makamaka majini omwe amakhudzidwa ndi ntchito ya mitochondria. Ntchito yake yotsutsa antioxidant akuti imakhala nthawi 100 kuposa ya vitamini C.

Kuphatikiza kwa PQQ kwawonetsedwa kuti kwayambitsa njira za CREB ndi PGC-1a zosonyeza zomwe zimakhudzidwa mwachindunji ndi mitochondria biogeneis.

Imagwira ngati antioxidant

Ntchito ya anti-oxidative ya Pyrroloquinoline quine makamaka chifukwa choti imatha kuchepetsedwa PQQH2 kudzera munjira ndi othandizira ochepetsa monga cysteine, glutathione kapena nicotinamide adenine dinucleotide phosphate (NADPH).

• Imalepheretsa michere

Pyrroloquinoline quinone amalepheretsanso enzyme kuchiritsa kwa thioredoxin 1 (TrxR1), yomwe imayambitsa zochitika za Nuclear factor erythroid 2-N factor 2 (Nrf2) yomwe imalimbikitsa kupanga antioxidant.

PQQ idadziwikanso kuti imalepheretsa kukula kwa quinoproteins (mapuloteni owonongeka) omwe amatsogolera ku vuto la Parkinson.

Zopindulitsa zazikulu (PQQ) za pyrroloquinoline quinone

Pali zabwino zambiri za pyrroloquinoline quinone kuphatikiza:

i. PQQ imalimbikitsa ntchito ya mitochondrial

Mitochondria ndi ma organelles omwe amapanga mphamvu mu maselo mu mawonekedwe a ATP kudzera kupuma kwa ma cell. Amakonda kutumiziridwa ku nyumba zamagetsi zamagetsi kapena mafoni.

Kupanga mphamvu ndiye chinsinsi cha kukhala wathanzi.

Kusowa kwa Mitochondrial kwalumikizidwa ndi zovuta zingapo monga kufupika kwa kufalikira, kufooka kwa minofu, vuto la neurodegenerative monga matenda amtima, kukhumudwa ndi matenda ashuga pakati pazinthu zina zathanzi.

Pyrroloquinoline quinone imawonjezera ntchito ya mitochondrial polimbikitsa kupanga maselo atsopano a mitochondria (mitochondrial biogenesis). Izi zimachitika ndikuyambitsa kwa CAMP reaction protein protein 1 (CREB) ndi Peroxisome proliferator-activated receptor-gamma coactivator (PGC) -1alpha, njira zomwe zimakulitsa mitochondrial biogenesis.

Pyrroloquinoline quinone amathandizanso zolemba zomwe zimagwira ngati ma antioxidants mkati mwa mitochondria motero amatiteteza ku kupsinjika kwa oxidative.

Pqq imayambitsa michere mu mitochondria yomwe imawonjezera kupanga mphamvu.

Mu mtundu wa rat, kusowa kwa PQQ muzakudya kunanenedwa kuti kumachepetsa mphamvu ya mitochondrial.

mapindu a pyrroloquinoline quinone

ii. Amasiya kutupa

Kutupa kosalekeza kuli m'munsi mwa zovuta zambiri monga matenda amtima ndi matenda ashuga. Pyrroloquinoline quinone ili ndi antioxidant katundu omwe amathandizira kuti achotsere zopitilira muyeso motero amateteza kutupa ndi kuwonongeka kwa maselo.

Kafukufuku wina akusonyeza kuti PQQ yowonjezera zimapangitsa kutsika kwakukulu kwa zikhomo zambiri zamatenda monga nitric oxide m'masiku atatu okha.

Pakufufuza kwa mbewa zomwe zimadwala nyamakazi, PQQ yomwe idayendetsedwa idanenedwa kuti imateteza ku matenda obwera pambuyo pa masiku 45.

iii. Imasintha thanzi laubongo ndi ntchito

Pyrroloquinoline quinone amatha kukulitsa ubongo kachiwiri (neurogeneis) kudzera pakupanga zinthu zambiri zokulira m'mitsempha.

Kafukufuku wina adatsimikiza kuti pqq yowonjezera imalimbikitsa kukula kwa mitsempha ya mitsempha (NGF) ndi maselo a neuron.

Pyrroloquinoline quinone wakhala akugwirizanitsidwa ndi kukumbukira kwakumbuyo ndi kuphunzira chifukwa chakutha kukonzanso maselo aubongo.

Mu kafukufuku wopangidwa ndi anthu 41 wathanzi koma achikulire, PQQ yoyendetsedwa 20 mg / tsiku kwa masabata 12 idapezeka kuti ikulepheretsa kuchepa kwa ubongo, makamaka pakumvetsera komanso kukumbukira.

Pyrroloquinoline quinone amathanso kuthandizira kupewa kuvulala muubongo.

Mu 2012, kafukufuku wama makoswe adapatsidwa pqq kwa masiku atatu asanavulazidwe koopsa kwa ubongo adapeza kuti chowonjezeracho chidatha kuteteza maselo aubongo kuti asavulale.

iv. PQQ imasintha kugona

Pyrroloquinoline quinone (PQQ) imathandizira kukulitsa kugona kwanu pochepetsa nthawi yomwe mumagona, kumawonjezera nthawi yogona komanso kumathandizanso kugona kwambiri.

Pyrroloquinoline quinone amathanso kuchepetsa kuchuluka kwa mahomoni opsinjika (cortisol) mwa anthu ndipo chifukwa chake amawongolera kugona.

Pakufufuza kwa achikulire 17, PQQ yomwe idaperekedwa pa 20 mg / tsiku kwa masabata a 8 adapezeka kuti akupititsa patsogolo luso la kugona malinga ndi kuchuluka kwa nthawi yogona komanso kugona pang'ono.

PQQ imasintha kugona

v. Amasintha thanzi la mtima

Kutha kwa pyrroloquinoline quinone kuwongolera kuchuluka kwa cholesterol kumapangitsa kuti muchepetse chiopsezo cha matenda a mtima monga stroke.

Pakufufuza kwa akuluakulu 29, kuwonjezereka kwa pqq kwambiri kunachepetsa kuyipa kwama cholesterol a LDL.

Pyrroloquinoline quinone amachepetsa miyeso ya triglycerides yomwe imatsogolera ku ntchito yopambana ya mitochondrial. Pakufufuza ndi makoswe, ppq zoperekedwa zidapezeka kuti zichepetse milingo yawo ya triglyceride.

Pqq yowonjezera ingathandize kupewa kapena kusinthanso kwa atherosulinosis (sitiroko). Kafukufuku wina wawonetsa kuti ppq ikhoza kutsitsa mapuloteni a C-reactive ndi trimethylamine-N-oxide omwe ali ofunikira pazovuta izi.

vi. Wothandizanso kukhala ndi moyo wautali

Pyrroloquinoline quinone amadziwika kuti ndi wopanda vitamini ndipo chifukwa chake amathandizira kukulitsa kukula kwanu komanso kukula.

Ntchito ya Pyrroloquinoline quinone polimbana ndi kutupa, kupewa kupsinjika kwa oxidative ndikuthandizira ntchito ya mitochondrial kumatsimikizira kuthekera kwake pakutalikitsa moyo.

PQQ yatsimikizidwanso kuti iyambitsa ma cell signaling omwe amasinthira kukalamba.

Zotsatira za synergetic zochokera pama njirayi zimapangitsa PQQ kukutetezani ku ukalamba wa m'magwiridwe am'mimba komanso kuwonjezera moyo wautali.

Mu chithunzi cha nyama, kuphatikiza ndi pqq kunapezeka kuti kuchepetsa nkhawa za oxidative komanso kukulitsa nthawi yayitali yazizungulire.

vii. Kutetezedwa ku oxidative nkhawa

PQQ imamangiriza mapuloteni chifukwa chake amalepheretsa makutidwe ndi okosijeni omwe amapezeka m'maselo. Ate era osobola okuggulawo omusango gw'obusungu mu mubiri.

Mu kafukufuku wazinyama, pqq supplementation idapezeka kuti ipewe kufa kwa cell ya oxidative.

Kafukufuku wina adachitika mu m'galasi adanenanso kuti PQQ inateteza maselo a mitochondria akutali kuti asaonongeke pambuyo pa kupsinjika kwa oxidative ndikuchotsa ma raderoxide radical.

Kafukufuku wowonjezeranso ndi mbewa za matenda a shuga a matenda a shuga a Cryptozotocin-ikiwa (STZ), PQQ yoperekedwa pa 20 mg / kg bodyweight kwa masiku 15 adapezeka kuti amachepetsa kuchuluka kwa seramu ya glucose ndi lipid peroxidation, komanso kukulitsa zochitika za antioxidants mu ubongo wama mbewa .

Zina za pyrroloquinoline quinone amagwiritsa ntchito ndipo maphatikizidwe amaphatikizapo:

Kupewa kunenepa

Amasintha chitetezo chamthupi

Amasintha chonde

Imathandizira magwiridwe antchito ndikukumbukira

Amathandizira kulimbana ndi kutopa

M'momwe zinthu ziliri mdziko lapansi, nkhani zoipa chifukwa cha COVID 19 zikubwera nthawi iliyonse. Nkhondo ya Pyrroloquinoline quinone coronavirus ingagwiritsidwe ntchito. Chosangalatsa ichi chidzakulitsa chitetezo chanu komanso kupereka chithandiziro chogona kuti muchepetse nkhawa.

pyrroloquinoline quinone amagwiritsa ntchito

Zotsatira zoyipa za pyrroloquinoline quinone (pqq) ndi ziti?

Mukapeza PQQ kuchokera kumagwero azakudya palibe zotsatira zoyipa zomwe zimyembekezeredwa pokhapokha munthu akakhala kuti alibe chakudya.

M'maphunziro a nyama ndi makoswe, vuto la impso lidalumikizidwa ndi PQQ yowonjezera. Phunziro limodzi lokhala ndi makoswe, PQQ yovulala pa 11-12 mg / kg kulemera kwa thupi imanenedwa kuti imayambitsa kutupa.

Pakufufuza kwina kwa makoswe, PQQ pa 20 mg / kg bodyweight adapezeka kuti ayambitsa kuwonongeka kwa minyewa ya impso ndi hepatic.

Imfa za makoswe zanenedwanso ndi mitundu yayikulu ya 500 mg.

Mwa anthu, palibe mavuto obwera chifukwa cha pyrroloquinoline quinone omwe adanenedwa ndi Mlingo wofika 20 mg / tsiku.

Komabe, pakachitika kawirikawiri, zovuta zina za pyrroloquinoline quinone zimatha kuchitika chifukwa cha kumwa mankhwala ochulukirapo. Zotsatira zoyipa izi zimaphatikizapo kupweteka mutu, kutopa, kugona, kuchepa mphamvu komanso kusowa tulo.

Mlingo wa PQQ

Popeza pyrroloquinoline quinone (pqq) sakavomerezedwa kwathunthu ndi Federal Drug Administration kuti agwiritse ntchito mankhwalawa, palibe muyezo wa pyrroloquinoline quinone womwe wakhazikitsidwa, ngakhale kafukufuku wina apeza kuti pyrroloquinoline quinone Mlingo wochokera pa 2 mg / tsiku ndiwothandiza. Komabe, zowonjezera zambiri za PQQ zili mu Mlingo wa 20 mpaka 40 mg.

Mlingo wa prinone wa quinone zitha kusintha kutengera cholinga chomwe wakonza. Kafukufuku wina akuwonetsa kuti mlingo wa 0.075 mpaka 0.3 mg / kg patsiku umagwira ntchito bwino pakulimbikitsa ntchito ya mitochondria, pomwe mlingo wapamwamba wa pafupifupi 20 mg patsiku ungakhale wofunikira kulimbana ndi kutupa.

Mukamatenga pamodzi ndi COQ10, Mlingo wa 20 mg PQQ ndi 200 mg COQ10 akulangizidwa, ngakhale maphunziro ena akugwiritsa ntchito 20 mg ya PQQ ndi 300 mg COQ10 sanatchulidwe zoyipa zilizonse.

Zowonjezera za PQQ ziyenera kumwedwa pakamwa komanso makamaka musanadye chakudya pamimba yopanda kanthu.

Chifukwa chake mwalangizidwa kwambiri kuti muyambe kuchokera pamiyeso yotsika ndikuwonjezereka pakufunika.

Ndipo chofunikira kudziwa ndikuti maphunziro ambiri salimbikitsa kumwa mlingo wopitilira 80 mg patsiku.

Ndi Zakudya Zanji Zomwe zili ndi pyrroloquinoline quinone (pqq)?

Pyrroloquinoline quinone (pqq) amapezeka muzakudya zambiri zam'mera, ngakhale nthawi zambiri zimakhala zochepa. Zomera zimapeza PQQ mwachindunji kuchokera ku bacteria ndi dothi monga methylotrophic, rhizobium, ndi bacteria wa acetobacter.

Pqq mu minofu yaumunthu imachokera gawo la chakudya komanso pang'ono kuchokera ku kupanga kwa bakiteriya.

Mlingo wa pyrroloquinoline quinine m'magawo azakudya amasiyana kwambiri kuyambira 0.19 mpaka 61ng / g. Komabe, pqq imakhazikika kwambiri mu zakudya zotsatirazi:

Pqq-Zakudya

Zakudya zina za PQQ zimaphatikizira kuphukira kwa broccoli, mpiru wamunda, nyemba za fava, maapulo, mazira, mkate, vinyo ndi mkaka.

Chifukwa cha kuchuluka kwa pqq m'zakudya zambiri, zingakhale zovuta kupeza ndalama zokwanira kulumpha zomwe zimaphatikizidwa ndi pqq pokhapokha titamwa chakudya chochuluka kwambiri. Chifukwa chake izi zimafunika kuti munthu agule zowonjezera pqq kuti zithetse zakudya zabwino.

PQQ ndi COQ10

Coenzyme Q10 (COQ10) nthawi zambiri yomwe imatchedwa mitochondria kupititsa patsogolo kumachitika mthupi laumunthu komanso muzakudya zambiri. Ndizofanana ndi PQQ; Komabe, pyrroloquinoline quinine ndi CQ10 amagwira ntchito m'njira zosiyana kwambiri kapena amagwiritsa ntchito njira zosiyanasiyana pokonzanso magwiridwe antchito a mitochondrial.

Coenzyme Q10 ndi cofactor yofunikira yomwe imagwira ntchito mkati mwa mitochondria ndipo imagwira gawo lofunikira pakupuma kwa ma cell ndi kugwiritsidwa ntchito kwa oxygen pakupanga mphamvu. PQQ inayo imakulitsa kuchuluka kwa maselo a mitochondria komanso kusintha bwino kwa mitochondria.

Tikatenge pamodzi, pyrroloquinoline quinine ndi CQ10, imapereka zotsatira za synergetic pokonzanso gawo la mitochondrial, kutiteteza ku kupsinjika kwa oxidative ndikuwongolera ma signature ama cellular.

Gulani Chowonjezera cha PQQ

Pali zabwino zambiri zosagwiritsidwa ntchito ndi pqq yowonjezera ufa ndipo muyenera kulingalira kuyamika zakudya zanu nacho. PQQ ufa wogulitsa ukupezeka mosavuta pa intaneti. Komabe, pazotsatira zabwino kwambiri khalani ogalamuka mukamagula pqq yowonjezera kuti mupeze zabwino kwambiri.

Ngati mukuganiza zogula pqq chochuluka ufa onetsetsani kuti mwalandira kuchokera kwa omwe amapereka mbiri yabwino.

Zothandizira

  1. Chowanadisai W., Bauerly KA, Tchaparian E., Wong A., Cortopassi GA, Rucker RB (2010). Pyrroloquinoline quinone imalimbikitsa mitochondrial biogenesis kudzera mu cAMP yankho lothandizira-mapuloteni omanga mapuloteni komanso kuchuluka kwa PGC-1α. Biol. Chem. 285: 142–152.
  2. Harris CB1, Chowanadisai W, Mishchuk KUTI, Satre MA, Slupsky CM, Rucker RB. (2013). Zakudya za pyrroloquinoline quinone (PQQ) zimasintha zomwe zimayambitsa matenda a metabolism komanso mitochondrial okhudzana ndi maphunziro aumunthu. J Nutritional Biochem.Dis; 24 (12): 2076-84. Doi: 10.1016 / j.jnutbio.2013.07.008.
  3. Kumazawa T., Sato K., Seno H., Ishii A., ndi Suzuki O. (1995). Mitundu ya pyrroloquinoline quinone mu zakudya zosiyanasiyana. J.307: 331-333.
  4. Nunome K., Miyazaki S., Nakano M., Iguchi-Ariga S., Ariga H. (2008). Pyrroloquinoline quinone amalepheretsa kufa kwa okosijeni a oxidative mwina kudzera mu kusintha kwa oxidative a DJ-1. Mankhwala. Bull. 31: 1321–1326.
  5. Paul Hwang & Darryn S. Willoughby (2018). Mechanisms Behind Pyrroloquinoline Quinone Supplement on Skeletal Muscle Mitochondrial Biogenesis: Zotheka Zotsatira za Synergistic Zolimbitsa Thupi, Journal of the American College of Nutrition, 37: 8, 738-748, DOI: 1080 / 07315724.2018.1461146.
  6. Amasokoneza T, Storms D, ndi Bauerly K, et al. (2006). Mawu athunthu: Pyrroloquinoline quinone modulates kuchuluka kwa mitochondrial ndikugwira ntchito pa mbewa. J Nutriti. Feb; 136 (2): 390-6.
  7. Zhang L, Liu J, Cheng C, Yuan Y, Yu B, Shen A, Yan M. (2012). Mphamvu ya neuroprotective ya pyrroloquinoline quinone pakumva kuwonongeka kwa ubongo. J Neurotrauma. Mar 20; 29 (5): 851-64.

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